TAp63α induces apoptosis by activating signaling via death receptors and mitochondria

A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry

Nicoletti, I., Migliorati, G., Pagliacci, M. C., Grignani, F., & Riccardi, C. (1991) · Journal of Immunological Methods · doi:10.1016/0022-1759(91)90198-o · Cited by 4,562

Minimum information about a microarray experiment (MIAME)-toward standards for microarray data

Brazma, A., Hingamp, P., Quackenbush, J., Sherlock, G., Spellman, P., Stoeckert, C., Aach, J., Ansorge, W., Ball, C. A., Causton, H. C., et al. (2001) · Nature Genetics · doi:10.1038/ng1201-365 · Cited by 4,109

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

Toshiyuki, M., & Reed, J. C. (1995) · Cell · doi:10.1016/0092-8674(95)90412-3 · Cited by 4,063

A simplified system for generating recombinant adenoviruses

He, T., Zhou, S., da Costa, L. T., Yu, J., Kinzler, K. W., & Vogelstein, B. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.5.2509 · Cited by 3,209

p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development

Yang, A., Schweitzer, R., Sun, D., Kaghad, M., Walker, N., Bronson, R. T., Tabin, C. J., Sharpe, A. H., Caput, D., Crum, C. P., et al. (1999) · Nature · doi:10.1038/19539 · Cited by 2,264

p63 is a p53 homologue required for limb and epidermal morphogenesis

Mills, A. A., Zheng, B., Wang, X., Vogel, H. S., Roop, D. R., & Bradley, A. (1999) · Nature · doi:10.1038/19531 · Cited by 2,015

Definition of a consensus binding site for p53

El-Deiry, W. S., Kern, S. E., Pietenpol, J. A., Kinzler, K. W., & Vogelstein, B. (1992) · Nature Genetics · doi:10.1038/ng0492-45 · Cited by 1,985

Monoclonal Antibody-Mediated Tumor Regression by Induction of Apoptosis

Trauth, B. C., Klas, C., Peters, A. M. J., Matzku, S., Mӧller, P., Falk, W., Debatin, K., & Krammer, P. H. (1989) · Science · doi:10.1126/science.2787530 · Cited by 1,716

A novel form of Epstein-Barr virus latency in normal B cells in vivo

Miyashita, E. M., Yang, B., Lam, K. M. C., Crawford, D., & Thorley‐Lawson, D. A. (1995) · Cell · doi:10.1016/0092-8674(95)90513-8 · Cited by 1,591

STXBP4 regulates APC/C-mediated p63 turnover and drives squamous cell carcinogenesis

Rokudai, S., Li, Y.-C., Otaka, Y., Fujieda, M., Owens, D. M., Christiano, A. M., Nishiyama, M., & Prives, C. L. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1718546115 · Cited by 38

Panax ginseng C.A. Meyer (Rg3) Ameliorates Gastric Precancerous Lesions in Atp4a −/− Mice via Inhibition of Glycolysis through PI3K/AKT/miRNA‐21 Pathway

Liu, W., Pan, H., Yang, L., Zhao, Z., Yuan, D.-S., Liu, Y., & Lin, L. (2020) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2020/2672648 · Cited by 37

p63 regulates the caspase-8-FLIP apoptotic pathway in epidermis

Borrelli, S., Candi, E., Alotto, D., Castagnoli, C., Melino, G., Viganò, M., & Mantovani, R. (2008) · Cell Death and Differentiation · doi:10.1038/cdd.2008.147 · Cited by 37

Differential Regulation of Vitamin D Receptor (VDR) by the p53 Family

Kommagani, R., Payal, V., & Kadakia, M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m703641200 · Cited by 37

Interactions of the p53 Protein Family in Cellular Stress Response in Gastrointestinal Tumors

Vilgelm, A. E., Washington, M. K., Wei, J., Chen, H., Prassolov, V., & Zaika, A. I. (2010) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-09-0912 · Cited by 37

p63 Transcriptional Regulation of Epithelial Integrity and Cancer

Trink, B., Osada, M., Ratovitski, E. A., & Sidransky, D. (2007) · Cell Cycle · doi:10.4161/cc.6.3.3803 · Cited by 36

Cell death pathology: The war against cancer

Rufini, A., & Melino, G. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.09.110 · Cited by 36

