The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Glucocorticoids: exemplars of multi-tasking
Open accessAbstract
Well over 80 years ago Philip Smith described the beneficial clinical effects of adrenocortical extracts in animal models of adrenal insufficiency. In the ensuing years, scientists across the globe have sought to understand the mechanisms by which adrenal hormones and their synthetic analogues produce their complex and varied actions. Particular attention has focused on the glucocorticoids, partly because they have a vital place in the treatment of inflammatory and autoimmune disorders but also because dysregulation of the secretion and/or activity of endogenous glucocorticoids is increasingly implicated in a number of common disorders that pose a growing clinical burden, such as obesity, type II diabetes, the metabolic syndrome, hypertension and depression. This review considers some of the key advances that have been made in our understanding of the physiology, pathology and pharmacology of the glucocorticoids. Emphasis is placed on the molecular mechanisms of glucocorticoid signalling and the complex mechanisms that regulate the access of steroids in the systemic circulation to their receptors in their various target cells and tissues. In addition, consideration is given to the irreversible 'organisational' actions of glucocorticoids in perinatal life and to the potential role of the steroids in the aetiology of disease.
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“HPA axis dysfunction is linked to a decline in cognitive function, aging, immune system dysfunction, and systemic inflammation (135).”
From Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis (2023) · cites this paper as [135]
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“These peptides stimulate the release of adrenocorticotropic hormone (ACTH) from corticotropic cells of the anterior pituitary gland, which in turn targets the zona fasciculata of the adrenal cortex to produce glucocorticoids, such as cortisol in humans and corticosterone in rodents (133–135).”
From Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis (2023) · cites this paper as [135]
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The brain and the stress axis: the neural correlates of cortisol regulation in response to stress
Dedovic, K., Duchesne, A., Andrews, J., Engert, V., & Pruessner, J. C. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.05.074 · Cited by 699
Boutros, T., Chevet, É., & Metrakos, P. P. (2008) · Pharmacological Reviews · doi:10.1124/pr.107.00106 · Cited by 558
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Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis
Rusch, J. A., Layden, B. T., & Dugas, L. R. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1130689 · Cited by 415
Regulation of the Hypothalamic-Pituitary-Adrenal Axis
Papadimitriou, A., & Priftis, K. Ν. (2009) · NeuroImmunoModulation · doi:10.1159/000216184 · Cited by 382
Metadata
- Authors
- Buckingham, J. C.
- Affiliations
- Imperial College London (GB)
- Corresponding author
- Buckingham, Julia C
- Venue
- British Journal of Pharmacology
- Publisher
- Wiley
- Published
- 2006-01
- Volume
- 147
- Issue
- S1
- Pages
- S258-68
- ISSN
- 0007-1188 (ISSN-L)
- 1476-5381
- PMC
- PMC1760726
- OpenAlex
- W1594205240
- Cited by
- 276
- References
- 37
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 6 · 2023: 9 · 2022: 5 · 2021: 11 · 2020: 16 · 2019: 13 · 2018: 14 · 2017: 15 · 2016: 15 · 2015: 16 · 2014: 12 · 2013: 11 · 2012: 18
- FWCI
- 2.26
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal of Pharmacology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Biotechnology and Biological Sciences Research Council (BB/E52708X/1)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- glucocorticoids, glucocorticoid signaling, steroid hormone receptors, adrenal insufficiency, adrenocortical extract, obesity, type 2 diabetes, metabolic syndrome, hypertension, depression, etiology
- MeSH terms
- Animals, Arthritis, Rheumatoid, Depressive Disorder, Diabetes Mellitus, Type 2, Glucocorticoids, Humans, Hypertension, Hypothalamo-Hypophyseal System, Obesity, Pituitary-Adrenal System, Receptors, Glucocorticoid, Signal Transduction
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