The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
Supplementation With Goldenseal (Hydrastis canadensis), but not Kava Kava (Piper methysticum), Inhibits Human CYP3A Activity In Vivo
Abstract
The effects of goldenseal (Hydrastis canadensis) and kava kava (Piper methysticum) supplementation on human CYP3A activity were evaluated using midazolam (MDZ) as a phenotypic probe. Sixteen healthy volunteers were randomly assigned to receive either goldenseal or kava kava for 14 days. Each supplementation phase was followed by a 30-day washout period. MDZ (8 mg, per os) was administered before and after each phase, and pharmacokinetic parameters were determined using standard non-compartmental methods. Comparisons of pre- and post-supplementation MDZ pharmacokinetic parameters revealed significant inhibition of CYP3A by goldenseal (AUC(0-infinity), 107.9+/-43.3 vs 175.3+/-74.8 ng x h/ml; Cl/F/kg, 1.26+/-0.59 vs 0.81+/-0.45 l/h/kg; T(1/2), 2.01+/-0.42 vs 3.15+/-1.12 h; Cmax, 50.6+/-26.9 vs 71.2+/-50.5 ng/ml). MDZ disposition was not affected by kava kava supplementation. These findings suggest that significant herb-drug interactions may result from the concomitant ingestion of goldenseal and CYP3A substrates.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Goldenseal supplementation markedly inhibited the metabolism of midazolam, a CYP3A probe substrate, with an increase in exposure on the order of 40-60%.
“Goldenseal supplementation markedly inhibited the metabolism of midazolam, a CYP3A probe substrate, with an increase in exposure on the order of 40–60% [72,73].”
From Berberine-Drug Interactions: Mechanisms, Clinical Relevance and Risk Stratification-A Narrative Review (2026) · cites this paper as [73]
Citations
Cites
Statistical power analysis for the behavioral sciences
Cohen, J. (1990) · Computers Environment and Urban Systems · doi:10.1016/0198-9715(90)90050-4 · Cited by 65,415
St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor
Moore, L. B., Goodwin, B. J., Jones, S. A., Wisely, G. B., Serabjit‐Singh, C. J., Willson, T. M., Collins, J. L., & Kliewer, S. A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.130155097 · Cited by 946
Gorski, J. C., Jones, D. R., HAEHNERDANIELS, B., Hamman, M. A., O'Mara, E. M., & Hall, S. D. (1998) · Clinical Pharmacology & Therapeutics · doi:10.1016/s0009-9236(98)90146-1 · Cited by 409
Interactions of Herbs with Cytochrome P450
Zhou, S.-F., Gao, Y.-H., Jiang, W.-Q., Huang, M., Xu, A., & Paxton, J. (2003) · Drug metabolism reviews (Softcover ed.) · doi:10.1081/dmr-120018248 · Cited by 404
Budzinski, J. W., Foster, B. C., Vandenhoek, S., & Arnason, J. T. (2000) · Phytomedicine · doi:10.1016/s0944-7113(00)80044-6 · Cited by 352
Cytochrome P450 phenotypic ratios for predicting herb‐drug interactions in humans
Gurley, B. J., Gardner, S. F., Hubbard, M. A., Williams, D. K., Gentry, W. B., Cui, Y., & ANG, C. Y. W. (2002) · Clinical Pharmacology & Therapeutics · doi:10.1067/mcp.2002.126913 · Cited by 345
Self-citationZuo, F., Nakamura, N., Akao, T., & Hattori, M. (2006) · Drug Metabolism and Disposition · doi:10.1124/dmd.106.011361 · Cited by 284
Effects of ginseng components on c-DNA-expressed cytochrome P450 enzyme catalytic activity
Henderson, G. L., Harkey, M. R., Gershwin, M. E., Hackman, R. M., Stern, J. S., & Stresser, D. M. (1999) · Life Sciences · doi:10.1016/s0024-3205(99)00407-5 · Cited by 274
GURLEY, B., GARDNER, S., HUBBARD, M., WILLIAMS, D., GENTRY, W., KHAN, I., & SHAH, A. (2005) · Clinical Pharmacology & Therapeutics · doi:10.1016/j.clpt.2005.01.009 · Cited by 271
Self-citationComa from the Health Food Store: Interaction between Kava and Alprazolam
