Bisphenol A affects glucose transport in mouse 3T3‐F442A adipocytes
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Recently, environmental chemicals have appeared in daily human life, and these chemicals have been incidentally taken in by humans. The serum concentrations of some of these chemicals have been found to be associated with the onset and incidence rate of diabetes mellitus. It has been suggested that one of the environmental chemicals, bisphenol A (BPA), has hormone‐like activity. It has also been demonstrated that some hormones affect insulin resistance and fat distribution in the body. To study the effects of these environmental chemicals on glucose metabolism, the effect of BPA on glucose transport in mouse 3T3‐F442A adipocytes was investigated. The 3T3‐F442A adipocytes were incubated with various concentrations of BPA in a medium. Deoxyglucose uptake assay was performed with and without insulin. Immunoblot analysis was performed with a glucose transporter (GLUT) 4‐specific antibody and antiphosphotyrosine antibody. The BPA treatment enhanced basal and insulin‐stimulated glucose uptake, and caused an increased amount of GLUT4 protein. Thus, the enhanced glucose uptake resulting from the BPA treatment was at least partially due to the increased amount of GLUT4. Tyrosine phosphorylation of insulin receptor substrate‐1 with insulin stimulation was not significantly affected. In conclusion, it was demonstrated that BPA, one of the chemicals that we intake incidentally, affects the glucose transport in adipocytes, and also that the environmental chemicals may be identified as one of the environmental factors that affect diabetes and obesity. British Journal of Pharmacology (2004) 141, 209–214. doi:10.1038/sj.bjp.0705520
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Endocrine disrupters may be involved in the glycolytic pathway and in regulation of glucose transporters, with compounds such as BPA, 4-nonylphenol, 4-octylphenol, and 4-propylphenol.
“Endocrine disrupters may also be involved in different estrogenic intervention processes, such as the glycolytic pathway and during the regulation of glucose transporters with compounds like BPA, 4-nonylphenol (NP), 4-octylphenol (OP), and 4-propylphenol [116, 153, 154].”
From Estrogen deficiency and the origin of obesity during menopause (2014) · cites this paper as [153]
Endocrine disruption using these substances interferes with tricarboxylic acid metabolism by decreasing key enzymes in mitochondrial activity, which could be partially related to obesity.
“Endocrine disruption using these substances also interferes with tricarboxylic acid metabolism by decreasing key enzymes in mitochondrial activity, which could be partially related to obesity (Figure 4).”
From Estrogen deficiency and the origin of obesity during menopause (2014) · cites this paper as [153]
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- Authors
- Sakurai, K., Kawazuma, M., Adachi, T., Harigaya, T., Saito, Y., Hashimoto, N., & Mori, C.
- Affiliations
- Chiba University (JP)
- Meiji University (JP)
- Corresponding author
- Mori, Chisato
- Venue
- British Journal of Pharmacology
- Publisher
- Wiley
- Published
- 2004-01
- Volume
- 141
- Issue
- 2
- Pages
- 209-214
- ISSN
- 0007-1188 (ISSN-L)
- 1476-5381
- PMC
- PMC1574186
- OpenAlex
- W2000180814
- Cited by
- 156
- References
- 29
- Citations by year
- 2025: 1 · 2024: 4 · 2023: 6 · 2022: 6 · 2021: 3 · 2020: 9 · 2019: 5 · 2018: 4 · 2017: 7 · 2016: 7 · 2015: 5 · 2014: 17 · 2013: 17 · 2012: 10
- FWCI
- 3.92
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal of Pharmacology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- bisphenol A, glucose transport, adipocytes, GLUT4, insulin-stimulated glucose uptake, IRS-1, tyrosine phosphorylation, insulin resistance, diabetes mellitus, environmental chemicals, endocrine disruptors, obesity
- MeSH terms
- Bisphenol A Compounds, Animals, Benzhydryl Compounds, Biological Transport, Deoxyglucose, Dose-Response Relationship, Drug, Glucose, Monosaccharide Transport Proteins, Muscle Proteins, Phenols, 3T3 Cells, Adipocytes, Glucose Transporter Type 4, Mice
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