Duration of Treatment with Corticosteroids and Recovery of Kidney Function in Acute Interstitial Nephritis
Open accessAbstract
Background and objectives: Drug-induced acute interstitial nephritis represents an emerging cause of acute kidney disease, especially among polymedicated elderly patients. Although corticosteroids are frequently used, controversy exists about the timing of initiation, efficacy, safety, and duration of treatment. Design, setting, participants, & measurements: We performed a retrospective study of 182 patients with biopsy-proven drug-induced acute interstitial nephritis from 13 Spanish centers. Exposure was defined as the length of corticosteroid treatment. The main outcome was the level of serum creatinine at month 6, with respect to baseline values. Results: The most common offending agents were nonsteroidal anti-inflammatory drugs (27%). In 30% of patients, the offending drug could not be identified. The median time to suspected drug withdrawal was 11 days (interquartile range, 5–22). All patients presented with acute kidney disease and were treated with corticosteroids. The mean initial dose of prednisone was 0.8±0.2 mg/kg per day. High-dose corticosteroid treatment was maintained for 2 weeks (interquartile range, 1–4). After 6 months, the mean recovered GFR was 34±26 ml/min per 1.73 m 2 and ten patients required maintenance dialysis. Use of high-dose corticosteroids for 3 weeks or treatment duration >8 weeks were not associated with better recovery of kidney function. In the multivariable analysis, delayed onset of steroid treatment (odds ratio, 1.02; 95% confidence interval, 1.0 to 1.04) and the presence of interstitial fibrosis of >50% on the kidney biopsy specimen (odds ratio, 8.7; 95% confidence interval, 2.7 to 27.4) were both associated with serum creatinine level at month 6 of >75%, with respect to baseline values. Conclusions: High-dose corticosteroid treatment for 3 weeks or prolonged treatment for >8 weeks were not associated with greater kidney function recovery in drug-induced acute interstitial nephritis. A delay in the initiation of corticosteroids resulted in worse recovery of kidney function.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The culprit drug cannot be precisely identified in nearly 30% of AIN cases.
“A recent case series published by Fernandez-Juarez et al. [27] demonstrated that the culprit drug cannot be precisely identified in nearly 30% of cases.”
From The diagnosis of acute interstitial nephritis caused by infection versus antibiotic-induced interstitial nephritis: a narrative review (2024) · cites this paper as [27]
Cites
KDIGO Clinical Practice Guidelines for Acute Kidney Injury
Khwaja, A. (2012) · Nephron Clinical Practice · doi:10.1159/000339789 · Cited by 8,039 · see citing works
Praga, M., & González, E. (2010) · Kidney International · doi:10.1038/ki.2010.89 · Cited by 507 · see citing works
Self-citationGonzález, E., Gutiérrez, E., Galeano, C., Chevia, C., de Sequera, P., Bernis, C., Parra, E. G., Delgado, R., Sanz, M., Ortiz, M., et al. (2008) · Kidney International · doi:10.1038/sj.ki.5002776 · Cited by 466 · see citing works
Self-citationThe changing profile of acute tubulointerstitial nephritis
Baker, R. J., & Pusey, C. D. (2004) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfg464 · Cited by 347 · see citing works
Acute interstitial nephritis: clinical features and response to corticosteroid therapy
Clarkson, M. R. (2004) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfh485 · Cited by 343 · see citing works
Biopsy-proven acute interstitial nephritis, 1993-2011: a case series
Muriithi, A. K., Leung, N., Valeri, A. M., Cornell, L. D., Sethi, S., Fidler, M. E., & Nasr, S. H. (2014) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2014.04.027 · Cited by 337 · see citing works
Haas, M., Spargo, B. H., Wit, E. C., & Meehan, S. M. (2000) · American Journal of Kidney Diseases · doi:10.1016/s0272-6386(00)70196-x · Cited by 262 · see citing works
Drug-Induced Hypersensitivity Syndrome
m’rad, M. B., Leclerc‐Mercier, S., Blanche, P., Franck, N., Rozenberg, F., Fulla, Y., Guesmi, M., Rollot, F., Dehoux, M., Guillevin, L., et al. (2009) · Medicine · doi:10.1097/md.0b013e3181a4d1a1 · Cited by 194 · see citing works
Acute interstitial nephritis â a reappraisal and update
Raghavan, R., & Eknoyan, G. (2014) · Clinical Nephrology · doi:10.5414/cn10838 · Cited by 180 · see citing works
Clinical characteristics, causes and outcomes of acute interstitial nephritis in the elderly
Muriithi, A. K., Leung, N., Valeri, A. M., Cornell, L. D., Sethi, S. M., Fidler, M. E., & Nasr, S. H. (2014) · Kidney International · doi:10.1038/ki.2014.294 · Cited by 136 · see citing works
Drug-Induced Acute Interstitial Nephritis
Moledina, D. G., & Perazella, M. A. (2017) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.07630717 · Cited by 133 · see citing works
Drug use and nephrotoxicity in the intensive care unit
Perazella, M. A. (2010) · Kidney International · doi:10.1038/ki.2010.475 · Cited by 124 · see citing works
Increased prevalence of acute tubulointerstitial nephritis.
