Iatrogenic skin injury in the neonatal intensive care unit
Abstract
Although neonatal care has become more and more meticulous with significant changes in technology in the neonatal intensive care unit (NICU) in the past 50 years, iatrogenic cutaneous injuries continue to occur. Although the incidence of severe injuries is decreasing because the more difficult procedures are being replaced by improved techniques, skin injuries have not yet been completely eliminated. However, the nature and causes of cutaneous injuries have changed, and the injuries are frequent but generally minor. The major risk factors are low birth weight, gestational age, length of stay, a central venous line, mechanical ventilation, and support with continuous positive airway pressure. The rate of iatrogenic events is about 57% at gestational ages of 24-27 weeks, compared with 3% at term. There are no current comprehensive reviews of iatrogenic cutaneous injury. The purpose of this review is to describe the iatrogenic cutaneous injuries that may occur in the newborns as a consequence of perinatal and postnatal medical procedures. With increased survival of extremely-low-birth-weight (ELBW) infants and changing modes of management in the NICU, neonatologists must make every effort to recognize injuries and prevent their occurrence in the NICU.
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Current monitoring systems can cause iatrogenic skin injuries including adhesive-related tears, burns, infections, or pressure sores, leading to long-term morbidity.
“These systems can also cause iatrogenic skin injuries including adhesive-related tears, burns, infections, or pressure sores, leading to long-term morbidity. 3”
From Advanced wireless monitoring for children in the cardiac perioperative setting (2023) · cites this paper as [3]
Cites
Moritz, A. R., & Henriques, F. C. (1947) · PubMed · Cited by 1,198 · see citing works
Fitzgerald, M., Millard, C., & McIntosh, N. (1989) · Pain · doi:10.1016/0304-3959(89)90172-3 · Cited by 381 · see citing works
Mosby's Guide to Physical Examination.
Rogers, A. W. (1988) · Annals of Internal Medicine · doi:10.7326/0003-4819-108-3-500_8 · Cited by 201 · see citing works
Yong, S.-C., Chen, S.-J., & Boo, N. Y. (2005) · Archives of Disease in Childhood Fetal & Neonatal · doi:10.1136/adc.2004.069351 · Cited by 188 · see citing works
Garland, J. S., Buck, R. K., MALONEY, P., et al. (1995) · The Pediatric Infectious Disease Journal · doi:10.1097/00006454-199506000-00008 · Cited by 162 · see citing works
Major intravenous extravasation injuries
Upton, J. M., Mulliken, J. B., & Murray, J. E. (1979) · The American Journal of Surgery · doi:10.1016/0002-9610(79)90121-1 · Cited by 158 · see citing works
Extravasation injuries on regional neonatal units: Figure 1
Wilkins, C. E., & Emmerson, A. J. B. (2004) · Archives of Disease in Childhood Fetal & Neonatal · doi:10.1136/adc.2003.028241 · Cited by 152 · see citing works
Iatrogenic events in admitted neonates: a prospective cohort study
Ligi, I., Arnaud, F., Jouve, É., et al. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60204-4 · Cited by 137 · see citing works
Skin Necrosis From Extravasation of Intravenous Fluids in Children
Brown, A. S., Hoelzer, D. J., & Piercy, S. A. (1979) · Plastic & Reconstructive Surgery · doi:10.1097/00006534-197908000-00002 · Cited by 117 · see citing works
Alleviation of the pain of heel prick in preterm infants.
McIntosh, N., van Veen, L., & Brameyer, H. (1994) · Archives of Disease in Childhood Fetal & Neonatal · doi:10.1136/fn.70.3.f177 · Cited by 113 · see citing works
Experience with latrogenic Pediatric Vascular Injuriese
Flanigan, D. P., KEIFER, T. J., Schuler, J. J., Ryan, T. J., & Castronuovo, J. J. (1983) · Annals of Surgery · doi:10.1097/00000658-198310000-00003 · Cited by 104 · see citing works
NEONATAL VASCULAR CATHETERS AND THEIR COMPLICATIONS
Hogan, M. (1999) · Radiologic Clinics of North America · doi:10.1016/s0033-8389(05)70252-9 · Cited by 98 · see citing works
The scars of newborn intensive care
Cartlidge, P. H. T., Fox, P. E., & Rutter, N. (1990) · Early Human Development · doi:10.1016/0378-3782(90)90105-r · Cited by 95 · cited 2× · see citing works
“About 4% of infants leave the NICU with cosmetically or functionally significant scars [2].”
