Isoflavonoid photoprotection in mouse and human skin is dependent on metallothionein

Effects of flavonoids on immune and inflammatory cell functions

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Isoflavonoid Compounds from Red Clover (Trifolium pratense) Protect from Inflammation and Immune Suppression Induced by UV Radiation¶

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Protective Effect of the Isoflavonoid Equol Against Hairless Mouse Skin Carcinogenesis Induced by UV Radiation Alone or with a Chemical Cocarcinogen¶

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EFFECT OF IMMUNOSUPPRESSIVE AGENTS AND SUNSCREENS ON UV CARCINOGENESIS IN THE HAIRLESS MOUSE

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Novel Function of Metallothionein in Photoprotection: Metallothionein-Null Mouse Exhibits Reduced Tolerance Against Ultraviolet B Injury in the Skin

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Distribution of metallothionein in normal and pathological human skin

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Immunoprotective UVA (320–400 nm) Irradiation Upregulates Heme Oxygenase-1 in the Dermis and Epidermis of Hairless Mouse Skin

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Protective effects of cadmium chloride against UVB injury in mouse skin and in cultured human cells: a possible role of cadmium-induced metallothionein.

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Carnosine (beta-alanylhistidine) protects from the suppression of contact hypersensitivity by ultraviolet B (280-320 nm) radiation or by cis urocanic acid.

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Cutaneous Metallothionein Induction by Ultraviolet B Irradiation in Interleukin-6 Null Mice

Nishimura, N., Satoh, M., Tohyama, C., Reeve, V. E., & Nishimura, H. (2000) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2000.00862.x · Cited by 37 · see citing works

Possible role of cutaneous metallothionein in protection against photo-oxidative stress--epidermal localization and scavenging activity for superoxide and hydroxyl radicals.

Hanada, K., Baba, T., Hashimoto, I., Fukui, R., & Watanabe, S. (1992) · PubMed · Cited by 35 · see citing works

IN VIVO PHOTOINDUCTION OF METALLOTHIONEIN IN HUMAN SKIN BY ULTRAVIOLET IRRADIATION

Anstey, A. V., Marks, R., LONG, C., Navabi, H., Pearse, A. D., Wynford‐Thomas, D., & Jasani, B. (1996) · The Journal of Pathology · doi:10.1002/(sici)1096-9896(199601)178:1 · Cited by 33 · see citing works

Ultraviolet radiation and the contact hypersensitivity reaction in mice

Reeve, V. E. (2002) · Methods · doi:10.1016/s1046-2023(02)00206-2 · Cited by 32 · see citing works

Lack of metallothionein‐I and ‐II exacerbates the immunosuppressive effect of ultraviolet B radiation and cis‐urocanic acid in mice

Reeve, V. E., Nishimura, N., Bosnic, M., Michalska, A., & Choo, K. H. A. (2000) · Immunology · doi:10.1046/j.1365-2567.2000.00026.x · Cited by 32 · see citing works

Regulation of metallothionein gene expression by TNF-α and IFN-β in human fibroblasts

Sciavolino, P. J., & Vilček, J. (1995) · Cytokine · doi:10.1006/cyto.1995.0028 · Cited by 29 · see citing works

Genistein increases metallothionein expression in human intestinal cells, Caco-2

Kuo, S., & Leavitt, P. S. (1999) · Biochemistry and Cell Biology · doi:10.1139/o99-012 · Cited by 26 · see citing works

Induction of Metallothionein in Human Skin by Routine Exposure to Sunlight: Evidence for a Systemic Response and Enhanced Induction at Certain Body Sites

Ablett, E. M., Whiteman, D. C., Boyle, G. M., Green, A. C., & Parsons, P. G. (2003) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2003.12025.x · Cited by 25 · see citing works

Estrogen response element-independent regulation of gene expression by genistein in intestinal cells

Hua, P., Tsai, W.-J., & Kuo, S. (2003) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/s0167-4781(03)00075-7 · Cited by 22 · see citing works

Quercetin Cumulatively Enhances Copper Induction of Metallothionein in Intestinal Cells

Kuo, S., Huang, C.-T., Blum, P. S., & Chang, C. (2001) · Biological Trace Element Research · doi:10.1385/bter:84:1-3:001 · Cited by 20 · see citing works

Animal models of ultraviolet radiation-induced skin cancer

Reeve, V. E., & Ley, R. D. (2004) · Cancer prevention, cancer causes · doi:10.1007/978-94-017-0511-0_10 · Cited by 10 · see citing works

Expression of metallothioneins‐I and ‐II isoforms at positive patch‐test sites

Santucci, B., Amantea, A., Giuliano, M., Valenzano, C., & Cristaudo, A. (2000) · Contact Dermatitis · doi:10.1034/j.1600-0536.2000.043002103.x · Cited by 8 · see citing works

Biological Weighting Function of the UV-B–induced Impairment of Phototaxis in the Freshwater Ciliate Ophryoglena flava¶

Marangoni, R., Marroni, F., Gioffré, D., Ghetti, F., & Colombetti, G. (2004) · Photochemistry and Photobiology · doi:10.1562/0031-8655(2004)080 · Cited by 2 · see citing works

