Obesity reduces the bioavailability of nitric oxide in juveniles
Abstract
Objective There is growing evidence that nitric oxide (NO) is critically involved in obesity and its clinical consequences like cardiovascular disease, hypertension and diabetes. We hypothesize that NO is already involved in the pathophysiology of juvenile obesity. We here determined the role of NO, its metabolites arginine and citrulline in obese and normal weight children. Design We investigated 57 obese and 57 normal weight age- and gender-matched juveniles. Various clinical parameters as well as body measurements and intima media thickness were determined. Results Obese juveniles revealed highly significant alterations in the NO pathway. NOX and citrulline were decreased in obese compared to normal weight juveniles and negatively correlated with body weight. Arginine was increased in obese juveniles and positively correlated with body weight. We found a significant negative correlation between NOX and oxidized low-density lipoprotein. Analysis of gamma-aminobutyric acid (GABA) revealed correlations with the NO pathway as NOX and citrulline were negatively correlated with GABA and arginine showed a positive correlation. Conclusion We show here that NO and its metabolites arginine and citrulline are already involved in juvenile obesity that may contribute to atherogenesis via reduced bioavailability of NO. Moreover, we identify GABA as a new parameter in the mechanism of obesity-related NO reduction.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
NO bioavailability is decreased in animal models of diet-induced obesity and in obese and insulin-resistant patients.
“NO bioavailability is decreased in animal models of diet-induced obesity and in obese and insulin resistant patients”
From Regulation of obesity and insulin resistance by nitric oxide (2014) · cites this paper as [119]
Cites
Endothelial Nitric Oxide Synthase in Vascular Disease: From Marvel to Menace
Förstermann, U., & Münzel, T. (2006) · Circulation · doi:10.1161/circulationaha.105.602532 · Cited by 1,957 · see citing works
Ziccardi, P., Nappo, F., Giugliano, G., Esposito, K., Marfella, R., Cioffi, M., D’Andrea, F., Molinari, A. M., & Giugliano, D. (2002) · Circulation · doi:10.1161/hc0702.104279 · Cited by 994 · see citing works
Silha, J. V., Kršek, M., Škrha, J., Sucharda, P., Nyomba, B. L. G., & Murphy, L. (2003) · European Journal of Endocrinology · doi:10.1530/eje.0.1490331 · Cited by 589 · see citing works
McDonald, K., Zharikov, S. I., Block, E. R., & Kilberg, M. S. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.50.31213 · Cited by 436 · see citing works
Demonstration of Rapid Onset Vascular Endothelial Dysfunction After Hyperhomocysteinemia
Chambers, J. C., McGregor, A., Jean-Marie, J., Obeid, O., & Kooner, J. S. (1999) · Circulation · doi:10.1161/01.cir.99.9.1156 · Cited by 427 · see citing works
Adipocytokines - novel link between inflammation and vascular function?
Guzik, T. J., Mangalat, D., & Korbut, R. (2006) · PubMed · Cited by 420 · see citing works
Pathways and Regulation of Homocysteine Metabolism in Mammals
Finkelstein, J. D. (2000) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-2000-8466 · Cited by 329 · see citing works
Peroxynitrite and Vascular Endothelial Dysfunction in Diabetes Mellitus
Zou, M., Cohen, R. A., & Ullrich, V. (2004) · Endothelium · doi:10.1080/10623320490482619 · Cited by 270 · see citing works
Williams, I. L., Wheatcroft, S. B., Shah, A. M., & Kearney, M. T. (2002) · International Journal of Obesity · doi:10.1038/sj.ijo.0801995 · Cited by 261 · see citing works
Modulation of nitric oxide bioavailability by erythrocytes
Huang, K., Han, T. H., Hyduke, D. R., Vaughn, M. W., Herle, H. M.-L. V., Hein, T. W., Zhang, C., Kuo, L., & Liao, J. C. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.201276698 · Cited by 171 · see citing works
Marfella, R., Esposito, K., Siniscalchi, M., Cacciapuoti, F., Giugliano, F., Labriola, D., Ciotola, M., Di Palo, C., Misso, L., & Giugliano, D. (2004) · Diabetes Care · doi:10.2337/diacare.27.1.47 · Cited by 170 · see citing works
Mather, K. J., Lteif, A. A., Steinberg, H. O., & Baron, A. (2004) · Diabetes · doi:10.2337/diabetes.53.8.2060 · Cited by 157 · see citing works
Dysfunction of the endothelial nitric oxide signalling pathway in diabetes and hyperglycaemia
