Cited by 2,345Endoplasmic Reticulum Stress and DiseaseCell death mechanisms and regulationIon Channels and Receptors

The DOI matches its Crossref record; 44 of the 45 references it cites were found in a registry or an index.

Mediators of endoplasmic reticulum stress-induced apoptosis

Open access

Szegezdi, Eva, Logue, Susan E, Gorman, Adrienne M, Samali, Afshin·2006·The EMBO Reports

DOI 10.1038/sj.embor.7400779PMC PMC1559676

Open this paper in CoChat — free account Open PDF

Abstract

The efficient functioning of the endoplasmic reticulum (ER) is essential for most cellular activities and survival. Conditions that interfere with ER function lead to the accumulation and aggregation of unfolded proteins. ER transmembrane receptors detect the onset of ER stress and initiate the unfolded protein response (UPR) to restore normal ER function. If the stress is prolonged, or the adaptive response fails, apoptotic cell death ensues. Many studies have focused on how this failure initiates apoptosis, as ER stress-induced apoptosis is implicated in the pathophysiology of several neurodegenerative and cardiovascular diseases. In this review, we examine the role of the molecules that are activated during the UPR in order to identify the molecular switch from the adaptive phase to apoptosis. We discuss how the activation of these molecules leads to the commitment of death and the mechanisms that are responsible for the final demise of the cell.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/sj.embor.7400779

Cites

44 of 44 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

1 retracted

Proapoptotic BAX and BAK Modulate the Unfolded Protein Response by a Direct Interaction with IRE1α
Hetz, C. A., Bernasconi, P., Fisher, J. K., Lee, A., Bassik, M. C., Antonsson, B. E., Brandt, G. S., Iwakoshi, N. N., Schinzel, A. C., Glimcher, L. H., et al. (2006) · Science · doi:10.1126/science.1123480 · Cited by 688
Retracted
Control of inositol 1,4,5-trisphosphate-induced Ca2+ release by cytosolic Ca2+
Bootman, M. D., Missiaen, L., Parys, J. B., SMEDT, H. D., & Casteels, R. (1995) · Biochemical Journal · doi:10.1042/bj3060445 · Cited by 5,131
Signal transduction by the JNK group of MAP kinases
Davis, R. J. (2000) · Cell · doi:10.1016/s0092-8674(00)00116-1 · Cited by 4,237
XBP1 mRNA Is Induced by ATF6 and Spliced by IRE1 in Response to ER Stress to Produce a Highly Active Transcription Factor
Yoshida, H., Matsui, T., Yamamoto, A., Okada, T., & Mori, K. (2001) · Cell · doi:10.1016/s0092-8674(01)00611-0 · Cited by 4,054
Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death
Wei, M. C., Zong, W.-X., Cheng, E. H.-Y., Lindsten, T., Panoutsakopoulou, V., Ross, A. J., Roth, K. A., MacGregor, G. R., Thompson, C. B., & Korsmeyer, S. J. (2001) · Science · doi:10.1126/science.1059108 · Cited by 3,988
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837
An Integrated Stress Response Regulates Amino Acid Metabolism and Resistance to Oxidative Stress
Harding, H. P., Zhang, Y., Zeng, H., Novoa, I., Lu, P. D., Calfon, M. A., Sadri, N., Yun, C., Popko, B., Paules, R. S., et al. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00105-9 · Cited by 3,336
Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β
Nakagawa, T., Zhu, H., Morishima, N., Li, E., Xu, J., Yankner, B. A., & Yuan, J. (2000) · Nature · doi:10.1038/47513 · Cited by 3,292
THE MAMMALIAN UNFOLDED PROTEIN RESPONSE
Schröder, M., & Kaufman, R. J. (2005) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.73.011303.074134 · Cited by 3,099
Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1.
Urano, F., Wang, X.-Z., Bertolotti, A., Zhang, Y.-H., Chung, P., Harding, H., & Ron, D. (2000) · Science · doi:10.1126/science.287.5453.664 · Cited by 3,081

