The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Transcription in four dimensions: nuclear receptor‐directed initiation of gene expression
Open accessAbstract
Regulated gene expression, achieved through the coordinated assembly of transcription factors, co‐regulators and the basal transcription machinery on promoters, is an initial step in accomplishing cell specificity and homeostasis. Traditional models of transcriptional regulation tend to be static, although gene expression profiles change with time to adapt to developmental and environmental cues. Furthermore, biochemical and structural studies have determined that initiation of transcription progresses through a series of ordered events. By integrating time into the analysis of transcription, chromatin immunoprecipitation assays and live‐cell imaging techniques have revealed the dynamic, cooperative, functionally redundant and cyclical nature of gene expression. In this review, we present a dynamic model of gene transcription that integrates data obtained by these two techniques.
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Cites
Histone demethylation mediated by the nuclear amine oxidase homolog LSD1
Shi, Y., Lan, F., Matson, C., Mulligan, P., Whetstine, J. R., Cole, P. A., Casero, R. A., & Shi, Y. (2004) · Cell · doi:10.1016/j.cell.2004.12.012 · Cited by 4,051
The coregulator exchange in transcriptional functions of nuclear receptors
Glass, C. K., & Rosenfeld, M. G. (2000) · Genes & Development · doi:10.1101/gad.14.2.121 · Cited by 2,233
The glucocorticoid receptor: rapid exchange with regulatory sites in living cells
McNally, J. G., Müller, W. G., Walker, D., Wolford, R., & Hager, G. L. (2000) · Science · doi:10.1126/science.287.5456.1262 · Cited by 802 · cited 2×
“…of NR-directed transcription has been greatly facilitated by the use of tandem arrays of responsive promoters, which generate a high local concentration of responsive elements that are visible as a discrete locus when associated with labelled proteins (McNally et al, 2000; Tsukamoto et al, 2000).”
BackgroundDiverse signaling pathways modulate nuclear receptor recruitment of N-CoR and SMRT complexes.
Lavinsky, R. M., Jepsen, K., Heinzel, T., Torchia, J., Mullen, T.-M., Schiff, R., Del-Rio, A. L., Ricote, M., Ngo, S., Gemsch, J., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.6.2920 · Cited by 660
Disassembly of Transcriptional Regulatory Complexes by Molecular Chaperones
Freeman, B. C., & Yamamoto, K. R. (2002) · Science · doi:10.1126/science.1073051 · Cited by 400
Wallace, A. D., & Cidlowski, J. A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m106033200 · Cited by 394
Expanding functional diversity of the coactivators
Lonard, D. M., & O'Malley, B. W. (2005) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2005.01.001 · Cited by 172
DNA recognition by nuclear receptors
Claessens, F., & Gewirth, D. T. (2004) · Essays in Biochemistry · doi:10.1042/bse0400059 · Cited by 108
Cited by
Overview of nomenclature of nuclear receptors
Germain, P., Staels, B., Dacquet, C., Spedding, M., & Laudet, V. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.4.2 · Cited by 688
Lin, C., Yang, L., Tanasa, B., Hutt, K., Ju, B.-G., Ohgi, K. A., Zhang, J., Rose, D. W., Fu, X.-D., Glass, C. K., et al. (2009) · Cell · doi:10.1016/j.cell.2009.11.030 · Cited by 576
Eukaryotic transcriptional dynamics: from single molecules to cell populations
Coulon, A., Chow, C. C., Singer, R. H., & Larson, D. R. (2013) · Nature Reviews Genetics · doi:10.1038/nrg3484 · Cited by 309
Vitamin D Receptor Signaling Mechanisms: Integrated Actions of a Well-Defined Transcription Factor
Carlberg, C., & Campbell, M. J. (2013) · Steroids · doi:10.1016/j.steroids.2012.10.019 · Cited by 293
Androgen receptor coregulators: recruitment via the coactivator binding groove
van de Wijngaart, D. J., Dubbink, H. J., van Royen, M. E., Trapman, J., & Jenster, G. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.08.007 · Cited by 122
Metadata
- Authors
- Métivier, R., Reid, G., & Gannon, F.
- Venue
- EMBO reports
- Published
- 2006-02
- Volume
- 7
- Issue
- 2
- Pages
- 161-167
- ISSN
- 1469-221X (ISSN-L)
- 1469-3178
- OpenAlex
- W2107093842
- Cited by
- 194
- References
- 8
- FWCI
- 9.58
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
