Effect of obesity on HDL and LDL particle sizes in carriers of the null P207L or defective D9N mutation in the lipoprotein lipase gene: the Québec LipD Study
Abstract
Background We have recently demonstrated that French Canadians bearing a mutation in the lipoprotein lipase (LPL) gene present an impaired lipoprotein-lipid profile characterized by small low-density lipoprotein (LDL) and high-density lipoprotein (HDL) particles compared with healthy subjects. It has also been documented that obesity has a significant impact on HDL and LDL particle sizes.Objective To examine the extent to which obesity modulates HDL and LDL particle sizes among carriers of mutations in the LPL gene.Subjects Analyses were carried out in 206 heterozygous carriers of the D9N mutation (N=118) or the P207L mutation (N=88).Measurements Lipoprotein particle sizes were measured on whole plasma by nondenaturing polyacrylamide gradient gel electrophoresis.Results In general, body mass index (BMI) and waist circumference were significant correlates of LDL and HDL particle sizes among heterozygous carriers of the P207L or D9N mutation in the LPL gene, with relatively similar associations among men and women. Multivariate analyses indicated that variations in waist circumference but not BMI were an independent predictor of variations in both HDL particle size (5.2%, P=0.0005) and LDL particle size (5.9%, P=0.01) in the entire group of heterozygotes for LPL mutation in a model that included the nature of the LPL mutation (D9N vs P207L), gender, age, cholesterol and plasma TG levels. Interestingly, there was a significant interaction between plasma TG levels and waist circumference or BMI in modulating HDL particle size. Indeed, an increased waist circumference or BMI was associated with a significant reduction in HDL particle size among subjects with plasma TG levels <or=3.5 mmol/l, but not among those with marked hypertriglyceridemia (TG levels >3.5 mmol/l).Conclusion These results suggest that abdominal obesity, more so that overall obesity, is an important determinant of variations in LDL and HDL particle size among heterozygous carriers of mutations in the LPL gene, perhaps further contributing to modulate the risk of CHD in these individuals.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Various polymorphisms in genes affecting lipoprotein metabolism are associated with worsening dyslipidemia in obese people.
“For example, a variety of polymorphisms in genes affecting lipoprotein metabolism are associated with worsening of dyslipidemia in obese people.55,56”
From Diagnosis and Management of the Metabolic Syndrome: An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement (2005) · cites this paper as [56]
Cites
(1998) · PsycEXTRA Dataset · doi:10.1037/e565682010-001 · Cited by 9,452 · see citing works
High density lipoprotein as a protective factor against coronary heart disease
Gordon, T., Castelli, W. P., Hjortland, M. C., Kannel, W. B., & Dawber, T. R. (1977) · The American Journal of Medicine · doi:10.1016/0002-9343(77)90874-9 · Cited by 5,059 · see citing works
Quantitative estimation of proteins by electrophoresis in agarose gel containing antibodies
Laurell, C. (1966) · Analytical Biochemistry · doi:10.1016/0003-2697(66)90246-6 · Cited by 4,428 · see citing works
Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI.
Hixson, J., & Vernier, D. (1990) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)43176-1 · Cited by 2,933 · see citing works
Warnick, G. R., Benderson, J., & Albers, J. J. (1982) · Clinical Chemistry · doi:10.1093/clinchem/28.6.1379 · Cited by 2,171 · see citing works
Flier, J. S., Underhill, L. H., & Eckel, R. H. (1989) · New England Journal of Medicine · doi:10.1056/nejm198904203201607 · Cited by 973 · see citing works
(1998) · Obesity Research · doi:10.1002/j.1550-8528.1998.tb00690.x · Cited by 758 · see citing works
Abdominal obesity as important component of insulin-resistance syndrome.