Show all 45 references

Sorted by citations

Items 901–1,000 of 1,004

Natural compounds against cytotoxic drug‐induced cardiotoxicity: A review on the involvement of PI3K/Akt signaling pathway
Yarmohammadi, F., Hayes, A. W., & Karimi, G. (2020) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.22683 · Cited by 37
Targeting unfolded protein response: a new horizon for disease control
Khanna, M., Agrawal, N., Chandra, R., & Dhawan, G. (2021) · Expert Reviews in Molecular Medicine · doi:10.1017/erm.2021.2 · Cited by 37
The Novel Diagnostic Techniques and Biomarkers of Canine Mammary Tumors
Kaszak, I., Witkowska‐Piłaszewicz, O., Domrazek, K., & Jurka, P. (2022) · Veterinary Sciences · doi:10.3390/vetsci9100526 · Cited by 37
Chronic stress elicits prolonged activation of α‐MSH secretion and subsequent degeneration of melanotroph
Ogawa, T., Shishioh‐Ikejima, N., Konishi, H., Makino, T., Séi, H., Kiryu‐Seo, S., Tanaka, M., Watanabe, Y., & Kiyama, H. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06057.x · Cited by 37
Wogonin induced cytotoxicity in human hepatocellular carcinoma cells by activation of unfolded protein response and inactivation of AKT
Xu, M. J., Lu, N., Zhang, H., Dai, Q., Wei, L., Li, Z., You, Q., & Guo, Q. (2012) · Hepatology Research · doi:10.1111/hepr.12036 · Cited by 37
LPA rescues ER stress‐associated apoptosis in hypoxia and serum deprivation‐stimulated mesenchymal stem cells
Li, Z., Wei, H., Liu, X., Hu, S., Cong, X., & Chen, X. (2010) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22731 · Cited by 36
Cdc37/Hsp90 Protein-mediated Regulation of IRE1α Protein Activity in Endoplasmic Reticulum Stress Response and Insulin Synthesis in INS-1 Cells
Ota, A., & Wang, Y. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.331264 · Cited by 36
gp78: a Multifaceted Ubiquitin Ligase that Integrates a Unique Protein Degradation Pathway from the Endoplasmic Reticulum
Chen, Z., Du, S., & Fang, S. (2012) · Current Protein and Peptide Science · doi:10.2174/138920312802430590 · Cited by 37
Ceramide Transfer Protein Deficiency Compromises Organelle Function and Leads to Senescence in Primary Cells
Rao, R. P., Scheffer, L., Madabushi, S. S., Parthibane, V., Kosakowska‐Cholody, T., Masood, M. A., Nagashima, K., Gudla, P. R., Lockett, S., Acharya, U. R., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0092142 · Cited by 36
ATF4 regulates arsenic trioxide-mediated NADPH oxidase, ER-mitochondrial crosstalk and apoptosis
Srivastava, R. K., Li, C., Ahmad, A. M., Abrams, O., Gorbatyuk, M. S., Harrod, K. S., Wek, R. C., Afaq, F., & Athar, M. (2016) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2016.09.003 · Cited by 36
Defining cutaneous molecular pathobiology of arsenicals using phenylarsine oxide as a prototype
Srivastava, R. K., Li, C., Weng, Z., Agarwal, A., Elmets, C. A., Afaq, F., & Athar, M. (2016) · Scientific Reports · doi:10.1038/srep34865 · Cited by 36
ONC201 activates ER stress to inhibit the growth of triple-negative breast cancer cells
Yuan, X., Kho, D., Xu, J., Gajan, A., Wu, K., & Wu, G. S. (2017) · Oncotarget · doi:10.18632/oncotarget.15451 · Cited by 36
Tail Vein Infusion of Adipose-Derived Mesenchymal Stem Cell Alleviated Inflammatory Response and Improved Blood Brain Barrier Condition by Suppressing Endoplasmic Reticulum Stress in a Middle Cerebral Artery Occlusion Rat Model
Chi, L., Huang, Y., Mao, Y. Q., Wu, K., Zhang, L., & Nan, G. (2018) · Medical Science Monitor · doi:10.12659/msm.907096 · Cited by 38
Increased sensitivity to apoptosis upon endoplasmic reticulum stress-induced activation of the unfolded protein response in chemotherapy-resistant malignant pleural mesothelioma
Xu, D., Liang, S., Yang, H., Lüthi, U., Riether, C., Berezowska, S., Marti, T. M., Hall, S. R. R., Bruggmann, R., Kocher, G. J., et al. (2018) · British Journal of Cancer · doi:10.1038/s41416-018-0145-3 · Cited by 36
Glycine supplementation to breast-fed piglets attenuates post-weaning jejunal epithelial apoptosis: a functional role of CHOP signaling
Fan, X., Li, S., Wu, Z., Dai, Z., Li, J., Wang, X., & Wu, G. (2018) · Amino Acids · doi:10.1007/s00726-018-2681-9 · Cited by 36
KSHV activates unfolded protein response sensors but suppresses downstream transcriptional responses to support lytic replication
Johnston, B. P., Pringle, E. S., & McCormick, C. (2019) · PLoS Pathogens · doi:10.1371/journal.ppat.1008185 · Cited by 36
Hydrogen Sulfide Plays an Important Protective Role through Influencing Endoplasmic Reticulum Stress in Diseases