Sobrevía, L., & Mann, G. E. (1997) · Experimental Physiology · doi:10.1113/expphysiol.1997.sp004038 · Cited by 126 · see citing works
Higashi, Y. (2001) · American Journal of Hypertension · doi:10.1016/s0895-7061(01)02191-4 · Cited by 125 · see citing works
Reinehr, T., Stoffel‐Wagner, B., Roth, C. L., & Andler, W. (2005) · Metabolism · doi:10.1016/j.metabol.2005.03.022 · Cited by 118 · see citing works
Red Blood Cell Nitric Oxide as an Endocrine Vasoregulator
Datta, B. N., Tufnell-Barret, T., Bleasdale, R. A., Jones, C. J. H., Beeton, I., Paul, V., Frenneaux, M. P., & James, P. E. (2004) · Circulation · doi:10.1161/01.cir.0000124450.07016.1d · Cited by 102 · see citing works
Roles of adipocyte derived hormone adiponectin and resistin in insulin resistance of type 2 diabetes
Lü, H. (2006) · World Journal of Gastroenterology · doi:10.3748/wjg.v12.i11.1747 · Cited by 81 · see citing works
Neurons of the Rostral Ventrolateral Medulla Contribute to Obesity-Induced Hypertension in Rats
Stocker, S. D., Meador, R., & Adams, J. M. (2006) · Hypertension · doi:10.1161/01.hyp.0000254828.71253.dc · Cited by 77 · see citing works
Quantifying the l-arginine paradox in vivo
Vukosavljevic, N., Jaron, D., Barbee, K. A., & Buerk, D. G. (2005) · Microvascular Research · doi:10.1016/j.mvr.2005.10.006 · Cited by 70 · see citing works
Naseem, K. M., & Bruckdorfer, K. R. (1995) · Biochemical Journal · doi:10.1042/bj3100149 · Cited by 61 · see citing works
Yanfei, W., Lin, S., Du, J., & Chaoshu, T. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.04.162 · Cited by 57 · see citing works
Pereira, F. O., Fröde, T. S., & Medeiros, Y. S. (2006) · Mediators of Inflammation · doi:10.1155/mi/2006/39062 · Cited by 52 · see citing works
Elahi, M. M., Naseem, K. M., & Matata, B. M. (2007) · FEBS Journal · doi:10.1111/j.1742-4658.2007.05660.x · Cited by 49 · see citing works
Leptin and the control of obesity
Wilding, J. P. H. (2001) · Current Opinion in Pharmacology · doi:10.1016/s1471-4892(01)00111-4 · Cited by 43 · see citing works
Konukoğlu, D., Serin, O., & Turhan, M. S. (2006) · Archives of Medical Research · doi:10.1016/j.arcmed.2005.12.002 · Cited by 43 · see citing works
Exhaled nitric oxide in severe obesity: Effect of weight loss
Maniscalco, M., de Laurentiis, G., Zedda, A., Faraone, S., Giardiello, C., Cristiano, S., & Sofia, M. (2006) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2006.10.003 · Cited by 41 · see citing works
Zou, C. C., Liang, L., & Hong, F. (2007) · PubMed · Cited by 35 · see citing works
Konukoğlu, D., Serin, O., & Turhan, M. S. (2005) · PubMed · Cited by 26 · see citing works
Leptin and Nitric Oxide Production in Normotensive and Hypertensive Men
Tsuda, K., & Nishio, I. (2004) · Obesity Research · doi:10.1038/oby.2004.154 · Cited by 21 · see citing works
Bäckberg, M., & Meister, B. (2004) · Synapse · doi:10.1002/syn.20024 · Cited by 15 · see citing works
Upregulation of GAD65 mRNA in the medulla of the rat model of metabolic syndrome
Buck, B. J., Kerman, I. A., Burghardt, P. R., Koch, L. G., Britton, S. L., Akil, H., & Watson, S. J. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.04.042 · Cited by 12 · see citing works
Boesgaard, T. W., Castella, S., Andersen, G., Albrechtsen, A., Sparsø, T., Borch‐Johnsen, K., Jørgensen, T., Hansen, T. F., & Pedersen, O. B. (2007) · Diabetic Medicine · doi:10.1111/j.1464-5491.2007.02110.x · Cited by 12 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Positive and Negative Regulation of Insulin Signaling by Reactive Oxygen and Nitrogen Species
Bashan, N., Kovsan, J., Kachko, I., Ovadia, H., & Rudich, A. (2009) · Physiological Reviews · doi:10.1152/physrev.00014.2008 · Cited by 542 · see citing works
McCormack, S. E., Shaham, O., McCarthy, M. A., Deik, A., Wang, T. J., Gerszten, R. E., Clish, C. B., Mootha, V. K., Grinspoon, S. K., & Fleischman, A. (2012) · Pediatric Obesity · doi:10.1111/j.2047-6310.2012.00087.x · Cited by 439 · see citing works
Hemostasis, endothelial stress, inflammation, and the metabolic syndrome
Grandl, G., & Wolfrum, C. (2017) · Seminars in Immunopathology · doi:10.1007/s00281-017-0666-5 · Cited by 344 · see citing works
Regulation of obesity and insulin resistance by nitric oxide
Sansbury, B. E., & Hill, B. G. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.05.016 · Cited by 274 · see citing works
“diabetes [116,117] and in obese and diabetic humans [118,119].”
