The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Prognostic value of Dicer expression in human breast cancers and association with the mesenchymal phenotype
Open accessAbstract
BACKGROUND: Dicer, a ribonuclease, is the key enzyme required for the biogenesis of microRNAs and small interfering RNAs and is essential for both mammalian development and cell differentiation. Recent evidence indicates that Dicer may also be involved in tumourigenesis. However, no studies have examined the clinical significance of Dicer at both the RNA and the protein levels in breast cancer. METHODS: In this study, the biological and prognostic value of Dicer expression was assessed in breast cancer cell lines, breast cancer progression cellular models, and in two well-characterised sets of breast carcinoma samples obtained from patients with long-term follow-up using tissue microarrays and quantitative reverse transcription-PCR. RESULTS: We have found that Dicer protein expression is significantly associated with hormone receptor status and cancer subtype in breast tumours (ER P=0.008; PR P=0.019; cancer subtype P=0.023, luminal A P=0.0174). Dicer mRNA expression appeared to have an independent prognostic impact in metastatic disease (hazard ratio=3.36, P=0.0032). In the breast cancer cell lines, lower Dicer expression was found in cells harbouring a mesenchymal phenotype and in metastatic bone derivatives of a breast cancer cell line. These findings suggest that the downregulation of Dicer expression may be related to the metastatic spread of tumours. CONCLUSION: Assessment of Dicer expression may facilitate prediction of distant metastases for patients suffering from breast cancer.
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Cites
MicroRNA Gene Expression Deregulation in Human Breast Cancer
Iorio, M. V., Ferracin, M., Liu, C.-G., Veronese, A., Spizzo, R., Sabbioni, S., Magri, E., Pedriali, M., Fabbri, M., Campiglio, M., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1783 · Cited by 4,053
A Mammalian microRNA Expression Atlas Based on Small RNA Library Sequencing
Landgraf, P., Rusu, M., Sheridan, R., Sewer, A., Iovino, N., Aravin, A., Pfeffer, S., Rice, A., Kamphorst, A. O., Landthaler, M., et al. (2007) · Cell · doi:10.1016/j.cell.2007.04.040 · Cited by 3,626
Widespread changes in protein synthesis induced by microRNAs
Selbach, M., Schwanhäusser, B., Thierfelder, N., Fang, Z., Khanin, R., & Rajewsky, N. (2008) · Nature · doi:10.1038/nature07228 · Cited by 3,429 · cited 4×
“In some cancer cells, let-7 downregulation may render the long 30UTR variants accessible to other miRNAs or RNA binding proteins that affect mRNA stability and thus may lead to a switch in the variant’s downregulation (Selbach et al, 2008).”
BackgroundInfluentialHuman breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells
Elenbaas, B., Spirio, L., Koerner, F., Fleming, M. D., Zimonjic, D. B., Donaher, J. L., Popescu, N. C., Hahn, W. C., & Weinberg, R. A. (2001) · Genes & Development · doi:10.1101/gad.828901 · Cited by 878
Characterization of Dicer-deficient murine embryonic stem cells
Murchison, E. P., Partridge, J. F., Tam, O. H., Cheloufi, S., & Hannon, G. J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505479102 · Cited by 800
Cited by
MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review
Iorio, M. V., & Croce, C. M. (2012) · EMBO Molecular Medicine · doi:10.1002/emmm.201100209 · Cited by 1,739
Cancer Exosomes Perform Cell-Independent MicroRNA Biogenesis and Promote Tumorigenesis
Melo, S. A., Sugimoto, H., O’Connell, J. T., Kato, N., Villanueva, A., Vidal, A., Qiu, L., Vitkin, E., Perelman, L. T., Melo, C. A., et al. (2014) · Cancer Cell · doi:10.1016/j.ccell.2014.09.005 · Cited by 1,531
p53 and its mutants in tumor cell migration and invasion
Muller, P. A. J., Vousden, K. H., & Norman, J. C. (2011) · Journal of Cell Biology · doi:10.1083/jcb.201009059 · Cited by 463
Recurrent Somatic DICER1 Mutations in Nonepithelial Ovarian Cancers
Heravi-Moussavi, A., Anglesio, M. S., Cheng, S.-W. G., Senz, J., Yang, W., Prentice, L., Fejes, A. P., Chow, C., Tone, A., Kalloger, S. E., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1102903 · Cited by 466
Control of metastatic progression by microRNA regulatory networks
Pencheva, N., & Tavazoie, S. F. (2013) · Nature Cell Biology · doi:10.1038/ncb2769 · Cited by 295
Metadata
- Authors
- Grelier, G., Voirin, N., Ay, A.-S., Cox, D. G., Chabaud, S., Treilleux, I., Léon-Goddard, S., Rimokh, R., Mikaelian, I., Venoux, C., Puisieux, A., Lasset, C., & Moyret-Lalle, C.
- Venue
- British Journal of Cancer
- Published
- 2009-08
- Volume
- 101
- Issue
- 4
- Pages
- 673-683
- ISSN
- 0007-0920 (ISSN-L)
- 1532-1827
- OpenAlex
- W2019805139
- Cited by
- 198
- References
- 5
- FWCI
- 6.31
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Grelier, G., Voirin, N., Ay, A.-S., Cox, D. G., Chabaud, S., Treilleux, I., Léon-Goddard, S., Rimokh, R., Mikaelian, I., Venoux, C., Puisieux, A., Lasset, C., & Moyret-Lalle, C. (2009). Prognostic value of Dicer expression in human breast cancers and association with the mesenchymal phenotype. British Journal of Cancer. https://doi.org/10.1038/sj.bjc.6605193
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