Wang, H., Shi, X., Qiu, M., Lv, S., & Liu, H. (2019) · International Journal of Biological Sciences · doi:10.7150/ijbs.38143 · Cited by 37
Dehydrocostus lactone inhibits cell proliferation and induces apoptosis by PI3K/Akt/Bad and ERS signalling pathway in human laryngeal carcinoma
Zhang, R., Hao, J., Wu, Q., Guo, K., Wang, C., Zhang, W. K., Liu, W., Wang, Q., & Yang, X. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.15131 · Cited by 36
New developments in chondrocyte ER-stress and related diseases
Briggs, M. D., Dennis, E. P., Dietmar, H. F., & Piróg, K. A. (2020) · F1000Research · doi:10.12688/f1000research.22275.1 · Cited by 36
Rosuvastatin and simvastatin attenuate cisplatin-induced cardiotoxicity via disruption of endoplasmic reticulum stress-mediated apoptotic death in rats: targeting ER-Chaperone GRP78 and Calpain-1 pathways
Saleh, D. O., Mansour, D. F., & Mostafa, R. E. (2020) · Toxicology Reports · doi:10.1016/j.toxrep.2020.08.026 · Cited by 36
Endoplasmic Reticulum-Mitochondria Crosstalk and Beta-Cell Destruction in Type 1 Diabetes
Vig, S., Lambooij, J. M., Zaldumbide, A., & Guigas, B. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.669492 · Cited by 38
Glycoursodeoxycholic acid ameliorates diet-induced metabolic disorders with inhibiting endoplasmic reticulum stress
Cheng, L., Chen, T., Guo, M., Liu, P., Qiao, X., Wei, Y., She, J., Li, B., Xi, W., Zhou, J., et al. (2021) · Clinical Science · doi:10.1042/cs20210198 · Cited by 36
The Pathogenesis of HCC Driven by NASH and the Preventive and Therapeutic Effects of Natural Products
Shao, G., Liu, Y., Lu, L., Zhang, G., Zhou, W., Wu, T., Wang, L., Xu, H., & Ji, G. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.944088 · Cited by 37
Endoplasmic reticulum stress contributes to CRH-induced hippocampal neuron apoptosis
Zhang, Y., Liu, W., Ma, C., Geng, J., Li, Y., Li, S., Yu, F., Zhang, X., & Cong, B. (2012) · Experimental Cell Research · doi:10.1016/j.yexcr.2012.01.006 · Cited by 36
Rescue of F508del-CFTR by RXR motif inactivation triggers proteome modulation associated with the unfolded protein response
Gomes‐Alves, P., Couto, F. M., Pesquita, C., Coelho, A. V., & Penque, D. (2010) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2009.12.013 · Cited by 36
Platycodin D Induces Reactive Oxygen Species–Mediated Apoptosis Signal–Regulating Kinase 1 Activation and Endoplasmic Reticulum Stress Response in Human Breast Cancer Cells
Yu, J. S., & Kim, A. K. (2012) · Journal of Medicinal Food · doi:10.1089/jmf.2011.2024 · Cited by 36
Interaction of Nck1 and PERK phosphorylated at Y 561 negatively modulates PERK activity and PERK regulation of pancreatic β-cell proinsulin content
Yamani, L., Latreille, M., & Larose, L. (2013) · Molecular Biology of the Cell · doi:10.1091/mbc.e13-09-0511 · Cited by 36
Mechanostasis in apoptosis and medicine
Chan, D. D., Dyke, W. S. V., Bahls, M., Connell, S., Critser, P. J., Kelleher, J. E., Kramer, M. A., Pearce, S. M., Sharma, S., & Neu, C. P. (2011) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2011.08.002 · Cited by 36
Repression of Mcl-1 and disruption of the Mcl-1/Bak interaction in myeloma cells couple ER stress to mitochondrial apoptosis
Gomez‐Bougie, P., Halliez, M., Moreau, P., Pellat‐Deceunynck, C., & Amiot, M. (2016) · Cancer Letters · doi:10.1016/j.canlet.2016.09.030 · Cited by 37
Transcriptional profiling suggests that Nevirapine and Ritonavir cause drug induced liver injury through distinct mechanisms in primary human hepatocytes
Terelius, Y., Figler, R. A., Marukian, S., Collado, M. S., Lawson, M. J., Mackey, A. J., Manka, D., Qualls, C. W., Blackman, B. R., Wamhoff, B. R., et al. (2016) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2015.11.023 · Cited by 33
Unfolded Protein Response Pathways in Neurodegenerative Diseases
Shah, S. Z. A., Zhao, D., Khan, S. H., & Yang, L. (2015) · Journal of Molecular Neuroscience · doi:10.1007/s12031-015-0633-3 · Cited by 35
Trichostatin A ameliorates myocardial ischemia/reperfusion injury through inhibition of endoplasmic reticulum stress-induced apoptosis.
Yu, L., Lu, M., Wang, P., & Chen, X. (2012) · Archives of Medical Research · doi:10.1016/j.arcmed.2012.04.007 · Cited by 34
V8, a newly synthetic flavonoid, induces apoptosis through ROS-mediated ER stress pathway in hepatocellular carcinoma
Zhang, Y., Zhao, L., Li, X., Wang, Y., Yao, J., Wang, H., Li, F., Li, Z., & Guo, Q. (2013) · Archives of Toxicology · doi:10.1007/s00204-013-1085-6 · Cited by 35