BackgroundMontero, D., Walther, G., Pérez‐Martin, A., Roche, E., & Vinet, A. (2011) · Obesity Reviews · doi:10.1111/j.1467-789x.2011.00956.x · Cited by 166 · see citing works
Wang, C., Lundh, M., Fu, A., Kriszt, R., Huang, T. L., Lynes, M. D., Leiria, L. O., Shamsi, F., Darcy, J., Greenwood, B. P., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aaz8664 · Cited by 148 · see citing works
Inflammation, adiponectin, obesity and cardiovascular risk
Mangge, H., Almer, G., Truschnig-Wilders, M., Schmidt, A., Gasser, R., & Fuchs, D. (2010) · Current Medicinal Chemistry · doi:10.2174/092986710794183006 · Cited by 142 · see citing works
Self-citationNitric oxide and energy metabolism in mammals
Dai, Z., Wu, Z., Yang, Y., Wang, J., Satterfield, M. C., Meininger, C. J., Bazer, F. W., & Wu, G. (2013) · BioFactors · doi:10.1002/biof.1099 · Cited by 127 · see citing works
Codoñer‐Franch, P., Tavárez-Alonso, S., Murria-Estal, R., Megías-Vericat, J., Tortajada‐Girbés, M., & Alonso‐Iglesias, E. (2011) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2010.12.035 · Cited by 120 · see citing works
Liang, C., Liu, J. T., Wang, Y., Xu, A., & Vanhoutte, P. M. (2013) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.112.301087 · Cited by 112 · see citing works
The vital role for nitric oxide in intraocular pressure homeostasis
Reina‐Torres, E., Ieso, M. L. D., Pasquale, L. R., Madekurozwa, M., Sherwood, J. M., Overby, D. R., & Stamer, W. D. (2020) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2020.100922 · Cited by 108 · see citing works
Regulatory roles for L-arginine in reducing white adipose tissue
Tan, B. (2012) · Frontiers in bioscience · doi:10.2741/4047 · Cited by 103 · see citing works
Obesity-Related Renal Injury in Childhood
Savino, A., Pelliccia, P., Chiarelli, F., & Mohn, A. (2010) · Hormone Research in Paediatrics · doi:10.1159/000308161 · Cited by 89 · see citing works
Gheibi, S., Jeddi, S., Carlström, M., Gholami, H., & Ghasemi, A. (2018) · Nitric Oxide · doi:10.1016/j.niox.2018.02.002 · Cited by 90 · see citing works
Gheibi, S., Bakhtiarzadeh, F., Jeddi, S., Farrokhfall, K., Zardooz, H., & Ghasemi, A. (2017) · Nitric Oxide · doi:10.1016/j.niox.2017.01.003 · Cited by 79 · see citing works
Impact of Obesity in Kidney Diseases
Kotsis, V., Martínez, F., Trakatelli, C., & Redón, J. (2021) · Nutrients · doi:10.3390/nu13124482 · Cited by 76 · see citing works
Blot, S. (2021) · Intensive Care Medicine · doi:10.1007/s00134-020-06276-z · Cited by 73 · see citing works
Mitochondrial involvement in skeletal muscle insulin resistance: A case of imbalanced bioenergetics
Affourtit, C. (2016) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2016.07.008 · Cited by 67 · see citing works
Childhood Obesity: Immune Response and Nutritional Approaches
Magrone, T., & Jirillo, E. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00076 · Cited by 67 · see citing works
“However, other studies have found no modifications of NO levels in obese children (105).”