BackgroundMaking heel pricks less painful.
Harpin, V., & Rutter, N. (1983) · Archives of Disease in Childhood · doi:10.1136/adc.58.3.226 · Cited by 95 · see citing works
Advantages and disadvantages of different nasal CPAP systems in newborns
Buettiker, V., Hug, M., Baenziger, O., et al. (2004) · Intensive Care Medicine · doi:10.1007/s00134-004-2267-8 · Cited by 91 · see citing works
Kugelman, A., Inbar-Sanado, E., Shinwell, E. S., et al. (2008) · PEDIATRICS · doi:10.1542/peds.2007-2729 · Cited by 84 · see citing works
Treatment of peripheral tissue ischemia with topical nitroglycerin ointment in neonates
Wong, A., McCulloch, L. M., & Sola, A. (1992) · The Journal of Pediatrics · doi:10.1016/s0022-3476(05)80356-7 · Cited by 82 · see citing works
Alcohol burns in extremely low birthweight infants: still occurring: Figure 1
Reynolds, P. R., Banerjee, S., & Meek, J. H. (2004) · Archives of Disease in Childhood Fetal & Neonatal · doi:10.1136/adc.2004.054338 · Cited by 69 · see citing works
Percutaneous catheterization of the radial artery in the critically ill neonate
Todres, I. D., Rogers, M. C., Shannon, D. C., Moylan, F. M. B., & Ryan, J. F. (1975) · The Journal of Pediatrics · doi:10.1016/s0022-3476(75)80601-9 · Cited by 68 · see citing works
Reversal of Dopamine Extravasation Injury with Topical Nitroglycerin Ointment
Denkler, K. A., Cohen, B. E., & Denkler, K. A. (1989) · Plastic & Reconstructive Surgery · doi:10.1097/00006534-198911000-00017 · Cited by 64 · see citing works
Baserga, M. C., Puri, A., & Sola, A. (2002) · Journal of Perinatology · doi:10.1038/sj.jp.7210713 · Cited by 64 · see citing works
The Safety and Efficacy of Peripheral Intravenous Catheters in Ill Neonates
Franck, L. S., Hummel, D. L., Connell, K., et al. (2001) · Neonatal Network The Journal of Neonatal Nursing · doi:10.1891/0730-0832.20.5.33 · Cited by 61 · see citing works
Mannan, K., Chow, P., Lissauer, T., et al. (2007) · Acta Paediatrica · doi:10.1111/j.1651-2227.2007.00376.x · Cited by 59 · see citing works
WATKINS, A. M. C., & Keogh, E. J. (1992) · Journal of Paediatrics and Child Health · doi:10.1111/j.1440-1754.1992.tb02673.x · Cited by 58 · see citing works
FLETCHER, M. A., Brown, D., Landers, S., & Seguin, J. (1994) · American Journal of Perinatology · doi:10.1055/s-2007-994564 · Cited by 54 · see citing works
Mallon, E., Wojnarowska, F., Hope, P. L., et al. (1995) · Journal of the American Academy of Dermatology · doi:10.1016/0190-9622(95)91428-5 · Cited by 51 · see citing works
Neonatal nasal deformities secondary to nasal continuous positive airway pressure
Loftus, B. C., Ahn, J. M., & Haddad, J. (1994) · The Laryngoscope · doi:10.1288/00005537-199408000-00018 · Cited by 51 · see citing works
Severe Burns from a Pulse Oximeter
Murphy, K., SECUNDA, J. A., & Rockoff, M. A. (1990) · Anesthesiology · doi:10.1097/00000542-199008000-00028 · Cited by 51 · see citing works
Preventing the scars of neonatal intensive care.
