The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Cytokine signals modulated via lipid rafts mimic niche signals and induce hibernation in hematopoietic stem cells
Open accessAbstract
Hematopoietic stem cells (HSCs) reside in the bone marrow (BM) niche in a noncycling state and enter the cell cycle at long intervals. However, little is known about inter- and intracellular signaling mechanisms underlying this unique property of HSCs. Here, we show that lipid raft clustering is a key event in the regulation of HSC dormancy. Freshly isolated HSCs from the BM niche lack lipid raft clustering, exhibit repression of the AKT-FOXO signaling pathway, and express abundant p57(Kip2) cyclin-dependent kinase inhibitor. Lipid raft clustering induced by cytokines is essential for HSC re-entry into the cell cycle. Conversely, inhibition of lipid raft clustering caused sustained nuclear accumulation of FOXO transcription factors and induced HSC hibernation ex vivo. These data establish a critical role for lipid rafts in regulating the cell cycle, the survival, and the entry into apoptosis of HSCs and uncover a striking similarity in HSC hibernation and Caenorhabditis elegans dauer formation.
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“low levels of p57 have been associated with stem cell hibernation (Yamazaki et al., 2006)”
From Canonical Wnt Signaling Ameliorates Aging of Intestinal Stem Cells (2017) · cites this paper as Yamazaki et al., 2006
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Osteoblastic cells regulate the haematopoietic stem cell niche
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Long-Term Lymphohematopoietic Reconstitution by a Single CD34-Low/Negative Hematopoietic Stem Cell
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Self-citationTie2/Angiopoietin-1 Signaling Regulates Hematopoietic Stem Cell Quiescence in the Bone Marrow Niche
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Socializing with the Neighbors
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Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress
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AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1
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Hematopoietic Stem Cell Quiescence Maintained by p21 cip1/waf1
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Foxo3a is essential for maintenance of the hematopoietic stem cell pool
Miyamoto, K., Kazuhito, N., & Atsushi, H. (2009) · Kanazawa University Repository for Academic Resources (DSpace) (Kanazawa University) · Cited by 888
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Metadata
- Authors
- Yamazaki, S., Iwama, A., Takayanagi, S., Morita, Y., Eto, K., Ema, H., & Nakauchi, H.
- Affiliations
- Institute of Medical Science, The University of Tokyo (JP)
- Chiba University (JP)
- Corresponding author
- Nakauchi, Hiromitsu
- ORCID
- Venue
- The EMBO Journal
- Published
- 2006-07-20
- Volume
- 25
- Issue
- 15
- Pages
- 3515-3523
- ISSN
- 0261-4189 (ISSN-L)
- 1460-2075
- PMC
- PMC1538571
- OpenAlex
- W2125723206
- Cited by
- 270
- References
- 33
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 9 · 2023: 7 · 2022: 11 · 2021: 9 · 2020: 7 · 2019: 7 · 2018: 4 · 2017: 9 · 2016: 18 · 2015: 14 · 2014: 17 · 2013: 22 · 2012: 17
- FWCI
- 12.55
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- The EMBO Journal (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
- Keywords
- hematopoietic stem cells, lipid rafts, cell cycle re-entry, p57KIP2, cytokine signaling, bone marrow microenvironment, apoptosis, dauer formation, Caenorhabditis elegans
- MeSH terms
- Animals, Cell Cycle, Cells, Cultured, Fluorescent Antibody Technique, Hematopoietic Stem Cells, Mice, Inbred C57BL, Stem Cells, Signal Transduction, Cytokines, Caenorhabditis elegans, Apoptosis, Membrane Microdomains, Mice
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