Goicoechea, M., Rivera, F., & López-Gómez, J. (2013) · Nephrology, Dialysis and Transplantation · doi:10.1093/ndt/gfs143 · Cited by 96 · see citing works
Long-term outcome in biopsy-proven acute interstitial nephritis treated with steroids
Prendecki, M., Tanna, A., Salama, A. D., Tam, F. W. K., Cairns, T., Taube, D., Cook, H. T., Ashby, D., Duncan, N. D., & Pusey, C. D. (2016) · Clinical Kidney Journal · doi:10.1093/ckj/sfw116 · Cited by 63 · see citing works
Davison, A. M. (1998) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/13.suppl_7.12 · Cited by 56 · see citing works
Acute tubulointerstitial nephritis in Scotland.
Valluri, A., Hetherington, L., McQuarrie, E., Fleming, S., Kipgen, D., Geddes, C., Mackinnon, B., & Bell, S. (2015) · QJM : monthly journal of the Association of Physicians · doi:10.1093/qjmed/hcu236 · Cited by 56 · see citing works
Proton Pump Inhibitors and CKD
Moledina, D. G., & Perazella, M. A. (2016) · Journal of the American Society of Nephrology · doi:10.1681/asn.2016020192 · Cited by 44 · see citing works
Does hypophosphataemia induce hypoparathyroidism in pre-dialysis patients?
Carvalho, A. B. F. (1998) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/13.suppl_3.12 · Cited by 12 · see citing works
Proton pump inhibitors and chronic kidney disease: is it time to sound the alarm?
Wyatt, C. M. (2016) · Kidney International · doi:10.1016/j.kint.2016.02.007 · Cited by 11 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Clinical features and outcomes of immune checkpoint inhibitor-associated AKI: a multicenter study
Cortazar, F. B., Kibbelaar, Z. A., Glezerman, I. G., Abudayyeh, A., Mamlouk, O., Motwani, S. S., Murakami, N., Herrmann, S. M., Manohar, S., Shirali, A. C., et al. (2020) · Journal of the American Society of Nephrology · doi:10.1681/asn.2019070676 · Cited by 407 · see citing works
Drug-Induced Acute Kidney Injury
Perazella, M. A., & Rosner, M. H. (2022) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.11290821 · Cited by 357 · see citing works
Overview of Antibiotic-Induced Nephrotoxicity
Campbell, R. E., Chen, C. H., & Edelstein, C. L. (2023) · Kidney International Reports · doi:10.1016/j.ekir.2023.08.031 · Cited by 157 · see citing works
Manohar, S., Ghamrawi, R., Chengappa, M., Goksu, B. N. B., Kottschade, L., Finnes, H. D., Dronca, R., Leventakos, K., Herrmann, J., & Herrmann, S. M. (2020) · Kidney360 · doi:10.34067/kid.0000152019 · Cited by 52 · see citing works
Facing the Challenge of Drug-Induced Acute Interstitial Nephritis
Álamo, B. S., Cases‐Corona, C., & Juarez, G. M. F. (2022) · The Nephron journals/Nephron journals · doi:10.1159/000525561 · Cited by 71 · see citing works
Lin, J. S., Mamlouk, O., Selamet, U., Tchakarov, A. S., Glass, W. F., Sheth, R. A., Layman, R. M., Dadu, R., Abdel‐Wahab, N., Abdelrahim, M., et al. (2021) · OncoImmunology · doi:10.1080/2162402x.2021.1877415 · Cited by 66 · see citing works
García-Carro, C., Bolufer, M., Bury, R., Castañeda, Z., Muñoz‐Couselo, E., Felip, E., Lorente, D., Carreras, M. J., Gabaldón, A., Agraz, I., et al. (2021) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfab034 · Cited by 62 · see citing works
Eosinophilia and Kidney Disease: More than Just an Incidental Finding?
