Delphinidin, an active compound of red wine, inhibits endothelial cell apoptosis via nitric oxide pathway and regulation of calcium homeostasis

Martin, Sophie; Giannone, Grégory; Andriantsitohaina, Ramaroson; Carmen Martinez, M

doi:10.1038/sj.bjp.0705347

Cited by 107Phytochemicals and Antioxidant ActivitiesNitric Oxide and Endothelin EffectsSirtuins and Resveratrol in Medicine

Delphinidin, an active compound of red wine, inhibits endothelial cell apoptosis via nitric oxide pathway and regulation of calcium homeostasis

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Martin, Sophie, Giannone, Grégory, Andriantsitohaina, Ramaroson, Carmen Martinez, M·2003·British Journal of Pharmacology

DOI 10.1038/sj.bjp.0705347PMC PMC1573941

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Abstract

Epidemiological studies have suggested that moderate consumption of natural dietary polyphenolic compounds might reduce the risk of cardiovascular disease and also protect against cancer. The present study investigates the effects of delphinidin, an anthocyanin present in red wine, on bovine aortic endothelial cells apoptosis. Based on flow cytometry, terminal deoxynucleotidyl transferase‐mediated dUTP nick‐end labeling analysis and detection of mitochondrial cytochrome c release, we show that delphinidin (10−2 g l−1) alone had no effect either on necrosis or on apoptosis, but it significantly reduced apoptosis elicited by actinomycin D (1 μ g ml−1, 24 h) and 7 β‐hydroxycholesterol (10 μ g ml−1, 18 h). The protective effect of delphinidin was abolished by inhibitors of nitric oxide‐synthase (NOS) (L‐NA, 100 μM and SMT, 100 μM), guanylyl cyclase (ODQ, 100 μM) and MAP kinase (PD98059, 30 μM). Western blot analysis and protein detection by confocal microscopy demonstrate that the antiapoptotic effect of delphinidin was associated with an increased endothelial NOS expression mediated by a MAP kinase pathway. Finally, delphinidin alone had no effect on cytosolic‐free calcium ([Ca 2+]i), but normalized the changes in [Ca 2+]i produced by actinomycin D towards the control values, suggesting that the antiapoptotic effect of delphinidin is associated with the maintenance of [Ca 2+]i in the physiological range. All of the observed effects of delphinidin may preserve endothelium integrity, the alteration of which lead to pathologies including cardiovascular diseases, such as atherosclerosis, and is often associated with cancers. In conclusion, the protective effect of delphinidin against endothelial cell apoptosis contributes to understand the potential benefits of a consumption rich in polyphenols. British Journal of Pharmacology (2003) 139, 1095–1102. doi:10.1038/sj.bjp.0705347

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Delphinidin possesses ROS scavenging properties and is able to prevent apoptosis of endothelial cells under in vitro conditions via interference with NO-signaling pathways.
“Delphinidin, an anthocyanin, a primary plant pigment, containing 6 hydroxyl groups in its structure possesses ROS scavenging properties and is able to prevent apoptosis of endothelial cells under in vitro conditions via interference with NO-signaling pathways (Martin et al. 2003).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Martin et al. 2003

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The biochemistry of apoptosis
Hengartner, M. O. (2000) · Nature · doi:10.1038/35037710 · Cited by 7,295 · see citing works
Caspases: Enemies Within
Thornberry, N. A., & Lazebnik, Y. A. (1998) · Science · doi:10.1126/science.281.5381.1312 · Cited by 6,857 · see citing works
Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis
Xia, Z., Dickens, M., Raingeaud, J., Davis, R. J., & Greenberg, M. E. (1995) · Science · doi:10.1126/science.270.5240.1326 · Cited by 5,290 · see citing works
The Effects of Plant Flavonoids on Mammalian Cells:Implications for Inflammation, Heart Disease, and Cancer
Middleton, E., Kandaswami, C., & Theoharides, T. C. (2000) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01472-8 · Cited by 4,882 · see citing works
Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study
Hertog, M. G. L., Feskens, E. J. M., Kromhout, D., Hertog, M. G. L., Hollman, P. C. H., Hertog, M. G. L., & Katan, M. (1993) · The Lancet · doi:10.1016/0140-6736(93)92876-u · Cited by 4,336 · see citing works
The Flavonoids. A Class of Semi-Essential Food Components: Their Role in Human Nutrition
K�hnau, J. (2015) · World review of nutrition and dietetics · doi:10.1159/000399407 · Cited by 1,491 · see citing works
Nitric oxide inhibits apoptosis by preventing increases in caspase-3-like activity via two distinct mechanisms
Kim, Y.-M., Talanian, R. V., & Billiar, T. R. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.49.31138 · Cited by 887 · see citing works
Suppression of Apoptosis by Nitric Oxide via Inhibition of Interleukin-1β–converting Enzyme (ICE)-like and Cysteine Protease Protein (CPP)-32–like Proteases
Dimmeler, S., Haendeler, J., Nehls, M. C., & Zeiher, A. M. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.4.601 · Cited by 806 · see citing works
Nitric oxide produced by human B lymphocytes inhibits apoptosis and Epstein-Barr virus reactivation
Mannick, J. B., Asano, K., Izumi, K. M., Kieff, E. D., & Stamler, J. S. (1994) · Cell · doi:10.1016/0092-8674(94)90005-1 · Cited by 498 · see citing works
Nitric Oxide as a Bifunctional Regulator of Apoptosis
Kim, Y., Bombeck, C. A., & Billiar, T. R. (1999) · Circulation Research · doi:10.1161/01.res.84.3.253 · Cited by 463 · see citing works
Early Activation of c-Jun N-terminal Kinase and p38 Kinase Regulate Cell Survival in Response to Tumor Necrosis Factor α
Roulston, A., Reinhard, C., Amiri, P., & Williams, L. T. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.17.10232 · Cited by 371 · see citing works
Orally Administered Delphinidin 3-Rutinoside and Cyanidin 3-Rutinoside Are Directly Absorbed in Rats and Humans and Appear in the Blood as the Intact Forms
Matsumoto, H., Inaba, H., Kishi, M., Tominaga, S., Hirayama, M., & Tsuda, T. (2001) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf001246q · Cited by 342 · see citing works
Nitric oxide production and endothelium‐dependent vasorelaxation induced by wine polyphenols in rat aorta
Andriambeloson, E., Kleschyov, A. L., Müller, B., Beretz, A., Stoclet, J., & Andriantsitohaina, R. (1997) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0701011 · Cited by 323 · see citing works
Self-citation
Concentration-dependent Effects of Nitric Oxide on Mitochondrial Permeability Transition and Cytochrome cRelease
Brookes, P. S., Salinas, E. P., Darley-Usmar, K., Eiserich, J. P., Freeman, B. A., Darley-Usmar, V. M., & Anderson, P. G. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001077200 · Cited by 321 · see citing works
Natural Dietary Polyphenolic Compounds Cause Endothelium-Dependent Vasorelaxation in Rat Thoracic Aorta
Andriambeloson, E., Magnier, C., Haan-Archipoff, G., Lobstein, A., Anton, R., Beretz, A., Stoclet, J., & Andriantsitohaina, R. (1998) · Journal of Nutrition · doi:10.1093/jn/128.12.2324 · Cited by 284 · see citing works
Self-citation
The Anthocyanidins Cyanidin and Delphinidin Are Potent Inhibitors of the Epidermal Growth-Factor Receptor
Meiers, S., Kemény, M., Weyand, U., Gastpar, R., Angerer, E. V., & Marko, D. (2001) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0009100 · Cited by 250 · see citing works
Wine Polyphenols Decrease Blood Pressure, Improve NO Vasodilatation, and Induce Gene Expression
Diebolt, M., Bucher, B., & Andriantsitohaina, R. (2001) · Hypertension · doi:10.1161/01.hyp.38.2.159 · Cited by 239 · see citing works
Self-citation
Molecular Regulation of the Bovine Endothelial Cell Nitric Oxide Synthase by Transforming Growth Factor–β 1
Inoue, N., Venema, R. C., Sayegh, H. S., Ohara, Y., Murphy, T. J., & Harrison, D. G. (1995) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.15.8.1255 · Cited by 192 · see citing works
Wine polyphenols improve cardiovascular remodeling and vascular function in NO-deficient hypertension
