The DOI matches its Crossref record; 41 of the 42 references it cites were found in a registry or an index.
Fractionated Illumination Significantly Improves the Response of Superficial Basal Cell Carcinoma to Aminolevulinic Acid Photodynamic Therapy
Open accessAbstract
Photodynamic therapy (PDT) of superficial basal cell carcinoma (sBCC) using topical 5-aminolevulinic acid (ALA) and a light fluence of 75-100 J cm(-2) yields unsatisfactory long-term results. In several animal models, illumination with two light fractions 2 hours apart was considerably more effective than single illumination. Response is further enhanced if the fluence of the first light fraction is reduced, although the cumulative fluence is maintained. We compared the response of sBCC to a single illumination and 2-fold illumination scheme in which two light fractions of 20 and 80 J cm(-2) are performed 4 and 6 hours after the application of a single dose of 20% ALA. We randomly assigned 154 patients with a total of 505 primary sBCC into two treatment groups. Two hundred and forty-three lesions were treated using a single illumination of 75 J cm(-2) at a fluence rate of 50 mW cm(-2). Fractionated PDT, at the same fluence rate, was performed on 262 lesions. The complete response (CR) following a 2-fold illumination scheme is significantly greater than that following a single light fraction (P=0.002, log-rank test). Twelve months after therapy, CR rate to a 2-fold illumination is 97%, whereas the CR to a single illumination is 89%.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Compared with single-illumination PDT, double-illumination PDT resulted in a significantly higher complete response rate at one year after treatment in patients with AK [66] or superficial BCC [65] lesions.”
From 5-Aminolevulinic Acid as a Theranostic Agent for Tumor Fluorescence Imaging and Photodynamic Therapy (2023) · cites this paper as [65]
In the citing paper
“PDT protocols with fractionated light illumination have been shown to enhance PDT outcomes [65].”
From 5-Aminolevulinic Acid as a Theranostic Agent for Tumor Fluorescence Imaging and Photodynamic Therapy (2023) · cites this paper as [65]
In the citing paper
“Particularly, a double-illumination PDT scheme with 20 and 80 J/cm2 at 4 and 6 h after topical ALA application yields a much better clinical response than conventional single 75 J/cm2 illumination at 4 h after ALA.”
From 5-Aminolevulinic Acid as a Theranostic Agent for Tumor Fluorescence Imaging and Photodynamic Therapy (2023) · cites this paper as [65]
Citations
Cites
Photodynamic therapy with endogenous protoporphyrin
Kennedy, J. C., Pottier, R. H., & Pross, D. C. (1990) · Journal of Photochemistry and Photobiology B: Biology · doi:10.1016/1011-1344(90)85083-9 · Cited by 1,509
Kennedy (1992) · doi:10.1016/1011-1344(92)85108-7 · Cited by 1,166
Optical-Thermal Response of Laser-Irradiated Tissue
Welch, A. J., & van Gemert, M. J. C. (1995) · Springer eBooks · doi:10.1007/978-1-4757-6092-7 · Cited by 705
Svanberg, K., Andersson, T., Killander, D., WANG, I., Stenram, U., Andersson‐Engels, S., Berg, R., Johansson, J., & Svanberg, S. R. (1994) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1994.tb03412.x · Cited by 414
Photodynamic Therapy Using Topical Methyl Aminolevulinate vs Surgeryfor Nodular Basal Cell Carcinoma
Rhodes, L. E., de Rie, M. A., Enström, Y., Groves, R. W., Morken, T., Goulden, V., Wong, G. A. E., Grob, J., Varma, S., & Wolf, P. (2004) · Archives of Dermatology · doi:10.1001/archderm.140.1.17 · Cited by 356
Comparison of photodynamic therapy with cryotherapy in the treatment of Bowen's disease
MORTON, C. A., WHITEHURST, C., MOSELEY, H., MCCOLL, J. H., MOORE, J. V., & MACKIE, R. M. (1996) · British Journal of Dermatology · doi:10.1046/j.1365-2133.1996.d01-1076.x · Cited by 306
Robinson, D. J., de Bruijn, H. S., van der Veen, N., Stringer, M. R., Brown, S. B., & Star, W. M. (1998) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1998.tb05177.x · Cited by 266
Self-citationCalzavara‐Pinton, P. (1995) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/1011-1344(95)90253-8 · Cited by 264
Soler, A., Warloe, T., Berner, A., & Giercksky, K. E. (2001) · British Journal of Dermatology · doi:10.1046/j.1365-2133.2001.04407.x · Cited by 224
Horn, M., Wolf, P., Wulf, H. C., Warloe, T., Fritsch, C., Rhodes, L. E., Kaufmann, R., de Rie, M. A., Legat, F. J., Stender, I., et al. (2003) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2003.05600.x · Cited by 202
Flagged first, then by citations
1 of the 42 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Oseroff, 1998, PDT for cutaneous malignancies: clinical applications and basic mechanisms, Photochem Photobiol, 67, 17S
Cited by
Sorted by citations
Items 101–118 of 118
Krlov, J., Z�ruba, K., ezanka, P., Poukov, P., Veverkov, L., & Kr�l, V. (2012) · InTech eBooks · doi:10.5772/26051
Terapia fotodynamiczna (PDT) w chorobach skóry - co nowego?