Regulation of p63 Protein Stability via Ubiquitin-Proteasome Pathway

Li, C., & Xiao, Z. J. (2014) · BioMed Research International · doi:10.1155/2014/175721 · Cited by 36

In-vitro and in-vivo anti-breast cancer activity of synergistic effect of berberine and exercise through promoting the apoptosis and immunomodulatory effects

Ma, W., Zhang, Y., Yu, M., Wang, B., Xu, S., Zhang, J., Li, X., & Ye, X. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.106787 · Cited by 36

Gc-globulin (vitamin D binding protein) is synthesized and secreted by hepatocytes and internalized by hepatic stellate cells through Ca2+-dependent interaction with the megalin/gp330 receptor

Gressner, O. A., Lahme, B., & Gressner, A. M. (2007) · Clinica Chimica Acta · doi:10.1016/j.cca.2007.12.011 · Cited by 37

Plk1 regulates liver tumor cell death by phosphorylation of TAp63

Komatsu, S., Takenobu, H., Ozaki, T., Ando, K., Koida, N., Suenaga, Y., Ichikawa, T., Hishiki, T., Chiba, T., Iwama, A., et al. (2009) · Oncogene · doi:10.1038/onc.2009.216 · Cited by 35

Distinct Apoptotic Signaling Characteristics of the Anti-CD40 Monoclonal Antibody Dacetuzumab and Rituximab Produce Enhanced Antitumor Activity in Non-Hodgkin Lymphoma

Lewis, T. S., McCormick, R. S., Emmerton, K. K., Lau, J., Yu, S., McEarchern, J. A., Grewal, I. S., & Law, C. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-0479 · Cited by 35

Interference with the p53 family network contributes to the gain of oncogenic function of mutant p53 in hepatocellular carcinoma

Schilling, T., Kairat, A., Melino, G., Krammer, P. H., Stremmel, W., Oren, M., & Müller, M. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.03.082 · Cited by 36

Metabolic pathways regulated by p63

Candi, E., Smirnov, A., Panatta, E., Lena, A. M., Novelli, F., Mancini, M., Viticchiè, G., Piro, M. C., Daniele, N. D., Annicchiarico‐Petruzzelli, M., et al. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.10.094 · Cited by 37

Analysis of a new therapeutic target and construction of a prognostic model for breast cancer based on ferroptosis genes

Li, Q., Liu, H.-C., Jin, Y., Yu, Y.-Q., Wang, Y., Wu, D., Guo, Y., Xi, L., Ye, D., Pan, Y.-Q., et al. (2023) · Comput. Biol. Medicine · doi:10.1016/j.compbiomed.2023.107370 · Cited by 34

Contributions of Rad9 to tumorigenesis

Broustas, C. G., & Lieberman, H. B. (2011) · Journal of Cellular Biochemistry · doi:10.1002/jcb.23424 · Cited by 33

Both intrinsic and extrinsic apoptotic pathways are involved in Toll-like receptor 4 (TLR4)-induced cell death in monocytic THP-1 cells

Liu, B., Sun, R., Luo, H. R., Liu, X., Jiang, M., Yuan, C., Yang, L., & Hu, J. (2016) · Immunobiology · doi:10.1016/j.imbio.2016.10.002 · Cited by 33

Mitochondrial metabolism in macrophages

Nassef, M. Z., Hanke, J. E., & Hiller, K. (2021) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00126.2021 · Cited by 32

Characterization of specific p63 and p63-N-terminal isoform antibodies and their application for immunohistochemistry

Nekulová, M., Holčáková, J., Nenutil, R., Stratmann, R., Bouchalová, P., Müller, P., Mouková, L., Coates, P. J., & Vojtěšek, B. (2013) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-013-1459-4 · Cited by 33

Vitamin D protects keratinocytes from deleterious effects of ionizing radiation

Langberg, M., Rotem, C., Fenig, E., Koren, R., & Ravid, A. (2008) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2008.08797.x · Cited by 33

The microRNA feedback regulation of p63 in cancer progression

Lin, C., Li, X., Zhang, Y., Guo, Y., Zhou, J., Gao, K., Dai, J., Hu, G. M., Lv, L., Du, J., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.3020 · Cited by 31

p63 and p53: Collaborative Partners or Dueling Rivals?