Bernátová, I., Pecháňová, O., Babál, P., Kyselá, S., Štvrtina, S., & Andriantsitohaina, R. (2002) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00724.2001 · Cited by 191 · see citing works
Self-citation
Report on consensus conference on cervical cancer screening and management
Miller, A. B., Nazeer, S., Fonn, S., BRANDRUP-LUKANOW, A., Rehman, R., Cronje, H., Sankaranarayanan, R., Koroltchouk, V., Syrjänen, K. J., Singer, A., et al. (2000) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(20000501)86:3 · Cited by 163 · see citing works
The Inhibitory Potency and Selectivity of Arginine Substrate Site Nitric-Oxide Synthase Inhibitors Is Solely Determined by Their Affinity toward the Different Isoenzymes
Boer, R., Ulrich, W., Klein, T., Mirau, B., Haas, S., & Baur, I. (2000) · Molecular Pharmacology · doi:10.1124/mol.58.5.1026 · Cited by 156 · see citing works
Adenoviral transfer of the inducible nitric oxide synthase gene blocks endothelial cell apoptosis
Tzeng, E., Kim, Y.-M., Pitt, B. R., Lizonová, A., Kovesdi, I., & Billiar, T. R. (1997) · Surgery · doi:10.1016/s0039-6060(97)90016-7 · Cited by 153 · see citing works
Red wine polyphenols increase calcium in bovine aortic endothelial cells: a basis to elucidate signalling pathways leading to nitric oxide production
Martin, S., Andriambeloson, E., Takeda, K., & Andriantsitohaina, R. (2002) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704603 · Cited by 150 · see citing works
Self-citation
Nitric Oxide Down-regulates MKP-3 mRNA Levels
Rössig, L., Haendeler, J., Hermann, C., Malchow, P., Urbich, C., Zeiher, A. M., & Dimmeler, S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002283200 · Cited by 122 · see citing works
Bacterial Lipopeptides Induce Nitric Oxide Synthase and Promote Apoptosis through Nitric Oxide-independent Pathways in Rat Macrophages
Terenzi, F., Díaz-Guerra, M. J. M., Casado, M., Hortelano, S., Leoni, S., & Boscá, L. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.11.6017 · Cited by 100 · see citing works
Delphinidin inhibits endothelial cell proliferation and cell cycle progression through a transient activation of ERK-1/-2
Martin, S., Favot, L., Matz, R. L., Lugnier, C., & Andriantsitohaina, R. (2003) · Biochemical Pharmacology · doi:10.1016/s0006-2952(02)01568-x · Cited by 91 · see citing works
Self-citation
Actinomycin D-induced apoptosis involves the potassium channel Kv1.3
Bock, J., Szabó, I., Jekle, A., & Gulbins, E. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)00695-2 · Cited by 79 · see citing works
Induction of Endothelial Nitric-oxide Synthase Phosphorylation by the Raloxifene Analog LY117018 Is Differentially Mediated by Akt and Extracellular Signal-regulated Protein Kinase in Vascular Endothelial Cells
Hisamoto, K., Ohmichi, M., Kanda, Y., Adachi, K., Nishio, Y., Hayakawa, J., Mabuchi, S., Takahashi, K., Tasaka, K., Miyamoto, Y., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103853200 · Cited by 71 · see citing works
Up-regulation of Endothelial Nitric-oxide Synthase Promoter by the Phosphatidylinositol 3-Kinase γ/Janus Kinase 2/MEK-1-dependent Pathway
Cieslik, K. A., Abrams, C. S., & Wu, K. K. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m005305200 · Cited by 65 · see citing works
Organization of the Olivocerebellar Projection to the Uvula in the Rat
Eisenman, L. M. (2008) · Brain Behavior and Evolution · doi:10.1159/000121300 · Cited by 59 · see citing works
Annexin V Delays Apoptosis While Exerting an External Constraint Preventing the Release of CD4+ and PrPc+ Membrane Particles in a Human T Lymphocyte Model
Gidon-Jeangirard, C., Hugel, B., Holl, V., Toti, F., Laplanche, J., Meyer, D., & Freyssinet, J. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.10.5712 · Cited by 53 · see citing works
Oyxsterols induce membrane procoagulant activity in monocytic THP-1 cells
Aupeix, K., Toti, F., Satta, N., Bischoff, P. L., & Freyssinet, J. (1996) · Biochemical Journal · doi:10.1042/bj3141027 · Cited by 45 · see citing works
Endothelium-dependent responses: the last three years.
