Clinically based evidence of drug–herb interactions: a systematic review
Abstract
IMPORTANCE OF THE FIELD: Healthcare practitioners are deeply concerned about drug-herb interactions and how concurrent administration may affect both the safety and effectiveness of prescribed drugs. Interactions between botanical medicines and synthetic drugs can be clinically relevant and it is important to understand what kinds of interactions are possible. Better knowledge in this area will help avoid negative interactions and may also help enable synergistic interactions. AREAS COVERED IN THIS REVIEW: Includes articles related to the investigation of Western botanicals or whole herbal extracts in human subjects, investigating either the impact on Cytochrome P450 isoenzymes or an assessment of specific drug-herb interactions within a clinical trial. Searches were conducted in both Pubmed and EMBASE from inception to March 2009. WHAT THE READER WILL GAIN: Knowledge regarding specific interactions to consider in clinical practice. The reader will also gain an appreciation of the complexities associated with the area of drug-herb interactions. Summary tables of relevant drug-herb interactions are presented both for the individual herbs included and at the level of the CYP450 enzymes. TAKE HOME MESSAGE: Knowledge of drug-herb interactions is limited and much more research needs to be done to further document clinically relevant interactions. Even though preclinical data are often poorly generalizable to the human situation, caution must be taken in the absence of clinical evidence especially where drugs with narrow therapeutic windows are concerned.
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Coadministration of herbal drugs with prescribed drugs may cause serious adverse effects.
“Coadministration of herbal drugs with prescribed drugs may result in serious adverse effects.”
From Indian Medicinal Herbs and Formulations for Alzheimer’s Disease, from Traditional Knowledge to Scientific Assessment (2020) · cites this paper as [268]
Cites
Miletzki, B., & Gleiter, C. H. (2005) · Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz · doi:10.1007/s00103-005-1024-7 · Cited by 9,401 · see citing works
Complementary and Alternative Medicine Use Among Adults and Children: United States, 2007
Barnes, P. M., Bloom, B. E., & Nahin, R. L. (2008) · PsycEXTRA Dataset · doi:10.1037/e623942009-001 · Cited by 3,131 · see citing works
(2017) · Arzneimittelforschung · doi:10.1055/s-00000175 · Cited by 1,134 · see citing works
Grapefruit juice–drug interactions
Bailey, D. G., Malcolm, J., Arnold, O., & Spence, J. D. (1998) · British Journal of Clinical Pharmacology · doi:10.1046/j.1365-2125.1998.00764.x · Cited by 751 · see citing works
Role of Human Cytochromes P450 in the Metabolic Activation of Chemical Carcinogens and Toxins
Gonzalez, F. J., & Gelboin, H. V. (1994) · Drug Metabolism Reviews · doi:10.3109/03602539409029789 · Cited by 493 · see citing works
The effect of garlic supplements on the pharmacokinetics of saquinavir
Piscitelli, S. C., Burstein, A. H., Welden, N., Gallicano, K. D., & Falloon, J. (2002) · Clinical Infectious Diseases · doi:10.1086/324351 · Cited by 431 · see citing works
Boon, H. S., Olatunde, F., & Zick, S. M. (2007) · BMC Women s Health · doi:10.1186/1472-6874-7-4 · Cited by 380 · see citing works
Abou-Donia, M. B., EL-Masry, E. M., Abdel-Rahman, A. A., McLendon, R. E., & Schiffman, S. S. (2008) · Journal of Toxicology and Environmental Health · doi:10.1080/15287390802328630 · Cited by 342 · see citing works