Davies, J. M., Gault, D. T., & Buchdahl, R. (1994) · Archives of Disease in Childhood Fetal & Neonatal · doi:10.1136/fn.70.1.f50 · Cited by 49 · see citing works
Erosive Pustular Dermatosis of the Scalp after Perinatal Scalp Injury
Siegel, D. H., Holland, K. E., Phillips, R. J., et al. (2006) · Pediatric Dermatology · doi:10.1111/j.1525-1470.2006.00304.x · Cited by 45 · see citing works
Ultraviolet Light Burn:A Cutaneous Complication of Visible Light Phototherapy of Neonatal Jaundice
Siegfried, E. C., Stone, M. S., & Madison, K. C. (1992) · Pediatric Dermatology · doi:10.1111/j.1525-1470.1992.tb00348.x · Cited by 44 · see citing works
Subhani, M., Sridhar, S., & DeCristofaro, J. D. (2001) · Journal of Perinatology · doi:10.1038/sj.jp.7200493 · Cited by 43 · see citing works
Vivier, P. M., Lewander, W. J., Martin, H. F., et al. (1994) · Pediatric Emergency Care · doi:10.1097/00006565-199404000-00008 · Cited by 43 · see citing works
Adhesives and emollients in the preterm infant
Hoath, S. B., & Narendran, V. (2000) · Seminars in Neonatology · doi:10.1053/siny.2000.0015 · Cited by 43 · see citing works
Incidence of forearm and hand ischaemia related to radial artery cannulation in newborn infants
Hack, W. W. M., Vos, A., & Okken, A. (1990) · Intensive Care Medicine · doi:10.1007/bf01706325 · Cited by 39 · see citing works
Diller, K. R. (1985) · Springer eBooks · doi:10.1007/978-1-4684-8285-0_3 · Cited by 38 · see citing works
Wolf, G. D. (1948) · The American Journal of the Medical Sciences · doi:10.1097/00000441-194809000-00017 · Cited by 36 · see citing works
Gluteal skin necrosis after umbilical artery catheterisation.
Mann, N. P. (1980) · Archives of Disease in Childhood · doi:10.1136/adc.55.10.815 · Cited by 35 · see citing works
Gowdar, K. (1980) · American journal of diseases of children · doi:10.1001/archpedi.1980.02130220032010 · Cited by 35 · see citing works
Nasal trauma due to nasal continuous positive airway pressure in newborns: Figure 1
Shanmugananda, K., & Rawal, J. (2006) · Archives of Disease in Childhood Fetal & Neonatal · doi:10.1136/adc.2006.095034 · Cited by 34 · see citing works
Cohen, R. S., Ramachandran, P., Kim, E. H., et al. (1995) · PubMed · Cited by 34 · see citing works
Major full thickness skin burn injuries in premature neonate twins
Rimdeika, R., & Bagdonas, R. (2004) · Burns · doi:10.1016/j.burns.2004.04.009 · Cited by 33 · see citing works
Malloy, M. H., Cutter, G., Shannon, S. F., et al. (1992) · PEDIATRICS · Cited by 33 · see citing works
Mosby's Guide to Physical Examination.
(1991) · Annals of Internal Medicine · doi:10.7326/0003-4819-114-9-815_3 · Cited by 32 · see citing works
Tanzi, E. L., Hornung, R. L., & Silverberg, N. B. (2002) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/archpedi.156.2.188 · Cited by 32 · see citing works
Scalp changes after fetal monitoring.
Ashkenazi, S., Metzker, A., Merlob, P., et al. (1985) · Archives of Disease in Childhood · doi:10.1136/adc.60.3.267 · Cited by 31 · see citing works
Burning of a Neonate due to a Pulse Oximeter: Arterial Saturation Monitoring
Sobel, D. B. (1992) · PEDIATRICS · doi:10.1542/peds.89.1.154 · Cited by 30 · see citing works
Iatrogenic Burns by Warming Bottles in the Neonatal Period
Möhrenschlager, M., Weigl, L. B., Haug, S., et al. (2003) · Journal of Burn Care & Rehabilitation · doi:10.1097/00004630-200301000-00012 · Cited by 30 · see citing works
Iatrogenic vascular lesions in extremely low birth weight and low birth weight neonates
Gamba, P., Tchaprassian, Z., Verlato, F., et al. (1997) · Journal of Vascular Surgery · doi:10.1016/s0741-5214(97)70064-8 · Cited by 30 · see citing works
Experience With Percutaneous Indwelling Peripheral Arterial Catheterization in Neonates
Randel, S. N. (1987) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/archpedi.1987.04460080034022 · Cited by 29 · see citing works
Heel blood sampling in preterm infants: which technique?
