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Calcineurin: a central controller of signalling in eukaryotes: Workshop on the Calcium/Calcineurin/NFAT Pathway: Regulation and Function
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“Calcineurin is a serine and threonine-specific protein phosphatase specialized in the transduction of Ca 2+ -signals in eukaryotes (Aramburu et al. 2004).”
From Functional characterization of the Candida albicans CRZ1 gene encoding a calcineurin-regulated transcription factor (2005) · cites this paper as Aramburu et al. 2004
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A Calcineurin-Dependent Transcriptional Pathway for Cardiac Hypertrophy
Molkentin, J. D., Lu, J., Antos, C. L., Markham, B. E., Richardson, J. A., Robbins, J. M., Grant, S. R., & Olson, E. N. (1998) · Cell · doi:10.1016/s0092-8674(00)81573-1 · Cited by 2,566
Calcineurin/NFAT Coupling Participates in Pathological, but not Physiological, Cardiac Hypertrophy
Wilkins, B. J., Dai, Y., Bueno, O. F., Parsons, S. A., Xu, J., Plank, D. M., Jones, F. S., Kimball, T. R., & Molkentin, J. D. (2003) · Circulation Research · doi:10.1161/01.res.0000109415.17511.18 · Cited by 762
Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins
Heissmeyer, V., Macián, F., Im, S., Varma, R., Feske, S., Venuprasad, K., Gu, H., Liu, Y., Dustin, M. L., & Rao, A. (2004) · Nature Immunology · doi:10.1038/ni1047 · Cited by 515
L-type calcium channels and GSK-3 regulate the activity of NF-ATc4 in hippocampal neurons
Graef, I. A., Mermelstein, P. G., Stankunas, K., Neilson, J. R., Deisseroth, K. A., Tsien, R. W., & Crabtree, G. R. (1999) · Nature · doi:10.1038/44378 · Cited by 514
Self-citationZeng, H., Chattarji, S., Barbarosie, M., Rondi-Reig, L., Philpot, B. D., Miyakawa, T., Bear, M. F., & Tonegawa, S. (2001) · Cell · doi:10.1016/s0092-8674(01)00585-2 · Cited by 498
Conditional calcineurin knockout mice exhibit multiple abnormal behaviors related to schizophrenia
Miyakawa, T., Leiter, L. M., Gerber, D. J., Gainetdinov, R. R., Sotnikova, T. D., Zeng, H., Caron, M. G., & Tonegawa, S. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1432926100 · Cited by 489
Malleret, G., Haditsch, U., Genoux, D., Jones, M. W., Bliss, T. V. P., Vanhoose, A. M., Weitlauf, C., Kandel, E. R., Winder, D. G., & Mansuy, I. M. (2001) · Cell · doi:10.1016/s0092-8674(01)00264-1 · Cited by 470
Selective Inhibition of Vascular Endothelial Growth Factor–Mediated Angiogenesis by Cyclosporin a
Hernández, G., Volpert, O. V., Iñiguez, M. A., Lorenzo, E., Martı́nez-Martı́nez, S., Grau, R., Fresno, M., & Redondo, J. M. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.193.5.607 · Cited by 430
Signals Transduced by Ca2+/Calcineurin and NFATc3/c4 Pattern the Developing Vasculature
Graef, I. A., Chen, F., Chen, L., Kuo, A., & Crabtree, G. R. (2001) · Cell · doi:10.1016/s0092-8674(01)00396-8 · Cited by 421
Self-citationWinder, D. G., Mansuy, I. M., Osman, M., Moallem, T. M., & Kandel, E. R. (1998) · Cell · doi:10.1016/s0092-8674(00)80896-x · Cited by 350
Autoregulation of NFATc1/A expression facilitates effector T cells to escape from rapid apoptosis.