Skin aging and oxidative stress: Equol’s anti-aging effects via biochemical and molecular mechanisms

Lephart, E. D. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.08.001 · Cited by 325 · see citing works

The latest on skin photoprotection

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Metallothionein: A Comprehensive Review of Its Classification, Structure, Biological Functions, and Applications

Yang, R., Roshani, D., Gao, B., Li, P., & Shang, N. (2024) · Antioxidants · doi:10.3390/antiox13070825 · Cited by 175 · see citing works

Recent advances in urocanic acid photochemistry, photobiology and photoimmunology

Gibbs, N. K., Tye, J., & Norval, M. (2008) · Photochemical & Photobiological Sciences · doi:10.1039/b717398a · Cited by 159 · see citing works

The Consequences of UV‐Induced Immunosuppression for Human Health

Norval, M., & Halliday, G. M. (2011) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.2011.00969.x · Cited by 155 · see citing works

Hepatoprotection of quercetin against oxidative stress by induction of metallothionein expression through activating MAPK and PI3K pathways and enhancing Nrf2 DNA-binding activity

Weng, C., Chen, M.-J., Yeh, C., & Yen, G. (2011) · New Biotechnology · doi:10.1016/j.nbt.2011.05.003 · Cited by 106 · see citing works

Flavonoids as photoprotective agents: A systematic review

Filho, J. M. T. D. A., Sampaio, P. A., Emanuella, C. V. P., Raimundo, G. D. O.-J., Fabrício, S. S., Jackson, R. G. D. S. A., Larissa, A. R., Nunes, X. P., & Edigênia, C. D. C. A. (2016) · Journal of Medicinal Plants Research · doi:10.5897/jmpr2016.6273 · Cited by 85 · see citing works

Nutrition for Healthy Skin

Krutmann, J., & Humbert, P. G. (2010) · Springer eBooks · doi:10.1007/978-3-642-12264-4 · Cited by 81 · see citing works

Evaluation of drug and sunscreen permeation via skin irradiated with UVA and UVB: Comparisons of normal skin and chronologically aged skin

Hung, C., Fang, C.-L., Al‐Suwayeh, S. A., Yang, S.-Y., & Fang, J. (2012) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2012.09.005 · Cited by 63 · see citing works

Identification of phenylpropanoid biosynthetic genes and phenylpropanoid accumulation by transcriptome analysis of Lycium chinense

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Estrogen receptor signaling protects against immune suppression by UV radiation exposure

Widyarini, S., Domanski, D., Painter, N., & Reeve, V. E. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603642103 · Cited by 58 · see citing works

Phytoestrogens (Resveratrol and Equol) for Estrogen-Deficient Skin—Controversies/Misinformation versus Anti-Aging In Vitro and Clinical Evidence via Nutraceutical-Cosmetics

Lephart, E. D. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222011218 · Cited by 55 · see citing works

Topical ‘Sydney’ Propolis Protects against UV-Radiation-Induced Inflammation, Lipid Peroxidation and Immune Suppression in Mouse Skin

Cole, N., Sou, P. W., Ngo, A., Tsang, K. H., Severino, J. A. J., Arun, S. J., Duke, C. C., & Reeve, V. E. (2009) · International Archives of Allergy and Immunology · doi:10.1159/000265530 · Cited by 46 · see citing works

Vitamin D and Death by Sunshine

Dixon, K. M., Tongkao‐on, W., Sequeira, V. B., Carter, S. E., Song, E., Rybchyn, M. S., Gordon‐Thomson, C., & Mason, R. S. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms14011964 · Cited by 45 · see citing works

Equol’s Anti-Aging Effects Protect against Environmental Assaults by Increasing Skin Antioxidant Defense and ECM Proteins While Decreasing Oxidative Stress and Inflammation

Lephart, E. (2018) · Cosmetics · doi:10.3390/cosmetics5010016 · Cited by 42 · see citing works

Protective effect of the isoflavone equol against DNA damage induced by ultraviolet radiation to hairless mouse skin

Widyarini, S. (2006) · Journal of Veterinary Science · doi:10.4142/jvs.2006.7.3.217 · Cited by 37 · see citing works

The two faces of metallothionein in carcinogenesis: photoprotection against UVR-induced cancer and promotion of tumour survival

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Red clover ( Trifolium pratense L.) isoflavones: root phenolic compounds affected by biotic and abiotic stress factors

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Phyto-SERM Constitutes from Flemingia macrophylla

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Topical isoflavonoids reduce experimental cutaneous inflammation in mice

Bandara, M., Arun, S. J., Allanson, M., Widyarini, S., Chai, Z., & Reeve, V. E. (2010) · Immunology and Cell Biology · doi:10.1038/icb.2010.26 · Cited by 21 · see citing works

Photoimmune protective effect of the phytoestrogenic isoflavonoid equol is partially due to its antioxidant activities