Curcumin Sensitizes Acute Promyelocytic Leukemia Cells to Unfolded Protein Response–Induced Apoptosis by Blocking the Loss of Misfolded N-CoR Protein
Ng, A. P. P., Chng, W. J., & Khan, M. (2011) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-10-0545 · Cited by 37
Protective role of Gipie, a Girdin family protein, in endoplasmic reticulum stress responses in endothelial cells
Matsushita, E., Asai, N., Enomoto, A., Kawamoto, Y., Kato, T., Mii, S., Maeda, K., Shibata, R., Hattori, S., Hagikura, M., et al. (2011) · Molecular Biology of the Cell · doi:10.1091/mbc.e10-08-0724 · Cited by 35
Activation of the endoplasmic reticulum stress pathway involving CHOP in the lungs of rats with hyperoxia-induced bronchopulmonary dysplasia
Lu, H., Zhang, J., WANG, Q.-X., Tang, W., & ZHANG, L.-J. (2015) · Molecular Medicine Reports · doi:10.3892/mmr.2015.3979 · Cited by 35
Live or let die: posttranscriptional gene regulation in cell stress and cell death
Thomas, M. P., & Lieberman, J. (2013) · Immunological Reviews · doi:10.1111/imr.12052 · Cited by 37
HDAC Inhibitor Modulation of Proteotoxicity as a Therapeutic Approach in Cancer
McConkey, D. J., White, M. C., & Yan, W. (2012) · Advances in cancer research · doi:10.1016/b978-0-12-394387-3.00004-5 · Cited by 35
Endoplasmic reticulum stress and apoptosis via PERK-eIF2α-CHOP signaling in the methamphetamine-induced chronic pulmonary injury
Gu, Y., Wang, Y., Bai, Y., Liu, M., & Wang, H. (2017) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2017.01.003 · Cited by 35
4PBA strongly attenuates endoplasmic reticulum stress, fibrosis, and mitochondrial apoptosis markers in cyclosporine treated human gingival fibroblasts
Rao, S. R., Subbarayan, R., Ajitkumar, S., & Dinesh, M. G. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.25836 · Cited by 35
Cellular Pathology of Pelizaeus-Merzbacher Disease Involving Chaperones Associated with Endoplasmic Reticulum Stress
Inoue, K. (2017) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2017.00007 · Cited by 35
Elaidic acid induces cell apoptosis through induction of ROS accumulation and endoplasmic reticulum stress in SH-SY5Y cells
Ma, W., Zhao, L., Yuan, L., Yu, H., Wang, H., Gong, X., Wei, F., & Xiao, R. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.7830 · Cited by 35
Total Saponins of Aralia Elata (Miq) Seem Alleviate Calcium Homeostasis Imbalance and Endoplasmic Reticulum Stress-Related Apoptosis Induced by Myocardial Ischemia/Reperfusion Injury
Wang, R., Yang, M., Wang, M., Liu, X., Xu, H., Xu, X., Sun, G., & Sun, X. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000493954 · Cited by 35
Yinchenhao decoction attenuates obstructive jaundice-induced liver injury and hepatocyte apoptosis by suppressing protein kinase RNA-like endoplasmic reticulum kinase-induced pathway
Wu, Y., Li, Z., Zhang, X., & Liu, H. (2019) · World Journal of Gastroenterology · doi:10.3748/wjg.v25.i41.6205 · Cited by 35
Type 2 diabetes – unmet need, unresolved pathogenesis, mTORC1-centric paradigm
Bar‐Tana, J. (2020) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-020-09545-w · Cited by 38
SMYD3–PARP16 axis accelerates unfolded protein response and mediates neointima formation
Long, F., Yang, D., Wang, J., Wang, Q., Ni, T., Wei, G., Zhu, Y. Z., & Liu, X. (2020) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2020.12.010 · Cited by 35
Thioredoxin-1 Is a Target to Attenuate Alzheimer-Like Pathology in Diabetic Encephalopathy by Alleviating Endoplasmic Reticulum Stress and Oxidative Stress
Guo, Y., Zhang, C., Wang, C., Huang, Y., Liu, J., Chu, H., Ren, X. S., Kong, L., & Ma, H. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.651105 · Cited by 35
Saponins and their derivatives: Potential candidates to alleviate anthracycline-induced cardiotoxicity and multidrug resistance
Qu, P., Jiang, Z., Song, P., Liu, L., Xiang, M., & Wang, J. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106352 · Cited by 37
Intricate Links between ER Stress and Apoptosis
Madeo, F., & Kroemer, G. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.03.002 · Cited by 35
Dual Functions for Cytosolic α-Mannosidase (Man2C1)
Wang, L., & Suzuki, T. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.425702 · Cited by 32
NOXA contributes to the sensitivity of PERK‐deficient cells to ER stress
Gupta, S., Giricz, Z., Natoni, A., Donnelly, N., Deegan, S., Szegezdi, É., & Afshin Samali, A. (2012) · FEBS Letters · doi:10.1016/j.febslet.2012.10.002 · Cited by 35
