Cited by 530Bacterial biofilms and quorum sensingBacterial Genetics and BiotechnologyMicrobial Community Ecology and Physiology

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Bacteria as Multicellular Organisms

Shapiro, James A.·1988·Scientific American

DOI 10.1038/scientificamerican0688-82

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Items 101–200 of 530

Characterization of Proteus mirabilis Precocious Swarming Mutants: Identification of rsbA , Encoding a Regulator of Swarming Behavior
Belas, R., Schneider, R. E., & Melch, M. (1998) · Journal of Bacteriology · doi:10.1128/jb.180.23.6126-6139.1998 · Cited by 111
Quorum sensing and the cell-cell communication dependent regulation of gene expression in pathogenic and non-pathogenic bacteria
Hardman, A., Stewart, G. S. A. B., & Williams, P. M. (1998) · Antonie van Leeuwenhoek · doi:10.1023/a:1001178702503 · Cited by 109
Biological emergences: evolution by natural experiment
(2007) · Choice Reviews Online · doi:10.5860/choice.45-1451 · Cited by 106
Seeking the foundations of cognition in bacteria: From Schrödinger's negative entropy to latent information
Jacob, E. B., Shapira, Y., & Tauber, A. I. (2005) · Physica A Statistical Mechanics and its Applications · doi:10.1016/j.physa.2005.05.096 · Cited by 101
“cellular community., It has been proposed [ 7-15 ] that these fundamental cognitive”
Background
Formation of colony patterns by a bacterial cell population
Matsushita, M., Wakita, J.-I., Itoh, H., et al. (1999) · Physica A Statistical Mechanics and its Applications · doi:10.1016/s0378-4371(99)00328-3 · Cited by 102
A Cellulose Synthase-Like Protein Involved in Hyphal Tip Growth and Morphological Differentiation in Streptomyces
Xu, H., Chater, K. F., Deng, Z., & Tao, M. (2008) · Journal of Bacteriology · doi:10.1128/jb.01849-07 · Cited by 99
Emergence is coupled to scope, not level
Ryan, A. (2007) · Complexity · doi:10.1002/cplx.20203 · Cited by 102
“Anabaena spatially separates the processes in separate heterocysts and passes the products between cells using filaments [35].”
Background
Mammalian hormones in microbial cells
Lenard, J. (1992) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(92)90323-2 · Cited by 98
Is Bacterial Persistence a Social Trait?
Gardner, A., West, S. A., & Griffin, A. S. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000752 · Cited by 94
“The prevalent view within the microbial literature is that this behaviour can explained by benefits accruing at the level of the population, since persister cells represent an insurance policy that permits population survival in the event of catastrophe [2–3,10,13–15].”
Background
Biofilms formed by the archaeon Haloferax volcaniiexhibit cellular differentiation and social motility, and facilitate horizontal gene transfer
Chimileski, S., Franklin, M. J., & Papke, R. T. (2014) · BMC Biology · doi:10.1186/s12915-014-0065-5 · Cited by 98
“Biofilms may aid in nutrient acquisition and storage [5], facilitate accelerated rates of recombination [9,10] and allow for coordinated multicellular behaviors [11–15].”
Background
Kinetic model of Proteus mirabilis swarm colony development
Esipov, S. E., & Shapiro, J. A. (1998) · Journal of Mathematical Biology · doi:10.1007/s002850050100 · Cited by 98
Self-citation
Understanding Multicellularity: The Functional Organization of the Intercellular Space
Bich, L., Pradeu, T., & Moreau, J. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.01170 · Cited by 107
“That should not be a surprise, given the importance of the social/communitarian dimension of life (Shapiro, 1988), which has inspired even possible scenarios on origins of life as emerging from colonies of protocells (Woese, 2002; Carrara et al., 2012; Mansy, 2017).”