Almeida, J. C., & Grimsley, E. W. (1996) · Annals of Internal Medicine · doi:10.7326/0003-4819-125-11-199612010-00023 · Cited by 258
Pharmacokinetic interactions between herbal remedies and medicinal drugs
Ioannides, C. (2002) · Xenobiotica · doi:10.1080/00498250210124147 · Cited by 236
Gorski, J. C. (2003) · Clinical Pharmacology & Therapeutics · doi:10.1016/s0009-9236(03)00187-5 · Cited by 210
Effects of herbal components on cDNA-expressed cytochrome P450 enzyme catalytic activity
Zou, L., Harkey, M. R., & Henderson, G. L. (2002) · Life Sciences · doi:10.1016/s0024-3205(02)01913-6 · Cited by 204
In Vitro Approaches to Predicting Drug Interactions In Vivo
Moltke, L. L., Greenblatt, D. J., Schmider, J., Wright, C. E., Harmatz, J. S., & Shader, R. I. (1998) · Biochemical Pharmacology · doi:10.1016/s0006-2952(97)00239-6 · Cited by 196
Inhibition of Human Cytochrome P450 Activities by Kava Extract and Kavalactones
Mathews, J. M., Etheridge, A. S., & Black, S. R. (2002) · Drug Metabolism and Disposition · doi:10.1124/dmd.30.11.1153 · Cited by 181
Factors Associated With Dietary Supplement Use Among Prescription Medication Users
Gardiner, P. M. (2006) · Archives of Internal Medicine · doi:10.1001/archinte.166.18.1968 · Cited by 171
Unger, M., & Frank, A. (2004) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.1621 · Cited by 164
Murray, M. T. (2000) · Current Drug Metabolism · doi:10.2174/1389200003339270 · Cited by 161
Brazier, N. C., & Levine, M. (2003) · American Journal of Therapeutics · doi:10.1097/00045391-200305000-00003 · Cited by 149
Foster, B. C., Vandenhoek, S., Hana, J., Krantis, A., Akhtar, M., Bryan, M., Budzinski, J. W., Ramputh, A., & Arnason, J. T. (2003) · Phytomedicine · doi:10.1078/094471103322004839 · Cited by 146
Chatterjee, P., & Franklin, M. R. (2003) · Drug Metabolism and Disposition · doi:10.1124/dmd.31.11.1391 · Cited by 146
Herbal Interactions Involving Cytochrome P450 Enzymes
Delgoda, R., & Westlake, A. C. G. (2004) · Toxicological Reviews · doi:10.2165/00139709-200423040-00004 · Cited by 141
The effect of St John’s wort extracts on CYP3A: a systematic review of prospective clinical trials
Whitten, D. L., Myers, S. P., Hawrelak, J. A., & Wohlmuth, H. (2006) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2006.02755.x · Cited by 120
Gurley, B. J., Hubbard, M. A., Williams, D. K., Thaden, J. J., Tong, Y., Gentry, W. B., Breen, P. J., Carrier, D. J., & Cheboyina, S. (2006) · The Journal of Clinical Pharmacology · doi:10.1177/0091270005284854 · Cited by 111
Self-citationPharmacokinetic and pharmacodynamic drug interactions with Kava (Piper methysticum Forst. f.)
Anke, J., & Ramzan, I. M. (2004) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2004.04.009 · Cited by 96
Strandell, J., Neil, A., & Carlin, G. (2004) · Phytomedicine · doi:10.1078/0944-7113-00379 · Cited by 92
Wold, R. S., Lopez, S. T., Yau, C. L., Butler, L. M., Pareo-Tubbeh, S. L., Waters, D. L., Garry, P. J., & Baumgartner, R. (2005) · Journal of the American Dietetic Association · doi:10.1016/j.jada.2004.11.002 · Cited by 90
Wu, X., Li, Q., Xin, H., Yu, A., & Zhong, M. (2005) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-005-0952-3 · Cited by 90
Composition and biological activity of traditional and commercial kava extracts
Côté, C. S., Kor, C., Cohen, J., & Auclair, K. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.07.093 · Cited by 89
Zeng, X., & Zeng, X. (1999) · Biomedical Chromatography · doi:10.1002/(sici)1099-0801(199911)13:7 · Cited by 84
Mathews, J. M., Etheridge, A. S., Valentine, J. L., Black, S. R., Coleman, D. P., Patel, P. R., So, J., & Burka, L. T. (2005) · Drug Metabolism and Disposition · doi:10.1124/dmd.105.004317 · Cited by 84