The effect of echinacea (Echinacea purpurea root) on cytochrome P450 activity in vivo
Gorski, J. C. (2004) · Clinical Pharmacology & Therapeutics · doi:10.1016/j.clpt.2003.09.013 · Cited by 305 · see citing works
Jiang, X., Williams, K. M., Liauw, W., Ammit, A. J., Roufogalis, B. D., Duke, C. C., Day, R. O., & McLachlan, A. J. (2004) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2003.02051.x · Cited by 275 · see citing works
GURLEY, B., GARDNER, S., HUBBARD, M., WILLIAMS, D., GENTRY, W., KHAN, I., & SHAH, A. (2005) · Clinical Pharmacology & Therapeutics · doi:10.1016/j.clpt.2005.01.009 · Cited by 271 · see citing works
Herb–drug interactions: an overview of the clinical evidence
Izzo, A. A. (2005) · Fundamental and Clinical Pharmacology · doi:10.1111/j.1472-8206.2004.00301.x · Cited by 247 · see citing works
Gurley, B. J., Gardner, S. F., Hubbard, M. A., Williams, D. K., Gentry, W. B., Cui, Y., & ANG, C. Y. W. (2005) · Drugs & Aging · doi:10.2165/00002512-200522060-00006 · Cited by 245 · see citing works
Brief Communication: American Ginseng Reduces Warfarin's Effect in Healthy Patients
Yuan, C., Wei, G., Dey, L., Karrison, T. G., Nahlik, L., Maleckar, S., Kasza, K., Ang-Lee, M. K., & Moss, J. (2004) · Annals of Internal Medicine · doi:10.7326/0003-4819-141-1-200407060-00011 · Cited by 242 · see citing works
Principles and Practice of Phytotherapy: Modern Herbal Medicine
Mills, S. Y., & Bone, K. M. (1999) · Cited by 236 · see citing works
Jiang, X., Williams, K. M., Liauw, W., Ammit, A. J., Roufogalis, B. D., Duke, C. C., Day, R. O., & McLachlan, A. J. (2005) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2005.02322.x · Cited by 221 · see citing works
Gurley, B. J., GARDNER, S., Hubbard, M. A., WILLIAMS, D., Gentry, W. B., CARRIER, J., KHAN, I., EDWARDS, D., & Shah, A. (2004) · Clinical Pharmacology & Therapeutics · doi:10.1016/j.clpt.2004.07.007 · Cited by 212 · see citing works
Pharmacogenetics and herb???drug interactions
Yin, O. Q. P., Tomlinson, B., Waye, M. M. Y., Chow, A. H. L., & Chow, M. S. (2004) · Pharmacogenetics · doi:10.1097/00008571-200412000-00007 · Cited by 178 · see citing works
Effects of Repeated Green Tea Catechin Administration on Human Cytochrome P450 Activity
Chow, H. ‐. S., Hakim, I. A., Vining, D. R., Crowell, J. A., Cordova, C. A., Chew, W. M., Xu, M., Hsu, C., Ranger‐Moore, J., & Alberts, D. S. (2006) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-06-0365 · Cited by 173 · see citing works
Gurley, B. J., Swain, A., Hubbard, M. A., Williams, D. K., Barone, G., Hartsfield, F., Tong, Y., Carrier, D. J., Cheboyina, S., & Battu, S. K. (2008) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200600300 · Cited by 169 · see citing works
Cytochrome P450 enzyme polymorphisms and adverse drug reactions
Pirmohamed, M., & Park, B. K. (2003) · Toxicology · doi:10.1016/s0300-483x(03)00247-6 · Cited by 152 · see citing works
Gallicano, K., Foster, B., & Choudhri, S. (2003) · British Journal of Clinical Pharmacology · doi:10.1046/j.1365-2125.2003.01736.x · Cited by 146 · see citing works
Gurley, B. J., Swain, A., Williams, D. K., Barone, G. W., & Battu, S. K. (2008) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200700081 · Cited by 143 · see citing works
Pharmacodynamic interaction of warfarin with cranberry but not with garlic in healthy subjects
Abdul, M. I. M., Jiang, X., Williams, K. M., Day, R. O., Roufogalis, B. D., Liauw, W., Xu, H., & McLachlan, A. J. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.210 · Cited by 138 · see citing works
Effect of Milk Thistle on the Pharmacokinetics of Indinavir in Healthy Volunteers
