Tissue engineering of blood vessel
Open accessAbstract
Introduction Components of blood vessel Principle of vessel engineering Seeding cells sources Biodegradable scaffolds Vessel engineering in vitro Clinical applications Future perspectives Vascular grafts are in large demand for coronary and peripheral bypass surgeries. Although synthetic grafts have been developed, replacement of vessels with purely synthetic polymeric conduits often leads to the failure of such graft, especially in the grafts less than 6 mm in diameter or in the areas of low blood flow, mainly due to the early formation of thrombosis. Moreover, the commonly used materials lack growth potential, and long‐term results have revealed several material‐related failures, such as stenosis, thromboembolization, calcium deposition and infection. Tissue engineering has become a promising approach for generating a bio‐compatible vessel graft with growth potential. Since the first success of constructing blood vessels with collagen and cultured vascular cells by Weinberg and Bell, there has been considerable progress in the area of vessel engineering. To date, tissue‐ engineered blood vessels (TEBVs) could be successfully constructed in vitro, and be used to repair the vascular defects in animal models. This review describes the major progress in the field, including the seeding cell sources, the biodegradable scaffolds, the construction technologies, as well as the encouraging achievements in clinical applications. The remaining challenges are also discussed.
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- Authors
- Zhang, W. J., Liu, W., Cui, L., & Cao, Y.
- Affiliations
- Shanghai Jiao Tong University (CN)
- Corresponding author
- Cao, Yilin
- Venue
- Journal of Cellular and Molecular Medicine
- Publisher
- Wiley
- Published
- 2007-09
- Volume
- 11
- Issue
- 5
- Pages
- 945-957
- ISSN
- 1582-1838 (ISSN-L)
- 1582-4934
- PMC
- PMC4401266
- OpenAlex
- W3099528961
- Semantic Scholar
- b25eb347cafbc13414ee554f6424f15b9c910792
- Cited by
- 217
- References
- 117
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 13 · 2023: 11 · 2022: 10 · 2021: 21 · 2020: 12 · 2019: 17 · 2018: 13 · 2017: 18 · 2016: 7 · 2015: 13 · 2014: 12 · 2013: 10 · 2012: 11
- FWCI
- 1.81
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Cellular and Molecular Medicine (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Keywords
- tissue-engineered blood vessels, vascular grafts, coronary artery bypass grafting, graft failure, thrombosis, biodegradable scaffolds, stenosis, clinical translation
- MeSH terms
- Animals, Biocompatible Materials, Blood Vessels, Humans, Absorbable Implants, Tissue Engineering
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