Widyarini, S., Domanski, D., Painter, N., & Reeve, V. E. (2012) · Photochemical & Photobiological Sciences · doi:10.1039/c2pp25022e · Cited by 16 · see citing works

Oral Administration of Fermented Soymilk Products Protects the Skin of Hairless Mice against Ultraviolet Damage

Mitsuyoshi, K. A. N. O., Kubota, N., Masuoka, N., Hori, T., Miyazaki, K., & Ishikawa, F. (2016) · Nutrients · doi:10.3390/nu8080514 · Cited by 15 · see citing works

The Role of Metallothioneins in Carcinogenesis

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Nanonutrition- and nanoparticle-based ultraviolet rays protection of skin

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PINGing Sunshine: A Review of the Evidence for Adding Non‐Filtering Photoprotective Ingredients to Sunscreens

Krutmann, J., Brown, A. E., Passeron, T., Granger, C., Gilaberte, Y., Trullàs, C., Piquero‐Casals, J., Leone, G., Schalka, S., & Lim, H. W. (2025) · Photodermatology Photoimmunology & Photomedicine · doi:10.1111/phpp.70062 · Cited by 8 · see citing works

The role of metallothionein in a dinitrofluorobenzene-induced atopic dermatitis-like murine model

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Induction of Biosynthetic Genes Related to Rosmarinic Acid in Plant Callus Culture and Antiproliferative Activity Against Breast Cancer Cell Line

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Posicionamiento de la Asociación Española para el Estudio de la Menopausia sobre el uso clínico de las isoflavonas en el climaterio

Juliá, M. D., Ferrer, J., Allué, J., Bachiller, L. I., Beltrán, E., Hidalgo, M. J. C., Castelo‐Branco, C., Durán, M., Forteza, A., Haya, J., et al. (2008) · Progresos de Obstetricia y Ginecología · doi:10.1016/s0304-5013(08)71069-0 · Cited by 3 · see citing works

The Beauty of Soy for Skin, Hair, and Nails

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Soybean Protective Effect to 8-OHdG on UVB Induced-Hairless Mice

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Sunlight Protection by Vitamin D Compounds

Mason, R. S., Rybchyn, M. S., & Dixon, K. M. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-809963-6.00110-3 · Cited by 2 · see citing works

Sunlight, skin cancer and vitamin D

Mason, R. S., & Dixon, K. M. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-91338-6.00043-4 · Cited by 1 · see citing works

Avaliação da atividade moduladora da expressão de proteínas de estresse de extratos de Anadenanthera colubrina, Pfaffia paniculata e Rhodiola rosea para aplicação cosmética antienvelhecimento

Magalhães, W. V. (2012) · doi:10.11606/d.9.2012.tde-10092012-135736

Potential Benefits of Soy for Skin, Hair, and Nails

Blair, R. M., & Tabor, A. (2010) · Springer eBooks · doi:10.1007/978-3-642-12264-4_10

FORO DE OPINIÓN

Juliá, M. D., Ferrer, J., Allué, J., Bachiller, L. I., Beltrán, E., Hidalgo, M. J. C., Castelo‐Branco, C., Durán, M., Forteza, A., Haya, J., et al. (2016)

Actualidad científica Cosmética al día

Comité, M. E. D., & De, E. (2016)

Vitamin D and Its Role in Photoprotection of the Skin

Gordon‐Thomson, C., Tongkao‐on, W., & Mason, R. S. (2012) · Oxidative stress and disease · doi:10.1201/b13714-10

Oral and Other Non-sunscreen Photoprotective Agents

González, S., & Gilaberte, Y. (2008) · Basic and clinical dermatology · doi:10.3109/9781420080858.016

Photoimmune protective effect of the phytoestrogenic isoflavonoid equol is partially due to its antioxidant activities

Widyarini, S., Domanski, D., Painter, N., & Reeve, V. E. (2012) · Photochemical & Photobiological Sciences · doi:10.1039/c2pp25022e · Cited by 16 · see citing works

The Topical Isoflavonoid NV‐07α Reduces Solar‐simulated UV‐induced Suppression of Mantoux Reactions in Humans¶

Friedmann, A. C., Halliday, G. M., Barnetson, R. S., Reeve, V. E., Walker, C., Patterson, C. R. S., & Damian, D. L. (2004) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.2004.tb00107.x · Cited by 7 · see citing works

Estrogen receptor signaling protects against immune suppression by UV radiation exposure

Widyarini, S., Domanski, D., Painter, N., & Reeve, V. E. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603642103 · Cited by 58 · see citing works

Protection Against Photoaging in the Hairless Mouse by the Isoflavone Equol

Reeve, V. E., Widyarini, S., Domanski, D., Chew, E., & Barnes, K. A. (2005) · Photochemistry and Photobiology · doi:10.1562/2005-07-26-ra-624 · Cited by 40 · see citing works

Topical isoflavonoids reduce experimental cutaneous inflammation in mice

Bandara, M., Arun, S. J., Allanson, M., Widyarini, S., Chai, Z., & Reeve, V. E. (2010) · Immunology and Cell Biology · doi:10.1038/icb.2010.26 · Cited by 21 · see citing works