Barker, D. P., Latty, B. W., & Rutter, N. (1994) · Archives of Disease in Childhood Fetal & Neonatal · doi:10.1136/fn.71.3.f206 · Cited by 28 · see citing works
The stickiness of newborn skin: bioadhesion and the epidermal barrier
Hoath, S. B. (1997) · The Journal of Pediatrics · doi:10.1016/s0022-3476(97)80052-2 · Cited by 27 · see citing works
Experience with iatrogenic pediatric vascular injuries
Andrassy, R. J. (1984) · Journal of Pediatric Surgery · doi:10.1016/s0022-3468(84)80466-2 · Cited by 27 · see citing works
Major Complication Secondary to Percutaneous Radial Artery Catheterization in the Neonate
Cartwright, G. W., & Schreiner, R. L. (1980) · PEDIATRICS · doi:10.1542/peds.65.1.139 · Cited by 26 · see citing works
Iatrogenic Scald Burn: A Consequence of Institutional Infection Control Measures
Mirowski, G. W., Frieden, I. J., & Miller, C. (1996) · PEDIATRICS · doi:10.1542/peds.98.5.963 · Cited by 25 · see citing works
Gowdar, K., Bull, M. J., Schreiner, R. L., et al. (1980) · PubMed · Cited by 25 · see citing works
The childhood scars of newborn intensive care
Fox, P. E., & Rutter, N. (1998) · Early Human Development · doi:10.1016/s0378-3782(97)00112-6 · Cited by 23 · see citing works
Breast Deformity in Adolescence as a Result of Pneumothorax Drainage During Neonatal Intensive Care
Rainer, C., Gardetto, A., Frühwirth, M., Trawöger, R., Meirer, R., Fritsch, H., & Piza‐Katzer, H. (2003) · PEDIATRICS · doi:10.1542/peds.111.1.80 · Cited by 23 · see citing works
Olnes, S. Q., Schwartz, R. H., & Bahadori, R. S. (2000) · Pediatrics in Review · doi:10.1542/pir.21-12-416 · Cited by 23 · see citing works
Iatrogenic radiant heat burns in severely asphyxic newborns
Simonsen, K., Græm, N., Lp, R., et al. (1995) · Acta Paediatrica · doi:10.1111/j.1651-2227.1995.tb13586.x · Cited by 22 · see citing works
Bryant, B. G. (1990) · PubMed · Cited by 19 · see citing works
Halo Scalp Ring: A Cause of Scarring Alopecia
Prendiville, J. (1987) · Archives of Dermatology · doi:10.1001/archderm.1987.01660320032006 · Cited by 18 · see citing works
The Use of Bubble CPAP in Premature Infants: Local Experience
Chan, K., & Chan, H. (2007) · Cited by 17 · see citing works
Iatrogenic second-degree burn caused by a transilluminator.
Mcartor, R. D., & Saunders, B. S. (1979) · PubMed · Cited by 15 · see citing works
Lignocaine ointment and local anaesthesia in preterm infants.
Barker, D. P., & Rutter, N. (1995) · Archives of Disease in Childhood Fetal & Neonatal · doi:10.1136/fn.72.3.f203 · Cited by 15 · see citing works
Changes in skin blood flow over the foot with warming of the contralateral heel
Dollberg, S., Atherton, H. D., & Hoath, S. B. (1998) · Acta Paediatrica · doi:10.1111/j.1651-2227.1998.tb01470.x · Cited by 15 · see citing works
Cumming, W. A., & Burchfield, D. J. (1994) · PubMed · Cited by 15 · see citing works
Alopecia Associated With Birth Injury
Lykoudis, E. G., Spyropoulou, G. C., LAVASIDIS, L. G., et al. (2007) · Obstetrics and Gynecology · doi:10.1097/01.aog.0000259909.77042.ec · Cited by 14 · see citing works
Gangrene in a neonate following dopamine therapy
Maggi, J. C., Angelats, J., & Scott, J. G. (1982) · The Journal of Pediatrics · doi:10.1016/s0022-3476(82)80666-5 · Cited by 14 · see citing works
ski, J. W., Bober, K., Gajewska, E., et al. (2007) · Pediatric Critical Care Medicine · doi:10.1097/01.pcc.0000257096.57260.3f · Cited by 14 · see citing works
Latrogenic Second-Degree Burn Caused by a Transilluminator
Mcartor, R. D., & Saunders, B. S. (1979) · PEDIATRICS · doi:10.1542/peds.63.3.422 · Cited by 14 · see citing works
Baxter, R. J., Johnson, J. D., Goetzman, B. W., et al. (1975) · PEDIATRICS · doi:10.1542/peds.55.6.884 · Cited by 13 · see citing works
Ultrasound study of heel to calcaneum depth in neonates
Jain, A., & Rutter, N. (1999) · Archives of Disease in Childhood Fetal & Neonatal · doi:10.1136/fn.80.3.f243 · Cited by 13 · see citing works
A cluster of atypical skin lesions in well-baby nurseries and a neonatal intensive care unit.