Gauckler, P., Shin, J., Mayer, G., & Kronbichler, A. (2018) · Journal of Clinical Medicine · doi:10.3390/jcm7120529 · Cited by 45 · see citing works
Urine interleukin-9 and tumor necrosis factor-α for prognosis of human acute interstitial nephritis
Moledina, D. G., Wilson, F. P., Kukova, L., Obeid, W., Luciano, R., Kuperman, M., Moeckel, G. W., Kashgarian, M., Perazella, M. A., Cantley, L. G., et al. (2021) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfaa169 · Cited by 47 · see citing works
Chen, C., Hung, W., Wang, C., Lee, C.-C., Chung, W., & Chung, W. (2023) · Frontiers in Medicine · doi:10.3389/fmed.2023.1187937 · Cited by 44 · see citing works
Acute kidney injury in interstitial nephritis
Caravaca-Fontán, F., Fernández-Juárez, G., & Praga, M. (2019) · Current Opinion in Critical Care · doi:10.1097/mcc.0000000000000654 · Cited by 39 · see citing works
Self-citationMoss, J., Parry, C. M., Holt, R. C. L., & McWilliam, S. J. (2022) · European journal of medical research · doi:10.1186/s40001-022-00687-y · Cited by 36 · see citing works
Shimamura, Y., Watanabe, S., Maeda, T., Abe, K., Ogawa, Y., & Takizawa, H. (2021) · Clinical and Experimental Nephrology · doi:10.1007/s10157-020-02008-1 · Cited by 37 · see citing works
Treatment of Drug-Induced Acute Tubulointerstitial Nephritis
Moledina, D. G., & Perazella, M. A. (2018) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.12001018 · Cited by 36 · see citing works
Drug-induced tubulointerstitial nephritis: hypersensitivity and necroinflammatory pathways
Eddy, A. A. (2019) · Pediatric Nephrology · doi:10.1007/s00467-019-04207-9 · Cited by 36 · see citing works
Immune checkpoint inhibitors and acute kidney injury
Zhou, P., Gao, Y., Kong, Z., Wang, J., Si, S., Han, W., Li, J., Lv, Z., & Wang, R. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1353339 · Cited by 33 · see citing works
The challenges of acute interstitial nephritis: time to standardize
Moledina, D. G., & Perazella, M. A. (2021) · Kidney360 · doi:10.34067/kid.0001742021 · Cited by 25 · see citing works
Mohan, A., Krisanapan, P., Tangpanithandee, S., Thongprayoon, C., Kanduri, S. R., Cheungpasitporn, W., & Herrmann, S. M. (2024) · American Journal of Nephrology · doi:10.1159/000538274 · Cited by 24 · see citing works
Li, Y., Wang, X., Liu, Z., Ma, J., Lin, X., Qin, Y., Nishihara, E., Miyauchi, A., & Kakudo, K. (2019) · Thyroid · doi:10.1089/thy.2019.0063 · Cited by 24 · see citing works
Draibe, J. B., García-Carro, C., Martínez-Valenzuela, L., Agraz, I., Fulladosa, X., Bolufer, M., Tango, A., Torrás, J., & Soler, M. J. (2020) · Clinical Kidney Journal · doi:10.1093/ckj/sfaa027 · Cited by 24 · see citing works
Zou, W., Dong, Y., Yang, S., Gong, L., Zhang, Y., Shi, B., La, L., Tang, L. Y., & Liu, M. (2021) · Phytomedicine · doi:10.1016/j.phymed.2021.153644 · Cited by 22 · see citing works
Shuker, E., Farhood, M. H., Al-Qudaihi, G., & Fouad, D. (2022) · Dose-Response · doi:10.1177/15593258221082877 · Cited by 20 · see citing works
Management of Drug-Associated Acute Interstitial Nephritis
Barreto, E. F., & Rule, A. D. (2020) · Kidney360 · doi:10.34067/kid.0000042019 · Cited by 16 · see citing works
Recurrent acute interstitial nephritis: what lies beneath
Caravaca-Fontán, F., Shabaka, A., Sánchez-Álamo, B., de Lorenzo, A., Díaz, M., Blasco, M., Rodríguez, E., Sierra-Carpio, M., Malek Marín, T., Urrestarazú, A., et al. (2021) · Clinical Kidney Journal · doi:10.1093/ckj/sfaa018 · Cited by 15 · see citing works
Self-citationYandián, F., Caravaca‐Fontán, F., Hernandez, L. P. H., Soler, M. J., Sethi, S. M., & Fervenza, F. C. (2023) · Kidney International Reports · doi:10.1016/j.ekir.2023.11.011 · Cited by 15 · see citing works
Self-citationAcute interstitial nephritis due to sodium-glucose co-transporter 2 inhibitor empagliflozin
Ryan, R., Choo, S., Willows, J., Walker, J., Prasad, K., & Tez, D. (2020) · Clinical Kidney Journal · doi:10.1093/ckj/sfaa033 · Cited by 15 · see citing works
Muhammad, A., Zhang, Y., Huang, L., Yuan, Q., Wang, W., Pu, J., Lin, W., Tang, R., & Xiao, X. (2024) · Clinical Kidney Journal · doi:10.1093/ckj/sfae054 · Cited by 13 · see citing works
“[27 ] demonstrated that the cul-prit drug cannot be precisely identified in nearly 30% of cases.”