Woodstock, D. L., Sammons, M. A., & Fischer, M. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.701986 · Cited by 31

Gene bi-targeting by viral and human miRNAs

Veksler‐Lublinsky, I., Shemer‐Avni, Y., Kedem, K., & Ziv-Ukelson, M. (2010) · BMC Bioinformatics · doi:10.1186/1471-2105-11-249 · Cited by 30

The proline-rich domain in p63 is necessary for the transcriptional and apoptosis-inducing activities of TAp63

Helton, E. S., Zhang, J., & Chen, X. (2007) · Oncogene · doi:10.1038/sj.onc.1210948 · Cited by 33

Parathyroid hormone‐related protein confers chemoresistance by blocking apoptosis signaling via death receptors and mitochondria

Gagiannis, S., Müller, M., Uhlemann, S., Koch, A., Melino, G., Krammer, P. H., Nawroth, P. P., Brune, M., & Schilling, T. (2009) · International Journal of Cancer · doi:10.1002/ijc.24471 · Cited by 31

Sensitization of p53-mutated epithelial ovarian cancer to CD95-mediated apoptosis is synergistically induced by cisplatin pretreatment

Bagnoli, M., Balladore, E., Luison, E., Alberti, P., Raspagliesi, F., Marcomini, B., Canevari, S., & Mezzanzanica, D. (2007) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-06-0357 · Cited by 31

p63 Isoforms Regulate Metabolism of Cancer Stem Cells

D’Aguanno, S., Barcaroli, D., Rossi, C., Zucchelli, M., Ciavardelli, D., Cortese, C., Cola, A. D., Volpe, S., D’Agostino, D., Todaro, M., et al. (2014) · Journal of Proteome Research · doi:10.1021/pr4012574 · Cited by 29

p63 protein is essential for the embryonic development of vibrissae and teeth

Rufini, A., Weil, M., McKeon, F., Barlattani, A., Melino, G., & Candi, E. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.12.065 · Cited by 27

Integrated epigenomic and transcriptomic analysis reveals TP63 as a novel player in clinically aggressive chronic lymphocytic leukemia

Papakonstantinou, N., Ntoufa, S., Tsagiopoulou, M., Moysiadis, T., Bhoi, S., Malousi, A., Psomopoulos, F. E., Mansouri, L., Laidou, S., Papazoglou, D., et al. (2018) · International Journal of Cancer · doi:10.1002/ijc.31999 · Cited by 26

Pro‐apoptotic TP 53 homolog TA p63 is repressed via epigenetic silencing and B ‐cell receptor signalling in chronic lymphocytic leukaemia

Humphries, L. A., Godbersen, J. C., Danilova, O. V., Kaur, P., Christensen, B. C., & Danilov, A. V. (2013) · British Journal of Haematology · doi:10.1111/bjh.12580 · Cited by 26

ΔNp63 drives metastasis in breast cancer cellsviaPI3K/CD44v6 axis

Franco, S. D., Turdo, A., Benfante, A., Colorito, M. L., Gaggianesi, M., Apuzzo, T., Kandimalla, R., Chinnici, A., Barcaroli, D., Mangiapane, L. R., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.11022 · Cited by 26

ΔN-P63α and TA-P63α exhibit intrinsic differences in transactivation specificities that depend on distinct features of DNA target sites

Monti, P., Ciribilli, Y., Bisio, A., Foggetti, G., Raimondi, I., Campomenosi, P., Menichini, P., Fronza, G., & Inga, A. (2014) · Oncotarget · doi:10.18632/oncotarget.1845 · Cited by 26

p63α protein up-regulates heat shock protein 70 expression via E2F1 transcription factor 1, promoting Wasf3/Wave3/MMP9 signaling and bladder cancer invasion

Jin, H., Xie, Q., Guo, X., Xu, J., Wang, A., Li, J., Zhu, J., Wu, X., Huang, H., & Huang, C. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.792010 · Cited by 26

Programmed Cell Death Not as Sledgehammer but as Chisel: Apoptosis in Normal and Abnormal Craniofacial Patterning and Development

Compagnucci, C., Martinus, K., Griffin, J. N., & Depew, M. J. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.717404 · Cited by 25