BackgroundInfluential
Hyphal Death during Colony Development in Streptomyces antibioticus: Morphological Evidence for the Existence of a Process of Cell Deletion in a Multicellular Prokaryote
Miguélez, E. M., Hardisson, C., & Manzanal, M. B. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.145.3.515 · Cited by 94
“Members of the genus Streptomyces (mycelial gram-positive soil bacteria) possess two characteristics which make them attractive microorganisms for the study of cell death at the prokaryote level: first, unlike Escherichia coli (the most studied and best known single-cell prokaryote), which continuously divides by bina…”
Background
Direct analysis of clinical relevant single bacterial cells from cerebrospinal fluid during bacterial meningitis by means of micro‐Raman spectroscopy
Harz, M., Kiehntopf, M., Stöckel, S., Rösch, P., Straube, E., Deufel, T., & Popp, J. (2009) · Journal of Biophotonics · doi:10.1002/jbio.200810068 · Cited by 94
All living cells are cognitive
Shapiro, J. A. (2020) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.08.120 · Cited by 100
Self-citation
Constructal pattern formation in stony corals, bacterial colonies and plant roots under different hydrodynamics conditions
Miguel, A. F. (2006) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2006.05.010 · Cited by 92
“We show that in order to persist in time, these systems must evolve in such a way that an easy access to nutrients is ensured: their shapes develop in such a way as to minimize the time to reach the nutrient source.”
Background
Probiotics and Psychobiotics: the Role of Microbial Neurochemicals
Oleskin, A. V., & Ba, S. (2019) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-019-09583-0 · Cited by 94
“This fact was mentioned by James Shapiro [35] who highlighted important similarities between bacterial supracellular structures and multicellular organisms.”
Background
LuxR- and Acyl-Homoserine-Lactone-Controlled Non- lux Genes Define a Quorum-Sensing Regulon in Vibrio fischeri
Callahan, S. M., & Dunlap, P. V. (2000) · Journal of Bacteriology · doi:10.1128/jb.182.10.2811-2822.2000 · Cited by 90
A microbial hormone, A-factor, as a master switch for morphological differentiation and secondary metabolism in streptomyces griseus
Horinouchi, S. (2002) · Frontiers in bioscience · doi:10.2741/horinouc · Cited by 90
An Evolutionary Model of Bounded Rationality and Intelligence
Brennan, T. J., & Lo, A. W. (2012) · PLoS ONE · doi:10.1371/journal.pone.0050310 · Cited by 89
“This perspective has received more recent support from the discovery of remarkably sophisticated social behavior among bacteria [68–76].”
Background
Escherichia coli K-12 cell-cell interactions seen by time-lapse video
Shapiro, J. A., & Hsu, C. (1989) · Journal of Bacteriology · doi:10.1128/jb.171.11.5963-5974.1989 · Cited by 89
Self-citation
Chemomodulation of cellular movement, collective formation of vortices by swarming bacteria, and colonial development
Ben‐Jacob, E., Cohen, I., Czirók, A., et al. (1997) · Physica A Statistical Mechanics and its Applications · doi:10.1016/s0378-4371(96)00457-8 · Cited by 89
Coaggregation between Aquatic Bacteria Is Mediated by Specific-Growth-Phase-Dependent Lectin-Saccharide Interactions
Rickard, A. H., Leach, S. A., Buswell, C. M., et al. (2000) · Applied and Environmental Microbiology · doi:10.1128/aem.66.1.431-434.2000 · Cited by 88
Dynamics of FtsZ Assembly during Sporulation in Streptomyces coelicolor A3(2)
Grantcharova, N., Lustig, U., & Flärdh, K. (2005) · Journal of Bacteriology · doi:10.1128/jb.187.9.3227-3237.2005 · Cited by 86
Heterocyst formation in Anabaena
Golden, J. W., & Yoon, H. (1998) · Current Opinion in Microbiology · doi:10.1016/s1369-5274(98)80106-9 · Cited by 86
Drivers of Spatial Structure in Social Microbial Communities
Yanni, D., Márquez-Zacarías, P., Yunker, P. J., et al. (2019) · Current Biology · doi:10.1016/j.cub.2019.03.068 · Cited by 85
Increased stress tolerance of Bifidobacterium longum and Lactococcus lactis produced during continuous mixed-strain immobilized-cell fermentation
Doleyres, Y., Fliss, I., & Lacroix, C. (2004) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2004.02326.x · Cited by 84
“In 1997, enhanced cell-to-cell signalling and cell– matrix interactions leading to coordinated behaviour of immobilized microorganisms were reported (Shapiro and Dworkin 1997).”
