Tegaserod accelerates orocecal transit in patients with constipation-predominant irritable bowel syndrome
Open accessAbstract
Background & aims This study evaluated the effects of a partial 5-hydroxytryptamine (5-HT)(4) agonist, tegaserod, on gastric small bowel and colonic transit in constipation-predominant irritable bowel syndrome (IBS).Methods After a 1 week run-in period, 24 patients with constipation-predominant IBS were randomized to 1 week of tegaserod, 2 mg twice daily, or placebo treatment. Scintigraphic gastric emptying, small bowel transit, and colonic transit were determined before administration of study drug and after 1 week on the medication. Colonic transit was also measured using radiopaque markers and a single radiograph on day 5.Results Gastric emptying was unaltered by tegaserod. Proximal colonic filling at 6 hours, a measure of orocecal transit, was accelerated by tegaserod (70.4% +/- 1.3% [mean +/- SEM] vs. placebo, 46.4 +/- 1.9; P = 0.015). Proximal colonic emptying half-time and geometric center at 48 hours were also accelerated by tegaserod compared with baseline, but not compared with placebo. Mean colonic transit time was similar in both groups at baseline and after drug administration (tegaserod, 59.5 +/- 2.1 hours; placebo, 62.1 +/- 2.1 hours).Conclusions Tegaserod accelerates orocecal transit, tends to accelerate colonic transit, and deserves further study in patients with constipation-predominant IBS.
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Sweetser, S. R., Camilleri, M., Nord, S. L., Burton, D. D., Castenada, L., Croop, R. S., Tong, G., Dockens, R. C., & Zinsmeister, A. R. (2009) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00011.2009 · Cited by 114 · see citing works
Self-citationSerotonin and colonic motility
Kendig, D. M., & Grider, J. R. (2015) · Neurogastroenterology & Motility · doi:10.1111/nmo.12617 · Cited by 113 · see citing works
Deiteren, A., Camilleri, M., Bharucha, A. E., Burton, D. D., McKinzie, S., Rao, A. S., & Zinsmeister, A. R. (2009) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2009.01441.x · Cited by 111 · see citing works
Self-citationPlasticity in serotonin control mechanisms in the gut
Gershon, M. D. (2003) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2003.07.005 · Cited by 111 · see citing works
Economic Burden of Irritable Bowel Syndrome
Camilleri, M., & Williams, D. E. (2000) · PharmacoEconomics · doi:10.2165/00019053-200017040-00003 · Cited by 109 · see citing works
Self-citationThe pharmacological treatment of acute colonic pseudo‐obstruction
GIORGIO, R. D., Barbara, G., Stanghellini, V., Tonini, M., Vasina, V. I., Cola, B., Corinaldesi, R., Biagi, G., & Ponti, F. D. (2001) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2001.01088.x · Cited by 108 · see citing works
METHODS FOR THE ASSESSMENT OF SMALL BOWEL AND COLONIC TRANSIT
Szarka, L., & Camilleri, M. (2012) · Seminars in nuclear medicine · doi:10.1053/j.semnuclmed.2011.10.004 · Cited by 96 · see citing works
Self-citationPATRICK, A., & Epstein, O. (2008) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2008.03637.x · Cited by 103 · see citing works
Cremonini, F., Camilleri, M., McKinzie, S., Carlson, P., Camilleri, C. E., Burton, D. D., Thomforde, G. M., Urrutia, R. A., & Zinsmeister, A. R. (2005) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2005.41081.x · Cited by 103 · see citing works
Self-citationPharmacodynamic effects of a novel prokinetic 5‐HT4 receptor agonist, ATI‐7505, in humans
Camilleri, M., Vázquez-Roque, M., Burton, D., Ford, T. J., Mckinzie, S., Zinsmeister, A., & Druzgala, P. (2007) · Neurogastroenterology and Motility · doi:10.1111/j.1365-2982.2006.00865.x · Cited by 98 · see citing works
Self-citationA dose‐ranging, placebo‐controlled, pilot trial of Acotiamide in patients with functional dyspepsia
Tack, J. F., Masclee, A., Heading, R. C., Berstad, A., Piessevaux, H. H., Popiela, T. J., Vandenberghe, A., & Kato, H. (2009) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2009.01261.x · Cited by 101 · see citing works
Buckles, D. C., Sarosiek, I., McCallum, R. W., & McMillin, C. (2004) · The American Journal of the Medical Sciences · doi:10.1097/00000441-200401000-00001 · Cited by 101 · see citing works
Manabe, N., Wong, B. S., & Camilleri, M. (2010) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2010.482927 · Cited by 97 · see citing works
Self-citationUpdate on Gastrointestinal Scintigraphy
Maurer, A. H., & Parkman, H. P. (2006) · Seminars in Nuclear Medicine · doi:10.1053/j.semnuclmed.2005.12.003 · Cited by 97 · see citing works
Medical management of fecal incontinence
Scarlett, Y. V. (2003) · Gastroenterology · doi:10.1053/j.gastro.2003.10.007 · Cited by 97 · see citing works
Tegaserod for the treatment of irritable bowel syndrome
Evans, B., Clark, W., Moore, D., & Whorwell, P. J. (2004) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003960.pub2 · Cited by 97 · see citing works
Bharucha, A. E., Low, P. A., Camilleri, M., Veil, E. B., Burton, D. D., Kudva, Y. C., Shah, P., Gehrking, T. L., & Zinsmeister, A. R. (2012) · Gut · doi:10.1136/gutjnl-2012-302483 · Cited by 95 · see citing works
Self-citationThe genetics of irritable bowel syndrome.
