The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Human arteries engineered in vitro
Open accessAbstract
There is a pressing need to develop methods to engineer small‐calibre arteries for bypass surgery. We hypothesized that the rate‐limiting step that has thwarted previous attempts to engineer such vessels from non‐neonatal tissues is the limited proliferative capacity of smooth muscle cells (SMCs), which are the main cellular component of these vessels. Ectopic expression of the human telomerase reverse transcriptase subunit (hTERT) has been shown recently to extend the lifespan of certain human cells. We therefore introduced hTERT into human SMCs and found that the resulting cells proliferated far beyond their normal lifespan but retained characteristics of normal control SMCs. Importantly, using these non‐neonatal SMCs, we were able to engineer mechanically robust human vessels, a crucial step towards creating arteries of clinical value for bypass surgery.
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Cites
Extension of Life-Span by Introduction of Telomerase into Normal Human Cells
Bodnar, A. G., Ouellette, M., Frolkis, M., Holt, S. E., Chiu, C.-P., Morin, G. B., Harley, C. B., Shay, J. W., Lichtsteiner, S., & Wright, W. E. (1998) · Science · doi:10.1126/science.279.5349.349 · Cited by 4,975
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Creation of human tumour cells with defined genetic elements
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“©2003 EUROPEAN MOLECULAR BIOLOGY ORGANIZATION EMBO reports VOL 4 | NO 6 | 2003 637 hybridized with a 32P-labelled (CCCTAA)3 probe, followed by three washes with 15× sodium chloride sodium citrate, as described previously (Counter et al., 1992).”
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“However, ectopic expression of hTERT in somatic cells restores telomerase activity, arrests telomere shortening and, in a subset of cell types, overcomes senescence (Bodnar et al., 1998; Vaziri & Benchimol, 1998; Harley, 2002).”
BackgroundHuman breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells
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Telomerase, Cell Immortality, and Cancer
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Cited by
Human tissue-engineered blood vessels for adult arterial revascularization
L'Heureux, N., Dusserre, N., Konig, G., Victor, B., Keire, P., Wight, T. N., Chronos, N. A. F., Kyles, A. E., Gregory, C. R., Hoyt, G., et al. (2006) · Nature Medicine · doi:10.1038/nm1364 · Cited by 1,083
Creation of long-lasting blood vessels
Koike, N., Fukumura, D., Gralla, O., Au, P., Schechner, J. S., & Jain, R. K. (2004) · Nature · doi:10.1038/428138a · Cited by 701
Matthews, C., Gorenne, I., Scott, S., Figg, N., Kirkpatrick, P., Ritchie, A., Goddard, M., & Bennett, M. (2006) · Circulation Research · doi:10.1161/01.res.0000233315.38086.bc · Cited by 615
Tissue engineering of blood vessel
Zhang, W. J., Liu, W., Cui, L., & Cao, Y. (2007) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2007.00099.x · Cited by 217
Vascular smooth muscle cell senescence in atherosclerosis
GORENNE, I., KAVURMA, M., SCOTT, S., & BENNETT, M. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.06.004 · Cited by 196
Metadata
- Authors
- McKee, J. A., Banik, S. S., Boyer, M. J., Hamad, N. M., Lawson, J. H., Niklason, L. E., & Counter, C. M.
- Venue
- EMBO reports
- Published
- 2003-05-16
- Volume
- 4
- Issue
- 6
- Pages
- 633-638
- ISSN
- 1469-221X (ISSN-L)
- 1469-3178
- OpenAlex
- W2030876656
- Cited by
- 184
- References
- 7
- FWCI
- 12.85
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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