Kawczyk‐Krupka, A., Ledwoń, A., Karpe, J., Simon-Sieroń, M., & Sieroń, A. (2011) · Journal of Ecology and Health
Photodynamic therapy- pain and aspects of pain relief
Halldin, C. B. (2011) · Gothenburg University Publications Electronic Archive (Gothenburg University)
Fractionated PDT with 5-aminolevulinic acid: effective, cost effective, and patient friendly
de Vijlder, H. C., Middelburg, T. A., de Bruijn, H. S., Robinson, D. J., Neumann, H. A. M., & de Haas, E. R. M. (2009) · Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE · doi:10.1117/12.828542
Self-citationDesign of matrix irradiation system for external tissue phototeraphy
Silva, F. Y. L., Isakina, S. S., & de la Rosa, J. (2013) · International Conference on Electronics, Communications, and Computers · doi:10.1109/conielecomp.2013.6525757
Photodynamische Therapie — Stand 2008
Szeimies, R., & Klein, A. (2009) · Fortschritte der praktischen Dermatologie und Venerologie · doi:10.1007/978-3-540-77148-7_55
Terapia fotodinámica intralesional en el tratamiento del carcinoma basocelular nodular
Sixto, B. G. (2015) · Buleria (Universidad de León) · doi:10.18002/10612/5594
Non-invasive treatment of epidermal keratinocyte neoplasms
Kessels, J. P. H. M. (2018) · Research Publications (Maastricht University) · doi:10.26481/dis.20180523jk
Principles of Photodynamic Therapy
Ibbotson, S. H., & McKenna, K. E. (2016) · Wiley eBooks · doi:10.1002/9781118441213.rtd0022
How We Perform Photodynamic Therapy MAL in Clinical Practice
de Vijlder, H. C., & Neumann, H. A. M. (2011) · Springer eBooks · doi:10.1007/978-1-4419-1298-5_16
Advances in Photodynamic Therapy Protocols for Nonmelanoma Skin Cancer
Requena, M. B., Sálvio, A. G., & Bagnato, V. S. (2022) · Handbook of Oxidative Stress in Cancer: Therapeutic Aspects · doi:10.1007/978-981-16-1247-3_198-1
Advances in Photodynamic Protocols for Nonmelanoma Skin Cancer
Requena, M. B., Sálvio, A. G., & Bagnato, V. S. (2022) · Handbook of Oxidative Stress in Cancer: Therapeutic Aspects · doi:10.1007/978-981-16-5422-0_198
Tageslicht‐PDT bei Hochrisiko‐AK: Kombination mit LED‐Licht steigert Wirksamkeit
Szeimies, R. (2025) · JDDG Journal der Deutschen Dermatologischen Gesellschaft · doi:10.1111/ddg.15830_g
Goldsberry, A., Hanke, C. W., Sălăvăstru, C., & Siegel, D. (2015) · Elsevier eBooks · doi:10.1016/b978-0-323-26027-5.00033-4
Photodynamic therapy with 5-aminolevulinic acid for basal squamous cell carcinoma
Филоненко, Е. В., & Иванова-Радкевич, В. И. (2025) · Biomedical Photonics · doi:10.24931/2413-9432-2025-14-3-43-51
Christensen, E. (2013) · NORA - Norwegian Open Research Archives
Metadata
- Authors
- de Haas, E. R. M., Kruijt, B., Sterenborg, H. J. C. M., Martino Neumann, H. A., & Robinson, D. J.
- Affiliations
- Erasmus MC (NL)
- Corresponding author
- de Haas, Ellen R.M.
- Venue
- Journal of Investigative Dermatology
- Publisher
- Elsevier BV
- Published
- 2006-12
- Volume
- 126
- Issue
- 12
- Pages
- 2679-2686
- ISSN
- 0022-202X (ISSN-L)
- OpenAlex
- W2030663435
- Cited by
- 118
- References
- 42
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 3 · 2023: 4 · 2022: 3 · 2021: 5 · 2020: 5 · 2019: 3 · 2018: 6 · 2017: 2 · 2016: 7 · 2015: 4 · 2014: 4 · 2013: 13 · 2012: 7
- FWCI
- 6.86
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Investigative Dermatology (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Nonmelanoma Skin Cancer Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Photodynamic Therapy Research Studies
- Health Sciences › Medicine › Otorhinolaryngology › Head and Neck Cancer Studies
- Keywords
- superficial basal cell carcinoma, photodynamic therapy, 5-aminolevulinic acid, light fluence, complete response, topical photosensitizer, skin cancer treatment
- MeSH terms
- Adult, Aged, Aged, 80 and over, Aminolevulinic Acid, Basal Cell Carcinoma, Carcinoma, Basal Cell, Darkness, Humans, Light, Middle Aged, Photochemotherapy, Skin Neoplasms, Time Factors, Treatment Outcome, Photosensitizing Agents
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
