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Rab‐interacting lysosomal protein (RILP): the Rab7 effector required for transport to lysosomes

Cantalupo, Giuseppina, Alifano, Pietro, Roberti, Vera, Bruni, Carmelo B., Bucci, Cecilia·2001·The EMBO Journal
DOI 10.1093/emboj/20.4.683
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Crossref · 10.1093/emboj/20.4.683

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  • Retrograde movement is regulated by Rab7 and its effector RILP, which recruits dynein to lysosomes.

    “Retrograde movement is regulated by Rab7 and its effector RILP. RILP interacts with the p150-glued subunit of dynactin, thus recruiting the minus-end-directed microtubule motor dynein to lysosomes23–25.”

    From TFEB regulates lysosomal positioning by modulating TMEM55B expression and JIP4 recruitment to lysosomes (2017) · cites this paper as [23]

    The Abstract and Discussion identify RILP as a Rab7 effector involved in late endocytic transport and lysosomal organization. The Discussion only proposes that RILP might link Rab7-containing organelles to a motor complex; it does not establish that RILP binds p150-Glued or recruits dynein to lysosomes. Page numbers are unavailable in our copy. (LLM, conf=0.88)

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Metadata

Authors
Cantalupo, G., Alifano, P., Roberti, V., Bruni, C. B., & Bucci, C.
Venue
The EMBO Journal
Publisher
Springer Science and Business Media LLC
Published
2001-02-15
Volume
20
Issue
4
Pages
683-693
ISSN
  • 0261-4189
  • 1460-2075
DOI
10.1093/emboj/20.4.683
Cited by
488
References
3
Language
en
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