Oren, Moshe

Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018.

Galluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., et al. (2018) · Cell Death & Differentiation

Cell death mechanisms and regulationAutophagy in Disease and Therapy

Cited by 6,680

Mdm2 promotes the rapid degradation of p53

Haupt, Y., Maya, R., Kazaz, A., & Oren, M. (1997) · Nature

Cancer-related Molecular PathwaysHeat shock proteins research

Cited by 4,506

The first 30 years of p53: growing ever more complex.

Levine, A. J., & Oren, M. (2009) · Nature Reviews Cancer

Cancer-related Molecular PathwaysCell death mechanisms and regulation

Cited by 1,967

mdm2 expression is induced by wild type p53 activity.

Barak, Y., Juven, T., Haffner, R., & Oren, M. (1993) · The EMBO Journal

Cancer-related Molecular PathwaysHeat shock proteins research

Cited by 1,290

Mutations in the p53 Tumor Suppressor Gene: Important Milestones at the Various Steps of Tumorigenesis

Rivlin, N., Brosh, R., Oren, M., & Rotter, V. (2011) · Genes & Cancer

Cancer-related Molecular PathwaysPI3K/AKT/mTOR signaling in cancer

Cited by 1,033

p53 Activates the CD95 (APO-1/Fas) Gene in Response to DNA Damage by Anticancer Drugs

Müller, M., Wilder, S., Bannasch, D., Israeli, D., Lehlbach, K., Li-Weber, M., Friedman, S. L., Galle, P. R., Stremmel, W., Oren, M., et al. (1998) · The Journal of Experimental Medicine

Cancer-related Molecular PathwaysCell death mechanisms and regulation

Cited by 878

ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage

Maya, R., Balass, M., Kim, S.-T., Shkedy, D., Leal, J.-F. M., Shifman, O., Moas, M., Buschmann, T., Ronai, Z., Shiloh, Y., et al. (2001) · Genes & Development

Cancer-related Molecular PathwaysDNA Repair Mechanisms

Cited by 731

Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage

Khosravi, R., Maya, R., Gottlieb, T., Oren, M., Shiloh, Y., & Shkedy, D. (1999) · Proceedings of the National Academy of Sciences

Cancer-related Molecular PathwaysDNA Repair Mechanisms

Cited by 461

The gut microbiome switches mutant p53 from tumour-suppressive to oncogenic

Kadosh, E., Snir-Alkalay, I., Venkatachalam, A., May, S., Lasry, A., Elyada, E., Zinger, A., Shaham, M., Vaalani, G., Mernberger, M., et al. (2020) · Nature

Cancer-related Molecular PathwaysWnt/β-catenin signaling in development and cancer

Cited by 378

Opposing Effects of Ras on p53

Ries, S., Biederer, C., Woods, D., Shifman, O., Shirasawa, S., Sasazuki, T., McMahon, M., Oren, M., & McCormick, F. (2000) · Cell

Cancer-related Molecular PathwaysProtein Kinase Regulation and GTPase Signaling

Cited by 357

p53-independent upregulation of miR-34a during oncogene-induced senescence represses MYC

Christoffersen, N. R., Shalgi, R., Frankel, L. B., Leucci, E., Lees, M., Klausen, M., Pilpel, Y., Nielsen, F. C., Oren, M., & Lund, A. H. (2010) · Cell Death & Differentiation

Telomeres, Telomerase, and SenescenceMicroRNA in disease regulation

Cited by 352

MDM2 suppresses p73 function without promoting p73 degradation

Zeng, X., Chen, L., Jost, C. A., Maya, R., Keller, D., Wang, X., Kaelin, W. G., Oren, M., Chen, J., & Lu, H. (1999) · Molecular and Cellular Biology

Cancer-related Molecular PathwaysHeat shock proteins research

Cited by 334

Regulation of mdm2 expression by p53: alternative promoters produce transcripts with nonidentical translation potential.