Piscitelli, S. C., Formentini, E., Burstein, A. H., Alfaro, R. M., Jagannatha, S., & Falloon, J. (2002) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1592/phco.22.8.551.33205 · Cited by 138 · see citing works
The physiological and pharmacological roles of cytochrome P450 isoenzymes
Chang, G. W., & Kam, P. C. A. (1999) · Anaesthesia · doi:10.1046/j.1365-2044.1999.00602.x · Cited by 137 · see citing works
Markowitz, J. S. (2003) · Clinical Pharmacology & Therapeutics · doi:10.1016/s0009-9236(03)00148-6 · Cited by 123 · see citing works
Robertson, S. M. C., Davey, R. T., Voell, J., Formentini, E., Alfaro, R. M., & Penzak, S. R. (2008) · Current Medical Research and Opinion · doi:10.1185/030079908x260871 · Cited by 119 · see citing works
Effect of Milk Thistle (Silybum marianum) on the Pharmacokinetics of Irinotecan
van Erp, N. P. H., Baker, S. D., Zhao, M., Rudek, M. A., Guchelaar, H., Nortier, J. W. R., Sparreboom, A., & Gelderblom, H. A. J. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-1288 · Cited by 113 · see citing works
Donovan, J. L., Chavin, K. D., DeVane, C. L., et al. (2004) · Drug Metabolism and Disposition · doi:10.1124/dmd.104.000083 · Cited by 111 · see citing works
Uchida, S., Yamada, H., Li, X. D., Maruyama, S., Ohmori, Y., Oki, T., Watanabe, H., Umegaki, K., Ohashi, K., & Yamada, S. (2006) · The Journal of Clinical Pharmacology · doi:10.1177/0091270006292628 · Cited by 111 · see citing works
Gurley, B. J., Hubbard, M. A., Williams, D. K., Thaden, J. J., Tong, Y., Gentry, W. B., Breen, P. J., Carrier, D. J., & Cheboyina, S. (2006) · The Journal of Clinical Pharmacology · doi:10.1177/0091270005284854 · Cited by 111 · see citing works
Coadministration of Milk Thistle and Indinavir in Healthy Subjects
DiCenzo, R., Shelton, M. J., Jordan, K. H., Koval, C. E., Forrest, A., Reichman, R. C., & Morse, G. D. (2003) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1592/phco.23.7.866.32723 · Cited by 110 · see citing works
Gurley, B. J., Barone, G. W., Williams, D. K., Carrier, J., Breen, P. J., Yates, C. R., Song, P.-F., Hubbard, M. A., Tong, Y., & Cheboyina, S. (2005) · Drug Metabolism and Disposition · doi:10.1124/dmd.105.006312 · Cited by 110 · see citing works
Effect of piperine on the steady‐state pharmacokinetics of phenytoin in patients with epilepsy
Pattanaik, S., Hota, D., Prabhakar, S. K., et al. (2006) · Phytotherapy Research · doi:10.1002/ptr.1937 · Cited by 109 · see citing works
Markowitz, J. S., Donovan, J. L., DeVane, C. L., Sipkes, L., & Chavin, K. D. (2003) · Journal of Clinical Psychopharmacology · doi:10.1097/01.jcp.0000095340.32154.c6 · Cited by 103 · see citing works
Gurley, B. J., Swain, A., Hubbard, M. A., Hartsfield, F., Thaden, J., Williams, D. K., Gentry, W. B., & Tong, Y. (2008) · Clinical Pharmacology & Therapeutics · doi:10.1038/sj.clpt.6100222 · Cited by 102 · see citing works
Drug interactions: Proteins, pumps, and P-450s
Shapiro, L. E., & Shear, N. H. (2002) · Journal of the American Academy of Dermatology · doi:10.1067/mjd.2002.126823 · Cited by 99 · see citing works
Pomelo juice, but not cranberry juice, affects the pharmacokinetics of cyclosporine in humans
Grenier, J., Fradette, C., MORELLI, G., Merritt, G. J., Vranderick, M., & Ducharme, M. P. (2006) · Clinical Pharmacology & Therapeutics · doi:10.1016/j.clpt.2005.11.010 · Cited by 97 · see citing works
Xin, H., Wu, X., Li, Q., et al. (2007) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2007.02922.x · Cited by 97 · see citing works
Greenblatt, D. J., VONMOLTKE, L., Perloff, E. S., et al. (2006) · Clinical Pharmacology & Therapeutics · doi:10.1016/j.clpt.2005.09.014 · Cited by 95 · see citing works