BackgroundReference values for serum nitric oxide metabolites in an adult population
Ghasemi, A., Zahediasl, S., & Azizi, F. (2009) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2009.09.011 · Cited by 62 · see citing works
Increased nitric oxide stress is associated with migraine
Gruber, H.-J., Bernecker, C., Lechner, A., Weiss, S., Wallner-Blazek, M., Meinitzer, A., Hoebarth, G., Renner, W., Fauler, G., Horejsi, R., et al. (2009) · Cephalalgia · doi:10.1111/j.1468-2982.2009.01964.x · Cited by 61 · see citing works
Self-citationFleury, N., Geldenhuys, S., & Gorman, S. (2016) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph13100999 · Cited by 61 · see citing works
Franklin, N. C., Robinson, A. T., Bian, J.-T., Ali, M. M., Norkeviciute, E., McGinty, P., & Phillips, S. A. (2015) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2014.0135 · Cited by 54 · see citing works
Genovesi, S., Giussani, M., Orlando, A., Lieti, G., Viazzi, F. C., & Parati, G. (2021) · Pediatric Nephrology · doi:10.1007/s00467-021-05144-2 · Cited by 53 · see citing works
Implications for kidney disease in obese children and adolescents
Savino, A., Pelliccia, P., Giannini, C., de Giorgis, T., Cataldo, I., Chiarelli, F., & Mohn, A. (2011) · Pediatric Nephrology · doi:10.1007/s00467-010-1659-y · Cited by 50 · see citing works
Correia‐Costa, L., Sousa, T., Morato, M., Cosme, D., Afonso, J., Areias, J. C., Schaefer, F. S., Guerra, A., Afonso, A. C., Azevedo, A., et al. (2016) · British Journal Of Nutrition · doi:10.1017/s0007114516002804 · Cited by 50 · see citing works
The Role of Nitric Oxide in Health and Diseases
Khazan, M., & Hdayati, M. (2014) · Scimetr · doi:10.5812/scimetr.20987 · Cited by 44 · see citing works
Beals, J. W., Binns, S. E., Davis, J., Giordano, G., Klochak, A. L., Paris, H. L. R., Schweder, M. M., Peltonen, G. L., Scalzo, R. L., & Bell, C. (2017) · Journal of Nutrition and Metabolism · doi:10.1155/2017/6436783 · Cited by 44 · see citing works
Hyperinsulinaemia in migraineurs is associated with nitric oxide stress
Gruber, H.-J., Bernecker, C., Pailer, S., Fauler, G., Horejsi, R., Möller, R., Lechner, A., Fazekas, F., & Truschnig-Wilders, M. (2009) · Cephalalgia · doi:10.1111/j.1468-2982.2009.02012.x · Cited by 44 · see citing works
Self-citationCombining Machine Learning and Metabolomics to Identify Weight Gain Biomarkers
Dias-Audibert, F. L., Navarro, L. C., de Oliveira, D. N., Delafiori, J., Melo, C. F. O. R., Guerreiro, T. M., Rosa, F. T., Petenuci, D. L., Watanabe, M. A. E., Velloso, L. A., et al. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.00006 · Cited by 43 · see citing works
Kresnajati, S., Lin, Y.-Y., Mündel, T., Bernard, J. R., Lin, H.-F., & Liao, Y. (2022) · Cells · doi:10.3390/cells11223544 · Cited by 42 · see citing works
Johnston, E. K., & Abbott, R. D. (2023) · Cells · doi:10.3390/cells12030407 · Cited by 41 · see citing works
Preeclampsia and Obesity—The Preventive Role of Exercise
Poniedziałek‐Czajkowska, E., Mierzyński, R., & Leszczyńska‐Gorzelak, B. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20021267 · Cited by 69 · see citing works
Ghasemi, A., & Zahediasl, S. (2011) · Europe PMC (PubMed Central) · Cited by 41 · see citing works
García-Sánchez, A., Gámez-Nava, J. I., la Cruz, E. N. D.-D., Cardona-Muñóz, E. G., Becerra-Alvarado, I. N., Aceves-Aceves, J. A., Sánchez-Rodríguez, E. N., & Miranda‐Díaz, A. G. (2020) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s245494 · Cited by 40 · see citing works