Barak, Y., Gottlieb, E., Juven-Gershon, T., & Oren, M. (1994) · Genes & Development

Cancer-related Molecular PathwaysRNA and protein synthesis mechanisms

Cited by 328

A functional p53-responsive intronic promoter is contained within the human mdm2 gene

Zauberman, A., Flusberg, D., Haupt, Y., Barak, Y., & Oren, M. (1995) · Nucleic Acids Research

Cancer-related Molecular PathwaysGenomics and Chromatin Dynamics

Cited by 276

TAp63α induces apoptosis by activating signaling via death receptors and mitochondria

Gressner, O., Schilling, T., Lorenz, K., Schulze Schleithoff, E., Koch, A., Schulze‐Bergkamen, H., Maria Lena, A., Candi, E., Terrinoni, A., Valeria Catani, M., et al. (2005) · The EMBO Journal

Cell death mechanisms and regulationCancer-related Molecular Pathways

Cited by 255

Capturing tumor complexity in vitro: Comparative analysis of 2D and 3D tumor models for drug discovery

Stock, K., Estrada, M. F., Vidic, S., Gjerde, K., Rudisch, A., Santo, V. E., Barbier, M., Blom, S., Arundkar, S. C., Selvam, I., et al. (2016) · Scientific Reports

3D Printing in Biomedical ResearchCancer Cells and Metastasis

Cited by 253

Modulation of the Vitamin D3 Response by Cancer-Associated Mutant p53

Stambolsky, P., Tabach, Y., Fontemaggi, G., Weisz, L., Maor-Aloni, R., Sigfried, Z., Shiff, I., Kogan, I., Shay, M., Kalo, E., et al. (2010) · Cancer Cell

Cancer-related Molecular PathwaysVitamin D Research Studies

Cited by 245

A Senescence-Inflammatory Switch from Cancer-Inhibitory to Cancer-Promoting Mechanism

Pribluda, A., Elyada, E., Wiener, Z., Hamza, H., Goldstein, R. E., Biton, M., Burstain, I., Morgenstern, Y., Brachya, G., Billauer, H., et al. (2013) · Cancer Cell

Telomeres, Telomerase, and SenescenceCancer-related Molecular Pathways

Cited by 239

The RING domain of Mdm2 mediates histone ubiquitylation and transcriptional repression

Minsky, N., & Oren, M. (2004) · Molecular Cell

Genomics and Chromatin DynamicsUbiquitin and proteasome pathways

Cited by 204

4sUDRB-seq: measuring genomewide transcriptional elongation rates and initiation frequencies within cells

Fuchs, G., Voichek, Y., Benjamin, S., Gilad, S., Amit, I., & Oren, M. (2014) · Genome Biology

Genomics and Chromatin DynamicsRNA Research and Splicing

Cited by 203

Regulation of AIF expression by p53

Stambolsky, P., Weisz, L., Shats, I., Klein, Y., Goldfinger, N., Oren, M., & Rotter, V (2006) · Cell Death & Differentiation

Cell death mechanisms and regulationCancer-related Molecular Pathways

Cited by 194

Importin 7 and Exportin 1 Link c-Myc and p53 to Regulation of Ribosomal Biogenesis

Golomb, L., Bublik, D. R., Wilder, S., Nevo, R., Kiss, V., Grabusic, K., Volarevic, S., & Oren, M. (2012) · Molecular Cell

Nuclear Structure and FunctionCancer-related Molecular Pathways

Cited by 137

Mutant p53 gain of function: repression of CD95(Fas/APO-1) gene expression by tumor-associated p53 mutants

Zalcenstein, A., Stambolsky, P., Weisz, L., Müller, M., Wallach, D., Goncharov, T. M., Krammer, P. H., Rotter, V., & Oren, M. (2003) · Oncogene

Cancer-related Molecular PathwaysCell death mechanisms and regulation

Cited by 123

New plays in the p53 theater

Aylon, Y., & Oren, M. (2011) · Current Opinion in Genetics & Development

Cancer-related Molecular PathwaysPI3K/AKT/mTOR signaling in cancer

Cited by 106