POT1 protects telomeres from a transient DNA damage response and determines how human chromosomes end

A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

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Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity.

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TRF2 Protects Human Telomeres from End-to-End Fusions

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DNA Damage Foci at Dysfunctional Telomeres

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Telomere Shortening Triggers Senescence of Human Cells through a Pathway Involving ATM, p53, and p21CIP1, but Not p16INK4a

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p53- and ATM-Dependent Apoptosis Induced by Telomeres Lacking TRF2

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Pot1, the Putative Telomere End-Binding Protein in Fission Yeast and Humans

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Long G Tails at Both Ends of Human Chromosomes Suggest a C Strand Degradation Mechanism for Telomere Shortening

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FOXP2 promotes the nuclear translocation of POT1, but FOXP2(R553H), mutation related to speech-language disorder, partially prevents it

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Telomerase activity is required for the telomere G-overhang structure in Trypanosoma brucei

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Telomere Crisis Shapes Cancer EvolutionPreprint

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Pot1 promotes telomere DNA replication via the Stn1-Ten1 complex in fission yeast

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Telomere dysfunction in human bone marrow failure syndromes

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DNA damage response, checkpoint activation and dysfunctional telomeres: face to face between mammalian cells and Drosophila.

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SmedOB1 is Required for Planarian Homeostasis and Regeneration

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Moderate expression of TRF2 in the hematopoietic system increases development of large cell blastic T-cell lymphomas

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POT of gold: modeling dyskeratosis congenita in the mouse: Figure 1.Preprint

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Ustilago maydis telomere protein Pot1 harbors an extra N-terminal OB fold and regulates homology-directed DNA repair factors in a dichotomous and context-dependent manner

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Expression of human protection of telomere 1 correlates with telomere length and radiosensitivity in the human laryngeal cancer Hep-2 cell line

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Analysis of telomeric DNA: Current approaches and methods

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Recent emergence and extinction of the protection of telomeres 1c gene in Arabidopsis thaliana

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Ku70 prevents genome instability resulting from heterozygosity of the telomerase RNA component in a vertebrate tumour line

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Telomere maintenance in African trypanosomes

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Detection of the rs10250202 polymorphism in protection of telomeres 1 gene through introducing a new restriction enzyme site for PCR–RFLP assay

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Associations between telomere attrition, genetic variants in telomere maintenance genes, and non-small cell lung cancer risk in the Jammu and Kashmir population of North India

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Characterization of a Cryptosporidium parvum protein that binds single-stranded G-strand telomeric DNA

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Telomeric dysfunction triggers an unstable growth arrest leading to irreparable genomic lesions and entry into cellular senescencePreprint

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POT1 mutations are frequent and associated with Ki-67 index in canine diffuse large B-cell lymphoma

Fanelli, A., Marconato, L., Licenziato, L., Minoli, L., Rouquet, N., & Aresu, L. (2022) · Frontiers in Veterinary Science · doi:10.3389/fvets.2022.968807 · Cited by 4

POT1 involved in telomeric DNA damage repair and genomic stability of cervical cancer cells in response to radiation

Li, Q., Wang, X., Liu, J., Wu, L., & Xu, S. (2023) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2023.503670 · Cited by 5

TERT-independent telomere elongation and shelterin dysregulation after pulmonary exposure to stainless-steel welding fume in-vivo

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CST Complex and Telomere Maintenance

Ishikawa, F. (2016) · Springer eBooks · doi:10.1007/978-4-431-55873-6_15 · Cited by 4

Application of created restriction site PCR-RFLP to identify POT1 gene polymorphism

Wang, T., Wang, S., Duan, X., Feng, X., Wang, P., Yao, W., Wu, Y., Feng, F., Yu, S., Yi-ming, W., et al. (2016) · Biochemistry (Moscow) · doi:10.1134/s0006297916060092 · Cited by 4

Dynamics and plasticity of chromosome ends: consequences in human pathologies

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Taking control of G-quadruplexes

Baumann, P. (2005) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1005-832 · Cited by 3

Murine Models of Dysfunctional Telomeres and Telomerase

Liu, Y., & Harrington, L. A. (2012) · Wiley eBooks · doi:10.1002/9781118268667.ch9 · Cited by 3