Leibowitz, A., Rehman, A., Paradis, P., & Schiffrin, E. L. (2013) · Hypertension · doi:10.1161/hypertensionaha.111.203521 · Cited by 39 · see citing works
Śledziński, T., Śledziński, M., Smolenski, R. T., & Świerczyński, J. (2009) · Obesity Surgery · doi:10.1007/s11695-009-0041-2 · Cited by 39 · see citing works
Role of NO/VASP Signaling Pathway against Obesity-Related Inflammation and Insulin Resistance
Kang, Y. M., Kim, F., & Lee, W. J. (2017) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2017.41.2.89 · Cited by 37 · see citing works
Nitric oxide and clustering of metabolic syndrome components in pediatrics
Ghasemi, A., Zahediasl, S., & Azizi, F. (2009) · European Journal of Epidemiology · doi:10.1007/s10654-009-9382-3 · Cited by 34 · see citing works
eNOS haplotype associated with hypertension in obese children and adolescents
Souza-Costa, D. C., Belo, V. D. A., Silva, P. S., Metzger, I. F., Lanna, C. M. M., Machado, M. A., & Tanus-Santos, J. E. (2010) · International Journal of Obesity · doi:10.1038/ijo.2010.146 · Cited by 34 · see citing works
Moon, J., Kim, O. Y., Jo, G., & Shin, M. (2017) · Nutrients · doi:10.3390/nu9070740 · Cited by 33 · see citing works
Say NO to Obesity-Related Hypertension
Rajapakse, N. W., Head, G. A., & Kaye, D. M. (2016) · Hypertension · doi:10.1161/hypertensionaha.116.06778 · Cited by 31 · see citing works
Bariatric Surgery Normalizes Protein Glycoxidation and Nitrosative Stress in Morbidly Obese Patients
Choromańska, B., Myśliwiec, P., Łuba, M., Wojskowicz, P., Myśliwiec, H., Choromańska, K., Dadan, J., Żendzian‐Piotrowska, M., Zalewska, A., & Maciejczyk, M. (2020) · Antioxidants · doi:10.3390/antiox9111087 · Cited by 30 · see citing works
Arginase inhibition restores endothelial function in diet-induced obesity
Chung, J. H., Moon, J., Lee, Y. S., Chung, H.-K., Lee, S.-M., & Shin, M. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.07.083 · Cited by 31 · see citing works
Augmented endothelial‐specific L ‐arginine transport prevents obesity‐induced hypertension
Rajapakse, N. W., Karim, F., Straznicky, N. E., Fernandez, S., Evans, R. G., Head, G. A., & Kaye, D. M. (2014) · Acta Physiologica · doi:10.1111/apha.12344 · Cited by 31 · see citing works
Foroumandi, E., Alizadeh, M., Kheirouri, S., & Jafarabadi, M. A. (2019) · PLoS ONE · doi:10.1371/journal.pone.0213307 · Cited by 29 · see citing works
Peyton, K. J., Liu, X., Shebib, A. R., Johnson, F. K., Johnson, R. A., & Durante, W. (2018) · Amino Acids · doi:10.1007/s00726-018-2567-x · Cited by 26 · see citing works
Sansbury, B. E., Bhatnagar, A., & Hill, B. G. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00453 · Cited by 24 · see citing works
Elevated nitric oxide metabolites are associated with obesity in women.
Ghasemi, A., Zahediasl, S., & Azizi, F. (2013) · PubMed · Cited by 26 · see citing works
Antiobesogenic Role of Endothelial Nitric Oxide Synthase
Sansbury, B. E., & Hill, B. G. (2014) · Vitamins and hormones · doi:10.1016/b978-0-12-800254-4.00013-1 · Cited by 25 · see citing works
Telomere shortening associates with elevated insulin and nuchal fat accumulation
Mangge, H., Herrmann, M., Almer, G., Zelzer, S., Moeller, R., Horejsi, R., & Renner, W. (2020) · Scientific Reports · doi:10.1038/s41598-020-63916-6 · Cited by 23 · see citing works
Self-citationAssociation of body mass index and insulin resistance with metabolic syndrome in Brazilian children.