Rf, F., Jothianandan, D., & Pd, C. (1984) · PubMed · Cited by 38 · see citing works
Morphological characterization of cultured bovine aortic endothelial cells and the effects of atriopeptin II and sodium nitroprusside on cellular and extracellular accumulation of cyclic GMP.
Schini‐Kerth, V. B., Grant, N. J., Rc, M., & Takeda, K. (1988) · PubMed · Cited by 27 · see citing works
Hepatocyte Fas-associating Death Domain Protein/Mediator of Receptor-induced Toxicity (FADD/MORT1) Levels Increase in Response to Pro-apoptotic Stimuli
Kim, P. K. M., Wang, Y., Gambotto, A. A., Kim, Y.-M., Weller, R., Zuckerbraun, B. S., Hua, Y., Watkins, S. C., & Billiar, T. R. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m203484200 · Cited by 26 · see citing works
Nitric Oxide Mediates LDL Uptake in the Artery Wall in Response to High Concentrations of 17β-Estradiol
Roberts, K. A., Woo, M. M., & Rutledge, J. C. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.10.2123 · Cited by 8 · see citing works
Pathophysiology of ischaemia-reperfusion injury
Carden, D. L., & Granger, D. N. (2000) · The Journal of Pathology · doi:10.1002/(sici)1096-9896(200002)190:3 · Cited by 5 · see citing works

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Jomova, K., Raptova, R., Alomar, S. Y., Alwasel, S. H., Nepovimova, E., Kuca, K., & Valko, M. (2023) · Archives of Toxicology · doi:10.1007/s00204-023-03562-9 · Cited by 2,638 · see citing works
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Wang, L., & Stoner, G. D. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.05.020 · Cited by 1,045 · see citing works
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Pan, M., Lai, C., & Ho, C. (2010) · Food & Function · doi:10.1039/c0fo00103a · Cited by 612 · see citing works
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Venil, C. K., Zakaria, Z. A., & Ahmad, W. A. (2013) · Process Biochemistry · doi:10.1016/j.procbio.2013.06.006 · Cited by 465 · see citing works
Flavonoids and Heart Health: Proceedings of the ILSI North America Flavonoids Workshop, May 31–June 1, 2005, Washington, DC1, , ,
Erdman, J. W., Balentine, D. A., Arab, L., Beecher, G. R., Dwyer, J. T., Folts, J. D., Harnly, J. M., Hollman, P. C. H., Keen, C. L., Mazza, G., et al. (2007) · Journal of Nutrition · doi:10.1093/jn/137.3.718s · Cited by 361 · see citing works
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Reis, J. F., Monteiro, V. S., Gomes, R. D. S., do Carmo, M. M., da Costa, G. V., Ribera, P. C., & Monteiro, M. C. (2016) · Journal of Translational Medicine · doi:10.1186/s12967-016-1076-5 · Cited by 265 · see citing works
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Prasad, S., Phromnoi, K., Yadav, V. R., Chaturvedi, M. M., & Aggarwal, B. B. (2010) · Planta Medica · doi:10.1055/s-0030-1250111 · Cited by 229 · see citing works
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Kampa, M., Nifli, A., Notas, G., & Castanas, E. (2007) · Springer eBooks · doi:10.1007/112_2006_0702 · Cited by 195 · see citing works
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Boo, H.-O., Hwang, S., Bae, C., Park, S., Heo, B., & Gorinstein, S. (2012) · Industrial Crops and Products · doi:10.1016/j.indcrop.2012.02.042 · Cited by 192 · see citing works
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Goszcz, K., Deakin, S. J., Duthie, G. G., Stewart, D., Leslie, S. J., & Megson, I. L. (2015) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2015.00029 · Cited by 184 · see citing works
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Chabane, M. N., Ahmad, A. A., Peluso, J., Muller, C. D., & Ubeaud-Séquier, G. (2009) · Journal of Pharmacy and Pharmacology · doi:10.1211/jpp.61.11.0006 · Cited by 161 · see citing works
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Prior, R. L., Wu, X., Gu, L., Hager, T., Hager, A., Wilkes, S., & Howard, L. (2009) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200900026 · Cited by 143 · see citing works