Chuvpilo, S., Jankevics, E., Tyrsin, D., Akimzhanov, A., Moroz, D., Jha, M., Schulze-Luehrmann, J., Santner‐Nanan, B., Feoktistova, E., König, T., et al. (2002) · Immunity · doi:10.1016/s1074-7613(02)00329-1 · Cited by 216
Calcineurin Is Essential for Candida albicans Survival in Serum and Virulence
Blankenship, J. R., Wormley, F. L., Boyce, M. K., Schell, W. A., Filler, S. G., Perfect, J. R., & Heitman, J. (2003) · Eukaryotic Cell · doi:10.1128/ec.2.3.422-430.2003 · Cited by 186
Self-citationGSK-3 kinases enhance calcineurin signaling by phosphorylation of RCNsPreprint
Hilioti, Z., Gallagher, D. A., Low-Nam, S. T., Ramaswamy, P., Gajer, P., Kingsbury, T. J., Birchwood, C. J., Levchenko, A., & Cunningham, K. W. (2003) · Genes & Development · doi:10.1101/gad.1159204 · Cited by 161
Negative Regulation and Gain Control of Sensory Neurons by the C. elegans Calcineurin TAX-6
Kuhara, A., Inada, H., Katsura, I., & Mori, I. (2002) · Neuron · doi:10.1016/s0896-6273(02)00607-4 · Cited by 153
A Constitutively Active NFATc1 Mutant Induces a Transformed Phenotype in 3T3-L1 Fibroblasts
Neal, J. W., & Clipstone, N. A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300528200 · Cited by 140
Ryeom, S. W., Greenwald, R. J., Sharpe, A. H., & McKeon, F. (2003) · Nature Immunology · doi:10.1038/ni966 · Cited by 128
Genescà, E., Aubareda, A., FUENTES, J. J., Estivill, X., de la Luna, S., & Pérez‐Riba, M. (2003) · Biochemical Journal · doi:10.1042/bj20030267 · Cited by 102
Negative regulation of calcineurin signaling by Hrr25p, a yeast homolog of casein kinase IPreprint
Kafadar, K. A., Zhu, H., Snyder, M. P., & Cyert, M. (2003) · Genes & Development · doi:10.1101/gad.1140603 · Cited by 84
Cited by
Sorted by citations
Calcium signalling in lymphocyte activation and disease
Feske, S. (2007) · Nature Reviews Immunology · doi:10.1038/nri2152 · Cited by 1,043
“Specific inhibitors of ORAI1 and CRAC channel function might have fewer unwanted adverse effects than cyclosporin A or FK506, because calcineurin function is crucial in many cell types and organs, whereas ORAI1 may have non-redundant functions only in a few cell types, including T cells, as judged by the phenotype in…”
BackgroundCribbs, J. T., & Strack, S. (2007) · EMBO Reports · doi:10.1038/sj.embor.7401062 · Cited by 1,061
“The serine/threonine phosphatase calcineurin is one of the main transducers of cytosolic calcium fluxes, with particularly important and well-characterized roles in immune cells and the nervous system (Aramburu et al, 2004).”
BackgroundFaul, C., Donnelly, M., Merscher, S., Chang, Y. H., Franz, S., Delfgaauw, J., Chang, J., Choi, H. Y., Campbell, K. N., Kim, K., et al. (2008) · Nature Medicine · doi:10.1038/nm.1857 · Cited by 993
Specialized roles for cysteine cathepsins in health and disease
Reiser, J., Adair, B. D., & Reinheckel, T. (2010) · Journal of Clinical Investigation · doi:10.1172/jci42918 · Cited by 582
Calcium–calcineurin signaling in the regulation of cardiac hypertrophy
Wilkins, B. J., & Molkentin, J. D. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.07.121 · Cited by 447
Metadata
- Authors
- Aramburu, J., Heitman, J., & Crabtree, G. R.
- Affiliations
- Howard Hughes Medical Institute (US)
- Venue
- The EMBO Reports
- Published
- 2004-04-01
- Volume
- 5
- Issue
- 4
- Pages
- 343-348
- ISSN
- 1469-221X (ISSN-L)
- 1469-3178
- PMC
- PMC1299038
- OpenAlex
- W1967336595
- Cited by
- 156
- References
- 18
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 4 · 2023: 3 · 2022: 1 · 2021: 13 · 2020: 1 · 2019: 3 · 2018: 7 · 2017: 4 · 2016: 6 · 2015: 13 · 2014: 9 · 2013: 9 · 2012: 8
- FWCI
- 3.44
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- EMBO Reports (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Calpain Protease Function and Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Receptors and Signaling
- Keywords
- calcineurin, calcium signaling, NFAT, calcineurin-NFAT pathway
- MeSH terms
- Animals, DNA-Binding Proteins, Eukaryotic Cells, Heart, Humans, Lymphocytes, Nervous System Physiological Phenomena, Nuclear Proteins, Transcription Factors, Signal Transduction, Neovascularization, Physiologic, Calcineurin, NFATC Transcription Factors
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