Intracellular machinery for the transport of AMPA receptors.
Open accessAbstract
AMPA‐type glutamate receptors are one of the most dynamic components of excitatory synapses. Their regulated addition and removal from synapses leads to long‐lasting forms of synaptic plasticity, known as long‐term potentiation (LTP) and long‐term depression (LTD). In addition, AMPA receptors reach their synaptic targets after a complicated journey involving multiple transport steps through different membrane compartments. This review summarizes our current knowledge of the trafficking pathways of AMPARs and their relation to synaptic function and plasticity. British Journal of Pharmacology(2008)153, S35–S43; doi:10.1038/sj.bjp.0707525; published online 19 November 2007
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NMDAR-dependent LTD involves clathrin-dependent rapid endocytosis of AMPA receptors (AMPARs).
“NMDA receptor (NMDAR)–dependent LTD, an extensively studied form of LTD, involves a rise in postsynaptic Ca2+ concentration, activation of a serine-threonine protein phosphatase cascade, and clathrin-dependent rapid endocytosis of AMPA receptors (AMPARs) [1]–[10].”
From Regulated RalBP1 Binding to RalA and PSD-95 Controls AMPA Receptor Endocytosis and LTD (2009) · cites this paper as [6]
The “Activity-dependent internalization and sorting of AMPA receptors” section says that AMPAR internalization leading to LTD requires clathrin-mediated endocytosis and that NMDAR activation during LTD induction rapidly activates Rab5. It does not explicitly say that AMPAR endocytosis itself is rapid; the speed qualifier is supported for Rab5 activation, not for endocytosis. (LLM, conf=0.85)
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Cites
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PKA phosphorylation of AMPA receptor subunits controls synaptic trafficking underlying plasticity
Esteban, J. A., Shi, S.-H., Wilson, C., Nuriya, M., Huganir, R. L., & Malinow, R. (2003) · Nature Neuroscience · doi:10.1038/nn997 · Cited by 894 · see citing works
Self-citationRecycling Endosomes Supply AMPA Receptors for LTP
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“In hippocampal and parallel fibre-Purkinje cell synapses, PICK1 appears to drive the synaptic removal of phosphorylated GluR2 receptors (Kim et al., 2001; Chung et al., 2003; Steinberg et al., 2006).”
BackgroundSynaptic transmission and plasticity in the absence of AMPA glutamate receptor GluR2 and GluR3
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Research works printed but not linked: 1
- Hebb DO (1949). Organization of Behavior. Wiley: New York.
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Regulated RalBP1 Binding to RalA and PSD-95 Controls AMPA Receptor Endocytosis and LTD
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- Authors
- Esteban, J. A.
- Affiliations
- University of Michigan (US)
- Corresponding author
- Esteban, J A
- ORCID
- Esteban, J A
- Venue
- British Journal of Pharmacology
- Publisher
- Wiley
- Published
- 2008-03
- Volume
- 153
- Issue
- S1
- Pages
- S35-43
- ISSN
- 0007-1188 (ISSN-L)
- 1476-5381
- PMC
- PMC2268045
- OpenAlex
- W1568595509
- Cited by
- 29
- References
- 15
- Citations by year
- 2025: 1 · 2022: 2 · 2021: 2 · 2020: 1 · 2019: 1 · 2017: 2 · 2016: 1 · 2014: 3 · 2013: 5
- FWCI
- 0.20
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal of Pharmacology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Deep Blue (University of Michigan) (submittedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
- Funders
- National Institute of Mental Health (MH070417, R01MH070417, MH070205, F31MH070205)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Keywords
- AMPA receptors, receptor trafficking, synaptic plasticity, long-term potentiation, long-term depression, excitatory synapses, intracellular transport, membrane compartments
- MeSH terms
- Animals, Biological Transport, Active, Cytoskeleton, Endoplasmic Reticulum, Humans, Neuronal Plasticity, Substrate Specificity, Synapses, Long-Term Potentiation, Receptors, AMPA
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