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Self-citation
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Na, J., Xiong, Y. L., Kong, B., Liu, Q., & Xia, X. (2012) · Journal of Functional Foods · doi:10.1016/j.jff.2012.01.009 · Cited by 67 · see citing works
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Jang, H. J., Ha, U., Kim, S., Yoon, B.-I., Han, D.-S., Yuk, S. M., & Kim, S.-W. (2010) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf102688g · Cited by 63 · see citing works
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Ritz, M., Ratajczak, P., Curin, Y., Cam, E., Mendelowitsch, A., Pinet, F., & Andriantsitohaina, R. (2008) · Journal of Nutrition · doi:10.1093/jn/138.3.519 · Cited by 62 · see citing works
Self-citation
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Persson, I. A. ‐., Persson, K., & Andersson, R. G. G. (2009) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf900128s · Cited by 60 · see citing works
Mitochondrial Dysfunction, Oxidative Stress and Diabetic Cardiovascular Disorders
Shen, G. X. (2012) · Cardiovascular & Haematological Disorders - Drug Targets · doi:10.2174/1871529x11202020106 · Cited by 50 · see citing works
Antitumor lignanamides from the aerial parts of Corydalis saxicola
Zhang, B., Huang, R.-Z., Hua, J., Liang, H., Pan, Y.-M., Dai, L., Liang, D., & Wang, H. (2016) · Phytomedicine · doi:10.1016/j.phymed.2016.09.006 · Cited by 48 · see citing works
Influence of Delphinidin-3-glucoside on Oxidized Low-Density Lipoprotein-Induced Oxidative Stress and Apoptosis in Cultured Endothelial Cells
Xie, X., Zhao, R., & Shen, G. X. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf204461z · Cited by 47 · see citing works
Anthocyanins attenuate vascular and inflammatory responses to a high fat high energy meal challenge in overweight older adults: A cross-over, randomized, double-blind clinical trial
do Rosario, V. A., Chang, C. R., Spencer, J., Alahakone, T., Roodenrys, S. J., François, M. E., Weston–Green, K., Hölzel, N., Nichols, D. S., Kent, K., et al. (2020) · Clinical Nutrition · doi:10.1016/j.clnu.2020.09.041 · Cited by 46 · see citing works
Hepatic uptake of grape anthocyanins and the role of bilitranslocase
Passamonti, S., Vanzo, A., Vrhovšek, U., Terdoslavich, M., Cocolo, A., Decorti, G., & Mattivi, F. (2005) · Food Research International · doi:10.1016/j.foodres.2005.02.015 · Cited by 46 · see citing works
Polyphenol-rich food general and on pregnancy effects: a review
Hahn, M., Baierle, M., Charão, M. F., Bubols, G., Gravina, F. S., Zielinsky, P., Arbo, M. D., & García, S. C. (2016) · Drug and Chemical Toxicology · doi:10.1080/01480545.2016.1212365 · Cited by 44 · see citing works
Delphinidin attenuates stress injury induced by oxidized low-density lipoprotein in human umbilical vein endothelial cells
Chen, C.-Y., Yi, L., Jin, X., Mi, M., Zhang, T., Ling, W., & Yu, B. (2009) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2009.09.024 · Cited by 43 · see citing works
Impact of polyphenols on extracellular vesicle levels and effects and their properties as tools for drug delivery for nutrition and health
Soleti, R., Andriantsitohaina, R., & Martínez, M. C. (2018) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2018.03.004 · Cited by 42 · see citing works
Self-citation
Endoplasmic reticulum stress in diabetic mouse or glycated LDL-treated endothelial cells: protective effect of Saskatoon berry powder and cyanidin glycans
Zhao, R., Xie, X., Le, K., Li, W., Moghadasian, M. H., Trust Beta, & Shen, G. X. (2015) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2015.05.015 · Cited by 40 · see citing works
Acute treatment with red wine polyphenols protects from ischemia-induced excitotoxicity, energy failure and oxidative stress in rats