Ferreira, A. P., Nóbrega, O. D. T., & de França, N. M. (2009) · PubMed · doi:10.1590/s0066-782x2009000800013 · Cited by 23 · see citing works
Nitric Oxide Exerts Basal and Insulin-Dependent Anorexigenic Actions in POMC Hypothalamic Neurons
Wellhauser, L., Chalmers, J. A., & Belsham, D. D. (2016) · Molecular Endocrinology · doi:10.1210/me.2015-1275 · Cited by 22 · see citing works
Moreira, L. D. S. G., Fanton, S., Cardozo, L., Borges, N. A., Combet, E., Shiels, P. G., Stenvinkel, P., & Mafra, D. (2021) · Nutrition Reviews · doi:10.1093/nutrit/nuab074 · Cited by 23 · see citing works
Andrade, V. L., Sertorio, J. T. C., Eleuterio, N. M., Tanus-Santos, J. E., Fernandes, K., & Sandrim, V. C. (2013) · Nitric Oxide · doi:10.1016/j.niox.2013.07.005 · Cited by 20 · see citing works
de Miranda, J. A., Lacchini, R., Belo, V. D. A., Lanna, C. M. M., Sertorio, J. T. C., Luizon, M. R., & Tanus-Santos, J. E. (2014) · Journal of Human Hypertension · doi:10.1038/jhh.2014.48 · Cited by 19 · see citing works
de Assumpção, C. R. L., Brunini, T. M. C., Pereira, N. R., Godoy‐Matos, A. F., Siqueira, M. A. S., Mann, G. E., & Mendes‐Ribeiro, A. C. (2010) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2010.10.003 · Cited by 18 · see citing works
Obesity- and sex-related metabolism of arginine and nitric oxide in adults
Wierzchowska-McNew, R. A., ENGELEN, M. P. K. J., Thaden, J. J., Have, G. A. M. T., & Deutz, N. E. P. (2022) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqac277 · Cited by 17 · see citing works
Ralt, D. (2009) · Medical Hypotheses · doi:10.1016/j.mehy.2009.03.049 · Cited by 17 · see citing works
Pietro, N. D., Marcovecchio, M. L., Silvestre, S. D., de Giorgis, T., Cordone, V. G. P., Lanuti, P., Chiarelli, F., Bologna, G., Mohn, A., & Pandolfi, A. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.01.001 · Cited by 17 · see citing works
Bahadoran, Z., Mirmiran, P., Jeddi, S., Carlström, M., Azizi, F., & Ghasemi, A. (2019) · Free Radical Research · doi:10.1080/10715762.2019.1587168 · Cited by 17 · see citing works
Nitric oxide and insulin resistance
(2015) · Immunoendocrinology · doi:10.14800/ie.657 · Cited by 16 · see citing works
Alizadeh, M., Daneghian, S., Ghaffari, A., Ostadrahimi, A., Safaeiyan, A., Estakhri, R., & Gargari, B. P. (2010) · Europe PMC (PubMed Central) · Cited by 15 · see citing works
Impact of obesity and nitric oxide synthase gene G894T polymorphism on essential hypertension.
Wrzosek, M., Sokal, M., Sawicka, A., Włodarczyk, M., Głowala, M., Wrzosek, M., Kosior, M., Tałałaj, M., Biecek, P., & Nowicka, G. (2015) · PubMed · Cited by 15 · see citing works
Watve, M. (2012) · Springer eBooks · doi:10.1007/978-1-4614-4409-1_7 · Cited by 13 · see citing works
Role of iNOS in Insulin Resistance and Endothelial Dysfunction
Aggarwal, H., Kanuri, B., & Dikshit, M. (2019) · Springer eBooks · doi:10.1007/978-981-13-8273-4_21 · Cited by 12 · see citing works
Śladowska-Kozłowska, J., Litwin, M., Niemirska, A., Wierzbicka, A., Roszczynko, M., & Szperl, M. (2015) · Pediatric Nephrology · doi:10.1007/s00467-015-3164-9 · Cited by 12 · see citing works
Legumes: A component of a healthy diet.