Background
Do Bacterial Communities Transcend Darwinism?
Caldwell, D. E., Wolfaardt, G. M., Korber, D. R., & Lawrence, J. R. (1997) · Advances in microbial ecology · doi:10.1007/978-1-4757-9074-0_4 · Cited by 84
Evolution ‘on purpose’: how behaviour has shaped the evolutionary process
Corning, P. A. (2013) · Biological Journal of the Linnean Society · doi:10.1111/bij.12061 · Cited by 84
Minimalist Coherent Swarming of Wireless Networked Autonomous Mobile Robots
Nembrini, J., Winfield, A. F. T., & Melhuish, C. (2002) · The MIT Press eBooks · doi:10.7551/mitpress/3121.003.0064 · Cited by 80
The evolution of the mammalian pharynx
Smith, K. K. (1992) · Zoological Journal of the Linnean Society · doi:10.1111/j.1096-3642.1992.tb00926.x · Cited by 80
Plasticity of Candida albicans Biofilms
Soll, D. R., & Daniels, K. J. (2016) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00068-15 · Cited by 86
A novel role for RecA under non-stress: promotion of swarming motility in Escherichia coli K-12
Gómez‐Gómez, J., Manfredi, C., Alonso, J. C., & Blázquez, J. (2007) · BMC Biology · doi:10.1186/1741-7007-5-14 · Cited by 76
The SsgA-like proteins in actinomycetes: small proteins up to a big task
Traag, B. A., & van Wezel, G. P. (2008) · Antonie van Leeuwenhoek · doi:10.1007/s10482-008-9225-3 · Cited by 76
Smart Swarms of Bacteria-Inspired Agents with Performance Adaptable Interactions
Shklarsh, A., Ariel, G., Schneidman, E., & Ben‐Jacob, E. (2011) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1002177 · Cited by 78
“They construct intricate multicellular structures utilized for protection and cooperation of cells [30–33].”
Background
Control by A-Factor of a Metalloendopeptidase Gene Involved in Aerial Mycelium Formation in Streptomyces griseus
Kato, J., Suzuki, A., Yamazaki, H., et al. (2002) · Journal of Bacteriology · doi:10.1128/jb.184.21.6016-6025.2002 · Cited by 75
Social behavior of bacteria: from physics to complex organization
Ben‐Jacob, E. (2008) · The European Physical Journal B · doi:10.1140/epjb/e2008-00222-x · Cited by 71
“It then collectively expands by both gliding movements and cell division growth towards the newly detected food source [ 4 ].”
Background
Levels of selection in biofilms: multispecies biofilms are not evolutionary individuals
Clarke, E. (2016) · Biology & Philosophy · doi:10.1007/s10539-016-9517-3 · Cited by 75
Characterization of the Sequence Specificity Determinants Required for Processing and Control of Sex Pheromone by the Intramembrane Protease Eep and the Plasmid-Encoded Protein PrgY
Chandler, J. R., & Dunny, G. M. (2007) · Journal of Bacteriology · doi:10.1128/jb.01327-07 · Cited by 71
A Novel Membrane Protein Influencing Cell Shape and Multicellular Swarming of Proteus mirabilis
Hay, N. A., Tipper, D. J., Gygi, D., et al. (1999) · Journal of Bacteriology · doi:10.1128/jb.181.7.2008-2016.1999 · Cited by 71
“Intimate cell-cell contact in rafts may be essential for the coordination of flagellar function and intercellular communication (32), and single cells detached from swarm rafts do not migrate.”
Background
Bacillus atrophaeus: main characteristics and biotechnological applications – a review
Sella, S. R. B. R., Vandenberghe, L. P. D. S., & Soccol, C. R. (2014) · Critical Reviews in Biotechnology · doi:10.3109/07388551.2014.922915 · Cited by 72
Bacterial cooperative organization under antibiotic stress
Ben-Jacob, E., Cohen, I., Golding, I., Gutnick, D., Tcherpakov, M., Helbing, D., & Ron, I. G. (2000) · Physica A Statistical Mechanics and its Applications · doi:10.1016/s0378-4371(00)00093-5 · Cited by 72
Localization and Extinction of Bacterial Populations under Inhomogeneous Growth Conditions
Lin, A. L., Mann, B. A., Torres‐Oviedo, G., et al. (2004) · Biophysical Journal · doi:10.1529/biophysj.103.034041 · Cited by 68
“Studies of bacterial growth in homogeneous environments have revealed the spontaneousformation of different spatial patterns in response to environmental stresses (Shapiro and Dworkin, 1997; Berg and Purcell, 1977; Ben-Jacob et al., 1994; Matsushita et al., 1998).”