Ritz, M., Curin, Y., Mendelowitsch, A., & Andriantsitohaina, R. (2008) · Brain Research · doi:10.1016/j.brainres.2008.08.073 · Cited by 38 · see citing works
Self-citation
Variation and Heritability Estimates of Anthocyanins and Their Relationship to Antioxidant Activity in a Red Raspberry Factorial Mating Design
Connor, A. M., McGhie, T. K., Stephens, M. J., Hall, H. K., & Alspach, P. A. (2005) · Journal of the American Society for Horticultural Science · doi:10.21273/jashs.130.4.534 · Cited by 38 · see citing works
The Mediterranean Lecture: Wine and Thrombosis – From Epidemiology to Physiology and Back
de Gaetano, G., Castelnuovo, A. F. D., Donati, M. B., & Iacoviello, L. (2003) · Pathophysiology of Haemostasis and Thrombosis · doi:10.1159/000083847 · Cited by 38 · see citing works
An update on alcohol and atherosclerosis
Li, J. M., & Mukamal, K. J. (2004) · Current Opinion in Lipidology · doi:10.1097/00041433-200412000-00008 · Cited by 38 · see citing works
Increased Microparticle Production and Impaired Microvascular Endothelial Function in Aldosterone-Salt-Treated Rats: Protective Effects of Polyphenols
López‐Andrés, N., Tesse, A., Regnault, V., Louis, H., Cattan, V., Thornton, S. N., Labat, C., Kakou, A., Tual‐Chalot, S., Faure, S., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039235 · Cited by 37 · see citing works
Self-citation
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Chen, C.-C., Ke, W.-H., Ceng, L.-H., Hsieh, C., & Wung, B. (2010) · Life Sciences · doi:10.1016/j.lfs.2010.10.014 · Cited by 36 · see citing works
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Connor, A. M., Finn, C. E., McGhie, T. K., & Alspach, P. A. (2005) · Journal of the American Society for Horticultural Science · doi:10.21273/jashs.130.5.680 · Cited by 35 · see citing works
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Duluc, L., Jacques, C., Soleti, R., Andriantsitohaina, R., & Simard, G. (2014) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2014.03.030 · Cited by 33 · see citing works
Self-citation
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Xie, X., Zhao, R., & Shen, G. X. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms131215867 · Cited by 33 · see citing works
The role of probiotics and natural bioactive compounds in modulation of the common molecular pathways in pathogenesis of atherosclerosis and cancer
Bomba, A., Brandeburová, A., Ričanyová, J., Strojný, L., Chmelařová, A., Szabadosova, V., Pramuková, B., Žofčáková, J., Salaj, R., Supuková, A., et al. (2012) · Biologia · doi:10.2478/s11756-011-0155-6 · Cited by 32 · see citing works
Pleiotropic Beneficial Effects of Epigallocatechin Gallate, Quercetin and Delphinidin on Cardiovascular Diseases Associated with Endothelial Dysfunction
Dayoub, O., Andriantsitohaina, R., & Clere, N. (2014) · Cardiovascular & Hematological Agents in Medicinal Chemistry · doi:10.2174/1871525712666140309233048 · Cited by 32 · see citing works
Self-citation
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Duluc, L., Jacques, C., Soleti, R., Iacobazzi, F., Simard, G., & Andriantsitohaina, R. (2013) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2013.01.007 · Cited by 30 · see citing works
Self-citation
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Shim, D., Kang, H. Y., Jeon, B. W., Kang, S. S., Chang, S., & Kim, H. Y. (2004) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2004.03.028 · Cited by 29 · see citing works
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Chen, L.-G., Liu, Y., Hsieh, C., Liao, B., & Wung, B. (2008) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200700335 · Cited by 25 · see citing works
Mitochondria As Potential Targets of Flavonoids: Focus on Adipocytes and Endothelial Cells
Duluc, L., Soleti, R., Clere, N., Andriantsitohaina, R., & Simard, G. (2012) · Current Medicinal Chemistry · doi:10.2174/092986712803251467 · Cited by 24 · see citing works