Lilja, J. J., Backman, J. T., & Neuvonen, P. J. (2007) · Clinical Pharmacology & Therapeutics · doi:10.1038/sj.clpt.6100149 · Cited by 90 · see citing works
Tanaka, E., & Hisawa, S. (1999) · Journal of Clinical Pharmacy and Therapeutics · doi:10.1046/j.1365-2710.1999.00200.x · Cited by 89 · see citing works
Dresser, G. K., Wacher, V. J., Wong, S., et al. (2002) · Clinical Pharmacology & Therapeutics · doi:10.1067/mcp.2002.126409 · Cited by 88 · see citing works
Donovan, J. L., DeVane, C. L., Chavin, K. D., Wang, J.-S., Gibson, B. B., Gefroh, H. A., & Markowitz, J. S. (2004) · Drug Metabolism and Disposition · doi:10.1124/dmd.104.001164 · Cited by 85 · see citing works
Markowitz, J. S. (2003) · Clinical Pharmacology & Therapeutics · doi:10.1016/j.clpt.2003.08.010 · Cited by 85 · see citing works
An Update on Clinical Drug Interactions with the Herbal Antidepressant St. Johns wort
Zhou, S., & Lai, X. (2008) · Current Drug Metabolism · doi:10.2174/138920008784746391 · Cited by 81 · see citing works
Milk thistle and indinavir: a randomized controlled pharmacokinetics study and meta-analysis
Mills, E. J., Wilson, K. R., Clarke, M. J., Foster, B., Walker, S. E., Rachlis, B., DeGroot, N., Montori, V. M., Gold, W. L., Phillips, E., et al. (2005) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-004-0843-z · Cited by 76 · see citing works
Donovan, J. L., DeVane, C. L., Chavin, K. D., Taylor, R. M., & Markowitz, J. S. (2003) · Drug Metabolism and Disposition · doi:10.1124/dmd.31.5.519 · Cited by 75 · see citing works
Reversal of cancer multidrug resistance by green tea polyphenols
Mei, Y., Qian, F., Wei, D., et al. (2004) · Journal of Pharmacy and Pharmacology · doi:10.1211/0022357044364 · Cited by 74 · see citing works
Medicinal Cannabis Does Not Influence the Clinical Pharmacokinetics of Irinotecan and Docetaxel
Engels, F. K., de Jong, F. A., Sparreboom, A., Mathôt, R. A. A., Loos, W. J., Kitzen, J. J. E. M., de Bruijn, P., Verweij, J., & Mathijssen, R. H. J. (2007) · The Oncologist · doi:10.1634/theoncologist.12-3-291 · Cited by 74 · see citing works
Ginkgo biloba: Evaluation of CYP2C9 Drug Interactions In Vitro and In Vivo
Mohutsky, M. A., Anderson, G. D., Miller, J. W., & Elmer, G. W. (2006) · American Journal of Therapeutics · doi:10.1097/01.mjt.0000143695.68285.31 · Cited by 72 · see citing works
Gurley, B. J., Swain, A., Barone, G. W., Williams, D. K., Breen, P. J., Yates, C. R., Stuart, L. B., Hubbard, M. A., Tong, Y., & Cheboyina, S. (2006) · Drug Metabolism and Disposition · doi:10.1124/dmd.106.012708 · Cited by 69 · see citing works
SAW PALMETTO FOR THE TREATMENT OF MEN WITH LOWER URINARY TRACT SYMPTOMS
Gerber, G. S. (2000) · The Journal of Urology · doi:10.1016/s0022-5347(05)67631-8 · Cited by 67 · see citing works
Cranberry Does Not Affect Prothrombin Time in Male Subjects on Warfarin
Li, Z., Seeram, N. P., Carpenter, C. L., Thames, G., Minutti, C., & Bowerman, S. (2006) · Journal of the American Dietetic Association · doi:10.1016/j.jada.2006.09.012 · Cited by 67 · see citing works
Interaction Study between Digoxin and a Preparation of Hawthorn (Crataegus oxyacantha)
Tankanow, R. M., Tamer, H. R., Streetman, D. S., et al. (2003) · The Journal of Clinical Pharmacology · doi:10.1177/0091270003253417 · Cited by 66 · see citing works
Gardner, C. D., Zehnder, J. L., Rigby, A. J., Nicholus, J. R., & Farquhar, J. W. (2007) · Blood Coagulation & Fibrinolysis · doi:10.1097/mbc.0b013e3282f102b1 · Cited by 66 · see citing works
The effect of garlic extract on human metabolism of acetaminophen.