Conserved and unique features of terminal telomeric sequences in ALT-positive cancer cellsPreprint

Azeroglu, B., Wu, W., Pavani, R., Sandhu, R. S., Matsumoto, T., Nussenzweig, A., & Denchi, E. L. (2025) · eLife · doi:10.7554/elife.106657 · Cited by 4

Telomere Metabolism and DNA Damage Response

Pandita, T. K. (2009) · Springer eBooks · doi:10.1007/978-90-481-2561-6_7 · Cited by 2

Chronic oxidative stress and telomere shortening

Houben, J. M. J., Moonen, H. J. J., van Schooten, F., & Hageman, G. J. (2007) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2007.06.013 · Cited by 2

CDK1 differentially regulates G-overhang generation at leading- and lagging-strand telomeres in telomerase-negative cells in G2phase

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Telomere G-Overhang Length Measurement Method 2: G-Tail Telomere HPA

Tahara, H. (2011) · Methods in molecular biology · doi:10.1007/978-1-61779-092-8_6 · Cited by 2

Molekulare Grundlagen der Apoptose

Daniel, P. T. (2008) · Springer eBooks · doi:10.1007/978-3-540-69414-4_8 · Cited by 2

Of wombats and whales: telomere tales in Madrid

Karlseder, J., & Cooper, J. P. (2007) · EMBO Reports · doi:10.1038/sj.embor.7400985 · Cited by 2

Inhibition of lagging strand replication by G-rich telomeric DNA and the shelterin subunit POT1

Leonard-Booker, C., Mazzucco, G., Fisher, C. E. L., Hussain, K., Deegan, T. D., Doksani, Y., & Douglas, M. E. (2026) · The EMBO Journal · doi:10.1038/s44318-026-00844-7 · Cited by 1

Control of telomerase recruitment and end protection by independent shelterin components

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Telomere length of both parents contributes to heritable POT1 cancer-predisposition syndrome

Martin, A., Lu, R., Blake, A., Nichols, K. E., Sanchez, S. E., Artandi, S. E., Savage, S. A., Sharma, R., & Hockemeyer, D. F. (2026) · Nature Communications · doi:10.1038/s41467-026-77414-2 · Cited by 1

The ATM-mediated DNA-damage response

Shiloh, Y. (2013) · Cambridge University Press eBooks · doi:10.1017/cbo9781139046947.035 · Cited by 1

Telomeres and Chromosome Stability

Chu, T. W., & Autexier, C. (2016) · Springer eBooks · doi:10.1007/978-3-319-38882-3_6 · Cited by 1

Stress factor – dependent differences in molecular mechanisms of premature cell senescence

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Molecular Epidemiology of Diffuse Low-Grade Glioma

Jacobs, D. I., Claus, E. B., & Wrensch, M. (2017) · Springer eBooks · doi:10.1007/978-3-319-55466-2_3 · Cited by 1

Targeting Genome Instability and DNA Repair

Locatelli, M., & Curigliano, G. (2017) · Springer eBooks · doi:10.1007/978-3-319-48848-6_68 · Cited by 1

Targeting DNA Repair

Curigliano, G. (2017) · Handbook of experimental pharmacology · doi:10.1007/164_2017_31 · Cited by 1

Telomere-Binding Proteins in Humans

Dimitrova, N. (2009) · Humana Press eBooks · doi:10.1007/978-1-60327-879-9_2 · Cited by 1

Telomere G-Overhang Length Measurement Method 2: G-Tail Telomere HPA

Tahara, H. (2017) · Methods in molecular biology · doi:10.1007/978-1-4939-6892-3_6 · Cited by 1

Polymerases ε and ∂ repair dysfunctional telomeres facilitated by salt

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Long G2 accumulates recombination intermediates and disturbs chromosome segregation at dysfunction telomere in Schizosaccharomyces pombe

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Telomere relocalization to the nuclear pore complex in response to replication stressPreprint

Pinzaru, A. M., Lamm, N., Kareh, M., Denchi, E. L., Cesare, A. J., & Sfeir, A. J. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.01.31.929059 · Cited by 1

