The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Antihypertensive effects of the flavonoid quercetin in spontaneously hypertensive rats
Open accessAbstract
The effects of an oral daily dose (10 mg kg−1) of the flavonoid quercetin for 5 weeks in spontaneously hypertensive (SHR) and normotensive Wistar Kyoto rats (WKY) were analysed. Quercetin induced a significant reduction in systolic (−18%), diastolic (−23%) and mean (−21%) arterial blood pressure and heart rate (−12%) in SHR but not in WKY rats. The left ventricular weight index and the kidney weight index in vehicle‐treated SHR were significantly greater than in control WKY and these parameters were significantly reduced in quercetin‐treated SHR in parallel with the reduction in systolic blood pressure. Quercetin had no effect on the vasodilator responses to sodium nitroprusside or to the vasoconstrictor responses to noradrenaline or KCl but enhanced the endothelium‐dependent relaxation to acetylcholine (E max=58±5%vs 78±5%, P<0.01) in isolated aortae. The 24 h urinary isoprostane F 2α excretion and the plasma malonyldialdehyde (MDA) levels in SHR rats were increased as compared to WKY rats. However, in quercetin‐treated SHR rats both parameters were similar to those of vehicle‐treated WKY. These data demonstrate that quercetin reduces the elevated blood pressure, the cardiac and renal hypertrophy and the functional vascular changes in SHR rats without effect on WKY. These effects were associated with a reduced oxidant status due to the antioxidant properties of the drug. British Journal of Pharmacology (2001) 133, 117–124; doi:10.1038/sj.bjp.0704064
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Hertog, M. G. L. (1995) · Archives of Internal Medicine · doi:10.1001/archinte.1995.00430040053006 · Cited by 1,853
Hertog, M. G. L., Hollman, P. C. H., Katan, M. B., & Kromhout, D. (1993) · Nutrition and Cancer · doi:10.1080/01635589309514267 · Cited by 1,216
Moore, T. J., Vollmer, W. M., Appel, L. J., Sacks, F. M., Svetkey, L. P., Vogt, T. M., Conlin, P. R., Simons-Morton, D. G., Carter-Edwards, L., & Harsha, D. W. (1999) · Hypertension · doi:10.1161/01.hyp.34.3.472 · Cited by 139
Cited by
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Boots, A. W., Haenen, G. R. M. M., & Bast, A. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.03.008 · Cited by 2,121
Flavonoids-potent and versatile biologically active compounds interacting with cytochromes P450
Hodek, P., Trefil, P., & Stiborová, M. (2002) · Chemico-Biological Interactions · doi:10.1016/s0009-2797(01)00285-x · Cited by 649
Flavonols and cardiovascular disease
Perez-Vizcaino, F., & Duarte, J. (2010) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2010.09.002 · Cited by 393
Self-citationSerban, M., Sahebkar, A., Zanchetti, A., Mikhailidis, D. P., Howard, G., Antal, D., Andrica, F., Ahmed, A., Aronow, W. S., Muntner, P., et al. (2016) · Journal of the American Heart Association · doi:10.1161/jaha.115.002713 · Cited by 317
Functional foods, herbs and nutraceuticals: towards biochemical mechanisms of healthy aging
Ferrari, C. K. B. (2004) · Biogerontology · doi:10.1007/s10522-004-2566-z · Cited by 227
Metadata
- Authors
- Duarte, J., Pérez‐Palencia, R., Vargas, F., Angeles Ocete, M., Pérez‐Vizcaino, F., Zarzuelo, A., & Tamargo, J.
- Venue
- British Journal of Pharmacology
- Publisher
- Wiley
- Published
- 2001-05
- Volume
- 133
- Issue
- 1
- Pages
- 117-124
- ISSN
- 0007-1188 (ISSN-L)
- 1476-5381
- OpenAlex
- W2170465739
- Cited by
- 464
- References
- 3
- FWCI
- 7.00
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Duarte, J., Pérez‐Palencia, R., Vargas, F., Angeles Ocete, M., Pérez‐Vizcaino, F., Zarzuelo, A., & Tamargo, J. (2001). Antihypertensive effects of the flavonoid quercetin in spontaneously hypertensive rats. British Journal of Pharmacology. https://doi.org/10.1038/sj.bjp.0704064
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