Saito, Y., Petersen, G., Locke, G., & Talley, N. J. (2005) · Clinical Gastroenterology and Hepatology · doi:10.1016/s1542-3565(05)00184-9 · Cited by 42 · see citing works
Effect of tegaserod on gut transit in male and female subjects
Degen, L. P., Petrig, C., Studer, D., Schroller, S., & Beglinger, C. (2005) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2005.00715.x · Cited by 89 · see citing works
Müller-Lissner, S. (2003) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(03)00027-1 · Cited by 91 · see citing works
Serotonergic modulation of visceral sensation: lower gut
Camilleri, M. (2002) · Gut · doi:10.1136/gut.51.suppl_1.i81 · Cited by 90 · see citing works
Self-citationPharmacologic therapy for the irritable bowel syndrome
Talley, N. J. (2003) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2003.07306.x · Cited by 89 · see citing works
Schikowski, A., Thewissen, M., Mathis, C., Ross, H., & Enck, P. (2002) · Neurogastroenterology & Motility · doi:10.1046/j.1365-2982.2002.00328.x · Cited by 88 · see citing works
Pathophysiology, Diagnosis, and Management of Chronic Intestinal Pseudo-Obstruction
Downes, T. J., Cheruvu, M. S., Karunaratne, T. B., GIORGIO, R. D., & Farmer, A. D. (2018) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000001047 · Cited by 87 · see citing works
Talley, N. J. (2006) · Internal Medicine Journal · doi:10.1111/j.1445-5994.2006.01217.x · Cited by 86 · see citing works
Constipation: Evaluation and Treatment of Colonic and Anorectal Motility Disorders
Rao, S. S. C. (2009) · Gastrointestinal Endoscopy Clinics of North America · doi:10.1016/j.giec.2008.12.006 · Cited by 79 · see citing works
Chronic constipation in children: Organic disorders are a major cause
Southwell, B. R., King, S. K., & Hutson, J. (2005) · Journal of Paediatrics and Child Health · doi:10.1111/j.1440-1754.2005.00527.x · Cited by 79 · see citing works
Pathophysiology as a basis for understanding symptom complexes and therapeutic targets
Camilleri, M., & Talley, N. J. (2004) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2004.00516.x · Cited by 79 · see citing works
Self-citationIrritable bowel syndrome in the 21st century: Perspectives from Asia or South‐east Asia
Chang, F., & Lu, C. (2006) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2006.04672.x · Cited by 77 · see citing works
Alvimopan, a selective peripherally acting μ‐opioid antagonist*
Camilleri, M. (2005) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2005.00640.x · Cited by 78 · see citing works
Self-citationThe SNMMI and EANM Practice Guideline for Small-Bowel and Colon Transit 1.0
Maurer, A. H., Camilleri, M., Donohoe, K. J., KNIGHT, L. C., Madsen, J. L., Mariani, G., Parkman, H. P., & Dolsen, J. V. (2013) · Journal of Nuclear Medicine · doi:10.2967/jnumed.113.129973 · Cited by 78 · see citing works
Self-citationSpectrum of Gastroparesis in Children
Waseem, S., Islam, S., Kahn, G., Moshiree, B., & Talley, N. J. (2012) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e31824cf06e · Cited by 78 · see citing works
Long‐term safety of tegaserod in patients with constipation‐predominant irritable bowel syndrome
Tougas, G. H., Snape, W. J., Otten, M. H., Earnest, D. L., Langaker, K. E., Pruitt, R. E., Pecher, E., Nault, B., & Rojavin, M. A. (2002) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2002.01347.x · Cited by 78 · see citing works
- Authors
- Prather, C. M., Camilleri, M., Zinsmeister, A. R., McKinzie, S., & Thomforde, G.
- Affiliations
- Mayo Clinic (US)
- ORCID
- Camilleri, Michael
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2000-03
- Volume
- 118
- Issue
- 3
- Pages
- 463-468
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W2095055104
- Cited by
- 410
- References
- 22
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 3 · 2023: 4 · 2022: 2 · 2021: 6 · 2020: 6 · 2019: 5 · 2018: 7 · 2017: 4 · 2016: 8 · 2015: 7 · 2014: 4 · 2013: 6 · 2012: 12
- FWCI
- 36.61
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases (K24DK02638-01, K24DK002638, R01-DK546881)
- National Center for Research Resources (RR-00585, M01RR000585)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Surgery › Enhanced Recovery After Surgery
- Health Sciences › Medicine › Rheumatology › Pelvic floor disorders treatments
- Keywords
- tegaserod, irritable bowel syndrome with constipation, orocecal transit, colonic transit, gastric emptying, small intestinal transit, 5-HT4 receptor agonist, scintigraphy, radiopaque markers
- MeSH terms
- Adult, Aged, Colon, Colonic Diseases, Functional, Constipation, Double-Blind Method, Gastrointestinal Transit, Guanidines, Humans, Indoles, Intestine, Small, Middle Aged, Radionuclide Imaging, Stomach, Time Factors, Serotonin Receptor Agonists
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