An Update of Molecular Basis of Telomere Biology DiseasesPreprint

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Telomere Targeting Approaches in Cancer: Over the Length Maintenance.Preprint

Vertecchi, E., Rizzo, A., & Salvati, E. (2021) · Preprints.org · doi:10.20944/preprints202111.0367.v1

Telomere Regulation by Metabolism ReprogrammingPreprint

Rubtsova, M. P., Никишин, Д. А., Koriagina, M. S., Vasiliev, A. V., & Донцова, О. А. (2024) · Preprints.org · doi:10.20944/preprints202401.0019.v1

Maintenance of Telomeres in Cancer

Denchi, E. L. (2010) · Springer eBooks · doi:10.1007/978-1-4419-1770-6_8

Differential Effects of the G-Quadruplex Ligand 360A in Human Normal and Cancer Cells

Granotier-Beckers, C., & Francois, D. (2011) · InTech eBooks · doi:10.5772/24130 · Cited by 1

Telomere Structure in Telomerase Regulation

Vodenicharov, M. D., & Wellinger, R. J. (2012) · Wiley eBooks · doi:10.1002/9781118268667.ch7

Rôle de protéines de la réparation des cassures double brin dans l'homéostasie télomérique chez Arabidopsis thaliana

Vannier, J. (2009) · HAL

Werner Syndrome, Telomeres, and Stress Signaling: Implications for Future Therapies?

Davis, T., & Kipling, D. (2007) · Springer eBooks · doi:10.1007/978-3-540-73709-4_14

Polymerase alpha components associate with telomeres to mediate overhang processing

Diotti, R. (2014) · CUNY Academic Works (City University of New York)

Expression of shelterin and shelterin-associated genes in breast cancer cell lines

Motevalli, A. (2014) · Brunel University Research Archive (BURA) (Brunel University London)

Shelterin complex in telomere protection: recent insights and pathological significance

Loayza, D., & Kalan, S. (2014) · Cell Health and Cytoskeleton · doi:10.2147/chc.s49687

The Influence of Biological Ageing in the Pathogenesis of Colorectal Cancer

Maxwell, F. (2013) · Enlighten: Theses (The University of Glasgow)

Telomere-Related Factors and Human Papillomavirus Genome Maintenance

Rogers, A. J. (2013) · Lincoln (University of Nebraska)

Role of RecQ Helicases in Nuclear DNA Repair and Telomere Maintenance

Ghosh, A. K., Liu, Y., & Bohr, V. A. (2009) · Springer eBooks · doi:10.1007/978-1-4419-1075-2_2

Mechanisms of Telomere Protection and Deprotection in Human Cells

Sarthy, J. F. (2011) · KU ScholarWorks (The University of Kansas)

Telomeres, Telomerase, and DNA Damage Response in Cancer Therapy

Tamakawa, R., Fleisig, H. B., & Wong, J. M. Y. (2012) · Springer eBooks · doi:10.1007/978-1-4614-4741-2_11

The Role of the Nonhomologous

Říha, K., Heacock, M. L., & Shippen, D. E. (2006)

LIM Protein Ajuba Participates in the Repression of ATR-Mediated DNA Damage Response in Human Cells

Kalan, S. (2016) · CUNY Academic Works (City University of New York)

Telomere-associated proteins in Arabidopsis thaliana

Surovtseva, Y. V. (2008) · OakTrust (Texas A&M University Libraries)

Molecular dissection of telomere dysfunction and analysis of G-overhangs in Arabidopsis thaliana

Heacock, M. L. (2009) · OakTrust (Texas A&M University Libraries)

Further Insight into the Two Functions of Telomeres: Determining the Role of Tankyrase1 in Telomere Length Regulation and Tin2 in Telomere Protection

Donigian, J. R. (2008) · Digital Commons - RU (Rockefeller University) · doi:10.48496/z32n-yn07

Identifying the Surfaces of Human Protein TPP1 and Telomerase RNA that Interact with One Another to Improve Enzyme Function and Association at the Telomere

Bell, C. (2012) · CU Scholar (University of Colorado Boulder)

Telomeres and the End Replication Problem

Bryan, T. M. (2009) · Royal Society of Chemistry eBooks · doi:10.1039/9781847559852-00217