Azadbakht, L., Haghighatdoost, F., & Esmaillzadeh, A. (2011) · Europe PMC (PubMed Central) · Cited by 11 · see citing works
Mietus‐Snyder, M., Narayanan, N., Krauss, R. M., Laine-Graves, K., McCann, J. C., Shigenaga, M. K., McHugh, T. H., Ames, B. N., & Suh, J. H. (2020) · PLoS ONE · doi:10.1371/journal.pone.0240437 · Cited by 11 · see citing works
Reference values for serum nitric oxide metabolites in pediatrics
Ghasemi, A., Zahediasl, S., & Azizi, F. (2010) · Nitric Oxide · doi:10.1016/j.niox.2010.07.007 · Cited by 11 · see citing works
Machado, E. D. A., Farinatti, P., Sicuro, F. L., Rodrigues, F., Bouskela, E., & Collett‐Solberg, P. F. (2021) · Obesity Research & Clinical Practice · doi:10.1016/j.orcp.2021.04.004 · Cited by 10 · see citing works
Increased Dopamine Is Associated With the cGMP and Homocysteine Pathway in Female Migraineurs
Gruber, H., Bernecker, C., Pailer, S., Lechner, A., Horejsi, R., Möller, R., Fazekas, F., & Truschnig‐Wilders, M. (2009) · Headache The Journal of Head and Face Pain · doi:10.1111/j.1526-4610.2009.01533.x · Cited by 10 · see citing works
Self-citationPietrantonio, N. D., Palmerini, C., Pipino, C., BALDASSARRE, M. P. A., Bologna, G., Mohn, A., Giannini, C., Lanuti, P., Chiarelli, F., Pandolfi, A., et al. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2021.166076 · Cited by 10 · see citing works
Adiponectin associates positively with nitrite levels in children and adolescents
Belo, V. D. A., Souza-Costa, D. C., Lacchini, R., Sertorio, J. T. C., Lanna, C. M. M., Carmo, V. P., & Tanus-Santos, J. E. (2012) · International Journal of Obesity · doi:10.1038/ijo.2012.104 · Cited by 9 · see citing works
Saghebjoo, M., Farrokhi-Fard, M., Hedayati, M., & Sadeghi-Tabas, S. (2019) · Obesity Medicine · doi:10.1016/j.obmed.2019.100139 · Cited by 9 · see citing works
Široká, M., Franco, C., Guľašová, Z., Hertelyová, Z., Tomečková, V., Rodella, L. F., & Rezzani, R. (2020) · European Journal of Histochemistry · doi:10.4081/ejh.2020.3081 · Cited by 9 · see citing works
Akçaboy, M., Kula, S., Göktaş, T., Nazlıel, B., Terlemez, S., Çelik, N., Çelik, B., & Buyan, N. (2015) · Pediatric Nephrology · doi:10.1007/s00467-015-3223-2 · Cited by 8 · see citing works
Jang, S., Palzer, E. F., Rudser, K. D., Fox, C. K., Hebbel, R. P., Dengel, D. R., Milbauer, L. C., Kelly, A. S., & Ryder, J. R. (2022) · Journal of the American Heart Association · doi:10.1161/jaha.122.026430 · Cited by 8 · see citing works
Impact of Vitamin D Supplementation on Inflammatory Markers’ Levels in Obese Patients
Wiciński, M., Ozorowski, M., Wódkiewicz, E., Otto, S. W., Kubiak, K., & Malinowski, B. (2021) · Current Issues in Molecular Biology · doi:10.3390/cimb43030114 · Cited by 7 · see citing works
Yousefzadeh, N., Jeddi, S., Shokri, M., Afzali, H., Norouzirad, R., Kashfi, K., & Ghasemi, A. (2021) · Archives of Medical Research · doi:10.1016/j.arcmed.2021.09.007 · Cited by 7 · see citing works
Free Radicals and Metabolic Disorders
Cohen, G., Riahi, Y., & Sasson, S. (2012) · Wiley eBooks · doi:10.1002/9781119953678.rad057 · Cited by 7 · see citing works
Metformin influences on respiratory system in obese mice induced by postnatal overnutrition
Dias, M. D., Goulart, M., Dalécio, C., Enes-Marques, S., Salles, É. L., Venâncio, M., Pereira, E. M., Paffaro, V. A., Incerpi, E. K., & Soncini, R. (2017) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2017.09.010 · Cited by 6 · see citing works
Son, W.-H., Jeong, W.-M., Park, I. Y., & Ha, M. (2024) · Mediators of Inflammation · doi:10.1155/mi/5520987 · Cited by 5 · see citing works
Different Natriuretic Responses in Obese and Lean Rats in Response to Nitric Oxide Reduction
Ambrozewicz, M. A., Khraibi, A. A., Simsek‐Duran, F., DeBose, S. C., Baydoun, H., & Dobrian, A. D. (2011) · American Journal of Hypertension · doi:10.1038/ajh.2011.79 · Cited by 5 · see citing works
Anti-Obesity Activity of Guava Branch Extract in the Co-Culture System of Adipocytes and Macrophages
Kim, Y., Choi, J.-M., & Kim, Y. (2022) · Journal of the Korean Society of Food Science and Nutrition · doi:10.3746/jkfn.2022.51.2.107 · Cited by 4 · see citing works
