The DOI matches its Crossref record; 41 of the 42 references it cites were found in a registry or an index.
Fractionated Illumination Significantly Improves the Response of Superficial Basal Cell Carcinoma to Aminolevulinic Acid Photodynamic Therapy
Open accessAbstract
Photodynamic therapy (PDT) of superficial basal cell carcinoma (sBCC) using topical 5-aminolevulinic acid (ALA) and a light fluence of 75-100 J cm(-2) yields unsatisfactory long-term results. In several animal models, illumination with two light fractions 2 hours apart was considerably more effective than single illumination. Response is further enhanced if the fluence of the first light fraction is reduced, although the cumulative fluence is maintained. We compared the response of sBCC to a single illumination and 2-fold illumination scheme in which two light fractions of 20 and 80 J cm(-2) are performed 4 and 6 hours after the application of a single dose of 20% ALA. We randomly assigned 154 patients with a total of 505 primary sBCC into two treatment groups. Two hundred and forty-three lesions were treated using a single illumination of 75 J cm(-2) at a fluence rate of 50 mW cm(-2). Fractionated PDT, at the same fluence rate, was performed on 262 lesions. The complete response (CR) following a 2-fold illumination scheme is significantly greater than that following a single light fraction (P=0.002, log-rank test). Twelve months after therapy, CR rate to a 2-fold illumination is 97%, whereas the CR to a single illumination is 89%.
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In the citing paper
“Compared with single-illumination PDT, double-illumination PDT resulted in a significantly higher complete response rate at one year after treatment in patients with AK [66] or superficial BCC [65] lesions.”
From 5-Aminolevulinic Acid as a Theranostic Agent for Tumor Fluorescence Imaging and Photodynamic Therapy (2023) · cites this paper as [65]
In the citing paper
“PDT protocols with fractionated light illumination have been shown to enhance PDT outcomes [65].”
From 5-Aminolevulinic Acid as a Theranostic Agent for Tumor Fluorescence Imaging and Photodynamic Therapy (2023) · cites this paper as [65]
In the citing paper
“Particularly, a double-illumination PDT scheme with 20 and 80 J/cm2 at 4 and 6 h after topical ALA application yields a much better clinical response than conventional single 75 J/cm2 illumination at 4 h after ALA.”
From 5-Aminolevulinic Acid as a Theranostic Agent for Tumor Fluorescence Imaging and Photodynamic Therapy (2023) · cites this paper as [65]
Citations
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Madan, V., Lear, J. T., & Szeimies, R. (2010) · The Lancet · doi:10.1016/s0140-6736(09)61196-x · Cited by 916
Guidelines for topical photodynamic therapy: update
Morton, C. A., McKenna, K. E., & Rhodes, L. E. (2008) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2008.08882.x · Cited by 474
Interventions for basal cell carcinoma of the skin
Bath-Hextall, F. J., Perkins, W. A., Bong, J. L., & Williams, H. C. (2007) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003412.pub2 · Cited by 371
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Update of the European guidelines for basal cell carcinoma management
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Metadata
- Authors
- de Haas, E. R. M., Kruijt, B., Sterenborg, H. J. C. M., Martino Neumann, H. A., & Robinson, D. J.
- Affiliations
- Erasmus MC (NL)
- Corresponding author
- de Haas, Ellen R.M.
- Venue
- Journal of Investigative Dermatology
- Publisher
- Elsevier BV
- Published
- 2006-12
- Volume
- 126
- Issue
- 12
- Pages
- 2679-2686
- ISSN
- 0022-202X (ISSN-L)
- OpenAlex
- W2030663435
- Cited by
- 118
- References
- 42
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 3 · 2023: 4 · 2022: 3 · 2021: 5 · 2020: 5 · 2019: 3 · 2018: 6 · 2017: 2 · 2016: 7 · 2015: 4 · 2014: 4 · 2013: 13 · 2012: 7
- FWCI
- 6.86
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Investigative Dermatology (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Nonmelanoma Skin Cancer Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Photodynamic Therapy Research Studies
- Health Sciences › Medicine › Otorhinolaryngology › Head and Neck Cancer Studies
- Keywords
- superficial basal cell carcinoma, photodynamic therapy, 5-aminolevulinic acid, light fluence, complete response, topical photosensitizer, skin cancer treatment
- MeSH terms
- Adult, Aged, Aged, 80 and over, Aminolevulinic Acid, Basal Cell Carcinoma, Carcinoma, Basal Cell, Darkness, Humans, Light, Middle Aged, Photochemotherapy, Skin Neoplasms, Time Factors, Treatment Outcome, Photosensitizing Agents
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