Gurley, B. J., Swain, A., Barone, G. W., Williams, D. K., Breen, P. J., Yates, C. R., Stuart, L. B., Hubbard, M. A., Tong, Y., & Cheboyina, S. (2006) · Drug Metabolism and Disposition · doi:10.1124/dmd.106.012708 · Cited by 71
Self-citationInhibition of Cytochrome P450 3A4 by Extracts and Kavalactones of Piper methysticum (Kava-Kava)
Unger, M., Holzgrabe, U., Jacobsen, W., Cummins, C. L., & Benet, L. Z. (2002) · Planta Medica · doi:10.1055/s-2002-36360 · Cited by 66
The effects of berberine on the pharmacokinetics of ciclosporin A in healthy volunteers
Xin, H.-W., Wu, X.-C., Li, Q., Yu, A.-R., & Zhong, M.-Y. (2006) · Methods and Findings in Experimental and Clinical Pharmacology · doi:10.1358/mf.2006.28.1.962774 · Cited by 63
Safety review of kava (Piper methysticum) by the Natural Standard Research Collaboration
Ulbricht, C. E., Basch, E., Boon, H. S., Ernst, E., Hammerness, P. G., Sollars, D., Tsourounis, C., Woods, J., & Bent, S. (2005) · Expert Opinion on Drug Safety · doi:10.1517/14740338.4.4.779 · Cited by 62
Zou, L., Henderson, G. L., Harkey, M. R., Sakai, Y., & Li, A. P. (2004) · Phytomedicine · doi:10.1078/0944711041495263 · Cited by 59
Influence of Goldenseal Root on the Pharmacokinetics of Indinavir
Sandhu, R. S., Prescilla, R. P., Simonelli, T. M., & Edwards, D. J. (2003) · The Journal of Clinical Pharmacology · doi:10.1177/0091270003258660 · Cited by 59
Abourashed, E. A., & Khan, I. A. (2001) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.1035 · Cited by 58
Identification of some human urinary metabolites of the intoxicating beverage kava
Duffield, A. M., Jamieson, D., Lidgard, R. O., Duffield, P. H., & Bourne, D. J. (1989) · Journal of Chromatography A · doi:10.1016/s0021-9673(01)89682-5 · Cited by 55
Clayton, N. P., Yoshizawa, K., Kissling, G. E., Burka, L. T., Chan, P., & Nyska, A. (2006) · Experimental and Toxicologic Pathology · doi:10.1016/j.etp.2006.08.002 · Cited by 54
Kinetics of kavain and its metabolites after oral application
Tarbah, F., MAHLER, H., Kardel, B., Weinmann, W., Häfner, D., & Daldrup, T. (2003) · Journal of Chromatography B · doi:10.1016/s1570-0232(03)00046-1 · Cited by 39
Analytical techniques for the determination of lactones inPiper methysticum forst
Ganzera, M., & Khan, I. A. (1999) · Chromatographia · doi:10.1007/bf02497298 · Cited by 39
Phytochemical Assays of Commercial Botanical Dietary Supplements
Krochmal, R., Hardy, M. L., Bowerman, S., Lu, Q., Hj, W., Elashoff, R., & Heber, D. (2004) · Evidence-based Complementary and Alternative Medicine · doi:10.1093/ecam/neh040 · Cited by 38
Nakajima, M., Suzuki, M., Yamaji, R., Takashina, H., Shimada, N., Yamazaki, H., & Yokoi, T. (1999) · Xenobiotica · doi:10.1080/004982599237877 · Cited by 35
Clinical Drug Interactions with Medicinal Herbs
Johne, A., & Roots, I. (2005) · Evidence-Based Integrative Medicine · doi:10.2165/01197065-200502040-00004 · Cited by 19
Hu, L., Jhoo, J., ANG, C. Y. W., Dinovi, M., & Mattia, A. (2005) · Journal of AOAC International · doi:10.1093/jaoac/88.1.16 · Cited by 16
Flagged first, then by citations
Research works printed but not linked: 1
- Almeida J., 1996, Arch. Int. Med., 125, 940
Cited by
Sorted by citations
Interactions Between Herbal Medicines and Prescribed Drugs: An Updated Systematic Review
Izzo, A. A., & Ernst, E. (2009) · Drugs · doi:10.2165/11317010-000000000-00000 · Cited by 801
Adverse Effects of Nutraceuticals and Dietary Supplements
Ronis, M. J. J., Pedersen, K. B., & Watt, J. D. (2017) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010617-052844 · Cited by 393
Interactions between Herbs and Conventional Drugs: Overview of the Clinical Data
Izzo, A. A. (2012) · Medical Principles and Practice · doi:10.1159/000334488 · Cited by 253