Keroack, M. A., Kotilainen, H. R., & Griffin, B. (1997) · PubMed · Cited by 13 · see citing works
Pulse oximeter-associated toe injuries in a premature neonate: a case report.
Lin, C.-S., Wang, H. Z., & Hsieh, K. (1999) · PubMed · Cited by 11 · see citing works
Iatrogenic burn caused by an alcohol lamp
Ho, W., & Ying, S. Y. (2000) · Burns · doi:10.1016/s0305-4179(00)00043-7 · Cited by 11 · see citing works
Use of tolazoline to counteract vasospasm in peripheral arterial catheters in neonates
Lemke, R., Al‐Saedi, S., Belik, J., et al. (1996) · Acta Paediatrica · doi:10.1111/j.1651-2227.1996.tb13959.x · Cited by 9 · see citing works
Extravasation of calcium gluconate concomitant with osteomyelitis in a neonate.
Chiang, M., Chou, Y.-H., Wang, C., et al. (2004) · PubMed · Cited by 8 · see citing works
Elastase-1 (EL-1) fecal em pacientes pediátricos com fibrose cística
Wiwanitkit, V. (2011) · Americanae (AECID Library) · doi:10.1590/s0021-75572011000300016 · Cited by 8 · see citing works
Chan, S.-Y., Chan, C.-K., Hou, S., et al. (2007) · Hong Kong Journal of Nephrology · doi:10.1016/s1561-5413(08)60006-x · Cited by 5 · see citing works
Iatrogenic burn in the newborn.
Piacentine, J., & Shwer, M. L. (1986) · PubMed · Cited by 2 · see citing works
Necrosis Related to the Use of Pulse Oximetry in a Very-Low-Birth-Weight Infant
Botet, F., Rodríguez‐Miguélez, J. M., & Figueras, J. (1999) · Clinical Pediatrics · doi:10.1177/000992289903800516 · Cited by 1 · see citing works
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- Authors
- Sardesai, S. R., Kornacka, M. K., Walas, W., & Ramanathan, R.
- Affiliations
- University of Southern California (US)
- Corresponding author
- Sardesai, Smeeta R.
- Venue
- The Journal of Maternal-Fetal & Neonatal Medicine
- Publisher
- Informa UK Limited
- Published
- 2010-06-14
- Volume
- 24
- Issue
- 2
- Pages
- 197-203
- ISSN
- 1476-4954 (ISSN-L)
- 1476-7058
- OpenAlex
- W2099799641
- Cited by
- 73
- References
- 82
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 6 · 2023: 4 · 2022: 5 · 2021: 4 · 2020: 4 · 2019: 11 · 2018: 7 · 2017: 7 · 2016: 10 · 2015: 4 · 2014: 5 · 2013: 2
- FWCI
- 0.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Maternal-Fetal & Neonatal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Health Professions › Speech and Hearing › Neonatal skin health care
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Infant Development and Preterm Care
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pediatric Pain Management Techniques
- Keywords
- neonatal intensive care, extremely low birth weight infants, central venous catheters, mechanical ventilation, continuous positive airway pressure, low birth weight, gestational age, neonatal procedures, skin damage prevention
- MeSH terms
- Burns, Cicatrix, Humans, Iatrogenic Disease, Infant, Newborn, Intensive Care Units, Neonatal, Scalp, Skin, Skin Diseases, Intensive Care, Neonatal, Infant, Extremely Low Birth Weight
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