Consequences of telomerase inhibition and telomere dysfunction in BRCA1 mutant cancer cells

Phipps, E. A. (2014) · IUScholarWorks (Indiana University) · doi:10.7912/c2/1953

Structural dynamics of telomeric overhang accessibility

Hwang, H. (2014) · Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)

from Resection by Exo1 and Apollo and Fill-In by POT1b-Associated CST

Wu, P. V., Takai, H., & de Lange, T. (2012)

Identification and characterization of tac5, a telomerase activation mutant, characterization of DNA damage responses and assessment of interactions between telomere-related proteins in Arabidopsis thaliana

Jasti, M. (2009) · OakTrust (Texas A&M University Libraries)

Cell cycle-dependent modification of Pot1 and its effects on telomere function

Kuznetsov, V. A. (2009) · OpenGrey (Institut de l'Information Scientifique et Technique)

Structural studies on proteins involved in human telomere maintenance

Borucu, U. (2017) · DR-NTU (Nanyang Technological University) · doi:10.32657/10356/72778

Telomere Dynamics and End Processing in Mammalian Cells

Sfeir, A. J. (2006)

POT1a depletion in the developing brain leads to p53-dependent neuronal cell death and ataxiaPreprint

She, R., Clapp, C., & Denchi, E. L. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/335059

Etiological and Epidemiological Aspects

Jacobs, D. I., Amirian, E. S., Claus, E. B., Jenkins, R. B., Bondy, M. L., & Wrensch, M. (2019) · Springer eBooks · doi:10.1007/978-3-030-04152-6_2

T-loops Refold after Telomerase Extension and Unfold Again at Late S/G2 for C-strand Fill-inPreprint

Mak, S. S. M., Smiraldo, P. G., Chow, T. T., Wright, W. E., & Shay, J. W. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/869982

MUTAGENIC POTENTIAL OF TELOMERIC REPEATS AND THE ROLE OF WERNER SYNDROME HELICASE PROTEIN IN FACILITATING TELOMERIC DNA REPLICATION

Damerla, R. R. (2011) · D-Scholarship@Pitt (University of Pittsburgh)

DNA, DNA Replication, and Aging

Sharma, B., Agarwal, M., Verma, V. K., & Dhar, S. K. (2020) · Springer eBooks · doi:10.1007/978-981-32-9005-1_2

THE PML PROTEIN IS NOT ESSENTIAL FOR TELOMERE MAINTENANCE BY THE ALTERNATIVE LENGTHENING OF TELOMERES PATHWAY (ALT) AND ITS DELETION MODIFIES ALT BIOMARKERS

Barry, W. T. (2017)

Structural studies of human telomerase complexes by cryo-electron microscopy

Jin, Y. (2020) · DR-NTU (Nanyang Technological University) · doi:10.32657/10356/139941

Chronic oxidative stress and telomere shortening

Houben, J. M. J. (2011) · Research Publications (Maastricht University) · doi:10.26481/dis.20110121jh

Avaliação da expressão dos principais complexos de manutenção telomérica na progressão do câncer de próstata

dos Santos, G. A. G. D. (2023) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.5.2023.tde-23082023-144910

Dissecting the oncogenic mechanisms of POT1 cancer mutations through deep scanning mutagenesisPreprint

Martin, A., Schabort, J. J., Bartke-Croughan, R., Tran, S., Preetham, A., Lu, R., Ho, R., Gao, J., Jenkins, S. S., Boyle, J., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.08.19.608636

Conserved and unique features of terminal telomeric sequences in ALT-positive cancer cells

Azeroglu, B., Wu, W., Pavani, R., Sandhu, R. S., Matsumoto, T., Nussenzweig, A., & Denchi, E. L. (2025) · eLife · doi:10.7554/elife.106657.3

Conserved and Unique Features of Terminal Telomeric Sequences in ALT-Positive Cancer CellsPreprint

Azeroglu, B., Wu, W., Pavani, R., Sandhu, R. S., Matsumoto, T., Nussenzweig, A., & Denchi, E. L. (2025) · eLife · doi:10.7554/elife.106657.1

