Cited by 167Mitochondrial Function and PathologyAdipose Tissue and MetabolismMuscle Physiology and Disorders

Transcriptional and post-transcriptional regulation of mitochondrial biogenesis in skeletal muscle: effects of exercise and aging

Ljubicic, Vladimir, Joseph, Anna-Maria, Saleem, Ayesha, Uguccioni, Giulia, Collu-Marchese, Melania, Lai, Ruanne Y.J., Nguyen, Linda M.-D., Hood, David A.·2010·Biochimica et Biophysica Acta (BBA) - General Subjects

Abstract

Acute contractile activity of skeletal muscle initiates the activation of signaling kinases. This promotes the phosphorylation of transcription factors, leading to enhanced DNA binding and transcriptional activation and/or repression. The mRNA products of nuclear genes encoding mitochondrial proteins are translated in the cytosol and imported into pre-existing mitochondria. When contractile activity is repeated, the recapitulation of these cellular events progressively leads to an expansion of the mitochondrial reticulum within muscle. This has physiologically relevant health benefit, including enhanced lipid metabolism and reduced muscle fatigability. In aging skeletal muscle, the response to contractile activity appears to be attenuated, suggesting that a greater contractile stimulus is required to attain a similar phenotype adaptation. This review summarizes our current understanding of the effects of exercise on the gene expression pathway leading to organelle biogenesis in muscle.

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Registry

Crossref · 10.1016/j.bbagen.2009.07.031

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  • TFAM regulates mtDNA transcription by directly interacting with the mitochondrial genome along with mitochondrial transcription specificity factors TFB1M and TFB2M.

    “Key in orchestrating this process is the nuclear-encoded mitochondrial transcription factor A (TFAM), which is pivotal in regulating mtDNA transcription by directly interacting with mitochondrial genome along with mitochondrial transcription specificity factors TFB1M and TFB2M (Figure 3; Gleyzer et al., 2005; Ljubicic et al., 2010).”

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Authors
Ljubicic, V., Joseph, A.-M., Saleem, A., Uguccioni, G., Collu-Marchese, M., Lai, R. Y. J., Nguyen, L. M.-D., & Hood, D. A.
Affiliations
York University (CA)
Corresponding author
Hood, David A.
Venue
Biochimica et Biophysica Acta (BBA) - General Subjects
Publisher
Elsevier BV
Published
2010-03
Volume
1800
Issue
3
Pages
223-234
ISSN
0304-4165 (ISSN-L)
OpenAlex
W2069587958
Cited by
167
References
194
Citations by year
2026: 2 · 2025: 4 · 2024: 5 · 2023: 5 · 2022: 4 · 2021: 16 · 2020: 7 · 2019: 6 · 2018: 9 · 2017: 15 · 2016: 13 · 2015: 14 · 2014: 13 · 2013: 11 · 2012: 21
FWCI
1.10
Type
journal article
Language
en
Open access
closed
Locations
  • Biochimica et Biophysica Acta (BBA) - General Subjects (publishedVersion)
  • PubMed (publishedVersion)
Funders
Canadian Institutes of Health Research
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Keywords
mitochondrial biogenesis, skeletal muscle, physical activity, aging, transcriptional regulation, post-transcriptional regulation, mitochondrial translation, mitochondrial protein import, transcription factors, lipid metabolism, muscle fatigue, mitochondrial reticulum
MeSH terms
Adenosine Triphosphate, Adult, Aged, Aging, Organelle Biogenesis, Calcium, Gene Expression Regulation, Humans, Middle Aged, Mitochondria, Muscle, RNA Processing, Post-Transcriptional, RNA, Messenger, Transcription Factors, Transcription, Genetic, Protein Biosynthesis, Exercise, Muscle, Skeletal, Muscle Fibers, Skeletal

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