Preclinical Evaluation of 4-Methylthiobutyl Isothiocyanate on Liver Cancer and Cancer Stem Cells with Different p53 Status

Lamy, E., Hertrampf, A., Herz, C., Schüler, J. B., Erlacher, M., Bertele, D., Bakare, A. A., Wagner, M., Weiland, T., Lauer, U. M., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0070846 · Cited by 25

Clinical utility of myb rearrangement detection and p63/p40 immunophenotyping in the diagnosis of adenoid cystic carcinoma of minor salivary glands: a pilot study

Argyris, P. P., Wetzel, S. L., Greipp, P. T., Wehrs, R. N., Knutson, D. L., Kloft‐Nelson, S. M., García, J. J., & Koutlas, I. G. (2015) · Oral Surgery Oral Medicine Oral Pathology and Oral Radiology · doi:10.1016/j.oooo.2015.10.016 · Cited by 25

Estrogen Enhances the Cell Viability and Motility of Breast Cancer Cells through the ERα-ΔNp63-Integrin β4 Signaling Pathway

Ho, J., Chang, F.-W., Huang, F. S., Liu, J., Liu, Y.-P., Chen, S.-P., Liu, Y.-L., Cheng, K., Yu, C., & Hsu, R. (2016) · PLoS ONE · doi:10.1371/journal.pone.0148301 · Cited by 24

TAp63 is a transcriptional target of NF‐κB

Wu, J., Bergholz, J. S., Lu, J., Sonenshein, G. E., & Xiao, Z. J. (2010) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22449 · Cited by 24

miR-301a plays a pivotal role in hypoxia-induced gemcitabine resistance in pancreatic cancer

Luo, G., Xia, X., Wang, X., Zhang, K., Cao, J., Jiang, T., Zhao, Q., & Qiu, Z. (2018) · Experimental Cell Research · doi:10.1016/j.yexcr.2018.05.013 · Cited by 24

DHX30 Coordinates Cytoplasmic Translation and Mitochondrial Function Contributing to Cancer Cell Survival

Bosco, B., Rossi, A., Rizzotto, D., Hamadou, M. H., Bisio, A., Giorgetta, S., Perzolli, A., Bonollo, F., Gaucherot, A., Catez, F., et al. (2021) · Cancers · doi:10.3390/cancers13174412 · Cited by 23

Loss of TACSTD2 contributed to squamous cell carcinoma progression through attenuating TAp63-dependent apoptosis

Wang, F., Liu, X., Yang, P. H., Guo, L., Liu, C., Li, H., Long, S., Shen, Y., & Wan, H. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.96 · Cited by 23

NAD(P)H Quinone Oxidoreductase Protects TAp63γ from Proteasomal Degradation and Regulates TAp63γ-Dependent Growth Arrest

Hershkovitz‐Rokah, O., Shpilberg, O., & Granot, G. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011401 · Cited by 23

p63 transcriptionally regulates the expression of matrix metallopeptidase 13

Celardo, I., Antonov, A., Amelio, I., Annicchiarico‐Petruzzelli, M., & Melino, G. (2014) · Oncotarget · doi:10.18632/oncotarget.1778 · Cited by 25

Crosstalk Between Vitamin D and p53 Signaling in Cancer: An Update

Reichrath, J., Reichrath, S., VOGT, T. M., & Römer, K. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-46227-7_15 · Cited by 23

ΔNp63α expression induces loss of cell adhesion in triple-negative breast cancer cells

Nekulová, M., Holčáková, J., Gu, X., Hrabal, V., Galtsidis, S., Orzol, P., Liu, Y., Logotheti, S., Zoumpourlis, V., Nylander, K., et al. (2016) · BMC Cancer · doi:10.1186/s12885-016-2808-x · Cited by 21

Neutralization of CD95 ligand protects the liver against ischemia-reperfusion injury and prevents acute liver failure

Al‐Saeedi, M., Steinebrunner, N., Kudsi, H., Halama, N., Mogler, C., Büchler, M. W., Krammer, P. H., Schemmer, P., & Müller, M. (2018) · Cell Death and Disease · doi:10.1038/s41419-017-0150-0 · Cited by 22

NF-κB regulates the stability and activity of p73 by inducing its proteolytic degradation through a ubiquitin-dependent proteasome pathway

