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LAMP proteins are required for fusion of lysosomes with phagosomes
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LAMP-1 and LAMP-2 promote coupling of lysosomes to dynein-dynactin.
“LAMP-1 and LAMP-2 promote coupling of lysosomes to dynein–dynactin26,27”
From TFEB regulates lysosomal positioning by modulating TMEM55B expression and JIP4 recruitment to lysosomes (2017) · cites this paper as [26]
The Distribution and motility section reports reduced dynein-mediated lysosome transport in cells lacking LAMP-1 and LAMP-2. The Discussion proposes that LAMPs help lysosomes associate with dynein–dynactin, but says the physical link is unclear; it does not establish coupling as a demonstrated mechanism. No page numbers are available in our copy. (LLM, conf=0.86)
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LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing.
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Changes in lysosome shape and distribution correlated with changes in cytoplasmic pH
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Metadata
- Authors
- Huynh, K. K., Eskelinen, E., Scott, C. C., Malevanets, A., Saftig, P., & Grinstein, S.
- Venue
- The EMBO Journal
- Published
- 2007-01-24
- Volume
- 26
- Issue
- 2
- Pages
- 313-324
- ISSN
- 0261-4189
- 1460-2075
- Cited by
- 619
- References
- 2
- Language
- en
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