Després, J. (1994) · PubMed · Cited by 568 · see citing works
Automated enzymatic standardized lipid analyses for plasma and lipoprotein fractions
McNamara, J. R., & Schaefer, E. J. (1987) · Clinica Chimica Acta · doi:10.1016/0009-8981(87)90188-4 · Cited by 524 · see citing works
Lemieux, S., Prud'homme, D., Bouchard, C., Tremblay, A., & Despres, J. (1996) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/64.5.685 · Cited by 519 · see citing works
Tchernof, A., Lamarche, B., Prud'homme, D., Nadeau, A., Moorjani, S., Labrie, F., Lupien, P. J., & Després, J.-P. (1996) · Diabetes Care · doi:10.2337/diacare.19.6.629 · Cited by 323 · see citing works
Self-citationSt-Pierre, A., Ruel, I. L., Cantin, B., Dagenais, G. R., Bernard, P., Després, J., & Lamarche, B. (2001) · Circulation · doi:10.1161/hc4401.098490 · Cited by 259 · see citing works
Self-citationPascot, A., Lemieux, I., Prud’homme, D., Tremblay, A., Nadeau, A., Couillard, C., Bergeron, J., Lamarche, B., & Després, J. (2001) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)31529-7 · Cited by 184 · see citing works
Self-citationHDL metabolism in hypertriglyceridemic states: an overview
Lamarche, B., Rashid, S., & Lewis, G. F. (1999) · Clinica Chimica Acta · doi:10.1016/s0009-8981(99)00098-4 · Cited by 184 · see citing works
Self-citationMolecular pathobiology of the human lipoprotein lipase gene
Murthy, V., Julien, P., & Gagné, C. (1996) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(96)00005-8 · Cited by 178 · see citing works
Self-citationDesprés, J., Ferland, M., Moorjani, S., Nadeau, A., Tremblay, A., Lupien, P. J., Thériault, G., & Bouchard, C. (1989) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.9.4.485 · Cited by 173 · see citing works
Associations of HDL 2 and HDL 3 Subfractions With Ischemic Heart Disease in Men
Lamarche, B., Moorjani, S., Cantin, B., Dagenais, G. R., Lupien, P. J., & Després, J. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.6.1098 · Cited by 170 · see citing works
Self-citationMonsalve, M. V., Henderson, H., Roederer, G. O., Julien, P., Deeb, S. S., Kastelein, J. J. P., Peritz, L. N., Devlin, R. H., Bruin, T., & Murthy, M. R. V. (1990) · Journal of Clinical Investigation · doi:10.1172/jci114769 · Cited by 169 · see citing works
Self-citationA Common Variant in the Gene for Lipoprotein Lipase (Asp9→Asn)
Mailly, F., Tugrul, Y., Reymer, P. W. A., Bruin, T., Seed, M., Groenemeyer, B. F., Asplund-Carlson, A., Vallance, D. T., WINDER, A. F., Miller, G. J., et al. (1995) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.15.4.468 · Cited by 153 · see citing works
A MULTIFUNCTIONAL ENZYME RELEVANT TO COMMON METABOLIC DISEASES
Eckel, R. H. (1989) · Cited by 149 · see citing works
Lamarche, B., St-Pierre, A., Ruel, I. L., Cantin, B., Dagenais, G. R., & Després, J.-P. (2001) · PubMed · Cited by 142 · see citing works
Self-citationJukema, J. W., Boven, A. J. V., Groenemeijer, B. E., Zwinderman, A. H., Reiber, J. H. C., Bruschke, A. V. G., Henneman, J. A., Molhoek, G. P., Bruin, T., Jansen, H., et al. (1996) · Circulation · doi:10.1161/01.cir.94.8.1913 · Cited by 123 · see citing works
Ma, Y., Henderson, H., Murthy, M. R. V., Roederer, G. O., Monsalve, M. V., Clarke, L. A., Normand, T., Julien, P., Gagné, C., Lambert, M. A., et al. (1991) · New England Journal of Medicine · doi:10.1056/nejm199106203242502 · Cited by 107 · see citing works
Self-citationGerdes, C., Fisher, R. M., Nicaud, V., Boer, J. M. A., Humphries, S. E., Talmud, P. J., & Færgeman, O. (1997) · Circulation · doi:10.1161/01.cir.96.3.733 · Cited by 103 · see citing works
Functional variants in the lipoprotein lipase gene and risk of cardiovascular disease