Kikuchi, H., Ozaki, T., Furuya, K., Hanamoto, T., Nakanishi, M., Yamamoto, H., Yoshida, K., Todo, S., & Nakagawara, A. (2006) · Oncogene · doi:10.1038/sj.onc.1209748 · Cited by 21

Decreased c-Myc mRNA Stability via the MicroRNA 141-3p/AUF1 Axis Is Crucial for p63α Inhibition of Cyclin D1 Gene Transcription and Bladder Cancer Cell Tumorigenicity

Li, X., Tian, Z., Jin, H., Xu, J., Hua, X., Yan, H., Liufu, H., Wang, J., Li, J., Zhu, J., et al. (2018) · Molecular and Cellular Biology · doi:10.1128/mcb.00273-18 · Cited by 22

Machine learning analysis of lung squamous cell carcinoma gene expression datasets reveals novel prognostic signatures

Joon, H. K., Thalor, A., & Gupta, D. K. (2023) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2023.107430 · Cited by 20

Harnessing Tumor Necrosis Factor Receptors to Enhance Antitumor Activities of Drugs

Muntané, J. (2011) · Chemical Research in Toxicology · doi:10.1021/tx2002349 · Cited by 20

GSK-3β-mediated fatty acid synthesis enhances epithelial to mesenchymal transition of TLR4-activated colorectal cancer cells through regulation of TAp63

Park, G. B., Chung, Y. H., Gong, J. H., Jin, D., & Kim, D. (2016) · International Journal of Oncology · doi:10.3892/ijo.2016.3679 · Cited by 20

Notch and the p53 Clan of Transcription Factors

Roemer, K. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-0899-4_17 · Cited by 20

Phospho‐ΔNp63α‐responsive microRNAs contribute to the regulation of necroptosis in squamous cell carcinoma upon cisplatin exposure

Ratovitski, E. A. (2015) · FEBS Letters · doi:10.1016/j.febslet.2015.04.020 · Cited by 21

ASK1/JNK-mediated TAp63 activation controls the cell survival signal of baicalein-treated EBV-transformed B cells

Park, G. B., Kim, Y. S., Lee, H.-K., Yang, J. W., Kim, D., & Hur, D. Y. (2015) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-015-2631-8 · Cited by 19

ZNF185 is a p53 target gene following DNA damage

Smirnov, A., Cappello, A., Lena, A. M., Anemona, L., Mauriello, A., Daniele, N. D., Annicchiarico‐Petruzzelli, M., Melino, G., & Candi, E. (2018) · Aging · doi:10.18632/aging.101639 · Cited by 20

TATA-binding Protein (TBP)-like Protein Is Engaged in Etoposide-induced Apoptosis through Transcriptional Activation of Human TAp63 Gene

Suenaga, Y., Ozaki, T., Tanaka, Y., Bu, Y., Kamijo, T., Tokuhisa, T., Nakagawara, A., & Tamura, T. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.050047 · Cited by 19

The dual role of p63 in cancer

Xu, Y., Yang, X., Xiong, Q., Han, J., & Zhu, Q. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1116061 · Cited by 19

TAp63α Mediates Chemotherapeutic Agent-Induced Apoptosis in Human Bone Marrow Mesenchymal Stem Cells

Lu, C., Lu, S., Liang, W. P., Li, J., Dou, X., Bian, C., Shi, D., Liao, L., & Zhao, R. C. (2010) · Stem Cells and Development · doi:10.1089/scd.2010.0329 · Cited by 18

Tumor Protein p63/Nuclear Factor κB Feedback Loop in Regulation of Cell Death

Sen, T., Sen, N., Huang, Y., Sinha, D., Luo, Z., Ratovitski, E. A., & Sidransky, D. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.257105 · Cited by 18

A functional interplay between Δ133p53 and ΔNp63 in promoting glycolytic metabolism to fuel cancer cell proliferation

Gong, L., Pan, X., Lim, C.-B., de Polo, A., Little, J. B., & Yuan, Z.-M. (2018) · Oncogene · doi:10.1038/s41388-017-0117-8 · Cited by 18

Highly expressed histone deacetylase 5 promotes the growth of hepatocellular carcinoma cells by inhibiting the TAp63-maspin pathway.

