Cited by 217Tissue Engineering and Regenerative MedicineElectrospun Nanofibers in Biomedical Applications3D Printing in Biomedical Research

Tissue engineering of blood vessel

Open access
Zhang, Wen Jie, Liu, Wei, Cui, Lei, Cao, Yilin·2007·Journal of Cellular and Molecular Medicine

Abstract

Introduction Components of blood vessel Principle of vessel engineering Seeding cells sources Biodegradable scaffolds Vessel engineering in vitro Clinical applications Future perspectives Vascular grafts are in large demand for coronary and peripheral bypass surgeries. Although synthetic grafts have been developed, replacement of vessels with purely synthetic polymeric conduits often leads to the failure of such graft, especially in the grafts less than 6 mm in diameter or in the areas of low blood flow, mainly due to the early formation of thrombosis. Moreover, the commonly used materials lack growth potential, and long‐term results have revealed several material‐related failures, such as stenosis, thromboembolization, calcium deposition and infection. Tissue engineering has become a promising approach for generating a bio‐compatible vessel graft with growth potential. Since the first success of constructing blood vessels with collagen and cultured vascular cells by Weinberg and Bell, there has been considerable progress in the area of vessel engineering. To date, tissue‐ engineered blood vessels (TEBVs) could be successfully constructed in vitro, and be used to repair the vascular defects in animal models. This review describes the major progress in the field, including the seeding cell sources, the biodegradable scaffolds, the construction technologies, as well as the encouraging achievements in clinical applications. The remaining challenges are also discussed.

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Crossref · 10.1111/j.1582-4934.2007.00099.x

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  1. [5]5. Kirklin JW, Barratt-Boyes BG. Ventricular Septal Defect and Pulmonary Stenosis or Atresia. In: Kirklin JW, Barratt-Boyes BG, editors. 2 nd ed. Cardiac sur- gery. New York: Churchill Livingstone; 1993. pp. 861-1612.
  2. [88]88. Greenwald SE, Berry CL. Improving vascular grafts: the importance of mechanical and haemodynamic properties. J Pathol. 2000; 190: 292-9.

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Authors
Zhang, W. J., Liu, W., Cui, L., & Cao, Y.
Affiliations
Shanghai Jiao Tong University (CN)
Corresponding author
Cao, Yilin
Venue
Journal of Cellular and Molecular Medicine
Publisher
Wiley
Published
2007-09
Volume
11
Issue
5
Pages
945-957
ISSN
  • 1582-1838 (ISSN-L)
  • 1582-4934
OpenAlex
W3099528961
Cited by
217
References
117
Citations by year
2026: 1 · 2025: 1 · 2024: 13 · 2023: 11 · 2022: 10 · 2021: 21 · 2020: 12 · 2019: 17 · 2018: 13 · 2017: 18 · 2016: 7 · 2015: 13 · 2014: 12 · 2013: 10 · 2012: 11
FWCI
1.81
Type
journal article
Language
en
Open access
Locations
  • Journal of Cellular and Molecular Medicine (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
  • Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
  • Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
Keywords
tissue-engineered blood vessels, vascular grafts, coronary artery bypass grafting, graft failure, thrombosis, biodegradable scaffolds, stenosis, clinical translation
MeSH terms
Animals, Biocompatible Materials, Blood Vessels, Humans, Absorbable Implants, Tissue Engineering

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