BackgroundInfluential
Dance of the microswimmers
Lauga, E., & Goldstein, R. E. (2012) · Physics Today · doi:10.1063/pt.3.1715 · Cited by 67
Getting Bacteria in Shape: Synthetic Morphology Approaches for the Design of Efficient Microbial Cell Factories
Volke, D. C., & Nikel, P. I. (2018) · Advanced Biosystems · doi:10.1002/adbi.201800111 · Cited by 66
Rock-scissors-paper game in a chaotic flow: The effect of dispersion on the cyclic competition of microorganisms
Károlyi, G., Neufeld, Z., & Scheuring, I. (2005) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2005.02.012 · Cited by 65
The Paleoproterozoic megascopic Stirling biota
Bengtson, S., Rasmussen, B., & Krapež, B. (2007) · Paleobiology · doi:10.1666/04040.1 · Cited by 69
Adhesion of Biodegradative Anaerobic Bacteria to Solid Surfaces
van Schie, P. M., & Fletcher, M. M. (1999) · Applied and Environmental Microbiology · doi:10.1128/aem.65.11.5082-5088.1999 · Cited by 66
Origin of multicellular organisms as an inevitable consequence of dynamical systems
Furusawa, C., & Kaneko, K. (2002) · The Anatomical Record · doi:10.1002/ar.10164 · Cited by 65
“On the other hand, the differentiation itself (stated as the property II) has a broader generality (Ko et al., 1994; Shapiro and Dworkin, 1997).”
Background
Trail following in ants: individual properties determine population behaviour
Edelstein‐Keshet, L., Watmough, J., & Ermentrout, G. B. (1995) · Behavioral Ecology and Sociobiology · doi:10.1007/bf00170717 · Cited by 65
“At the smallest size scale, unicellular organisms such as myxobacteria (Stanier 1942; Shapiro 1988) secrete slime trails.”
Background
Tar-dependent and -independent pattern formation by Salmonella typhimurium
Blat, Y., & Eisenbach, M. (1995) · Journal of Bacteriology · doi:10.1128/jb.177.7.1683-1691.1995 · Cited by 65
The Level of AdpA Directly Affects Expression of Developmental Genes in Streptomyces coelicolor
Wolański, M., Donczew, R., Kois, A., et al. (2011) · Journal of Bacteriology · doi:10.1128/jb.05734-11 · Cited by 64
Bacterial wisdom, Gödel's theorem and creative genomic webs
Ben‐Jacob, E. (1998) · Physica A Statistical Mechanics and its Applications · doi:10.1016/s0378-4371(97)00529-3 · Cited by 60
“Only recently have the notions of smart bacteria [30,31] and bacteria as multicellular organism [22,30, 32–40] (both with respect to bacterial colonies) started to gain attention.”
Background
Matrix Production and Sporulation in Bacillus subtilis Biofilms Localize to Propagating Wave Fronts
Srinivasan, S., Vladescu, I. D., Koehler, S. A., et al. (2018) · Biophysical Journal · doi:10.1016/j.bpj.2018.02.002 · Cited by 63
Models for contact-mediated pattern formation: cells that form parallel arrays
Edelstein‐Keshet, L., & Ermentrout, B. (1990) · Journal of Mathematical Biology · doi:10.1007/bf00173908 · Cited by 62
“Niibler-Jung (1987) suggested that in a field with two parallel boundaries, the pattern of orientations will simplify into a single parallel array, but we have shown that this property is not dependent on the boundaries.”