Yousefzadeh, N., Jeddi, S., Afzali, H., Kashfi, K., & Ghasemi, A. (2022) · Cell Biochemistry and Function · doi:10.1002/cbf.3741 · Cited by 4 · see citing works
Obesity, Intestinal Inflammation, and Antioxidant Bioavailability
Campbell, S. C. (2012) · Journal of Nutrition & Food Sciences · doi:10.4172/2155-9600.1000e102 · Cited by 3 · see citing works
Purwadianti, N., Oenzil, F., & Sulastri, D. (2015) · Jurnal Kesehatan Andalas · doi:10.25077/jka.v4i2.255 · Cited by 3 · see citing works
Nauli, F., Nurhasanah, N., Mahati, E., & Bahrudin, U. (2021) · Molecular and Cellular Biomedical Sciences · doi:10.21705/mcbs.v5i1.165 · Cited by 3 · see citing works
Nitric Oxide Bioavailability and Insulin Resistance: An Overview
Kobayashi, J. (2022) · Book Publisher International (a part of SCIENCEDOMAIN International) · doi:10.9734/bpi/capr/v8/4440a · Cited by 2 · see citing works
Decreased serum level of nitric oxide in children with excessive body weight
Czumaj, A., Sledzińska, M., Brzeziński, M., Szlagatys‐Sidorkiewicz, A., Slominska, E. M., & Śledziński, T. (2018) · Advances in Clinical and Experimental Medicine · doi:10.17219/acem/77982 · Cited by 2 · see citing works
Bi̇lgi̇n, G. D., Büyükuslu, N., Eyüpoğlu, O. E., & Cumbul, A. (2023) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2023.106784 · Cited by 2 · see citing works
Ganji, V., Taranikanti, M., KARRE, M., Kalpana, M., John, N. A., Umesh, M., & Archana Gaur, T. (2023) · Medical Research Archives · doi:10.18103/mra.v11i12.4798 · Cited by 1 · see citing works
Esposito, E., Indolfi, C., Pirozzi, C., Correale, M., Bello, I., Casale, V., Panza, E., Raso, G. M., Meli, R., Sorrentino, R., et al. (2026) · Life Sciences · doi:10.1016/j.lfs.2026.124448 · Cited by 1 · see citing works
Pluta, W. W., Lubkowska, A., & Dudzińska, W. (2026) · International Journal of Obesity · doi:10.1038/s41366-026-02127-x · Cited by 1 · see citing works
Lovejoy, J. C., & Sasagawa, M. (2010) · Current Cardiovascular Risk Reports · doi:10.1007/s12170-010-0094-8 · Cited by 1 · see citing works
Woo, J., Shin, K.-O., Kim, K., Kim, Y., & Kang, S. (2010) · Journal of Life Science · doi:10.5352/jls.2010.20.9.1394 · Cited by 1 · see citing works
L-ARGININE DETERMINATION IN BIOLOGICALLY ACTIVE ADDITIVE BY VOLTAMMETRY
Popova, V. A., Ponomareva, M., & Korotkova, E. I. (2020) · IZVESTIYA VYSSHIKH UCHEBNYKH ZAVEDENIY KHIMIYA KHIMICHESKAYA TEKHNOLOGIYA · doi:10.6060/ivkkt.20206307.6191 · Cited by 1 · see citing works
Campos, J., & Brill, A. G. (2020) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.120.315380 · Cited by 1 · see citing works
Bonifacio, K., Maes, M., de Farias, C., Matsumoto, A., Tomereli, C., da Silva, D. P., Cyrino, E. S., Nixdorf, S., Venturini, D., & Barbosa, D. (2020) · Preprints.org · doi:10.20944/preprints202006.0283.v1 · Cited by 1 · see citing works
- Authors
- Gruber, H.-J., Mayer, C., Mangge, H., Fauler, G., Grandits, N., & Wilders-Truschnig, M.
- Affiliations
- University of Graz (AT)
- Corresponding author
- Gruber, H-J
- Venue
- International Journal of Obesity
- Published
- 2008-01-15
- Volume
- 32
- Issue
- 5
- Pages
- 826-831
- ISSN
- 0307-0565 (ISSN-L)
- 1476-5497
- OpenAlex
- W1993701796
- Cited by
- 119
- References
- 32
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 1 · 2023: 7 · 2022: 7 · 2021: 8 · 2020: 13 · 2019: 6 · 2018: 4 · 2017: 8 · 2016: 7 · 2015: 8 · 2014: 9 · 2013: 6 · 2012: 6
- FWCI
- 5.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- International Journal of Obesity (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Bundesministerium für Gesundheit
- Medizinische Universität Graz
- Topics
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- nitric oxide bioavailability, youth obesity, children, L-arginine, citrulline, nitric oxide synthase, oxidized LDL, GABA, atherogenesis, intima-media thickness, body weight
- MeSH terms
- Adolescent, Arginine, Cardiovascular Diseases, Citrulline, Female, Humans, Insulin Resistance, Male, Nitric Oxide, Obesity
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review