Mechanism of cytotoxic action of perfluorinated acids. III. Disturbance in Ca2+ homeostasis
Kleszczyński, K., & Składanowski, A. C. (2011) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2011.01.002 · Cited by 36
Recruitment of cellular prion protein to mitochondrial raft-like microdomains contributes to apoptosis execution
Mattei, V., Matarrese, P., Garofalo, T., Tinari, A., Gambardella, L., Ciarlo, L., Manganelli, V., Tasciotti, V., Misasi, R., Malorni, W., et al. (2011) · Molecular Biology of the Cell · doi:10.1091/mbc.e11-04-0348 · Cited by 37
High Glucose-Induced Podocyte Injury Involves Activation of Mammalian Target of Rapamycin (mTOR)-Induced Endoplasmic Reticulum (ER) Stress
Lei, J., Zhao, L., Zhang, Y., Wu, Y., & Liu, Y. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000488231 · Cited by 36
Disruption of microRNA Biogenesis Confers Resistance to ER Stress-Induced Cell Death Upstream of the Mitochondrion
Cawley, K., Logue, S. E., Gorman, A. M., Zeng, Q., Patterson, J. B., Gupta, S., & Afshin Samali, A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0073870 · Cited by 34
Self-citation
Depletion of Molecular Chaperones from the Endoplasmic Reticulum and Fragmentation of the Golgi Apparatus Associated with Pathogenesis in Pelizaeus-Merzbacher Disease
Numata, Y., Morimura, T., Nakamura, S., Hirano, E., Kure, S., Goto, Y.-I., & Inoue, K. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.435388 · Cited by 34
Inhibition of 6-hydroxydopamine-induced endoplasmic reticulum stress by sulforaphane through the activation of Nrf2 nuclear translocation
Jin, H. (2012) · Molecular Medicine Reports · doi:10.3892/mmr.2012.894 · Cited by 34
H2 and H3 relaxin inhibit high glucose-induced apoptosis in neonatal rat ventricular myocytes
Zhang, X., Ma, X., Zhao, M., Zhang, B., Chi, J., Liu, W., Chen, W.-J., Fu, Y., Liu, Y., & Yin, X. (2014) · Biochimie · doi:10.1016/j.biochi.2014.11.004 · Cited by 34
BRCA1 Loss Induces GADD153-Mediated Doxorubicin Resistance in Prostate Cancer
Luca, P. D., Vazquez, E., Moiola, C., Zalazar, F., Cotignola, J., Gueron, G., Gardner, K., & Siervi, A. D. (2011) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-11-0155 · Cited by 38
Netrin-1 Protects Hepatocytes Against Cell Death Through Sustained Translation During the Unfolded Protein Response
Lahlali, T., Plissonnier, M., Romero‐López, C., Michelet, M., Ducarouge, B., Berzal‐Herranz, A., Zoulim, F., Mehlen, P., & Parent, R. (2016) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2015.12.011 · Cited by 36
Atorvastatin ameliorates myocardial ischemia/reperfusion injury through attenuation of endoplasmic reticulum stress-induced apoptosis.
Wu, H. B. K., Tang, Q., Yang, J., Ding, J., Ye, M., & Dong, W. (2014) · PubMed Central · Cited by 34
Caspase-4 is essential for saikosaponin a-induced apoptosis acting upstream of caspase-2 and γ-H2AX in colon cancer cells
Kang, S. J., Lee, Y. J., Kang, S. G., Cho, S., Yoon, W., Lim, J. H., Min, S., Lee, T. H., & Kim, B. M. (2017) · Oncotarget · doi:10.18632/oncotarget.22247 · Cited by 36
Melatonin ameliorates myocardial apoptosis by suppressing endoplasmic reticulum stress in rats with long‑term diabetic cardiomyopathy
Xiong, F., Tang, S., Su, H., Tang, H., Jiang, P., Zhou, Q., Wang, Y., & Zhu, H. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.7841 · Cited by 33
Estradiol Uses Different Mechanisms in Astrocytes from the Hippocampus of Male and Female Rats to Protect against Damage Induced by Palmitic Acid
Frago, L. M., Canelles, S., Freire‐Regatillo, A., Argente-Arizón, P., Barrios, V., Argente, J., García‐Segura, L. M., & Chowen, J. A. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00330 · Cited by 34
Silica nanoparticles induce caspase-dependent apoptosis through reactive oxygen species-activated endoplasmic reticulum stress pathway in neuronal cells
Lee, K.-I., Lin, J.-W., Su, C., Fang, K., Yang, C., Kuo, C.-Y., Wu, C.-C., Wu, C., & Chen, Y. (2019) · Toxicology in Vitro · doi:10.1016/j.tiv.2019.104739 · Cited by 34
Quercetin Attenuates High-Fat Diet-Induced Excessive Fat Deposition of Spotted Seabass (Lateolabrax maculatus) Through the Regulatory for Mitochondria and Endoplasmic Reticulum
Dong, Y., Xia, T., Lin, J., Wang, L., Song, K., & Zhang, C. (2021) · Frontiers in Marine Science · doi:10.3389/fmars.2021.746811 · Cited by 34
Geraniol-Mediated Suppression of Endoplasmic Reticulum Stress Protects against Cerebral Ischemia–Reperfusion Injury via the PERK-ATF4-CHOP Pathway