Model-Based Drug Development: A Rational Approach to Efficiently Accelerate Drug Development
Milligan, P. A., Brown, M. J., Marchant, B., Martin, S. W., van der Graaf, P. H., Benson, N., Nucci, G., Nichols, D. J., Boyd, R. A., Mandema, J. W., et al. (2013) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2013.54 · Cited by 238
Tsai, D. H., Lin, H.-W., Pickard, A. S., Tsai, H.-Y., & Mahady, G. B. (2012) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2012.03008.x · Cited by 202
Clinical Evidence of Herbal Drugs As Perpetrators of Pharmacokinetic Drug Interactions
Hermann, R., & von Richter, O. (2012) · Planta Medica · doi:10.1055/s-0032-1315117 · Cited by 198
Hanke, N., Frechen, S., Moj, D., Britz, H., Eissing, T., Wendl, T., & Lehr, T. (2018) · CPT: Pharmacometrics & Systems Pharmacology · doi:10.1002/psp4.12343 · Cited by 169
Gurley, B., Fifer, E., & Gardner, Z. (2012) · Planta Medica · doi:10.1055/s-0031-1298331 · Cited by 165
Self-citationDrug Interactions with Herbal Medicines
Shi, S., & Klotz, U. E. (2012) · Clinical Pharmacokinetics · doi:10.2165/11597910-000000000-00000 · Cited by 147
Rombolà, L., Scuteri, D., Straface, M., Watanabe, C., Morrone, L. A., Bagetta, G., & Corasaniti, M. T. (2020) · Life · doi:10.3390/life10070106 · Cited by 138
Herbal Medications in Cardiovascular Medicine
Liperoti, R., Vetrano, D. L., Bernabei, R., & Onder, G. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2016.11.078 · Cited by 127
Cytochrome P450 enzyme mediated herbal drug interactions (Part 2)
Wanwimolruk, S., Phopin, K., & Prachayasittikul, V. (2014) · PubMed Central · doi:10.17877/de290r-6855 · Cited by 126
Clinically based evidence of drug–herb interactions: a systematic review
Kennedy, D. A., & Seely, D. (2010) · Expert Opinion on Drug Safety · doi:10.1517/14740330903405593 · Cited by 116
Wang, Y.-H. (2010) · Drug Metabolism and Disposition · doi:10.1124/dmd.110.032177 · Cited by 103
Almond, L. M., Mukadam, S., Gardner, I., Okialda, K., Wong, S., Hatley, O., Tay, S., Rowland-Yeo, K., Jamei, M., Rostami-Hodjegan, A., et al. (2016) · Drug Metabolism and Disposition · doi:10.1124/dmd.115.066845 · Cited by 101
Pharmacokinetic drug interactions involvingGinkgo biloba
Unger, M. (2013) · Drug Metabolism Reviews · doi:10.3109/03602532.2013.815200 · Cited by 98
Einolf, H. J., Chen, L., Fahmi, O. A., Gibson, C. R., Obach, R. S., Shebley, M., Silva, J., Sinz, M., Unadkat, J. D., Zhang, L., et al. (2013) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2013.170 · Cited by 95
Herb-drug interactions: Focus on metabolic enzymes and transporters
Choi, Y. H., Chin, Y., & Kim, Y. G. (2011) · Archives of Pharmacal Research · doi:10.1007/s12272-011-1106-z · Cited by 91
Midazolam: an essential palliative care drug
Prommer, E. (2020) · Palliative Care and Social Practice · doi:10.1177/2632352419895527 · Cited by 88
Botanical-Drug Interactions: A Scientific Perspective
Vieira, M. D. L. T., & Huang, S. M. (2012) · Planta Medica · doi:10.1055/s-0032-1315145 · Cited by 78
Dose-response of berberine on hepatic cytochromes P450 mRNA expression and activities in mice
Guo, Y., Pope, C., Cheng, X., Zhou, H., & Klaassen, C. D. (2011) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2011.08.058 · Cited by 77
Chan, W.-J. J., Adiwidjaja, J., McLachlan, A. J., Boddy, A. V., & Harnett, J. (2023) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-023-04504-z · Cited by 68
Shord, S. S., Shah, K., & Lukose, A. (2009) · Integrative Cancer Therapies · doi:10.1177/1534735409340900 · Cited by 66
Cytochrome P450 enzyme mediated herbal drug interactions (Part 1)
Wanwimolruk, S., & Prachayasittikul, V. (2014) · Europe PMC (PubMed Central) · doi:10.17877/de290r-15628 · Cited by 64
