Adipose tissue as an endocrine organ
Abstract
The objective is to present a brief overview of peptide and non-peptide factors secreted from adipocytes and to describe some studies on the postulated role of the locally active triad angiotensinogen/angiotensinII/ prostacyclin in the development/enlargement of adipose tissue mass and increased blood pressure. In addition to the role of adipose tissue as an endocrine organ, the results emphasize the autocrine/paracrine mechanisms which are postulated to play a role in adipose tissue development and enlargement.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
White adipose tissue contributes to systemic inflammation by producing biomolecules, including pro-inflammatory mediators, whose synthesis is altered along with expansion of the adipose tissue.
“White adipose tissue (WAT), now considered as a pivotal endocrine organ, contributes to the systemic inflammation by producing biomolecules, including pro-inflammatory mediators, whose estimated number grows constantly and whose synthesis is altered along with the expansion of the adipose tissue [6,7].”
From Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity (2008) · cites this paper as [6]
Cited by
Sorted by citations
Brown Adipose Tissue: Function and Physiological Significance
CANNON, B., & NEDERGAARD, J. (2004) · Physiological Reviews · doi:10.1152/physrev.00015.2003 · Cited by 6,433 · see citing works
Physiological role of adipose tissue: white adipose tissue as an endocrine and secretory organ
Trayhurn, P., & Beattie, J. H. (2001) · Proceedings of The Nutrition Society · doi:10.1079/pns200194 · Cited by 1,259 · see citing works
State of the art paper Biochemistry of adipose tissue: an endocrine organ
Coelho, M., Oliveira, T., & Fernandes, R. (2013) · Archives of Medical Science · doi:10.5114/aoms.2013.33181 · Cited by 1,125 · see citing works
Unger, R. H. (2002) · Annual Review of Medicine · doi:10.1146/annurev.med.53.082901.104057 · Cited by 875 · see citing works
Henegar, C., Tordjman, J., Achard, V., Lacasa, D., Cremer, I., Guerre-Millo, M., Poitou, C., Basdevant, A., Stich, V., Viguerie, N., et al. (2008) · Genome Biology · doi:10.1186/gb-2008-9-1-r14 · Cited by 471 · see citing works
Diseases of liporegulation: new perspective on obesity and related disorders
Unger, R. H., & Orci, L. (2001) · The FASEB Journal · doi:10.1096/fj.00-0590 · Cited by 429 · see citing works
The secretory function of adipocytes in the physiology of white adipose tissue
Wang, P., Mariman, E., Renes, J., & Keijer, J. (2008) · Journal of Cellular Physiology · doi:10.1002/jcp.21386 · Cited by 318 · see citing works
Perivascular adipose tissue promotes vasoconstriction: the role of superoxide anion
GAO, Y., Takemori, K., SU, L., AN, W., Lu, C., SHARMA, A., & LEE, R. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.03.013 · Cited by 237 · see citing works
FAT CELLS: Afferent and Efferent Messages Define New Approaches to Treat Obesity
Lafontan, M. (2004) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.45.120403.095843 · Cited by 192 · see citing works
Changes in Proinflammatory Cytokine Activity after Menopause
Pfeilschifter, J. (2002) · Endocrine Reviews · doi:10.1210/er.23.1.90 · Cited by 182 · see citing works
Inhibition by insulin of resistin gene expression in 3T3‐L1 adipocytes
Haugen, F., Jørgensen, A., Drevon, C. A., & Trayhurn, P. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)02968-4 · Cited by 158 · see citing works
Interleukin‐6 production in human subcutaneous abdominal adipose tissue: the effect of exercise