Background
The mechanisms responsible for 2-dimensional pattern formation in bacterial macrofiber populations grown on solid surfaces: fiber joining and the creation of exclusion zones
Mendelson, N. H., Morales, D. A., & Thwaites, J. J. (2002) · BMC Microbiology · doi:10.1186/1471-2180-2-1 · Cited by 62
Theory of periodic swarming of bacteria: Application to Proteus mirabilis
Czirók, A., Matsushita, M., & Vicsek, T. (2001) · Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics · doi:10.1103/physreve.63.031915 · Cited by 62
“Therefore, a number of recent studies have focussed on experimental and theoretical aspects of colony formation and the related collective behavior of microorganisms [1,2].”
Background
Genome Informatics: The Role of DNA in Cellular Computations
Shapiro, J. A. (2006) · Biological Theory · doi:10.1162/biot.2006.1.3.288 · Cited by 59
Self-citation
Mutations that impair swarming motility in Serratia marcescens 274 include but are not limited to those affecting chemotaxis or flagellar function
O’Rear, J. J., Alberti, L., & Harshey, R. M. (1992) · Journal of Bacteriology · doi:10.1128/jb.174.19.6125-6137.1992 · Cited by 60
“These interactions have been shown to be important in ecology, medicine and industry (6, 27).”
Background
Genome-Wide Analysis of In Vivo Binding of the Master Regulator DasR in Streptomyces coelicolor Identifies Novel Non-Canonical Targets
Świątek, M., Bucca, G., Laing, E., Gubbens, J., Titgemeyer, F., Smith, C. P. S., Rigali, S., & van Wezel, G. P. (2015) · PLoS ONE · doi:10.1371/journal.pone.0122479 · Cited by 58
ATP-Binding Cassette Transport System Involved in Regulation of Morphological Differentiation in Response to Glucose in Streptomyces griseus
Seo, J.-W., Ohnishi, Y., Hirata, A., & Horinouchi, S. (2002) · Journal of Bacteriology · doi:10.1128/jb.184.1.91-103.2002 · Cited by 59
Genes without prominence: a reappraisal of the foundations of biology
Annila, A., & Baverstock, K. (2014) · Journal of The Royal Society Interface · doi:10.1098/rsif.2013.1017 · Cited by 59
“It also seems likely that bacteria operate on a one-to-one basis between coding sequence and phenotype, but achieve complex traits by cooperation between diverse species/strains [64].”
Background
Cytological and biochemical evidence for an early cell dismantling event in surface cultures of Streptomyces antibioticus
Manteca, Á., Fernández, M., & Sánchez, J. (2005) · Research in Microbiology · doi:10.1016/j.resmic.2005.07.003 · Cited by 57
Physical schemata underlying biological pattern formation—examples, issues and strategies
Levine, H., & Ben‐Jacob, E. (2004) · Physical Biology · doi:10.1088/1478-3967/1/2/p01 · Cited by 57
“On the positive side lie a vast array of microorganism colony structures (in Bacillus and related species [1], in myxobacteria [2] and in eukaryotes such as Dictyostelium [3]) and intracellular waves [4]; other unproven possibilities include activity-dependent structures in the developing nervous system, tropical fish…”
Background
Dynamics of pattern formation in bacterial swarms
Steager, E. B., Kim, C.-B., & Kim, M. J. (2008) · Physics of Fluids · doi:10.1063/1.2953245 · Cited by 57
Studying the Dynamics of Flagella in Multicellular Communities of Escherichia coli by Using Biarsenical Dyes
Copeland, M. F., Flickinger, S. T., Tuson, H. H., & Weibel, D. B. (2009) · Applied and Environmental Microbiology · doi:10.1128/aem.02153-09 · Cited by 56
“Dworkin and Shapiro were the first to describe the presence of this zone on a swarm plate (21).”
Background
The Order of Trait Emergence in the Evolution of Cyanobacterial Multicellularity
Hammerschmidt, K., Landan, G., Tria, F. D. K., Alcorta, J., & Dagan, T. (2020) · Genome Biology and Evolution · doi:10.1093/gbe/evaa249 · Cited by 51
“Several studies in the literature thus used Gloeobacter for rooting the cyanobacterial species tree (e.g., Shih et al. 2012; Shi & Falkowski 2008; Dagan et al. 2013; Sánchez-Baracaldo et al. 2014) .”