Self-citation
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Estrogen receptor α/HDAC/NFAT axis for delphinidin effects on proliferation and differentiation of T lymphocytes from patients with cardiovascular risks
Dayoub, O., Lay, S. L., Soleti, R., Clere, N., Hilairet, G., Dubois, S. G., Gagnadoux, F., Boursier, J., Martínez, M. C., & Andriantsitohaina, R. (2017) · Scientific Reports · doi:10.1038/s41598-017-09933-4 · Cited by 22 · see citing works
Self-citation
Anthocyanin-Rich Aronox Extract from Aroniamelanocarpa E Protects against 7β-Hydroxycholesterol-Induced Apoptosis of Endothelial Cells
Zapolska‐Downar, D., Nowicka, G., Sygitowicz, G., & Jarosz, M. (2008) · Annals of Nutrition and Metabolism · doi:10.1159/000191290 · Cited by 21 · see citing works
Relaxation induced by red wine polyphenolic compounds in rat pulmonary arteries: lack of inhibition by NO‐synthase inhibitor
Leblais, V., Krisa, S., Valls, J., Courtois, A., Abdelouhab, S., Vila, A. M., Mérillon, J., & Müller, B. (2008) · Fundamental and Clinical Pharmacology · doi:10.1111/j.1472-8206.2007.00546.x · Cited by 20 · see citing works
Red wine polyphenols prevent cyclosporine-induced nephrotoxicity at the level of the intrinsic apoptotic pathway
Rezzani, R., Tengattini, S., Bonomini, F., Filippini, F., Pecháňová, O., Bianchi, R., & Andriantsitohaina, R. (2009) · Physiological Research · doi:10.33549/physiolres.931570 · Cited by 20 · see citing works
Self-citation
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Peng, H., Zhang, S., Zhang, Z., Wang, X., Tian, X., Zhang, L., Du, J., Huang, Y., & Jin, H. (2022) · FEBS Open Bio · doi:10.1002/2211-5463.13362 · Cited by 18 · see citing works
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Martinelli, I., Tomassoni, D., Bellitto, V., Roy, P., Bonaventura, M. V. M. D., Amenta, F., Amantini, C., Cifani, C., & Tayebati, S. K. (2022) · Biology · doi:10.3390/biology11050646 · Cited by 17 · see citing works
Bioactive Chemicals and Health Benefits of Grapevine Products
Iriti, M., & Faoro, F. (2009) · Elsevier eBooks · doi:10.1016/b978-0-12-374628-3.00038-4 · Cited by 16 · see citing works
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Tsiogkas, S. G., Mavropoulos, Α., Skyvalidas, D. Ν., Patrikiou, E., Ntavari, N., Daponte, A., Grammatikopoulou, M. G., Dardiotis, E., Roussaki‐Schulze, A., Sakkas, L. I., et al. (2021) · Immunologic Research · doi:10.1007/s12026-021-09251-y · Cited by 15 · see citing works
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Tirumale, S., & Wani, N. A. (2018) · Springer eBooks · doi:10.1007/978-981-13-0393-7_23 · Cited by 15 · see citing works
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Lamoral‐Theys, D., Wauthoz, N., Heffeter, P., Mathieu, V., Jungwirth, U., Lefranc, F., Nève, J., Dubois, J., Dufrasne, F., Amighi, K., et al. (2011) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2011.01403.x · Cited by 15 · see citing works
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Self-citation
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Flavonoid Dietetics: Mechanisms and Emerging Roles of Plant Nutraceuticals
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Rivera-Tovar, P. R., Mariotti‐Celis, M. S., & Pérez‐Correa, J. R. (2018) · Mini-Reviews in Organic Chemistry · doi:10.2174/1570193x15666180627120609 · Cited by 11 · see citing works
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Health-Promoting Effects of Grape Bioactive Phytochemicals
Iriti, M., & Faoro, F. (2009) · Elsevier eBooks · doi:10.1016/b978-0-12-374228-5.00023-8 · Cited by 6 · see citing works
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Mandal, A., Hossain, U., & Sil, P. C. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-819096-8.00072-0 · Cited by 4 · see citing works
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Sun, Q., Lv, M., & Wang, Z. (2025) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2025.120006 · Cited by 3 · see citing works
