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Calcineurin: a central controller of signalling in eukaryotes: Workshop on the Calcium/Calcineurin/NFAT Pathway: Regulation and Function
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“Calcineurin is a serine and threonine-specific protein phosphatase specialized in the transduction of Ca 2+ -signals in eukaryotes (Aramburu et al. 2004).”
From Functional characterization of the Candida albicans CRZ1 gene encoding a calcineurin-regulated transcription factor (2005) · cites this paper as Aramburu et al. 2004
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Cites
A Calcineurin-Dependent Transcriptional Pathway for Cardiac Hypertrophy
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Calcineurin/NFAT Coupling Participates in Pathological, but not Physiological, Cardiac Hypertrophy
Wilkins, B. J., Dai, Y., Bueno, O. F., Parsons, S. A., Xu, J., Plank, D. M., Jones, F. S., Kimball, T. R., & Molkentin, J. D. (2003) · Circulation Research · doi:10.1161/01.res.0000109415.17511.18 · Cited by 762
Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins
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L-type calcium channels and GSK-3 regulate the activity of NF-ATc4 in hippocampal neurons
Graef, I. A., Mermelstein, P. G., Stankunas, K., Neilson, J. R., Deisseroth, K. A., Tsien, R. W., & Crabtree, G. R. (1999) · Nature · doi:10.1038/44378 · Cited by 514
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Conditional calcineurin knockout mice exhibit multiple abnormal behaviors related to schizophrenia
Miyakawa, T., Leiter, L. M., Gerber, D. J., Gainetdinov, R. R., Sotnikova, T. D., Zeng, H., Caron, M. G., & Tonegawa, S. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1432926100 · Cited by 489
Malleret, G., Haditsch, U., Genoux, D., Jones, M. W., Bliss, T. V. P., Vanhoose, A. M., Weitlauf, C., Kandel, E. R., Winder, D. G., & Mansuy, I. M. (2001) · Cell · doi:10.1016/s0092-8674(01)00264-1 · Cited by 470
Selective Inhibition of Vascular Endothelial Growth Factor–Mediated Angiogenesis by Cyclosporin a
Hernández, G., Volpert, O. V., Iñiguez, M. A., Lorenzo, E., Martı́nez-Martı́nez, S., Grau, R., Fresno, M., & Redondo, J. M. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.193.5.607 · Cited by 430
Signals Transduced by Ca2+/Calcineurin and NFATc3/c4 Pattern the Developing Vasculature
Graef, I. A., Chen, F., Chen, L., Kuo, A., & Crabtree, G. R. (2001) · Cell · doi:10.1016/s0092-8674(01)00396-8 · Cited by 421
Self-citationWinder, D. G., Mansuy, I. M., Osman, M., Moallem, T. M., & Kandel, E. R. (1998) · Cell · doi:10.1016/s0092-8674(00)80896-x · Cited by 350
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“The calcineurin signaling cascade is conserved across all eukaryotes (Aramburu, Heitman, and Crabtree 2004).”
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“Its most renowned function is the activation of the nuclear factor of activated T-cells (NFAT) [60–63], which upregulates interleukin-2 and induces T-cell response [64].”
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BackgroundCalcineurin Aα Contributes to IgE-Dependent Mast-Cell Mediator Secretion in Allergic Inflammation
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“…a specific serine/threonine protein phosphatase (serine/threonine), called CaN in the regulatory pathway of NFATc1 (Hogan & Li, 2005; Klee et al., 1998; Li et al., 2011; Rusnak & Mertz, 2000) which its dependence on Ca 2+ concentration is unique among other phosphatases (Aramburu et al., 2004).”
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“This active calcium-dependent phosphatase plays a crucial role by dephosphorylating the conserved serine residues in the N-terminal regulatory domain of NFAT proteins (NFATc1-c4), and concequently it neutralizes the nuclear export signals and exposes the nuclear localization sequence [ 76 , 77 ].”
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“DOI [16] Aramburu J, Heitman J, Crabtree GR.”
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Immunosuppressant treatment reduces cocaine-induced behavioral sensitization in mice
de Oliveira, G. L., da Silva, M. C. M., Gomes, G. F., Ribeiro, R. D. S., Cussat, G. R., Fernandes, R. A., Souza, J. L. N., Fernandes, H. D. B., de Miranda, A. S., Santos, V., et al. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1757023
“…with SUD, it has been shown that this phosphatase plays a central role in the regulation of transcription factors and synaptic proteins essential for long-term potentiation (LTP), long-term depression (LTD), and memory processing (Mulkey et al., 1994; Aramburu et al., 2004; Xia and Storm, 2005).”
Metadata
- Authors
- Aramburu, J., Heitman, J., & Crabtree, G. R.
- Affiliations
- Howard Hughes Medical Institute (US)
- Venue
- The EMBO Reports
- Published
- 2004-04-01
- Volume
- 5
- Issue
- 4
- Pages
- 343-348
- ISSN
- 1469-221X (ISSN-L)
- 1469-3178
- PMC
- PMC1299038
- OpenAlex
- W1967336595
- Cited by
- 156
- References
- 18
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 4 · 2023: 3 · 2022: 1 · 2021: 13 · 2020: 1 · 2019: 3 · 2018: 7 · 2017: 4 · 2016: 6 · 2015: 13 · 2014: 9 · 2013: 9 · 2012: 8
- FWCI
- 3.44
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- EMBO Reports (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Calpain Protease Function and Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Receptors and Signaling
- Keywords
- calcineurin, calcium signaling, NFAT, calcineurin-NFAT pathway
- MeSH terms
- Animals, DNA-Binding Proteins, Eukaryotic Cells, Heart, Humans, Lymphocytes, Nervous System Physiological Phenomena, Nuclear Proteins, Transcription Factors, Signal Transduction, Neovascularization, Physiologic, Calcineurin, NFATC Transcription Factors
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