Wu, Y. H., Fan, X., Chen, S., Deng, L., Jiang, L., Yang, S., & Dong, Z. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010544 · Cited by 34
Impairment of the Ubiquitin-Proteasome Pathway by Methyl N-(6-Phenylsulfanyl-1H-benzimidazol-2-yl)carbamate Leads to a Potent Cytotoxic Effect in Tumor Cells
Dogra, N., & Mukhopadhyay, T. K. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.324228 · Cited by 34
Activation of PKR/eIF2α signaling cascade is associated with dihydrotestosterone‐induced cell cycle arrest and apoptosis in human liver cells
Dai, R., Yan, D., Li, J., Chen, S., Liu, Y., Chen, R., Duan, C., Wei, M., Li, H., & He, T. (2012) · Journal of Cellular Biochemistry · doi:10.1002/jcb.24051 · Cited by 34
Calnexin Regulates Apoptosis Induced by Inositol Starvation in Fission Yeast
Guérin, R., Beauregard, P. B., Leroux, A., & Rokeach, L. A. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006244 · Cited by 34
Ca2+ store depletion and endoplasmic reticulum stress are involved in P2X7 receptor‐mediated neurotoxicity in differentiated NG108‐15 cells
Chao, C., Huang, C., Lu, D., Wong, K., Chen, Y., Cheng, T., & Leung, Y. (2011) · Journal of Cellular Biochemistry · doi:10.1002/jcb.24010 · Cited by 34
Differences in endoplasmic-reticulum quality control determine the cellular response to disease-associated mutants of proteolipid protein
Roboti, P., Swanton, E., & High, S. (2009) · Journal of Cell Science · doi:10.1242/jcs.055160 · Cited by 36
Protein-rich foods, sea foods, and gut microbiota amplify immune responses in chronic diseases and cancers – Targeting PERK as a novel therapeutic strategy for chronic inflammatory diseases, neurodegenerative disorders, and cancer
Saaoud, F., Lu, Y., Xu, K., Shao, Y., Praticò, D., Vázquez-Padrón, R. I., Wang, H., & Yang, X. (2024) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2024.108604 · Cited by 33
Translating endoplasmic reticulum biology into the clinic: a role for ER-targeted natural products?
Pereira, D. M., Valentão, P., Correia‐da‐Silva, G., Teixeira, N. A. A., & Andrade, P. B. (2015) · Natural Product Reports · doi:10.1039/c4np00102h · Cited by 33
Protein Misfolding and Obstructive Lung Disease
Greene, C. M., & McElvaney, N. G. (2010) · Proceedings of the American Thoracic Society · doi:10.1513/pats.201002-019aw · Cited by 33
Sulforaphane synergistically enhances the cytotoxicity of arsenic trioxide in multiple myeloma cells via stress-mediated pathways
Doudican, N. A., Wen, S. Y., Mazumder, A., & Orlow, S. J. (2012) · Oncology Reports · doi:10.3892/or.2012.1977 · Cited by 33
Endoplasmic reticulum stress mediates the arsenic trioxide-induced apoptosis in human hepatocellular carcinoma cells
Zhang, X., Yang, S., Zhang, H.-P., Yang, Y., Sun, S., Chang, J., Tao, X.-C., Yang, T., Liu, C., & Yang, Y.-M. (2015) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2015.09.009 · Cited by 33
Hydrogen-rich saline protects against small-scale liver ischemia-reperfusion injury by inhibiting endoplasmic reticulum stress
Li, H., Bai, G., Ge, Y., Zhang, Q., Kong, X., Meng, W., & Wang, H. (2017) · Life Sciences · doi:10.1016/j.lfs.2017.12.022 · Cited by 33
Inhibition of protein tyrosine phosphatase 1B protects against sevoflurane-induced neurotoxicity mediated by ER stress in developing brain
Liu, B., Ou, G., Chen, Y., & Zhang, J. (2018) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2018.12.006 · Cited by 33
VceC Mediated IRE1 Pathway and Inhibited CHOP-induced Apoptosis to Support Brucella Replication in Goat Trophoblast Cells
Zhi, F.-J., Zhou, D., Bai, F.-R., Li, J., Xiang, C., Zhang, G., Jin, Y.-P., & Wang, A.-H. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20174104 · Cited by 30
Translation Regulation by eIF2α Phosphorylation and mTORC1 Signaling Pathways in Non-Communicable Diseases (NCDs)
Rios-Fuller, T. J., Mahé, M., Walters, B., Abbadi, D., Pérez-Baos, S., Gadi, A., Andrews, J. J., Katsara, O., Vincent, C. T., & Schneider, R. J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21155301 · Cited by 34
Mycoplasmas bovis P48 induces apoptosis in EBL cells via an endoplasmic reticulum stress-dependent signaling pathway
Wu, X., Zhang, S., Long, C., An, Z., Xing, X., Wen, F., & Bao, S. (2021) · Veterinary Microbiology · doi:10.1016/j.vetmic.2021.109013 · Cited by 33
Endoplasmic reticulum stress pathway mediates T-2 toxin-induced chondrocyte apoptosis