Gu, H., Fang, Z., Cai, X., Song, R. Y., Lin, M., Ye, J., Ding, X., Ke, Q., Chen, H., Gong, C., et al. (2018) · PubMed Central · Cited by 18

The specific seroreactivity to ∆Np73 isoforms shows higher diagnostic ability in colorectal cancer patients than the canonical p73 protein

Garranzo‐Asensio, M., Guzmán‐Aránguez, A., Poves, C. F., Fernández‐Aceñero, M. J., Montero‐Calle, A., Cerón, M. Á., Fernández-Díez, S., Rodríguez, N., de Cedrón, M. G., de Molina, A. R., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-49960-x · Cited by 17

Aberrant miRNAs Regulate the Biological Hallmarks of Glioblastoma

Yu, W., Liang, S., & Zhang, C. (2018) · NeuroMolecular Medicine · doi:10.1007/s12017-018-8507-9 · Cited by 17

ΔNp63 Regulates Homeostasis, Stemness, and Suppression of Inflammation in the Adult Epidermis

Eyermann, C. E., Chen, X., Somuncu, O., Li, J., Joukov, A. N., Chen, J., & Alexandrova, E. M. (2023) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2023.07.005 · Cited by 16

Proapoptotic signaling activity of the anti-CD40 monoclonal antibody dacetuzumab circumvents multiple oncogenic transformation events and chemosensitizes NHL cells

Lewis, T. S., McCormick, R. S., Stone, I. J., Emmerton, K. K., Mbow, B., Miyamoto, J., Drachman, J. G., Grewal, I. S., & Law, C.-L. (2011) · Leukemia · doi:10.1038/leu.2011.21 · Cited by 16

ΔNp63 promotes IGF1 signalling through IRS1 in squamous cell carcinoma

Frezza, V., Fierro, C., Gatti, E., Peschiaroli, A., Lena, A. M., Annicchiarico‐Petruzzelli, M., Candi, E., Anemona, L., Mauriello, A., Pelicci, P. G., et al. (2018) · Aging · doi:10.18632/aging.101725 · Cited by 15

Gleevec Suppresses p63 Expression in Head and Neck Squamous Cell Carcinoma Despite p63 Activation by DNA‐Damaging Agents

Ongkeko, W. M., An, Y., Chu, T. S., Aguilera, J. A., Dang, C. L., & Wang‐Rodriguez, J. (2006) · The Laryngoscope · doi:10.1097/01.mlg.0000225941.60901.0f · Cited by 16

A Novel Ferroptosis-Related Gene Model for Overall Survival Predictions of Bladder Urothelial Carcinoma Patients

Zhang, M., Zhang, X., Yu, M., Zhang, W., Zhang, D., Zeng, S., Wang, X., & Hu, X. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.698856 · Cited by 15

TAp63 regulates oncogenic miR-155 to mediate migration and tumour growth

Mattiske, S., Ho, K., Noll, J. E., Neilsen, P. M., Callen, D. F., & Suetani, R. J. (2013) · Oncotarget · doi:10.18632/oncotarget.1228 · Cited by 15

p63 and p73, members of the p53 gene family, transactivate PKCδ

Ponassi, R., Terrinoni, A., Chikh, A., Rufini, A., Lena, A. M., Sayan, B. S., Melino, G., & Candi, E. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.07.031 · Cited by 15

p63 expression pattern in foetal and neonatal gonocytes after irradiation and role in the resulting apoptosis by using p63 knockout mice

Petre-Lazar, B., Moreno, S. G., Livera, G., Duquenne, C., Habert, R., & Coffigny, H. (2006) · International Journal of Radiation Biology · doi:10.1080/09553000600960019 · Cited by 15

c-Jun Regulates the Stability of Anti-Apoptotic ΔNp63 in Amyloid-β-Induced Apoptosis

Fonseca, M. B., Nunes, A. F., & Rodrigues, C. M. P. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-111547 · Cited by 14

TAp63 plays compensatory roles in p53-deficient cancer cells under genotoxic stress

Yao, J.-Y., & Chen, J.-K. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.11.025 · Cited by 14

The Roles of P53 and Its Family Proteins, P63 and P73, in the DNA Damage Stress Response in Organogenesis-Stage Mouse Embryos

Husseini, N. E., & Hales, B. F. (2017) · Toxicological Sciences · doi:10.1093/toxsci/kfx270 · Cited by 13