Background
Cross-membranes orchestrate compartmentalization and morphogenesis in Streptomyces
Celler, K., Koning, R. I., Willemse, J. J., Koster, A. J., & van Wezel, G. P. (2016) · Nature Communications · doi:10.1038/ncomms11836 · Cited by 51
Sequential events in bacterial colony morphogenesis
Shapiro, J. A., & Trubatch, D. (1991) · Physica D Nonlinear Phenomena · doi:10.1016/0167-2789(91)90209-r · Cited by 54
Self-citation
Genome sequence of the pattern forming Paenibacillus vortex bacterium reveals potential for thriving in complex environments
Sirota‐Madi, A., Olender, T., Helman, Y., Ingham, C. J., Brainis, I., Roth, D., Hagi, E., Brodsky, L., Leshkowitz, D., Galatenko, V., et al. (2010) · BMC Genomics · doi:10.1186/1471-2164-11-710 · Cited by 52
Comparative effects of various commercially available mouthrinse formulations on oral malodour
Saad, S., Greenman, J., & Shaw, H. (2010) · Oral Diseases · doi:10.1111/j.1601-0825.2010.01714.x · Cited by 52
Bacteria harnessing complexity
Jacob, E. B., Aharonov, Y., & Shapira, Y. (2004) · Biofilms · doi:10.1017/s1479050505001596 · Cited by 52
A novel locus for mycelial aggregation forms a gateway to improved Streptomyces cell factories
van Dissel, D., Claessen, D., Roth, M., & van Wezel, G. P. (2015) · Microbial Cell Factories · doi:10.1186/s12934-015-0224-6 · Cited by 51
On the advantages of information sharing
Lachmann, M., Sella, G., & Jablonka, E. (2000) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2000.1140 · Cited by 52
Structured morphological modeling as a framework for rational strain design of Streptomyces species
Celler, K., Picioreanu, C., van Loosdrecht, M. C. M., et al. (2012) · Antonie van Leeuwenhoek · doi:10.1007/s10482-012-9760-9 · Cited by 51
Nanoscale Visualization of a Fibrillar Array in the Cell Wall of Filamentous Cyanobacteria and Its Implications for Gliding Motility
Read, N., Connell, S. D., & Adams, D. G. (2007) · Journal of Bacteriology · doi:10.1128/jb.00706-07 · Cited by 50
Synthetic transitions: towards a new synthesis
Solé, R. V. (2016) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2015.0438 · Cited by 45
“Bacteria in particular exhibit multicellular traits [125] specially in the face of high-stress events [126,127].”
Background
Influence of Structural Properties and Kinetic Constraints on Bacillus cereus Growth
Stecchini, M. L., Torre, M. D., Sarais, I., et al. (1998) · Applied and Environmental Microbiology · doi:10.1128/aem.64.3.1075-1078.1998 · Cited by 50
An Evolutionary Stress-Response Hypothesis for Chronic Widespread Pain (Fibromyalgia Syndrome)
Lyon, P., Cohen, M. L., & Quintner, J. L. (2011) · Pain Medicine · doi:10.1111/j.1526-4637.2011.01168.x · Cited by 50
Modulation of bacterial multicellularity via spatio-specific polysaccharide secretion
Islam, S. T., Alvarez, I. V., Saïdi, F., Guiseppi, A., VINOGRADOV, E. V., Sharma, G., Espinosa, L., Morrone, C., Brasseur, G., Guillemot, J.-F., et al. (2020) · PLoS Biology · doi:10.1371/journal.pbio.3000728 · Cited by 46
Serrawettins and Other Surfactants Produced by Serratia
Matsuyama, T., Tanikawa, T., & Nakagawa, Y. (2010) · Microbiology monographs · doi:10.1007/978-3-642-14490-5_4 · Cited by 49
Differential activity of a transposable element in Escherichia coli colonies
Shapiro, J. A., & Higgins, N. (1989) · Journal of Bacteriology · doi:10.1128/jb.171.11.5975-5986.1989 · Cited by 52
Self-citation
Not plants or animals: a brief history of the origin of Kingdoms Protozoa, Protista and Protoctista.