Gougis, P., Hilmi, M., Géraud, A., Mir, O., & Funck‐Brentano, C. (2021) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2021.103342 · Cited by 63
Mandal, S. K., Maji, A. K., Mishra, S. K., Ishfaq, P. M., Devkota, H. P., Sanches-Silva, A. T., & Das, N. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105085 · Cited by 60
Mao, J., Mohutsky, M. A., Harrelson, J. P., Wrighton, S. A., & Hall, S. D. (2011) · Drug Metabolism and Disposition · doi:10.1124/dmd.110.036400 · Cited by 57
Bordes, C., Leguelinel, G., Lavigne, J.-P., Mauboussin, J. M., Laureillard, D., Faure, H., Rouanet, I., Sotto, A., & Loubet, P. (2020) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2020.04.019 · Cited by 49
Gómez-Garduño, J., León‐Rodríguez, R., Alemón‐Medina, R., Pérez-Guillé, B., Soriano‐Rosales, R. E., González-Ortíz, A., Chávez-Pacheco, J. L., Solorio, E., Fernández-Pérez, P. G., & Rivera-Espinosa, L. (2022) · Dose-Response · doi:10.1177/15593258221120485 · Cited by 48
Xu, Y., Zhou, Y., Hayashi, M., Shou, M., & Skiles, G. L. (2011) · Drug Metabolism and Disposition · doi:10.1124/dmd.111.038067 · Cited by 48
Modulations of cytochrome P450 expression in diabetic mice by berberine
Chatuphonprasert, W., Nemoto, N., Sakuma, T., & Jarukamjorn, K. (2012) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2012.01.006 · Cited by 44
Tseng, E., Eng, H. F., Lin, J., Cerny, M. A., Tess, D. A., Goosen, T. C., & Obach, R. S. (2021) · Drug Metabolism and Disposition · doi:10.1124/dmd.121.000497 · Cited by 43
Nguyen, J. T., Tian, D., Tanna, R. S., Hadi, D. L., Bansal, S., Calamia, J. C., Arian, C. M., Shireman, L. M., Molnár, B., Horváth, M., et al. (2021) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.2107 · Cited by 40
Liu, Y., Liu, Q. L., Liu, Y., Ju, F., Ma, Q., & He, Q. (2019) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2019.111619 · Cited by 39
Naramoto, K., Kato, M., & Ichihara, K. (2014) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf504034u · Cited by 38
An overview on plants cannabinoids endorsed with cardiovascular effects
Dimmito, M. P., Stefanucci, A., Valle, A. D., Scioli, G. A., Cichelli, A., & Mollica, A. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111963 · Cited by 37
A regulatory science viewpoint on botanical–drug interactions
Grimstein, M., & Huang, S. M. (2018) · Journal of Food and Drug Analysis · doi:10.1016/j.jfda.2018.01.013 · Cited by 37
Clinically Relevant Pharmacokinetic Herb-drug Interactions in Antiretroviral Therapy
Fasinu, P. S., Gurley, B. J., & Walker, L. (2015) · Current Drug Metabolism · doi:10.2174/1389200216666151103115053 · Cited by 36
Self-citationEffect of Botanical Immunomodulators on Human CYP3A4 Inhibition
Patil, D., Gautam, M., Gairola, S., Jadhav, S. S., & Patwardhan, B. (2013) · Integrative Cancer Therapies · doi:10.1177/1534735413503551 · Cited by 36
Methysticin and 7,8-Dihydromethysticin are Two Major Kavalactones in Kava Extract to Induce CYP1A1
Li, Y., Hu, M. Y., Wu, Q., Zhang, S., Fang, J., Shi, L. M., & Guo, L. (2011) · Toxicological Sciences · doi:10.1093/toxsci/kfr235 · Cited by 34
Herb–Drug Interactions: Worlds Intersect with the Patient at the Center
Babos, M. B., Heinan, M. L., Redmond, L., Moiz, F., Souza-Peres, J. V., Samuels, V., Masimukku, T., Hamilton, D., Khalid, M., & Herscu, P. (2021) · Medicines · doi:10.3390/medicines8080044 · Cited by 32
Current perspectives in herbal and conventional drug interactions based on clinical manifestations
Surana, A. R., Agrawal, S. P., Kumbhare, M. R., & Gaikwad, S. B. (2021) · Future Journal of Pharmaceutical Sciences · doi:10.1186/s43094-021-00256-w · Cited by 30
Duggan, S. T., Chwieduk, C. M., & Curran, M. P. (2010) · Drugs · doi:10.2165/11204360-000000000-00000 · Cited by 29
Nowack, R., Andrassy, J., Fischereder, M., & Unger, M. (2009) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2008.303 · Cited by 29
Shin, J., Pauly, D. F., Johnson, J. A., & Frye, R. F. (2008) · Journal of Chromatography B · doi:10.1016/j.jchromb.2008.06.050 · Cited by 29
Anthraquinones inhibit cytochromes P450 enzyme activity in silico and in vitro
Liu, Y., Mapa, M. S. T., & Sprando, R. L. (2021) · Journal of Applied Toxicology · doi:10.1002/jat.4134 · Cited by 28
Yi, S., Cho, J., Lim, K. S., Kim, K., Kim, J., Kim, B., Hong, J. H., Jang, I., Shin, S., & Yu, K. (2009) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/j.1742-7843.2009.00423.x · Cited by 28
Markowitz, J. S., Moltke, L. L., & Donovan, J. L. (2008) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200700159 · Cited by 28
&NA; (2011) · Drugs · doi:10.2165/11595520-000000000-00000 · Cited by 27
Mechanisms of intestinal pharmacokinetic natural product-drug interactions
Oyanna, V. O., & Clarke, J. D. (2024) · Drug Metabolism Reviews · doi:10.1080/03602532.2024.2386597 · Cited by 24
Zhang, X.-L., Chen, M., Zhu, L., & Zhou, Q. (2017) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2017/9296404 · Cited by 24
Cox, E. J., Tian, D., Clarke, J., Rettie, A. E., Unadkat, J. D., Thummel, K. E., McCune, J. S., & Paine, M. F. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000106 · Cited by 23
Bioactivation of herbal constituents: mechanisms and toxicological relevance
Wen, B., & Gorycki, P. D. (2019) · Drug Metabolism Reviews · doi:10.1080/03602532.2019.1655570 · Cited by 23
Drug Metabolism and Pharmacokinetic Diversity of Ranunculaceae Medicinal Compounds
Hao, D., Ge, G., Xiao, P., Wang, P., & Yang, L. (2015) · Current Drug Metabolism · doi:10.2174/1389200216666150803144631 · Cited by 22
Herb‐drug interactions: A short review on central and peripheral nervous system drugs
Bernardo, J., & Valentão, P. (2024) · Phytotherapy Research · doi:10.1002/ptr.8120 · Cited by 21
Gougis, P., Palmieri, L., Funck‐Brentano, C., Paci, A., Flippot, R., Mir, O., & Coriat, R. (2019) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2019.06.006 · Cited by 21
Zadoyan, G., & Fuhr, U. (2012) · Planta Medica · doi:10.1055/s-0031-1298536 · Cited by 21
Seasonal variation of biomass and bioactive alkaloid content of goldenseal, Hydrastis canadensis
Douglas, J. A., Follett, J. M., Parmenter, G. A., Sansom, C. E., Perry, N. B., & Littler, R. A. (2010) · Fitoterapia · doi:10.1016/j.fitote.2010.06.006 · Cited by 20
Brooks, K. M., George, J. M., & Kumar, P. (2016) · Expert Review of Clinical Pharmacology · doi:10.1080/17512433.2017.1246180 · Cited by 20
Wendl, T., Frechen, S., Gerisch, M., Heinig, R., & Eißing, T. (2021) · CPT Pharmacometrics & Systems Pharmacology · doi:10.1002/psp4.12746 · Cited by 20
McDonald, M. G., Tian, D., Thummel, K. E., Paine, M. F., & Rettie, A. E. (2020) · Drug Metabolism and Disposition · doi:10.1124/dmd.120.091041 · Cited by 19
Husain, I., Dale, O. R., Idrisi, M., Gurley, B. J., Avula, B., Katragunta, K., Ali, Z., Chittiboyina, A. G., Noonan, G. O., Khan, I. A., et al. (2023) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c07912 · Cited by 18
Self-citationGupta, P. K., Barone, G. W., Gurley, B. J., Fifer, E. K., & Hendrickson, H. P. (2015) · Drug Metabolism and Disposition · doi:10.1124/dmd.114.059410 · Cited by 17
Self-citationAdiwidjaja, J., Boddy, A. V., & McLachlan, A. J. (2022) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-021-03266-y · Cited by 14
Nguyen, J. T., Tian, D., Tanna, R. S., Arian, C. M., Calamia, J. C., Rettie, A. E., Thummel, K. E., & Paine, M. F. (2023) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.123.001681 · Cited by 13
Gurley, B. J., Markowitz, J. S., Williams, D. K., & Barone, G. W. (2016) · International Journal of Pharmacokinetics · doi:10.4155/ipk-2016-0009 · Cited by 13
Self-citationMorisaki, T., Hou, X., Takahashi, K., & Takahashi, K. (2013) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.12127 · Cited by 12
Haron, M. H., Dale, O. R., Martin, K., Avula, B., Chittiboyina, A. G., Khan, I. A., Gurley, B. J., & Khan, S. I. (2022) · Journal of Dietary Supplements · doi:10.1080/19390211.2022.2110351 · Cited by 12
Self-citationThe role of hepatic cytochrome P450s in the cytotoxicity of dronedarone
Chen, S., Wu, Q., Ning, B., Bryant, M., & Guo, L. (2018) · Archives of Toxicology · doi:10.1007/s00204-018-2196-x · Cited by 12
Roe, A. L., Krzykwa, J. C., Calderón, Á. I., Bascoul, C., Gurley, B. J., Koturbash, I., Li, A. P., Liu, Y., Mitchell, C. A., Oketch‐Rabah, H. A., et al. (2024) · Journal of Dietary Supplements · doi:10.1080/19390211.2024.2417679 · Cited by 11
Self-citationRecent Advances in the Electro-Active Therapeutic Phytochemical-Based Sensors
Gandhi, M., Amreen, K., & Tiwari, B. K. (2022) · Electrochem · doi:10.3390/electrochem3040041 · Cited by 10
Synergistic Effects of Chinese Herbal Medicine and Biological Networks
Bhuyan, D. J., Perera, S., Kaur, K., Alsherbiny, M. A., Low, M., Seto, S. W., Li, C.-G., & Zhou, X. (2020) · Human perspectives in health sciences and technology · doi:10.1007/978-3-030-32857-3_17 · Cited by 10
Interactions with herbal products: what do we know?
(2014) · Drug and Therapeutics Bulletin · doi:10.1136/dtb.2014.2.0234 · Cited by 10
An ex vivo approach to botanical–drug interactions: A proof of concept study
Wang, X., Zhu, H., Munoz, J., Gurley, B. J., & Markowitz, J. S. (2015) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2015.01.021 · Cited by 10
Self-citationWhayne, T. F. (2010) · Cardiovascular Therapeutics · doi:10.1111/j.1755-5922.2009.00101.x · Cited by 9
In vitro inhibition of carboxylesterase 1 by Kava (Piper methysticum) Kavalactones
Melchert, P. W., Qian, Y., Zhang, Q., Klee, B. O., Xing, C., & Markowitz, J. S. (2022) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2022.109883 · Cited by 8
Hunter, J., & Harnett, J. (2023) · Australian Journal of General Practice · doi:10.31128/ajgp-12-22-6631 · Cited by 6
Unger, M. (2011) · Forschende Komplementärmedizin / Research in Complementary Medicine · doi:10.1159/000330937 · Cited by 5
Hydrastis canadensis (Goldenseal) and Other Berberine-Containing Botanicals
Upton, R. (2020) · Elsevier eBooks · doi:10.1016/b978-0-323-43044-9.00086-8 · Cited by 5
Rougée, L. R. A., Hegde, P. V., Shin, K., Abraham, T. L., Bell, A., & Hall, S. D. (2024) · Drug Metabolism and Disposition · doi:10.1124/dmd.124.001820 · Cited by 4
Drug Metabolism and Pharmacokinetic Diversity of Ranunculaceae Medicinal Compounds
Hao, D. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-814232-5.00004-6 · Cited by 4
Likhodii, S. S., Chin, A., & Baskin, L. B. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-18649-3.00015-x · Cited by 3
Murray, M. T. (2012) · Wiley eBooks · doi:10.1002/9783527630905.ch19 · Cited by 3
ADME of Herbal Dietary Supplements
Paibir, S. G., & Rahavendran, S. V. (2012) · Wiley eBooks · doi:10.1002/9780470921920.edm039 · Cited by 3
Dumitru, C. N., Marcu, T., Dumitru, A. O., Tudor, S. S., Ferțu, I. D., Elisei, A.-M., & Goroftei, L. (2026) · Pharmaceuticals · doi:10.3390/ph19081313 · Cited by 2
“…(sirolimus); tacrolimus by extrapolation, PBPK-supported [63,81] Midazolam (CYP3A probe) CYP3A4 inhibition (goldenseal) [72,73] ↑ AUC ≈ 40–60% [73,74] B—clinical probe-substrate study (goldenseal) [72,73] Metformin OCT1/OCT2/MATE1inhibition[65,82] Bidirectional PK effect ( ↓ Cmax/AUC, ↑ renal…”
