Cited by 2,345Endoplasmic Reticulum Stress and DiseaseCell death mechanisms and regulationIon Channels and Receptors

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Mediators of endoplasmic reticulum stress-induced apoptosis

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Szegezdi, Eva, Logue, Susan E, Gorman, Adrienne M, Samali, Afshin·2006·The EMBO Reports

DOI 10.1038/sj.embor.7400779PMC PMC1559676

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Abstract

The efficient functioning of the endoplasmic reticulum (ER) is essential for most cellular activities and survival. Conditions that interfere with ER function lead to the accumulation and aggregation of unfolded proteins. ER transmembrane receptors detect the onset of ER stress and initiate the unfolded protein response (UPR) to restore normal ER function. If the stress is prolonged, or the adaptive response fails, apoptotic cell death ensues. Many studies have focused on how this failure initiates apoptosis, as ER stress-induced apoptosis is implicated in the pathophysiology of several neurodegenerative and cardiovascular diseases. In this review, we examine the role of the molecules that are activated during the UPR in order to identify the molecular switch from the adaptive phase to apoptosis. We discuss how the activation of these molecules leads to the commitment of death and the mechanisms that are responsible for the final demise of the cell.

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Authors: Szegezdi, E., Logue, S. E., Gorman, A. M., & Samali, A.
Affiliations: National University of Ireland (IE)
ORCID: Logue, Susan E
Gorman, Adrienne M
Venue: The EMBO Reports
Publisher: Springer Science and Business Media LLC
Published: 2006-09-01
Volume: 7
Issue: 9
Pages: 880-885
ISSN: 1469-221X (ISSN-L)
1469-3178
DOI: 10.1038/sj.embor.7400779
PMC: PMC1559676
OpenAlex: W2133644385
Cited by: 2,345
References: 45
Citations by year: 2026: 42 · 2025: 85 · 2024: 121 · 2023: 129 · 2022: 147 · 2021: 126 · 2020: 147 · 2019: 139 · 2018: 154 · 2017: 140 · 2016: 140 · 2015: 140 · 2014: 137 · 2013: 134 · 2012: 124
FWCI: 5.47
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: EMBO Reports (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Arrow@dit (Dublin Institute of Technology) (submittedVersion)
ARAN (University of Galway Research Repository) (Ollscoil na Gaillimhe – University of Galway) (submittedVersion, cc-by-nc-nd)
Funders: Science Foundation Ireland
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Endoplasmic Reticulum Stress and Disease
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Keywords: endoplasmic reticulum stress, apoptosis, unfolded protein response, ER stress-induced apoptosis, unfolded proteins, neurodegenerative diseases, cardiovascular disease, cell death mechanisms
MeSH terms: Animals, Endoplasmic Reticulum, Humans, Models, Biological, Signal Transduction, Apoptosis, Protein Folding, Oxidative Stress, Molecular Chaperones, Protein Transport, Mice

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