The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Role of serotonin in the pathophysiology of the irritable bowel syndrome
Open accessAbstract
The irritable bowel syndrome (IBS) is a complex disorder that is associated with altered gastrointestinal motility, secretion, and sensation. Serotonin (5‐HT) is an important neurotransmitter and paracrine signalling molecule in the gastrointestinal tract. 5‐HT release from enterochromaffin (EC) cells initiates peristaltic, secretory, vasodilatory, vagal and nociceptive reflexes. The enteric nervous system (ENS) comprises a semiautonomous effector system that is connected to the central autonomic network. Parasympathetic and sympathetic nerves modulate the ENS via afferent and efferent communications. Ongoing, bidirectional brain–gut interactions involving 5‐HT pathways occur that significantly influence the effector systems. Altered 5‐HT signalling may lead to both intestinal and extraintestinal symptoms in IBS. 5‐HT directly and indirectly affects intestinal motor and secretory function and abnormalities may lead to either constipation or diarrhea. 5‐HT modulates sensation and perception of visceral stimulation at peripheral and central sites. Therapeutic agents targeting altered 5‐HT signalling may provide new, effective treatments for patients with IBS. British Journal of Pharmacology (2004) 141, 1285–1293. doi:10.1038/sj.bjp.0705762
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Functional bowel disorders and functional abdominal pain
Thompson, W. G., Longstreth, G. F., Drossman, D. A., Heaton, K. W., Irvine, E. J., & Müller-Lissner, S. A. (1999) · Gut · doi:10.1136/gut.45.2008.ii43 · Cited by 2,440
Spiller, R. C., Jenkins, D., Thornley, J. P., Hebden, J. M., Wright, T., Skinner, M., & Neal, K. R. (2000) · Gut · doi:10.1136/gut.47.6.804 · Cited by 1,155
Whitehead, W. E., Palsson, O., & Jones, K. R. (2002) · Gastroenterology · doi:10.1053/gast.2002.32392 · Cited by 1,116
Prather, C. M., Camilleri, M., Zinsmeister, A. R., McKinzie, S., & Thomforde, G. (2000) · Gastroenterology · doi:10.1016/s0016-5085(00)70251-4 · Cited by 410
The Irritable Bowel Syndrome: Review and a Graduated Multicomponent Treatment Approach
Drossman, D. A., & Thompson, W. G. (1992) · Annals of Internal Medicine · doi:10.7326/0003-4819-116-12-1009 · Cited by 309
Effect of alosetron on responses to colonic distension in patients with irritable bowel syndrome
Delvaux, M., Louvel, D., Mamet, J. ‐., Campos‐Oriola, R., & Frexinos, J. (1998) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.1998.00375.x · Cited by 236
Houghton, Foster, & Whorwell (2000) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2000.00762.x · Cited by 132
Müller-Lissner, S. (2003) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(03)00027-1 · Cited by 91
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Tryptophan metabolism and gut-brain homeostasis
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Gut-brain Axis and migraine headache: a comprehensive review
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Park, J. H., Rhee, P., Kim, G., Lee, J. H., Kim, Y., Kim, J. J., Rhee, J. C., & Song, S. Y. (2006) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2006.00771.x · Cited by 89
Autonomic nervous system and secretion across the intestinal mucosal surface
Xue, J., Askwith, C., Javed, N. H., & Cooke, H. J. (2007) · Autonomic Neuroscience · doi:10.1016/j.autneu.2007.02.001 · Cited by 73
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Min, Y. W., & Rhee, P.-L. (2015) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756283x15572580 · Cited by 30
Drobny, A., Ngo, P. A., Neurath, M. F., Zunke, F., & López-Posadas, R. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.655123 · Cited by 24
Metadata
- Authors
- Crowell, M. D.
- Venue
- British Journal of Pharmacology
- Publisher
- Wiley
- Published
- 2004-04
- Volume
- 141
- Issue
- 8
- Pages
- 1285-1293
- ISSN
- 0007-1188 (ISSN-L)
- 1476-5381
- OpenAlex
- W1994781929
- Cited by
- 291
- References
- 8
- FWCI
- 10.91
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