Cytological Immunostaining of HMGA2, LRP1B, and TP63 as Potential Biomarkers for Triaging Human Papillomavirus-Positive Women

Jiang, Y., Zhu, C., He, D., Gao, Q., Tian, X., Ma, X., Wu, J., Das, B. C., Severinov, K., Hitzeroth, I. I., et al. (2019) · Translational Oncology · doi:10.1016/j.tranon.2019.04.012 · Cited by 13

Scotin: A new p63 target gene expressed during epidermal differentiation

Zocchi, L., Bourdon, J., Codispoti, A., Knight, R. A., Lane, D. P., Melino, G., & Terrinoni, A. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.12.115 · Cited by 13

p63 expression is a prognostic factor in colorectal cancer

Guo, H.-Q., Huang, G., Liu, O.-F., Liu, Y., Yao, Z.-H., Yao, S.-N., Zhao, Y., Liu, T., Pu, X.-X., Lin, T.-Y., et al. (2012) · The International Journal of Biological Markers · doi:10.5301/jbm.2012.9581 · Cited by 13

Death-associated protein 3 in cancer—discrepant roles of DAP3 in tumours and molecular mechanisms

Song, H., Liu, H., Wang, X., Yang, Y., Zhao, X., Jiang, W. G., Sui, L., & Song, X. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2023.1323751 · Cited by 13

Death associated protein‑3 (DAP3) and DAP3 binding cell death enhancer‑1 (DELE1) in human colorectal cancer, and their impacts on clinical outcome and chemoresistance

Sui, L., Zeng, J., Zhao, H., Ye, L., Martin, T. A., Sanders, A. J., Ruge, F., Jiang, A., Dou, Q. P., Hargest, R., et al. (2022) · International Journal of Oncology · doi:10.3892/ijo.2022.5455 · Cited by 12

UBE4B: A Promising Regulatory Molecule in Neuronal Death and Survival

Zeinab, R. A., Wu, H., Sergi, C. M., & Leng, R. P. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms131216865 · Cited by 12

Vesicular stomatitis virus infection triggers apoptosis associated with decreased ΔNp63α and increased Bax levels in the immortalized HaCaT keratinocyte cell line

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ΔNp63α mediates proliferation and apoptosis in human gastric cancer cells by the regulation of GATA-6

WANG, H., LIU, Z., Li, J.-X., Zhao, X., Wang, Z., & Xu, J. (2012) · Neoplasma · doi:10.4149/neo_2012_054 · Cited by 12

The BAG-1 cochaperone is a negative regulator of p73-dependent transcription

Wang, X., O’Connor, D. J., Brimmell, M., & Packham, G. (2009) · British Journal of Cancer · doi:10.1038/sj.bjc.6604985 · Cited by 12

Myoblasts rely on TAp63 to control basal mitochondria respiration

Ciuffoli, V., Lena, A. M., Gambacurta, A., Melino, G., & Candi, E. (2018) · Aging · doi:10.18632/aging.101668 · Cited by 12

PKCδ stabilizes TAp63 to promote cell apoptosis

Li, D., Li, C., Wu, M. C., Chen, Q., Wang, Q., Ren, J., & Zhang, Y. (2015) · FEBS Letters · doi:10.1016/j.febslet.2015.06.014 · Cited by 10

Benign and malignant odontogenic neoplasms of the jaws show a concordant nondiscriminatory p63/p40 positive immunophenotype

Argyris, P. P., Malz, C., Taleb, R., & Koutlas, I. G. (2018) · Oral Surgery Oral Medicine Oral Pathology and Oral Radiology · doi:10.1016/j.oooo.2018.08.018 · Cited by 10

DNA Demethylation Switches Oncogenic ΔNp63 to Tumor Suppressive TAp63 in Squamous Cell Carcinoma

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MicroRNAs Regulate Thymic Epithelium in Age-Related Thymic Involution via Down- or Upregulation of Transcription Factors

Xu, M., Zhang, X., Hong, R., Su, D., & Wang, L. (2017) · Journal of Immunology Research · doi:10.1155/2017/2528957 · Cited by 10

ΔNp63α Promotes Apoptosis of Human Epidermal Keratinocytes

Zhu, L., Rorke, E. A., & Eckert, R. L. (2007) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700797 · Cited by 9

