Cited by 278Estrogen and related hormone effectsAdrenal Hormones and DisordersStress Responses and Cortisol

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Glucocorticoids: exemplars of multi-tasking

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Buckingham, Julia C·2006·British Journal of Pharmacology

DOI 10.1038/sj.bjp.0706456PMC PMC1760726

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Abstract

Well over 80 years ago Philip Smith described the beneficial clinical effects of adrenocortical extracts in animal models of adrenal insufficiency. In the ensuing years, scientists across the globe have sought to understand the mechanisms by which adrenal hormones and their synthetic analogues produce their complex and varied actions. Particular attention has focused on the glucocorticoids, partly because they have a vital place in the treatment of inflammatory and autoimmune disorders but also because dysregulation of the secretion and/or activity of endogenous glucocorticoids is increasingly implicated in a number of common disorders that pose a growing clinical burden, such as obesity, type II diabetes, the metabolic syndrome, hypertension and depression. This review considers some of the key advances that have been made in our understanding of the physiology, pathology and pharmacology of the glucocorticoids. Emphasis is placed on the molecular mechanisms of glucocorticoid signalling and the complex mechanisms that regulate the access of steroids in the systemic circulation to their receptors in their various target cells and tissues. In addition, consideration is given to the irreversible 'organisational' actions of glucocorticoids in perinatal life and to the potential role of the steroids in the aetiology of disease.

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Authors: Buckingham, J. C.
Affiliations: Imperial College London (GB)
Corresponding author: Buckingham, Julia C
Venue: British Journal of Pharmacology
Publisher: Wiley
Published: 2006-01
Volume: 147
Issue: S1
Pages: S258-68
ISSN: 0007-1188 (ISSN-L)
1476-5381
DOI: 10.1038/sj.bjp.0706456
PMC: PMC1760726
OpenAlex: W1594205240
Cited by: 276
References: 37
Citations by year: 2026: 4 · 2025: 4 · 2024: 6 · 2023: 9 · 2022: 5 · 2021: 11 · 2020: 16 · 2019: 13 · 2018: 14 · 2017: 15 · 2016: 15 · 2015: 16 · 2014: 12 · 2013: 11 · 2012: 18
FWCI: 2.26
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 1128 d)
Locations: British Journal of Pharmacology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Biotechnology and Biological Sciences Research Council (BB/E52708X/1)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: glucocorticoids, glucocorticoid signaling, steroid hormone receptors, adrenal insufficiency, adrenocortical extract, obesity, type 2 diabetes, metabolic syndrome, hypertension, depression, etiology
MeSH terms: Animals, Arthritis, Rheumatoid, Depressive Disorder, Diabetes Mellitus, Type 2, Glucocorticoids, Humans, Hypertension, Hypothalamo-Hypophyseal System, Obesity, Pituitary-Adrenal System, Receptors, Glucocorticoid, Signal Transduction

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