Liu, Y., Mu, Y., Wang, H., Zhang, M., Shi, Y., Mi, G., Peng, L.-X., & Chen, J. (2021) · Toxicology · doi:10.1016/j.tox.2021.152989 · Cited by 33
HSP105 interacts with GRP78 and GSK3 and promotes ER stress-induced caspase-3 activation
Meares, G. P., Zmijewska, A. A., & Jope, R. S. (2007) · Cellular Signalling · doi:10.1016/j.cellsig.2007.10.032 · Cited by 33
Endosomal compartment contributes to the propagation of CD95/Fas-mediated signals in type II cells
Matarrese, P., Manganelli, V., Garofalo, T., Tinari, A., Gambardella, L., Ndebele, K., Khosravi‐Far, R., Sorice, M., Esposti, M. D., & Malorni, W. (2008) · Biochemical Journal · doi:10.1042/bj20071704 · Cited by 33
Endoplasmic reticulum stress-induced apoptosis accompanies enhanced expression of multiple inositol polyphosphate phosphatase 1 (Minpp1): a possible role for Minpp1 in cellular stress response
Kilaparty, S. P., Agarwal, R., Singh, P., Kannan, K., & Ali, N. (2016) · Cell Stress and Chaperones · doi:10.1007/s12192-016-0684-6 · Cited by 32
Intermedin1–53 Protects Against Myocardial Fibrosis by Inhibiting Endoplasmic Reticulum Stress and Inflammation Induced by Homocysteine in Apolipoprotein E-Deficient Mice
Zhang, J., Hou, Y.-L., Lu, W., Ni, X.-Q., Lin, F., Yu, Y.-R., Tang, C., & Qi, Y. (2016) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.34082 · Cited by 33
Tocotrienols induce endoplasmic reticulum stress and apoptosis in cervical cancer cells
Comitato, R., Guantario, B., Leoni, G., Nesaretnam, K., Ronci, M. B., Canali, R., & Virgili, F. (2016) · Genes & Nutrition · doi:10.1186/s12263-016-0543-1 · Cited by 33
Preservation of circadian rhythms by the protein folding chaperone, BiP
Pickard, A., Chang, J., Alachkar, N., Calverley, B. C., Garva, R., Arvan, P., Meng, Q., & Kadler, K. E. (2019) · The FASEB Journal · doi:10.1096/fj.201802366rr · Cited by 33
Endoplasmic Reticulum Stress in Brain Damage
Raghubir, R., Nakka, V. P., & Mehta, S. L. (2011) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/b978-0-12-385116-1.00015-7 · Cited by 32
Retraction: Fatty acid synthase is a novel therapeutic target in multiple myeloma
Okawa, Y., Hideshima, T., Ikeda, H., Raje, N. S., Vallet, S., Kiziltepe, T., Yasui, H., Enatsu, S., Pozzi, S., Breitkreutz, I., et al. (2008) · British Journal of Haematology · doi:10.1111/j.1365-2141.2008.07114.x · Cited by 33
Retracted
Genome-wide transcript and protein analysis highlights the role of protein homeostasis in the aging mouse heartPreprint
Gyuricza, I. G., Chick, J. M., Keele, G. R., Deighan, A. G., Munger, S. C., Korstanje, R., Gygi, S. P., & Churchill, G. A. (2022) · Genome Research · doi:10.1101/gr.275672.121 · Cited by 36
Glucagon-like peptide 1 and fibroblast growth factor-21 in non-alcoholic steatohepatitis: An experimental to clinical perspective
Yadav, P., Khurana, A., Bhatti, J. S., Weiskirchen, R., & Navik, U. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106426 · Cited by 32
Akt2: A Critical Regulator of Cardiomyocyte Survival and Metabolism
Muslin, A. J. (2011) · Pediatric Cardiology · doi:10.1007/s00246-010-9879-2 · Cited by 33
Impact of aging on heat shock protein expression in the substantia nigra and striatum of the female rat
Gleixner, A. M., Pulugulla, S. H., Pant, D. B., Posimo, J. M., Crum, T. S., & Leak, R. K. (2014) · Cell and Tissue Research · doi:10.1007/s00441-014-1852-6 · Cited by 33
Salubrinal promotes healing of surgical wounds in rat femurs
Zhang, P., Hamamura, K., Jiang, C., Zhao, L., & Yokota, H. (2012) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-012-0359-z · Cited by 32
Macrophage function in atherosclerosis
Tano, J.-Y., Lee, R. H., & Vázquez, G. (2012) · Channels · doi:10.4161/chan.20292 · Cited by 32
The Parkinson's disease‐associated GPR 37 receptor‐mediated cytotoxicity is controlled by its intracellular cysteine‐rich domain
Gandía, J., Fernández‐Dueñas, V., Morató, X., Caltabiano, G., González‐Muñiz, R., Pardo, L., Štagljar, I., & Ciruela, F. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12196 · Cited by 33
H elicobacter pylori vacuolating cytotoxin induces apoptosis via activation of endoplasmic reticulum stress in dendritic cells
Kim, J. M., Kim, N., Kim, N., Ko, S. H., Jeon, J. I., & Kim, Y. J. (2014) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.12663 · Cited by 32
Augmentation of endoplasmic reticulum stress in cerebral ischemia/reperfusion injury associated with comorbid type 2 diabetes
Srinivasan, K. K., & Sharma, S. S. (2011) · Neurological Research · doi:10.1179/1743132811y.0000000015 · Cited by 32