Lyngsø, D., Simonsen, L., & Bülow, J. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2002.019380 · Cited by 155 · see citing works
Mirsoian, A., Bouchlaka, M. N., Sckisel, G. D., Chen, M., Pai, C.-C. S., Maverakis, E. M., Spencer, R. G. S., Fishbein, K. W., Siddiqui, S., Monjazeb, A. M., et al. (2014) · The Journal of Experimental Medicine · doi:10.1084/jem.20140116 · Cited by 138 · see citing works
β-Adrenergic Receptors and Regulation of Energy Expenditure: A Family Affair
Robidoux, J., Martin, T. L., & Collins, S. (2004) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.44.101802.121659 · Cited by 130 · see citing works
dos Santos, E. L., Souza, K. D. P., da Silva, E. D., Batista, E. C., Martins, P. J. F., D’Almeida, V., & Pesquero, J. B. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2009.06.018 · Cited by 124 · see citing works
The Role of the Mesentery in Crohnʼs Disease
Li, Y., Zhu, W., Zuo, L., & Shen, B. (2016) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000791 · Cited by 111 · see citing works
White Adipocyte Vascular Endothelial Growth Factor: Regulation by Insulin
Mick, G. J., Wang, X., & McCormick, K. L. (2002) · Endocrinology · doi:10.1210/endo.143.3.8673 · Cited by 102 · see citing works
Adipose tissue-derived cells: from physiology to regenerative medicine
Casteilla, L., & Dani, C. (2006) · Diabetes & Metabolism · doi:10.1016/s1262-3636(07)70297-5 · Cited by 75 · see citing works
“BAT participates in cold- as well as in diet-induced thermogenesis whereas WAT is mainly involved in energy storage and now considered as an endocrine organ [1,4].”
BackgroundMoore, M. S., Reichard, J. D., Murtha, T. D., Zahedi, B., Fallier, R. M., & Kunz, T. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027430 · Cited by 68 · see citing works
Faloia, E., Gatti, C., Camilloni, M. A., Mariniello, B., Sardu, C., Garrapa, G., Mantero, F., & Giacchetti, G. (2002) · Journal of Endocrinological Investigation · doi:10.1007/bf03344010 · Cited by 67 · see citing works
Hazan, U., Romero, I. A., Cancello, R., et al. (2002) · The FASEB Journal · doi:10.1096/fj.01-0947fje · Cited by 65 · see citing works
Karpe, F., Fielding, B. A., Ilic, V., Humphreys, S. M., & Frayn, K. N. (2002) · International Journal of Obesity · doi:10.1038/sj.ijo.0801843 · Cited by 65 · see citing works
dos Santos, E. L., Souza, K. D. P., Guimarães, P. B., Reis, F. C. G., Silva, S. M. A., Costa-Neto, C. M., Luz, J., & Pesquero, J. B. (2007) · International Immunopharmacology · doi:10.1016/j.intimp.2007.07.021 · Cited by 60 · see citing works
“growth of many cell types, including adipocytes [25], and to influence the morpho-functional development of adipose tissue [26].”
BackgroundExpression of Ectolipid Phosphate Phosphohydrolases in 3T3F442A Preadipocytes and Adipocytes
Simon, M., Rey, A., Castan-Laurel, I., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201530200 · Cited by 45 · see citing works
L'obésité : origines et conséquences d'une épidémie
Basdevant, A. (2006) · Comptes Rendus Biologies · doi:10.1016/j.crvi.2006.03.018 · Cited by 45 · see citing works
Circulating leptin and adiponectin levels in patients with primary hyperparathyroidism
Delfini, E., Petramala, L., Caliumi, C., Cotesta, D., Toma, G. D., Cavallaro, G., Panzironi, G., Diacinti, D., Minisola, S., Erasmo, E. D., et al. (2006) · Metabolism · doi:10.1016/j.metabol.2006.08.019 · Cited by 43 · see citing works
Differentiation of embryonic stem cells for pharmacological studies on adipose cells
