The Use of Topical Nitroglycerin Ointment to Treat Peripheral Tissue Ischemia Secondary to Arterial Line Complications in Neonates
Abstract
Catheterization of the aorta through the umbilical artery and/or of peripheral arteries in neonates may be accompanied by a number of complications, of which thrombotic phenomena and peripheral vasospasm are the most common. Two neonates with peripheral ischemia caused by vasospasm from indwelling umbilical artery catheterization and one infant with left hand ischemia due to a left radial artery line were successfully treated with 2% nitroglycerin ointment. No adverse effects were noted.
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Continuous monitoring of certain vital signs such as blood pressure demands additional wired hardware such as peripheral and umbilical arterial catheters, which can induce complications including thrombus formation, occlusion, infection, rupture, pseudoaneurysm, bleeding, and death.
“Furthermore, continuous monitoring of certain vital signs, such as blood pressure, demands additional wired hardware, such as peripheral and umbilical arterial catheters4, which can induce other types of complications, including thrombus formation and occlusion, infection (e.g. sepsis), rupture, pseudoaneurysm, bleeding, and death5–7.”
From Skin-interfaced biosensors for advanced wireless physiological monitoring in neonatal and pediatric intensive-care units (2020) · cites this paper as [7]
Arterial lines for continuous blood pressure measurement in neonates can cause thrombosis, hematomas, infection, and even death.
“Although arterial lines offer a continuous measurement of blood pressure in neonates, these invasive interventions can cause thrombosis, hematomas, infection, and even death (34).”
From Binodal, wireless epidermal electronic systems with in-sensor analytics for neonatal intensive care (2019) · cites this paper as [34]
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- Authors
- Baserga, M. C., Puri, A., & Sola, A.
- Affiliations
- Cedars-Sinai Medical Center (US)
- Venue
- Journal of Perinatology
- Published
- 2002-06-27
- Volume
- 22
- Issue
- 5
- Pages
- 416-419
- ISSN
- 0743-8346 (ISSN-L)
- 1476-5543
- OpenAlex
- W2062978805
- Cited by
- 64
- References
- 14
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 4 · 2023: 5 · 2022: 4 · 2021: 11 · 2020: 5 · 2019: 2 · 2018: 1 · 2017: 2 · 2015: 1 · 2014: 4 · 2013: 3 · 2012: 5
- FWCI
- 1.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Perinatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Health Professions › Emergency Medical Services › Central Venous Catheters and Hemodialysis
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Vascular Procedures and Complications
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiovascular Conditions and Treatments
- Keywords
- peripheral vasospasm, thrombosis, radial artery catheterization
- MeSH terms
- Catheterization, Peripheral, Catheters, Indwelling, Female, Nitroglycerin, Humans, Infant, Newborn, Ischemia, Male, Ointments, Umbilical Arteries, Vasodilator Agents
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