Induction of TAp63 by histone deacetylase inhibitors

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The E3 ligase TRIM21 promotes progression of pancreatic ductal adenocarcinoma by down-regulating TAp63α and derepressing IL20RB

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OTX2 regulates the expression of TAp63 leading to macular and cochlear neuroepithelium development

Palombo, R., Porta, G., Bruno, E., Provero, P., Serra, V., Neduri, K., Viziano, A., Alessandrini, M., Micarelli, A., Ottaviani, F., et al. (2015) · Aging · doi:10.18632/aging.100839 · Cited by 8

Differential effects of p63 mutants on transactivation of p53 and/or p63 responsive genes

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Neurodevelopment on Route p63

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TP63 Transcripts Play Opposite Roles in Chicken Skeletal Muscle Differentiation

Luo, W., Ren, X., Chen, J., Li, L., Lu, S., Chen, T., Nie, Q., & Zhang, X. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01298 · Cited by 8

p63, a key regulator of Ago2, links to the microRNA-144 cluster

Wang, B., Wu, H. H., Abuetabh, Y., Leng, S., Davidge, S. T., Flores, E. R., Eisenstat, D. D., & Leng, R. P. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04854-1 · Cited by 8

TP63 truncating mutation causes increased cell apoptosis and premature ovarian insufficiency by enhanced transcriptional activation of CLCA2

Fan, Y., Chen, S., Chu, C., Yin, X., Jin, J., Zhang, L., Yan, H., Cao, Z., Liu, R., Xin, M., et al. (2024) · Journal of Ovarian Research · doi:10.1186/s13048-024-01396-2 · Cited by 7

Transcriptional Regulation of Apoptosis

Dudgeon, C., Qiu, W., Sun, Q., Zhang, L., & Yu, J. (2009) · Humana Press eBooks · doi:10.1007/978-1-60327-381-7_10 · Cited by 7

Targeting of p53-Transcriptional Dysfunction by Conditionally Replicating Adenovirus Is Not Limited by p53-Homologues

Kühnel, F., Gürlevik, E., Wirth, T. C., Strüver, N., Malek, N. P., Müller-Schilling, M., Manns, M. P., Carnero, A., Zender, L., & Kubicka, S. (2009) · Molecular Therapy · doi:10.1038/mt.2009.298 · Cited by 7

Eine neue Rolle für TAp63α in Apoptose und Chemosensitivität von Hepatomzellen

Gressner, O. A., Koch, A., Lorenz, K., Hill, P., Candi, E., Melino, G., Krammer, P., Stremmel, W., & Müller, M. (2005) · Zeitschrift für Gastroenterologie · doi:10.1055/s-2005-920107

TAp63alpha is involved in toll‐like receptor 3 (TLR3) induced apoptosis via death receptors and mitochondria

Hu, J., Sun, R., Zhang, Y., Liu, B., Jin, M., Zhang, W., Deng, M., Liu, X., Li, G., Li, Y., et al. (2011) · The FASEB Journal · doi:10.1096/fasebj.25.1_supplement.952.1

p63 induziert Apoptose durch Aktivierung von Signalwegen via Todesrezeptoren und Mitochondrien

Gressner, O. A., Koch, A., Lorenz, K., Schleithoff, A. S., Hill, P., Willen, D., Melino, G., Krammer, P., Stremmel, W., & Mueller-Schilling, M. (2004) · Zeitschrift für Gastroenterologie · doi:10.1055/s-2004-831669

TAp63 and ΔNp63 in Cancer and Epidermal Development

Candi, E., Dinsdale, D. D., Rufini, A., Salomoni, P., Knight, R. A., Mueller, M., Krammer, P. H., & Melino, G. (2007) · Cell Cycle · doi:10.4161/cc.6.3.3797 · Cited by 188

TAp73/ΔNp73 influences apoptotic response, chemosensitivity and prognosis in hepatocellular carcinoma

Schleithoff, E. S., Sayan, E., Koch, A., Pieper, C. C., Gressner, O. A., Melino, G., Krammer, P., Tannapfel, A., Stremmel, W., & Müller, M. (2005) · Zeitschrift für Gastroenterologie · doi:10.1055/s-2005-920108