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Lu, J., Tang, Y. J., Li, H., Tian, S., Chen, X., Song, X., Qin, P., Xu, J., Zhu, H., Ni, L., et al. (2025) · Natural Products and Bioprospecting · doi:10.1007/s13659-025-00523-w · Cited by 3 · see citing works
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Biological properties evaluation and chemical profiles of phenolic compounds in muscadine grapes (Vitis rotundifolia)
You, Q. (2012) · TigerPrints (Clemson University) · Cited by 2 · see citing works
Applications of Microbial Pigments in Pharmaceuticals and Cosmetics
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Prior, R. L. (2012) · CRC Press eBooks · doi:10.1201/b12893-9 · Cited by 1 · see citing works
Ameliorative Effects and Cellular Aspects of Phytoconstituents in Atherosclerosis
Alamgeer, Asif, H., Sandhu, M. Z. A., Aziz, M., Irfan, H. M., Moreno, K. G. T., & Gasparotto, A. (2020) · Current Pharmaceutical Design · doi:10.2174/1381612826666200214161139 · Cited by 1 · see citing works
Systematic analysis of molecular mechanisms of action of essential macro- and micronutrients on the neurotransmitter and vasodilator molecule nitric oxide (NO)
Громова, О. А., & Torshin, I. Y. (2025) · Epilepsy and Paroxysmal Conditions · doi:10.17749/2077-8333/epi.par.con.2024.208 · Cited by 1 · see citing works
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Yasmine, S., Firmanto, N. N., Sabrina, A. M., & Khaerunnisa, S. (2023) · Majalah Biomorfologi · doi:10.20473/mbiom.v33i1.2023.20-29 · Cited by 1 · see citing works
Effects of red wine and grape juice against foodborne pathogens and probiotics
Das, A. (2008) · doi:10.32469/10355/5701 · Cited by 1 · see citing works
French Paradox, Polyphenols and Cardiovascular Protection: The Oestrogenic Receptor-α Implication
Benaissa, T., Ragot, T., & Tesse, A. (2012) · InTech eBooks · doi:10.5772/38208

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Martin, S., Favot, L., Matz, R. L., Lugnier, C., & Andriantsitohaina, R. (2003) · Biochemical Pharmacology · doi:10.1016/s0006-2952(02)01568-x · Cited by 91 · see citing works
Self-citation
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Authors: Martin, S., Giannone, G., Andriantsitohaina, R., & Carmen Martinez, M.
Affiliations: Centre National de la Recherche Scientifique (FR)
Corresponding author: Andriantsitohaina, Ramaroson
ORCID: Martin, Sophie
Giannone, Grégory
Andriantsitohaina, Ramaroson
Venue: British Journal of Pharmacology
Publisher: Wiley
Published: 2003-07
Volume: 139
Issue: 6
Pages: 1095-1102
ISSN: 0007-1188 (ISSN-L)
1476-5381
DOI: 10.1038/sj.bjp.0705347
PMC: PMC1573941
OpenAlex: W2072230362
Cited by: 107
References: 37
Citations by year: 2026: 1 · 2025: 6 · 2024: 1 · 2023: 3 · 2022: 4 · 2021: 5 · 2020: 2 · 2019: 3 · 2018: 5 · 2017: 2 · 2016: 5 · 2015: 4 · 2014: 4 · 2013: 5 · 2012: 12
FWCI: 2.40
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 2040 d)
Locations: British Journal of Pharmacology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Topics: Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
Keywords: delphinidin, anthocyanins, red wine, endothelial cell apoptosis, nitric oxide pathway, endothelial nitric oxide synthase, MAPK signaling, cytosolic calcium homeostasis, actinomycin D, 7β-hydroxycholesterol, cytochrome c release, polyphenols, cardiovascular disease, atherosclerosis
MeSH terms: Animals, Anthocyanins, Calcium, Cattle, Cells, Cultured, Homeostasis, Nitric Oxide, Wine, Apoptosis, Nitric Oxide Synthase, Endothelial Cells, Nitric Oxide Synthase Type III

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Delphinidin, an active compound of red wine, inhibits endothelial cell apoptosis via nitric oxide pathway and regulation of calcium homeostasis

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