Scamardella, J. M. (1999) · PubMed · Cited by 49
Colonial organization and intercellular communication in microorganisms
Oleskin, A. V., Botvinko, V., & Tsavkelova, E. A. (2000) · Microbiology · doi:10.1007/bf02756730 · Cited by 48
SmeA, a small membrane protein with multiple functions in Streptomyces sporulation including targeting of a SpoIIIE/FtsK‐like protein to cell division septa
Ausmees, N., Wahlstedt, H., Bagchi, S., et al. (2007) · Molecular Microbiology · doi:10.1111/j.1365-2958.2007.05877.x · Cited by 48
Engineering of N-acetylglucosamine metabolism for improved antibiotic production in Streptomyces coelicolor A3(2) and an unsuspected role of NagA in glucosamine metabolism
Świątek, M., Urem, M., Tenconi, E., et al. (2012) · Bioengineered · doi:10.4161/bioe.21371 · Cited by 47
The Microbial Ecology of Dental Caries
Bowden, G. H. (2000) · Microbial Ecology in Health and Disease · doi:10.3402/mehd.v12i3.8194 · Cited by 47
Replisome Localization in Vegetative and Aerial Hyphae of Streptomyces coelicolor
Ruban-Ośmiałowska, B., Jakimowicz, D., Smulczyk-Krawczyszyn, A., et al. (2006) · Journal of Bacteriology · doi:10.1128/jb.00940-06 · Cited by 43
Autoregulation of stress response in microorganisms
Nikolaev, Y. A., Mulyukin, A. L., Stepanenko, I. Y., et al. (2006) · Microbiology · doi:10.1134/s0026261706040096 · Cited by 42
BACTERIA AS MODULAR ORGANISMS
Andrews, J. H. (1998) · Annual Review of Microbiology · doi:10.1146/annurev.micro.52.1.105 · Cited by 42
Analysis of novel kitasatosporae reveals significant evolutionary changes in conserved developmental genes between Kitasatospora and Streptomyces
Girard, G., Willemse, J. J., Zhu, H., Claessen, D., Bukarasam, K., Goodfellow, M., & van Wezel, G. P. (2014) · Antonie van Leeuwenhoek · doi:10.1007/s10482-014-0209-1 · Cited by 41
Self-regulation in self-propelled nematic fluids
Baskaran, A., & Marchetti, M. C. (2012) · The European Physical Journal E · doi:10.1140/epje/i2012-12095-8 · Cited by 40
Chemotactic-based adaptive self-organization during colonial development
Cohen, I., Czirók, A., & Ben‐Jacob, E. (1996) · Physica A Statistical Mechanics and its Applications · doi:10.1016/s0378-4371(96)00247-6 · Cited by 40
Microbiota of Cheese Ecosystems: A Perspective on Cheesemaking
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“Even the interaction with the surrounding environment can be crucial for defining cellular cooperation and the evolution of microbial communities [16–20].”
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Biofilms as a Mode of Existence of Bacteria in External Environment and Host Body: The Phenomenon, Genetic Control, and Regulation Systems of Development
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Studies of sector formation in expanding bacterial colonies
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“ulation, as well as an interesting and important subject by itself. During the course of evolution, bacteria have developed sophisticated cooperative behavior and intricate communication capabilities [16,17,18,19,20]. These include: direct cell-cell physical interactions via extra- membrane polymers [21,22], collectiv…”
Background
DNA replication during sporulation in Myxococcus xanthus fruiting bodies
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Authors: Shapiro, J. A.
Corresponding author: Shapiro, James A.
ORCID: Shapiro, James A.
Venue: Scientific American
Publisher: Springer Science and Business Media LLC
Published: 1988-06
Volume: 258
Issue: 6
Pages: 82-89
ISSN: 0036-8733 (ISSN-L)
DOI: 10.1038/scientificamerican0688-82
OpenAlex: W2037294630
Cited by: 524
References: 0
Citations by year: 2026: 3 · 2025: 13 · 2024: 12 · 2023: 11 · 2022: 4 · 2021: 15 · 2020: 10 · 2019: 11 · 2018: 12 · 2017: 11 · 2016: 18 · 2015: 17 · 2014: 20 · 2013: 13 · 2012: 21
FWCI: 2.37
Type: journal article
Language: en
Open access: closed
Locations: Scientific American (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Physical Sciences › Environmental Science › Ecology › Microbial Community Ecology and Physiology
Keywords: bacteria, multicellularity, bacterial aggregation, bacterial social behavior, biofilm

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