Interleukin‐6 production in human subcutaneous abdominal adipose tissue: the effect of exercise
Open accessAbstract
The interleukin‐6 (IL‐6) output from subcutaneous, abdominal adipose tissue was studied in nine healthy subjects before, during and for 3 h after 1 h two‐legged bicycle exercise at 60 % maximal oxygen consumption. Seven subjects were studied in control experiments without exercise. The adipose tissue IL‐6 output was measured by direct Fick technique. An artery and a subcutaneous vein on the anterior abdominal wall were catheterized. Adipose tissue blood flow was measured using the 133 Xe‐washout method. In both studies there was a significant IL‐6 output in the basal state and no significant change was observed during exercise. Post‐exercise the IL‐6 output began to increase after 30 min. Three hours post‐exercise it was 58.6 ± 22.2 pg (100 g) −1 min −1 . In the control experiments the IL‐6 output also increased, but it only reached a level of 3.5 ± 0.8 pg (100 g) −1 min −1 . The temporal profile of the post‐exercise change in the IL‐6 output closely resembles the changes in the outputs of glycerol and fatty acids, which we have described previously in the same adipose tissue depot. The difference is that it begins to increase ≈30 min before the glycerol and fatty acid outputs begin to increase. Thus, we suggest that the enhanced IL‐6 production post‐exercise in abdominal, subcutaneous adipose tissue may act locally via autocrine/paracrine mechanisms influencing lipolysis and fatty acid mobilization rate from this lipid depot.
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Infusion of recombinant human IL-6 into resting healthy humans does not impair whole body, lower limb, or subcutaneous adipose tissue glucose uptake or endogenous glucose production.
“Infusion of recombinant human (rh) IL-6 into resting healthy humans does not impair whole body, lower limb, or subcutaneous adipose tissue glucose uptake or endogenous glucose production [48, 49].”
From Exercise as a Mean to Control Low‐Grade Systemic Inflammation (2008) · cites this paper as [49]
Infusion of rhIL-6 into healthy humans to obtain physiological concentrations increased lipolysis in the absence of hypertriacylglyceridemia or changes in catecholamines, glucagon, insulin, or adverse effects in healthy individuals and patients with type 2 diabetes.
“Infusion of rhIL-6 into healthy humans to obtain physiological concentrations of IL-6 increased lipolysis in the absence of hypertriacylglyceridemia or changes in catecholamines, glucagon, insulin, or any adverse effects in healthy individuals as well as patients with type 2 diabetes [49, 50, 58].”
From Exercise as a Mean to Control Low‐Grade Systemic Inflammation (2008) · cites this paper as [49]
Both TNF-α and IL-6 induce lipolysis, but only IL-6 appears to induce fat oxidation.
“Of note, whereas it is known that both TNF-α and IL-6 induce lipolysis [40, 49], only IL-6 appears to induce fat oxidation [19, 59].”
From Exercise as a Mean to Control Low‐Grade Systemic Inflammation (2008) · cites this paper as [49]
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- Authors
- Lyngsø, D., Simonsen, L., & Bülow, J.
- Affiliations
- Bispebjerg Hospital (DK)
- Corresponding author
- Bülow, Jens
- ORCID
- Bülow, Jens
- Venue
- The Journal of Physiology
- Publisher
- Wiley
- Published
- 2002-08
- Volume
- 543
- Issue
- 1
- Pages
- 373-378
- ISSN
- 0022-3751 (ISSN-L)
- 1469-7793
- PMC
- PMC2290472
- OpenAlex
- W2078325369
- Cited by
- 155
- References
- 41
- Citations by year
- 2026: 6 · 2025: 4 · 2024: 2 · 2023: 5 · 2022: 4 · 2021: 6 · 2020: 9 · 2019: 6 · 2018: 5 · 2017: 7 · 2016: 5 · 2015: 7 · 2014: 4 · 2013: 8 · 2012: 6
- FWCI
- 6.53
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Journal of Physiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Novo Nordisk Fonden
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- interleukin-6, subcutaneous adipose tissue, abdominal fat, physical activity, lipolysis, fatty acid mobilization, glycerol release, autocrine and paracrine signaling, adipose tissue blood flow, cycling exercise
- MeSH terms
- Abdomen, Adipose Tissue, Adult, Humans, Male, Oxygen Consumption, Regional Blood Flow, Exercise, Interleukin-6, Subcutaneous Tissue
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