Phillips, B. W., Vernochet, C., & Dani, C. (2003) · Pharmacological Research · doi:10.1016/s1043-6618(03)00035-5 · Cited by 40 · see citing works
What the Genetics of Lipodystrophy Can Teach Us About Insulin Resistance and Diabetes
Vatier, C., Bidault, G., Briand, N., Guénantin, A.-C., Salle-Teyssières, L., Lascols, O., Capeau, J., & Vigouroux, C. (2013) · Current Diabetes Reports · doi:10.1007/s11892-013-0431-7 · Cited by 37 · see citing works
A new approach to study the sex differences in adipose tissue
Fitzgerald, S. J., Janorkar, A. V., Barnes, A., & Maranon, R. O. (2018) · Journal of Biomedical Science · doi:10.1186/s12929-018-0488-3 · Cited by 40 · see citing works
Martinez, A., Chioléro, R. L., Bollman, M., Revelly, J., Berger, M. M., Cayeux, C., & Tappy, L. (2003) · Clinical Physiology and Functional Imaging · doi:10.1046/j.1475-097x.2003.00512.x · Cited by 37 · see citing works
Zhang, M., Wang, B., Ni, Y., Liu, F., Li, F., Pan, X.-Q., Guo, M., Chen, R., & Guo, X. (2006) · Life Sciences · doi:10.1016/j.lfs.2006.04.012 · Cited by 36 · see citing works
Small non coding RNAs in adipocyte biology and obesity
Amri, E., & Scheideler, M. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.04.009 · Cited by 30 · see citing works
Dolley, G., Bertrais, S., Frochot, V., Bebel, J.-F., Guerre-Millo, M., Torès, F., Rousseau, F., Hager, J., Basdevant, A., Herçberg, S., et al. (2007) · International Journal of Obesity · doi:10.1038/sj.ijo.0803773 · Cited by 28 · see citing works
Differential expression of Dlk-1 in bovine adipose tissue depots
Vuocolo, T., Pearson, R. D., Campbell, P. M., et al. (2003) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/s1096-4959(02)00265-8 · Cited by 28 · see citing works
Obesity and Cancer Immunotherapy Toxicity
Mirsoian, A., & Murphy, W. J. (2015) · Immunotherapy · doi:10.2217/imt.15.12 · Cited by 26 · see citing works
Brown adipose tissue and lipid metabolism imaging
Paulus, A., Lichtenbelt, W. D. V. M., Mottaghy, F. M., & Bauwens, M. (2017) · Methods · doi:10.1016/j.ymeth.2017.05.001 · Cited by 27 · see citing works
Serazin-Leroy, V., Santos, E. D., Morot, M., & Giudicelli, Y. (2004) · Endocrine · doi:10.1385/endo:25:2:097 · Cited by 15 · see citing works
Iwase, M., Yamamoto, T., Nishimura, K., Takahashi, H., Mohri, S., Li, Y., Jheng, H., Nomura, W., Takahashi, N., Kim, C.-S., et al. (2017) · Lipids · doi:10.1007/s11745-017-4269-7 · Cited by 15 · see citing works
Fat mass predicts food-specific inhibitory control in children
da Costa, K. G., Price, M. J., Bortolotti, H., Rêgo, M. L. D. M., Cabral, D. A. R., Langer, R. D., Fernandes, G. A., Elsangedy, H. M., & Fontes, E. B. (2019) · Physiology & Behavior · doi:10.1016/j.physbeh.2019.02.031 · Cited by 12 · see citing works
PPARs and Adipose Cell Plasticity
Casteilla, L., Cousin, B., & Carmona, M. C. (2007) · PPAR Research · doi:10.1155/2007/68202 · Cited by 12 · see citing works
Adaptation of ghrelin levels to limit body weight gain in the obese Zucker rat
Beck, B., Max, J., Fernette, B., et al. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.04.106 · Cited by 11 · see citing works
Amaral, A. R., Finardi, G. L. F., Marchi, P. H., de Oliveira, N. M. C., Príncipe, L. D. A., Teixeira, N., Pappalardo, M. C. F., Lima, L. O. C., Cirillo, J. V., Balieiro, J. C. D. C., et al. (2025) · Frontiers in Veterinary Science · doi:10.3389/fvets.2024.1490290 · Cited by 11 · see citing works
“Understanding white adipose tissue’s role as an endocrine organ in obese animals has deepened insights into obesity’s pathophysiology and its links to other diseases (95, 96).”
