Cited by 251Neuroscience and Neuropharmacology ResearchMemory and Neural MechanismsGenetics and Neurodevelopmental Disorders

Synaptic transmission and plasticity in the absence of AMPA glutamate receptor GluR2 and GluR3

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Meng, Yanghong, Zhang, Yu, Jia, Zhengping·2003·Neuron

Abstract

The AMPA glutamate receptor (AMPAR) subunits GluR2 and GluR3 are thought to be important for synaptic targeting/stabilization of AMPARs and the expression of hippocampal long-term depression (LTD). In order to address this hypothesis genetically, we generated and analyzed knockout mice deficient in the expression of both GluR2 and GluR3. We show here that the double knockout mice are severely impaired in basal synaptic transmission, demonstrating that GluR2/3 are essential to maintain adequate synaptic transmission in vivo. However, these mutant mice are competent in establishing several forms of long-lasting synaptic changes in the CA1 region of the hippocampus, including LTD, long-term potentiation (LTP), depotentiation, and dedepression, indicating the presence of GluR2/3-independent mechanisms of LTD expression and suggesting that AMPA receptor GluR1 alone is capable of various forms of synaptic plasticity.

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Crossref · 10.1016/s0896-6273(03)00368-4

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  • Hippocampal LTD is still observed in knock-outs of GluA2/3, but not in neurons expressing GluA2 fused to the GluA1 C-tail.

    “Hippocampal LTD is still observed in knock-outs of GluA2/3 (Meng et al., 2003), but not in neurons expressing GluA2 fused to the GluA1 C-tail (Zhou et al., 2017).”

    From The AMPA Receptor Code of Synaptic Plasticity (2018) · cites this paper as Meng et al., 2003

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Authors
Meng, Y., Zhang, Y., & Jia, Z.
Affiliations
  • University of Toronto (CA)
  • Hospital for Sick Children (CA)
Corresponding author
Jia, Zhengping
Venue
Neuron
Publisher
Elsevier BV
Published
2003-07
Volume
39
Issue
1
Pages
163-176
ISSN
0896-6273 (ISSN-L)
OpenAlex
W2056366478
Cited by
251
References
56
Citations by year
2026: 2 · 2025: 4 · 2024: 8 · 2023: 6 · 2022: 6 · 2021: 11 · 2020: 8 · 2019: 2 · 2018: 12 · 2017: 14 · 2016: 10 · 2015: 6 · 2014: 11 · 2013: 13 · 2012: 12
FWCI
5.61
Type
journal article
Language
en
Open access
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Keywords
AMPA receptors, GluR2, GluR3, GluR1, synaptic transmission, synaptic plasticity, long-term depression, long-term potentiation, depotentiation, hippocampal CA1, knockout mice, synaptic targeting
MeSH terms
Animals, Electrophysiology, Female, Hippocampus, Immunohistochemistry, Male, Microscopy, Electron, Synaptic Transmission, Neuronal Plasticity, Organ Culture Techniques, Immunoblotting, Long-Term Potentiation, Receptors, AMPA, Mice, Knockout, Excitatory Postsynaptic Potentials, Long-Term Synaptic Depression, Mice

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