Reading the DNA of telomeres

Roy, S., & Azzalin, C. M. (2025) · eLife · doi:10.7554/elife.107648

Conserved and Unique Features of Terminal Telomeric Sequences in ALT-Positive Cancer CellsPreprint

Azeroglu, B., Wu, W., Pavani, R., Sandhu, R. S., Matsumoto, T., Nussenzweig, A., & Denchi, E. L. (2025) · eLife · doi:10.7554/elife.106657.2

Omeostasi dei telomeri nelle sindromi mielodisplastiche

Berardinelli, E. (2014) · Università Politecnica delle Marche (Università Politecnica delle Marche)

Processing of Alternative DNA Structures in the Human Telomere

Nora, G. J. (2010) · D-Scholarship@Pitt (University of Pittsburgh)

Additional file 2 of Associations between telomere attrition, genetic variants in telomere maintenance genes, and non-small cell lung cancer risk in the Jammu and Kashmir population of North India

Bhat, G. R., Jamwal, R. S., Sethi, I., Bhat, A., Shah, R., Verma, S., Sharma, M., Sadida, H. Q., Al-Marzooqi, S. K., Masoodi, T., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26617912

Additional file 3 of Associations between telomere attrition, genetic variants in telomere maintenance genes, and non-small cell lung cancer risk in the Jammu and Kashmir population of North India

Bhat, G. R., Jamwal, R. S., Sethi, I., Bhat, A., Shah, R., Verma, S., Sharma, M., Sadida, H. Q., Al-Marzooqi, S. K., Masoodi, T., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26617915

Additional file 1 of Associations between telomere attrition, genetic variants in telomere maintenance genes, and non-small cell lung cancer risk in the Jammu and Kashmir population of North India

Bhat, G. R., Jamwal, R. S., Sethi, I., Bhat, A., Shah, R., Verma, S., Sharma, M., Sadida, H. Q., Al-Marzooqi, S. K., Masoodi, T., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26617909

Additional file 4 of Associations between telomere attrition, genetic variants in telomere maintenance genes, and non-small cell lung cancer risk in the Jammu and Kashmir population of North India

Bhat, G. R., Jamwal, R. S., Sethi, I., Bhat, A., Shah, R., Verma, S., Sharma, M., Sadida, H. Q., Al-Marzooqi, S. K., Masoodi, T., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26617918

Single-stranded DNA-binding proteins at healthy and diseased telomeres

Lescalet, G., Monterroso, A. D. D., Kochman, R., Coulon, S., & Maréchal, A. (2026) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2025.11.010

Proteomics method for identifying POT1-associated complexes at telomeres using ChIP-Mass spectrometry

Zade, N. H., Jain, M., Garg, M., Checker, R., Ghosh, A., & Khattar, E. (2026) · Methods · doi:10.1016/j.ymeth.2026.01.007

The Role of Pot1 in Telomere Protection and Maintenance

Hockemeyer, D. F. (2025) · Digital Commons - RU (Rockefeller University) · doi:10.48496/f38z-3x19

POT1b protects telomeres from end‐to‐end chromosomal fusions and aberrant homologous recombination

He, H., Multani, A. S., Cosme‐Blanco, W., Tahara, H., Ma, J., Pathak, S., Deng, Y., & Chang, S. S. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601294 · Cited by 135

Role of telomere dysfunction, DNA damage response and p53 mutations in tumorigenesis and aging

Cosme‐Blanco, W. (2008) · Digital Commons-TMC (Texas Medical Center)

Pot1 Deficiency Initiates DNA Damage Checkpoint Activation and Aberrant Homologous Recombination at Telomeres

Wu, L., Multani, A. S., He, H., Cosme-Blanco, W., Deng, Y., Deng, J. M., Bachilo, O., Pathak, S., Tahara, H., Bailey, S. M., et al. (2006) · Cell · doi:10.1016/j.cell.2006.05.037 · Cited by 422

Dysfunctional telomeres activate an ATM‐ATR‐dependent DNA damage response to suppress tumorigenesis

Guo, X., Deng, Y., Lin, Y., Cosme‐Blanco, W., Chan, S., He, H., Yuan, G., Brown, E. J., & Chang, S. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601893 · Cited by 258