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Cited by 143Phytochemicals and Antioxidant ActivitiesDiet, Metabolism, and DiseaseNutritional Studies and Diet

Purified berry anthocyanins but not whole berries normalize lipid parameters in mice fed an obesogenic high fat diet

Prior, Ronald L., Wu, Xianli, Gu, Liwei, Hager, Tiffany, Hager, Aaron, Wilkes, Sam, Howard, Luke·2009·Molecular Nutrition & Food Research
DOI 10.1002/mnfr.200900026
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Abstract

Male C57BL/6 mice received diets with either 10% of kcal from fat, or a high fat diet [45% (HF45) or 60% (HF60) kcal from fat]. Diets were prepared with or without freeze-dried powders (10%) from whole blueberries (BB), strawberries (SB), Concord grape or black raspberry. In the 2nd study, purified anthocyanins (ACNs) from SB or BB were added to the drinking water of the treatments fed the HF60 diet. In Study 1, serum triglycerides were increased by feeding the HF45 diet but were elevated further when black raspberry or BB was included in the HF45 diet. Liver total lipids and triglycerides were increased in mice fed HF45 diet and inclusion of any of the berry powders in the HF45 diet did not alter concentrations compared to HF45 controls. In the 2nd study, mice fed the HF60 diet plus purified ACNs from BB in the water had lower body weight gains and body fat than the HF60 fed. Serum cholesterol and triglyceride levels were elevated with the HF60 diet and decreased to control levels when ACNs from either SB or BB were included in the drinking water. Serum leptin levels were consistently decreased to control low fat levels in those ACN treatments in which measures of body fat were decreased. Administering purified ACNs from BB and strawberry via drinking water prevented the development of dyslipidemia and obesity in mice, but feeding diets containing whole berries or purple corn (PC) ACNs did not alter the development of obesity.

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Crossref · 10.1002/mnfr.200900026

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  • Berry anthocyanins affect lipid metabolism in cellular and animal models of dyslipidemia.

    “Berry anthocyanins have also been shown to affect lipid metabolism in cellular and animal models of dyslipidemia.”

    From Berries: emerging impact on cardiovascular health (2010) · cites this paper as [71]

  • Purified anthocyanins from blueberries and strawberries added to drinking water prevented the development of dyslipidemia and obesity in mice fed a high-fat diet for 90 days.

    “Purified anthocyanins from blueberries and strawberries added to drinking water were shown to prevent the development of dyslipidemia and obesity in mice fed a high-fat diet for a period of 90 days.”

    From Berries: emerging impact on cardiovascular health (2010) · cites this paper as [71]

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Authors
Prior, R. L., Wu, X., Gu, L., Hager, T., Hager, A., Wilkes, S., & Howard, L.
Affiliations
  • Agricultural Research Service (US)
  • Arkansas Children's Nutrition Center (US)
  • University of Florida (US)
  • University of Arkansas at Fayetteville (US)
Corresponding author
Prior, Ronald L.
ORCID
Venue
Molecular Nutrition & Food Research
Publisher
Wiley
Published
2009-11
Volume
53
Issue
11
Pages
1406-1418
ISSN
  • 1613-4125 (ISSN-L)
  • 1613-4133
DOI
10.1002/mnfr.200900026
OpenAlex
W2137082630
Cited by
143
References
34
Citations by year
2026: 1 · 2024: 4 · 2023: 5 · 2022: 4 · 2021: 5 · 2020: 8 · 2019: 7 · 2018: 8 · 2017: 11 · 2016: 13 · 2015: 12 · 2014: 11 · 2013: 25 · 2012: 8
FWCI
6.19
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Molecular Nutrition & Food Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Keywords
anthocyanins, high-fat diet, obesity, dyslipidemia, serum triglycerides, serum cholesterol, fat mass, leptin, blueberry, strawberry, Concord grape, black raspberry
MeSH terms
Animals, Anthocyanins, Blood Glucose, Body Composition, Cholesterol, Dietary Fats, Fruit, Male, Mice, Inbred C57BL, Obesity, Triglycerides, Leptin, Blueberry Plants, Fragaria, Mice

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