Screening for early gastric cancer
McColl, K. E. L. (2005) · Gut · doi:10.1136/gut.2004.058461 · Cited by 9 · see citing works
Alexander, E. (2013) · InTech eBooks · doi:10.5772/55634 · Cited by 8 · see citing works
Dani, C., Foissac, R., Ladoux, A., et al. (2017) · Current Surgery Reports · doi:10.1007/s40137-017-0178-1 · Cited by 8 · see citing works
Regulatory Small and Long Noncoding RNAs in Brite/Brown Adipose Tissue
Scheideler, M. (2018) · Handbook of experimental pharmacology · doi:10.1007/164_2018_123 · Cited by 9 · see citing works
PROCESSOS INFLAMATÓRIOS DA OBESIDADE
Sippel, C. A., Bastian, R. M. D. A., Giovanella, J., Faccin, C., Contini, V., & Bosco, S. M. D. (2014) · Revista de Atenção à Saúde · doi:10.13037/rbcs.vol12n42.2310 · Cited by 7 · see citing works
Obesity: Pathophysiological concepts
Basdevant, A. (2008) · Joint Bone Spine · doi:10.1016/j.jbspin.2008.06.007 · Cited by 4 · see citing works
Gastro-oesophageal reflux disease: symptoms, erosions, and Barrett’s—what is the interplay?
Sharma, P. (2005) · Gut · doi:10.1136/gut.2004.052225 · Cited by 4 · see citing works
Pandol, S. J. (2005) · Gut · doi:10.1136/gut.2004.054080 · Cited by 4 · see citing works
Authors’ Response: Dietary Fat and Androgens
Wang, C., & Swerdloff, R. S. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0764 · Cited by 4 · see citing works
Ye, Z., Zheng, S., Chen, J., Zhang, Y., Yang, S., Hong, Y., Yang, H., Xuan, Z., & Zhao, Q. D. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.108738 · Cited by 2 · see citing works
Obesity and Weight Loss: The Influence of Thyroid Hormone on Adipokines
Luvizotto, R. D. A. M., Jos, S., de, M., Síbio, M. T. D., Nagamati, K., & Regina, C. (2012) · InTech eBooks · doi:10.5772/46179 · Cited by 2 · see citing works
Who is considered obese? Why? Clinical and therapeutic implications
Ciangura, C., Touizer, E., & Basdevant, A. (2010) · Journal of Visceral Surgery · doi:10.1016/j.jviscsurg.2010.08.012 · Cited by 3 · see citing works
Epicardial adipose tissue thickness in young Indian overweight and obese individuals
Chakravarthy, K., Maiya, A., Gopee, M., Vora, V., & Shah, A. (2014) · Annals of Medical and Health Sciences Research · doi:10.4103/2141-9248.131720 · Cited by 2 · see citing works
Hormonal regulation of human adipocytes at the cross-roads between obesity and hypertension
Tikhonoff, V., & Staessen, J. A. (2002) · Journal of Hypertension · doi:10.1097/00004872-200205000-00014 · Cited by 2 · see citing works
Noda, T., Kamiya, K., Hamazaki, N., Nozaki, K., Ichikawa, T., Yamashita, M., Uchida, S., Maekawa, E., Terada, T., Reed, J. L., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-1268673/v1 · Cited by 2 · see citing works
Miyamoto, M. V., de Melo, C. M., & Ribeiro, S. M. L. (2008) · Medicina (Ribeirão Preto) · doi:10.11606/issn.2176-7262.v41i1p58-66 · Cited by 1 · see citing works
Factors Affecting Blood Leptin, Ghrelin and Adiponectin Levels:Review
Altıner, A., ŞAHİN, I., Bilal, T., & Vural, H. A. (2016) · Turkiye Klinikleri Journal of Veterinary Sciences · doi:10.5336/vetsci.2016-51738 · Cited by 1 · see citing works
FUNÇÃO, CONTROLE TRANSCRICIONAL E ATIVIDADE ENDÓCRINA DO TECIDO ADIPOSO NOS MAMÍFEROS
de Souza, A. L., de Arruda, I. J., & Rondina, D. (2010) · AGROPECUÁRIA CIENTÍFICA NO SEMIÁRIDO · doi:10.30969/acsa.v5i1.6 · Cited by 1 · see citing works
ADIPOCYTOKINES IN DEVELOPMENT INSULIN RESISTANCE IN OBESITY
Yarmysh, N. V., Кравченко, Н. А., & Voitenko, E. I. (2010) · PROBLEMS OF ENDOCRINE PATHOLOGY · doi:10.21856/j-pep.2010.3.17 · Cited by 1 · see citing works
Place du tissu adipeux dans la physiopathologie du diabète de type 2
Nobécourt, E. (2007) · Annales d Endocrinologie · doi:10.1016/j.ando.2007.01.016 · Cited by 1 · see citing works
Obésité: Regard médical, regard societal
Basdevant, A. (2007) · Revue Francophone des Laboratoires · doi:10.1016/s1773-035x(07)80144-4
Obésité : évolution des conceptions physiopathologiques
Basdevant, A. (2008) · Revue du Rhumatisme · doi:10.1016/j.rhum.2008.06.005
Hormonal regulation of immune modulators in human breast tissue
Morad, V. (2015) · Linköping University medical dissertations · doi:10.3384/diss.diva-117983
Qui est obèse ? Pourquoi ? Conséquences clinique et thérapeutique
Ciangura, C., Touizer, E., & Basdevant, A. (2010) · Journal de Chirurgie Viscérale · doi:10.1016/j.jchirv.2010.08.014
ReviewArticle PPARs and Adipose Cell Plasticity
Casteilla, L., & Carmona, M. C. (2007)
Nayar, H. S., Rubin, J. P., & Marra, K. G. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-397157-9.00049-7
International Research Journal of Medicine and Biomedical Sciences
(2019) · International Research Journal of Medicine and Biomedical Sciences · doi:10.15739/irjmbs.16
Sergiyenko, L. Y. (2011) · PROBLEMS OF ENDOCRINE PATHOLOGY · doi:10.21856/j-pep.2011.2.13
Mauro, L., Catalano, S., Bossi, G., et al. (2023) · doi:10.1158/0008-5472.c.6494909
Mauro, L., Catalano, S., Bossi, G., et al. (2023) · doi:10.1158/0008-5472.c.6494909.v1
Fesyun, A. D., Marchenkova, L., & Vasileva, V. A. (2023) · Bulletin of Rehabilitation Medicine · doi:10.38025/2078-1962-2023-22-3-66-74
Moreira, A. C. D. A. (2017) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.17.2017.tde-09052024-115645
(2000) · Time to knit · doi:10.1016/s1155-1941(19)30075-7
- Authors
- Ailhaud, G.
- Corresponding author
- Ailhaud, G
- ORCID
- Ailhaud, G
- Venue
- International Journal of Obesity
- Published
- 2000-06
- Volume
- 24
- Issue
- S2
- Pages
- S1-S3
- ISSN
- 0307-0565 (ISSN-L)
- 1476-5497
- OpenAlex
- W1981125603
- Cited by
- 79
- References
- 0
- Citations by year
- 2025: 1 · 2023: 3 · 2022: 2 · 2020: 1 · 2019: 3 · 2018: 3 · 2017: 5 · 2016: 2 · 2015: 3 · 2014: 4 · 2013: 3 · 2012: 1
- FWCI
- 3.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- International Journal of Obesity (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- adipose tissue endocrine function, adipocytes, adipokines, angiotensinogen, angiotensin II, prostacyclin, adipose tissue mass, blood pressure, autocrine signaling, paracrine signaling, adipose tissue development
- MeSH terms
- Adipose Tissue, Angiotensin II, Angiotensinogen, Endocrine Glands, Estrogens, Female, Humans, Male, Epoprostenol, Gonadal Steroid Hormones, Lipid Metabolism
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