Authors: Szegezdi, E., Logue, S. E., Gorman, A. M., & Samali, A.
Affiliations: National University of Ireland (IE)
ORCID: Logue, Susan E
Gorman, Adrienne M
Venue: The EMBO Reports
Publisher: Springer Science and Business Media LLC
Published: 2006-09-01
Volume: 7
Issue: 9
Pages: 880-885
ISSN: 1469-221X (ISSN-L)
1469-3178
DOI: 10.1038/sj.embor.7400779
PMC: PMC1559676
OpenAlex: W2133644385
Cited by: 2,345
References: 45
Citations by year: 2026: 42 · 2025: 85 · 2024: 121 · 2023: 129 · 2022: 147 · 2021: 126 · 2020: 147 · 2019: 139 · 2018: 154 · 2017: 140 · 2016: 140 · 2015: 140 · 2014: 137 · 2013: 134 · 2012: 124
FWCI: 5.47
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: EMBO Reports (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Arrow@dit (Dublin Institute of Technology) (submittedVersion)
ARAN (University of Galway Research Repository) (Ollscoil na Gaillimhe – University of Galway) (submittedVersion, cc-by-nc-nd)
Funders: Science Foundation Ireland
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Endoplasmic Reticulum Stress and Disease
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Keywords: endoplasmic reticulum stress, apoptosis, unfolded protein response, ER stress-induced apoptosis, unfolded proteins, neurodegenerative diseases, cardiovascular disease, cell death mechanisms
MeSH terms: Animals, Endoplasmic Reticulum, Humans, Models, Biological, Signal Transduction, Apoptosis, Protein Folding, Oxidative Stress, Molecular Chaperones, Protein Transport, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Mediators of endoplasmic reticulum stress-induced apoptosis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks