Cited by 116Complementary and Alternative Medicine StudiesPharmacogenetics and Drug MetabolismPhytochemistry Medicinal Plant Applications

Clinically based evidence of drug–herb interactions: a systematic review

Kennedy, Deborah A, Seely, Dugald·2010·Expert Opinion on Drug Safety

Abstract

IMPORTANCE OF THE FIELD: Healthcare practitioners are deeply concerned about drug-herb interactions and how concurrent administration may affect both the safety and effectiveness of prescribed drugs. Interactions between botanical medicines and synthetic drugs can be clinically relevant and it is important to understand what kinds of interactions are possible. Better knowledge in this area will help avoid negative interactions and may also help enable synergistic interactions. AREAS COVERED IN THIS REVIEW: Includes articles related to the investigation of Western botanicals or whole herbal extracts in human subjects, investigating either the impact on Cytochrome P450 isoenzymes or an assessment of specific drug-herb interactions within a clinical trial. Searches were conducted in both Pubmed and EMBASE from inception to March 2009. WHAT THE READER WILL GAIN: Knowledge regarding specific interactions to consider in clinical practice. The reader will also gain an appreciation of the complexities associated with the area of drug-herb interactions. Summary tables of relevant drug-herb interactions are presented both for the individual herbs included and at the level of the CYP450 enzymes. TAKE HOME MESSAGE: Knowledge of drug-herb interactions is limited and much more research needs to be done to further document clinically relevant interactions. Even though preclinical data are often poorly generalizable to the human situation, caution must be taken in the absence of clinical evidence especially where drugs with narrow therapeutic windows are concerned.

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Crossref · 10.1517/14740330903405593

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83 of 83 references verified0 citation errors · 0 not checkable

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Authors
Kennedy, D. A., & Seely, D.
Affiliations
Canadian College of Naturopathic Medicine (CA)
Venue
Expert Opinion on Drug Safety
Published
2009-12-20
Volume
9
Issue
1
Pages
79-124
ISSN
  • 1474-0338 (ISSN-L)
  • 1744-764X
OpenAlex
W2087313521
Cited by
116
References
83
Citations by year
2026: 3 · 2025: 4 · 2024: 2 · 2023: 2 · 2022: 4 · 2021: 9 · 2020: 5 · 2019: 5 · 2018: 8 · 2017: 3 · 2016: 8 · 2015: 5 · 2014: 9 · 2013: 13 · 2012: 20
FWCI
2.19
Type
journal article
Language
en
Open access
closed
Locations
  • Expert Opinion on Drug Safety (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Complementary and Alternative Medicine Studies
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry Medicinal Plant Applications
Keywords
herb-drug interactions, botanical medicine, plant extracts, cytochrome P450, drug interactions, clinical evidence, drug safety, synergistic interaction
MeSH terms
Clinical Trials as Topic, Cytochrome P-450 Enzyme System, Humans, Phytotherapy, Evidence-Based Medicine, Herb-Drug Interactions

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