Shay, Jerry W.

Specific Association of Human Telomerase Activity with Immortal Cells and Cancer

Kim, N. W., Piatyszek, M. A., Prowse, K. R., Harley, C. B., West, M. D., Ho, P. L. C., Coviello, G. M., Wright, W. E., Weinrich, S. L., & Shay, J. W. (1994) · Science

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Extension of Life-Span by Introduction of Telomerase into Normal Human Cells

Bodnar, A. G., Ouellette, M., Frolkis, M., Holt, S. E., Chiu, C.-P., Morin, G. B., Harley, C. B., Shay, J. W., Lichtsteiner, S., & Wright, W. E. (1998) · Science

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A survey of telomerase activity in human cancer

Shay, J. W., & Bacchetti, S. (1997) · European Journal of Cancer

Telomeres, Telomerase, and SenescenceCancer-related Molecular Pathways

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BRAFE600-associated senescence-like cell cycle arrest of human naevi

Michaloglou, C., Vredeveld, L. C. W., Soengas, M. S., Denoyelle, C., Kuilman, T., van der Horst, C. M. A. M., Majoor, D. M., Shay, J. W., Mooi, W. J., & Peeper, D. S. (2005) · Nature

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Telomeres and telomerase: three decades of progress

Shay, J. W., & Wright, W. E. (2019) · Nature Reviews Genetics

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Human Telomerase and Its Regulation

Cong, Y.-S., Wright, W. E., & Shay, J. W. (2002) · Microbiology and Molecular Biology Reviews

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

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Adult-onset pulmonary fibrosis caused by mutations in telomerase

Tsakiri, K. D., Cronkhite, J. T., Kuan, P. J., Xing, C., Raghu, G., Weissler, J. C., Rosenblatt, R. L., Shay, J. W., & Garcia, C. K. (2007) · Proceedings of the National Academy of Sciences

Interstitial Lung Diseases and Idiopathic Pulmonary FibrosisTelomeres, Telomerase, and Senescence

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Activation of telomerase in human lymphocytes and hematopoietic progenitor cells

Hiyama, K., Hirai, Y., Kyoizumi, S., Akiyama, M., Hiyama, E., Piatyszek, M. A., Shay, J. W., Ishioka, S., & Yamakido, M. (1995) · The Journal of Immunology

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

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Hayflick, his limit, and cellular ageing

Shay, J. W., & Wright, W. E. (2000) · Nature Reviews Molecular Cell Biology

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

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A role for both RB and p53 in the regulation of human cellular senescence*1

SHAY, J. (1991) · Experimental Cell Research

Telomeres, Telomerase, and SenescenceCancer-related Molecular Pathways

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Roles of telomeres and telomerase in cancer, and advances in telomerase-targeted therapies

Jafri, M. A., Ansari, S. A., Alqahtani, M. H., & Shay, J. W. (2016) · Genome Medicine

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

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Role of Telomeres and Telomerase in Aging and Cancer

Shay, J. W. (2016) · Cancer Discovery

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 668

Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death

Herbert, B.-S., Pitts, A. E., Baker, S. I., Hamilton, S. E., Wright, W. E., Shay, J. W., & Corey, D. R. (1999) · Proceedings of the National Academy of Sciences

Telomeres, Telomerase, and SenescenceDNA and Nucleic Acid Chemistry

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Role of telomeres and telomerase in cancer

Shay, J. W., & Wright, W. E. (2011) · Seminars in Cancer Biology

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Hallmarks of senescence in carcinogenesis and cancer therapy

Shay, J. W., & Roninson, I. B. (2004) · Oncogene

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

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Exome sequencing links mutations in PARN and RTEL1 with familial pulmonary fibrosis and telomere shortening

Stuart, B. D., Choi, J., Zaidi, S., Xing, C., Holohan, B., Chen, R., Choi, M., Dharwadkar, P., Torres, F., Girod, C. E., et al. (2015) · Nature Genetics

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Comparative biology of mammalian telomeres: hypotheses on ancestral states and the roles of telomeres in longevity determination

Gomes, N. M. V., Ryder, O. A., Houck, M. L., Charter, S. J., Walker, W., Forsyth, N. R., Austad, S. N., Venditti, C., Pagel, M., Shay, J. W., et al. (2011) · Aging Cell

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Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions

Ramirez, R. D., Morales, C. P., Herbert, B.-S., Rohde, J. M., Passons, C., Shay, J. W., & Wright, W. E. (2001) · Genes & Development

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Telomere dynamics in cancer progression and prevention: fundamental differences in human and mouse telomere biology

Wright, W. E., & Shay, J. W. (2000) · Nature Medicine

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Telomerase, Cell Immortality, and Cancer

Harley, C. B., Kim, N. W., Prowse, K. R., Weinrich, S. L., Hirsch, K. S., West, M. D., Bacchetti, S., Hirte, H. W., Counter, C. M., Greider, C. W., et al. (1994) · Cold Spring Harbor Symposia on Quantitative Biology

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The two-stage mechanism controlling cellular senescence and immortalization

Wright, W. E., & Shay, J. W. (1992) · Experimental Gerontology

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

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Telomerase and differentiation in multicellular organisms: Turn it off, turn it on, and turn it off again

Forsyth, N. R., Wright, W. E., & Shay, J. W. (2002) · Differentiation

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POT1 protects telomeres from a transient DNA damage response and determines how human chromosomes end

Hockemeyer, D., Sfeir, A. J., Shay, J. W., Wright, W. E., & de Lange, T. (2005) · The EMBO Journal

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Cellular senescence as a tumor-protection mechanism: the essential role of counting

Wright, W. E., & Shay, J. W. (2001) · Current Opinion in Genetics & Development

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