Gwilt, P. R., Lear, C. L., Tempero, M. A., Birt, D. D., Grandjean, A. C., Ruddon, R. W., & Nagel, D. L. (1994) · PubMed · Cited by 66 · see citing works
Cytochrome P450 enzyme isoforms and their therapeutic implications: An update
Kalra, B. S. (2007) · Indian Journal of Medical Sciences · doi:10.4103/0019-5359.30351 · Cited by 65 · see citing works
Study on the Influence of Silymarin Pretreatment on Metabolism and Disposition of Metronidazole
Rajnarayana, K., Reddy, M., Vidyasagar, J., et al. (2011) · Arzneimittelforschung · doi:10.1055/s-0031-1296944 · Cited by 64 · see citing works
Effect of Silymarin Supplement on the Pharmacokinetics of Rosuvastatin
Deng, J. W., Shon, J., Shin, H. J., et al. (2008) · Pharmaceutical Research · doi:10.1007/s11095-007-9492-0 · Cited by 62 · see citing works
Juan, H., Terhaag, B., Cong, Z., et al. (2007) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-007-0298-0 · Cited by 62 · see citing works
Effect of Oral Administration of Glycyrrhizin on the Pharmacokinetics of Prednisolone.
CHEN, M.-F., SHIMADA, F., Kato, H., et al. (1991) · Endocrinologia Japonica · doi:10.1507/endocrj1954.38.167 · Cited by 61 · see citing works
Aruna, D., & Naidu, M. U. R. (2006) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2006.02759.x · Cited by 60 · see citing works
Zhang, Q., Wei, D., & Liu, J. (2004) · Cancer Letters · doi:10.1016/j.canlet.2004.01.033 · Cited by 60 · see citing works
Influence of Goldenseal Root on the Pharmacokinetics of Indinavir
Sandhu, R. S., Prescilla, R. P., Simonelli, T. M., & Edwards, D. J. (2003) · The Journal of Clinical Pharmacology · doi:10.1177/0091270003258660 · Cited by 59 · see citing works
Fan, L., Mao, X., Tao, G., et al. (2009) · Xenobiotica · doi:10.1080/00498250802687657 · Cited by 58 · see citing works
Impact of Ginkgo Biloba on the Pharmacokinetics of Digoxin
Mauro, V. F., Mauro, L. S., Kleshinski, J., Khuder, S., Wang, Y., & Erhardt, P. (2003) · American Journal of Therapeutics · doi:10.1097/00045391-200307000-00003 · Cited by 57 · see citing works
The Effect of Silymarin on Oral Nifedipine Pharmacokinetics
Fuhr, U., Beckmann‐Knopp, S., Jetter, A., et al. (2007) · Planta Medica · doi:10.1055/s-2007-990256 · Cited by 56 · see citing works
Yoshioka, M., Ohnishi, N., Koishi, T., Obata, Y., Nakagawa, M., Matsumoto, T., Tagagi, K., Takara, K., Ohkuni, T., Yokoyama, T., et al. (2004) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.27.2006 · Cited by 56 · see citing works
Kudolo, G. B., Wang, W., Javors, M. A., & Blodgett, J. (2006) · Clinical Nutrition · doi:10.1016/j.clnu.2005.12.012 · Cited by 52 · see citing works
Wolf, H. R. D. (2006) · Drugs in R&D · doi:10.2165/00126839-200607030-00003 · Cited by 47 · see citing works
Effect of daidzein on CYP1A2 activity and pharmacokinetics of theophylline in healthy volunteers
Wen-xing, P., Huan-de, L., & Zhou, H. (2003) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-003-0596-0 · Cited by 46 · see citing works
Lee, L., Wise, S. D., Chan, C., Parsons, T. L., Flexner, C. W., & Lietman, P. S. (2008) · The Journal of Clinical Pharmacology · doi:10.1177/0091270008314252 · Cited by 45 · see citing works