Hokanson, J. E. (1999) · Current Opinion in Lipidology · doi:10.1097/00041433-199910000-00003 · Cited by 83 · see citing works
Hokanson, J. E. (1997) · International Journal of Clinical & Laboratory Research · doi:10.1007/bf02827239 · Cited by 80 · see citing works
Mailly, F., Olivecrona, G., Tugrul, Y., Reymer, P. W. A., Bruin, T., Seed, M., Groenemeyer, B. F., Lansberg, P. J., Asplund-Carlson, A., Vallance, D. T., et al. (1994) · Atherosclerosis · doi:10.1016/0021-9150(94)93262-x · Cited by 72 · see citing works
Pérusse, M., Pascot, A., Després, J., Couillard, C., & Lamarche, B. (2001) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)31585-6 · Cited by 66 · see citing works
Self-citationHall, S., Chu, G., Miller, G. J., Cruickshank, K. J., Cooper, J. A., Humphries, S. E., & Talmud, P. J. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.10.1969 · Cited by 55 · see citing works
Ma, Y., Wilson, B. I., Bijvoet, S. M., Henderson, H., Cramb, E., Roederer, G. O., Murthy, M. R. V., Julien, P., Bakker, H. D., Kastelein, J. J. P., et al. (1992) · Genomics · doi:10.1016/0888-7543(92)90136-g · Cited by 43 · see citing works
Self-citationGaudet, D., Vohl, M., Julien, P., Tremblay, G., Perron, P., Gagné, C., Bergeron, J., Moorjani, S., & Després, J. (1998) · The American Journal of Cardiology · doi:10.1016/s0002-9149(98)00328-2 · Cited by 40 · see citing works
Self-citationBijvoet, S. M., & Hayden, M. R. (1992) · Human Molecular Genetics · doi:10.1093/hmg/1.7.541 · Cited by 32 · see citing works
[Risk factors associated with obesity: a metabolic perspective].
Després, J., Pascot, A., & Lemieux, I. (2000) · PubMed · Cited by 21 · see citing works
Julien, P., Gagné, C., Murthy, M. R. V., et al. (1998) · Human Mutation · doi:10.1002/humu.1380110150 · Cited by 21 · see citing works
Self-citationRuel, I. L., Gaudet, D., Perron, P., Bergeron, J., Julien, P., & Lamarche, B. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000020677.33243.1c · Cited by 12 · see citing works
Self-citationRuel, I. L., Gaudet, D., Perron, P., Pascot, A., Després, J., Bergeron, J., Julien, P., & Lamarche, B. (2002) · Atherosclerosis · doi:10.1016/s0021-9150(01)00716-x · Cited by 9 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Grundy, S. M., Cleeman, J. I., Daniels, S. R., Donato, K. A., Eckel, R. H., Franklin, B. A., Gordon, D. J., Krauss, R. M., Savage, P. J., Smith, S. C., et al. (2005) · Circulation · doi:10.1161/circulationaha.105.169404 · Cited by 11,961 · see citing works
- Authors
- Ruel, I. L., Gaudet, D., Perron, P., Bergeron, J., Julien, P., & Lamarche, B.
- Affiliations
- Université Laval (CA)
- Hôpital de Chicoutimi (CA)
- Centre hospitalier de l'Université Laval (CA)
- Corresponding author
- Lamarche, B
- Venue
- International Journal of Obesity
- Published
- 2003-04-17
- Volume
- 27
- Issue
- 5
- Pages
- 631-637
- ISSN
- 0307-0565 (ISSN-L)
- 1476-5497
- OpenAlex
- W1970395973
- Cited by
- 18
- References
- 36
- Citations by year
- 2021: 1 · 2019: 1 · 2017: 2 · 2016: 1 · 2015: 1 · 2014: 1
- FWCI
- 1.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- International Journal of Obesity (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- lipoprotein lipase gene, heterozygous carriers, obesity, abdominal obesity, waist circumference, body mass index, HDL particle size, LDL particle size, plasma triglycerides, cardiovascular risk, French Canadians
- MeSH terms
- Female, Heterozygote, Humans, Lipoprotein Lipase, Lipoproteins, HDL, Lipoproteins, LDL, Male, Middle Aged, Mutation, Obesity, Particle Size, Body Mass Index
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
