Regulation of AIF expression by p53

Surfing the p53 network

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Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

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PUMA, a Novel Proapoptotic Gene, Is Induced by p53

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Definition of a consensus binding site for p53

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p53 Has a Direct Apoptogenic Role at the Mitochondria

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The antioxidant function of the p53 tumor suppressor

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Unbiased mapping of transcription factor binding sites along human chromosomes 21 and 22 points to widespread regulation of noncoding RNAs

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Decision making by p53: life, death and cancer

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Cellular Senescence

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Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD

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Mitochondrial Release of Caspase-2 and -9 during the Apoptotic Process

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Apaf-1 and Caspase-9 in p53-Dependent Apoptosis and Tumor Inhibition

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Mechanisms of p53-dependent apoptosis

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AIF deficiency compromises oxidative phosphorylation

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The harlequin mouse mutation downregulates apoptosis-inducing factor

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Mechanisms of p53-dependent apoptosis

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Role of AIF in caspase-dependent and caspase-independent cell death

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Apoptosis-inducing factor (AIF): key to the conserved caspase-independent pathways of cell death?

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Dexamethasone-induced apoptosis involves cleavage of DNA to large fragments prior to internucleosomal fragmentation.

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Sequence-specific transcriptional activation is essential for growth suppression by p53.

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NADH Oxidase Activity of Mitochondrial Apoptosis-inducing Factor

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p53-Induced Up-Regulation of MnSOD and GPx but not Catalase Increases Oxidative Stress and Apoptosis

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DNA binding is required for the apoptogenic action of apoptosis inducing factor

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Loss of m-AAA protease in mitochondria causes complex I deficiency and increased sensitivity to oxidative stress in hereditary spastic paraplegia

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Dominant cell death induction by extramitochondrially targeted apoptosis‐inducing factor

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Bnip3L is induced by p53 under hypoxia, and its knockdown promotes tumor growth

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Apoptosis-inducing factor (AIF): caspase-independent after all

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p53-dependent Caspase-2 Activation in Mitochondrial Release of Apoptosis-inducing Factor and Its Role in Renal Tubular Epithelial Cell Injury

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AIF suppresses chemical stress‐induced apoptosis and maintains the transformed state of tumor cells

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Deregulated manganese superoxide dismutase expression and resistance to oxidative injury in p53-deficient cells.

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Respiration-dependent Removal of Exogenous H2O2 in Brain Mitochondria

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Mutant p53 gain of function: repression of CD95(Fas/APO-1) gene expression by tumor-associated p53 mutants

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Identification of a novel class of genomic DNA-binding sites suggests a mechanism for selectivity in target gene activation by the tumor suppressor protein p53Preprint

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Caspase-Dependent Cytosolic Release of Cytochrome c and Membrane Translocation of Bax in p53-Induced Apoptosis

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Redox proteins in mammalian cell death: an evolutionarily conserved function in mitochondria and prokaryotes

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Monitoring of Stress Responses

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p53 can promote mitochondria- and caspase-independent apoptosis

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p53: Guardian of a Genome's Guardian?

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β‐amyloid binds to p75NTR and activates NFκB in human neuroblastoma cells

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Putting p53 in context

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P53 in survival, death and metabolic health: a lifeguard with a licence to kill.

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Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells

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Census and evaluation of p53 target genes

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Transcriptional and post-transcriptional regulation of mitochondrial biogenesis in skeletal muscle: effects of exercise and aging

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The transcription factor p53: Not a repressor, solely an activator.

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Regulation of Metabolic Activity by p53

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The mitochondrial genome in aging and senescence

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