InfluentialNascimento, M. D. L., do Nascimento, S. B., Lima, E. D. S. P., de Oliveira, F. M., dos Santos, R. R., César, I. C., & de Castro, W. V. (2024) · Planta Medica · doi:10.1055/a-2360-4808 · Cited by 2
Nguyen, J. T., Arian, C. M., Tanna, R. S., Cherel, M. G., Layton, M. E., White, J. R., Thummel, K. E., & Paine, M. F. (2025) · Clinical and Translational Science · doi:10.1111/cts.70120 · Cited by 2
Effect of Herbal Supplement–Drug Interactions on Therapeutic Drug Monitoring
Chin, A., & Baskin, L. B. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-385467-4.00019-1 · Cited by 2
Gurley, B. J., Fifer, K. E., & Gardner, Z. (2012) · Wiley eBooks · doi:10.1002/9780470921920.edm086 · Cited by 2
Self-citation(2013) · Elsevier eBooks · doi:10.1016/b978-0-443-06992-5.00010-4 · Cited by 2
Kadam, J. D., & Auti, S. T. (2025) · Wiley eBooks · doi:10.1002/9781394203680.ch21 · Cited by 1
Use In Silico and In Vitro Methods to Screen Hepatotoxic Chemicals and CYP450 Enzyme Inhibitors
Liu, Y. (2022) · Methods in molecular biology · doi:10.1007/978-1-0716-2213-1_17 · Cited by 1
Potential herb–drug interactions for commonly used herbs
(2013) · Elsevier eBooks · doi:10.1016/b978-0-443-06992-5.00073-6 · Cited by 1
Ziani, B. E. C., Mohamed, A., Ziani, C., & Saher, L. (2023) · Springer eBooks · doi:10.1007/978-3-031-18587-8_7 · Cited by 1
Hydrastis canadensis (Goldenseal) and Other Berberine-Containing Botanicals
Murray, M. T. (2013) · Elsevier eBooks · doi:10.1016/b978-1-4377-2333-5.00097-3
McLachlan, A. J., & Clarke, S. J. (2015) · Wiley eBooks · doi:10.1002/9781119006039.ch21
Subaş, T., Gökkaya, İ., Özgen, U., Renda, G., & Şahin, S. (2022) · Journal of Literature Pharmacy Sciences · doi:10.5336/pharmsci.2021-84642
(2008) · Focus on Alternative and Complementary Therapies · doi:10.1211/fact.13.3.0007
Antagonistic Herb-Drug Interactions
Hemaiswarya, S., Prabhakar, P. K., & Doble, M. (2022) · Springer eBooks · doi:10.1007/978-981-19-5125-1_5
Drug–Drug Interactions and Drug–Dietary Chemical Interactions
Yang, M., Lyu, Y., & Zuo, Z. (2023) · Wiley eBooks · doi:10.1002/9781119660699.ch26
Metadata
- Authors
- Gurley, B. J., Swain, A., Hubbard, M. A., Hartsfield, F., Thaden, J., Williams, D. K., Gentry, W. B., & Tong, Y.
- Affiliations
- University of Arkansas for Medical Sciences (US)
- Corresponding author
- Gurley, B J
- Venue
- Clinical Pharmacology & Therapeutics
- Publisher
- Wiley
- Published
- 2007-05-09
- Volume
- 83
- Issue
- 1
- Pages
- 61-69
- ISSN
- 0009-9236 (ISSN-L)
- 1532-6535
- OpenAlex
- W2103333792
- Cited by
- 102
- References
- 46
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 6 · 2023: 6 · 2022: 8 · 2021: 8 · 2020: 8 · 2019: 3 · 2018: 4 · 2017: 3 · 2016: 3 · 2015: 5 · 2014: 4 · 2013: 8 · 2012: 12
- FWCI
- 3.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Pharmacology & Therapeutics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of General Medical Sciences (R01GM071322, GM71322)
- National Center for Research Resources (M01RR014288, RR-14288)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Health Sciences › Medicine › Complementary and alternative medicine › Complementary and Alternative Medicine Studies
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Keywords
- goldenseal, Hydrastis canadensis, kava, CYP3A inhibition, herb-drug interactions, CYP3A substrates
- MeSH terms
- Adult, Cytochrome P-450 Enzyme System, Enzyme Induction, Enzyme Inhibitors, Female, Humans, Male, Midazolam, Models, Biological, Phenotype, Rifampin, Substrate Specificity, Clarithromycin, Risk Assessment, Dietary Supplements, Kava, Plant Preparations, Hydrastis, Herb-Drug Interactions, Cytochrome P-450 CYP3A, Cytochrome P-450 Enzyme Inhibitors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