Al‐Omari, A., & Murry, D. J. (2007) · Journal of Pharmacy Practice · doi:10.1177/0897190007304821 · Cited by 43 · see citing works
Andrade, A. S., Hendrix, C. W., Parsons, T. L., Caballero, B. H., Yuan, C.-S., Flexner, C. W., Dobs, A. S., & Brown, T. T. (2008) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-8-50 · Cited by 37 · see citing works
Smith, M. L., Lin, K., & Zheng, Y. (2001) · Clinical Pharmacology & Therapeutics · Cited by 35 · see citing works
CHEN, M.-F., SHIMADA, F., Kato, H., et al. (1990) · Endocrinologia Japonica · doi:10.1507/endocrj1954.37.331 · Cited by 34 · see citing works
Influence of silymarin on drug metabolizing enzymes in rat and man.
Leber, H. W., & Knauff, S. (1976) · PubMed · Cited by 31 · see citing works
Chatterjee, S. S., Doelman, C. J. A., Nöldner, M., et al. (2005) · Journal of Pharmacy and Pharmacology · doi:10.1211/0022357056046 · Cited by 23 · see citing works
EFFECT OF SILYMARIN ON THE ORAL BIOAVAILABILITY OF RANITIDINE IN HEALTHY HUMAN VOLUNTEERS
Rao, B. N., Maddi, S., Kumar, Y. S., et al. (2007) · Drug metabolism and drug interactions · doi:10.1515/dmdi.2007.22.2-3.175 · Cited by 20 · see citing works
A randomized, double-blind trial of the interaction between cranberry juice and warfarin
Ansell, J., McDonough, M., Harmatz, J. S., et al. (2007) · Journal of Thrombosis and Thrombolysis · doi:10.1007/s11239-007-0120-y · Cited by 14 · see citing works
SAW PALMETTO FOR THE TREATMENT OF MEN WITH LOWER URINARY TRACT SYMPTOMS
Gerber, G. S. (2000) · The Journal of Urology · doi:10.1097/00005392-200005000-00003 · Cited by 6 · see citing works
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Mehla, J., Gupta, P., Pahuja, M., Diwan, D., & Diksha, D. (2020) · Brain Sciences · doi:10.3390/brainsci10120964 · Cited by 108 · see citing works
- Authors
- Kennedy, D. A., & Seely, D.
- Affiliations
- Canadian College of Naturopathic Medicine (CA)
- ORCID
- Seely, Dugald
- Venue
- Expert Opinion on Drug Safety
- Publisher
- Informa Healthcare
- Published
- 2009-12-20
- Volume
- 9
- Issue
- 1
- Pages
- 79-124
- ISSN
- 1474-0338 (ISSN-L)
- 1744-764X
- OpenAlex
- W2087313521
- Cited by
- 116
- References
- 83
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 2 · 2023: 2 · 2022: 4 · 2021: 9 · 2020: 5 · 2019: 5 · 2018: 8 · 2017: 3 · 2016: 8 · 2015: 5 · 2014: 9 · 2013: 13 · 2012: 20
- FWCI
- 2.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Expert Opinion on Drug Safety (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Complementary and Alternative Medicine Studies
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry Medicinal Plant Applications
- Keywords
- herb-drug interactions, botanical medicine, plant extracts, cytochrome P450, drug interactions, clinical evidence, drug safety, synergistic interaction
- MeSH terms
- Clinical Trials as Topic, Cytochrome P-450 Enzyme System, Humans, Phytotherapy, Evidence-Based Medicine, Herb-Drug Interactions
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