Subcutaneous adipose tissue expression of plasminogen activator inhibitor-1 gene during very low calorie diet in obese subjects

Bastard, J-P; Vidal, H; Jardel, C; Bruckert, E; Robin, D; Vallier, P; Blondy, P; Turpin, G; Forest, C; Hainque, B

doi:10.1038/sj.ijo.0801087

Cited by 35Adipokines, Inflammation, and Metabolic DiseasesCardiovascular Disease and AdiposityAdipose Tissue and Metabolism

Subcutaneous adipose tissue expression of plasminogen activator inhibitor-1 gene during very low calorie diet in obese subjects

Bastard, J-P, Vidal, H, Jardel, C, Bruckert, E, Robin, D, Vallier, P, Blondy, P, Turpin, G +2 more·2000·International Journal of Obesity

DOI 10.1038/sj.ijo.0801087

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Abstract

Objective To determine whether changes in subcutaneous adipose tissue plasminogen activator inhibitor-1 (PAI-1) expression influence plasma PAI-1 level during weight loss in obese humans.Design Study of the variations of PAI-1 levels both in plasma and in subcutaneous abdominal adipose tissue in 15 volunteer non-diabetic obese subjects, body mass index (BMI) 40.4.+/-1.9 kg/m2, aged 48+/-3 y, before and after a 3 week very low calorie diet (VLCD) programme (3.9+/-0.1 MJ/day).Measurements Plasma and adipose tissue PAI-1 protein levels were measured by enzyme-linked immunosorbent assay and PAI-1 mRNA levels were quantified by quantitative RT-competitive PCR.Results VLCD induced weight loss (5.8+/-0.8 kg) and decreased plasma PAI-1 concentration (-26% (P<0. 01)). Surprisingly, PAI-1 mRNA and protein abundance in subcutaneous adipose tissue increased by 87% (P<0.05) and by 44% (P<0.01), respectively.Conclusion These data indicate thus that changes in subcutaneous adipose tissue PAI-1 expression are not involved in the decrease of plasma PAI-1 levels during VLCD in obese subjects. International Journal of Obesity (2000)24, 70-74

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Subcutaneous abdominal, but not femoral fat expression of plasminogen activator inhibitor-1 (PAI-1) is related to plasma PAI-1 levels and insulin resistance and decreases after weight loss
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Authors: Bastard, J.-P., Vidal, H., Jardel, C., Bruckert, E., Robin, D., Vallier, P., Blondy, P., Turpin, G., Forest, C., & Hainque, B.
Affiliations: Inserm (FR)
Assistance Publique – Hôpitaux de Paris (FR)
Centre National de la Recherche Scientifique (FR)
ORCID: Vidal, H
Jardel, C
Forest, C
Venue: International Journal of Obesity
Publisher: Springer Science and Business Media LLC
Published: 2000-01
Volume: 24
Issue: 1
Pages: 70-74
ISSN: 0307-0565 (ISSN-L)
1476-5497
DOI: 10.1038/sj.ijo.0801087
OpenAlex: W2023752959
Cited by: 35
References: 19
Citations by year: 2022: 1 · 2021: 1 · 2017: 1 · 2016: 1 · 2014: 1 · 2012: 2
FWCI: 1.09
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: International Journal of Obesity (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Keywords: plasminogen activator inhibitor-1, PAI-1 gene expression, subcutaneous adipose tissue, very low calorie diet, weight loss, obesity, plasma PAI-1 levels, abdominal fat
MeSH terms: Abdomen, Adipose Tissue, Energy Intake, Diet, Reducing, Female, Gene Expression Regulation, Humans, Male, Middle Aged, Obesity, Skin, Weight Loss, Plasminogen Activator Inhibitor 1

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Subcutaneous adipose tissue expression of plasminogen activator inhibitor-1 gene during very low calorie diet in obese subjects

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