MethodZhou, P., Liu, B., Shen, N., Fan, X., Lu, S., Kong, Z., Gao, Y., Lv, Z., & Wang, R. (2024) · Renal Failure · doi:10.1080/0886022x.2024.2326186 · Cited by 13 · see citing works
COVID-19 infection and renal injury: where is the place for acute interstitial nephritis disease?
León-Román, J. C., Agraz, I., Vergara, A., Ramos-Terrades, N., Toapanta, N., García-Carro, C., Gabaldón, A., Bury, R., Bermejo, S., Bestard, O., et al. (2022) · Clinical Kidney Journal · doi:10.1093/ckj/sfac079 · Cited by 13 · see citing works
Şahutoğlu, T., & Perazella, M. A. (2025) · Kidney International Reports · doi:10.1016/j.ekir.2025.03.050 · Cited by 15 · see citing works
Donati, A., & Krishnan, N. (2022) · Kidney360 · doi:10.34067/kid.0006642021 · Cited by 11 · see citing works
Differentiating Acute Interstitial Nephritis From Immune Checkpoint Inhibitors From Other Causes
Casals, J., Acosta, Y., Caballero, G., Morantes, L., Zamora, C. A., Xipell, M., Viladot, M., Guillén, E., Piñeiro, G. J., Blasco, M., et al. (2022) · Kidney International Reports · doi:10.1016/j.ekir.2022.12.017 · Cited by 11 · see citing works
Self-citationRivaroxaban-Induced Acute Interstitial Nephritis: A Case Report
Zafar, F., Iqbal, A. M., Mubarik, A., Rojas, M., & Muddassir, S. M. (2019) · American Journal of Case Reports · doi:10.12659/ajcr.917492 · Cited by 11 · see citing works
Immune checkpoint inhibitor induced nephrotoxicity: An ongoing challenge
Catalano, M., Roviello, G., Galli, I. C., Santi, R., & Nesi, G. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.1014257 · Cited by 10 · see citing works
Therapeutics in rheumatology and the kidney
Harty, T., O'Shaughnessy, M. M., & Harney, S. (2022) · Lara D. Veeken · doi:10.1093/rheumatology/keac460 · Cited by 10 · see citing works
Wendt, R., Schliecker, J., & Beige, J. (2019) · Clinical Kidney Journal · doi:10.1093/ckj/sfz097 · Cited by 10 · see citing works
Eosinophils: A Friend or Foe in Human Health and Diseases
Syeda, M. Z., Tu, H., Zhang, C., Ying, S., & Shen, H. (2022) · Kidney Diseases · doi:10.1159/000528156 · Cited by 9 · see citing works
Ho, C.-W., Kang, N., Yeh, T.-H., Chuang, M., Tsai, W.-W., Wang, H., Wu, V., Pan, H., & Chen, J. (2025) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-025-04147-4 · Cited by 9 · see citing works
Cutaneous manifestations of acute kidney injury
Esson, G. A., Hussain, A. B., Meggitt, S. J., Reynolds, N. J., & Sayer, J. A. (2021) · Clinical Kidney Journal · doi:10.1093/ckj/sfab255 · Cited by 7 · see citing works
Shiratori-Aso, S., Nakazawa, D., Nishio, S., Ueda, Y., Eguchi, M., Yokoyama, A., Yoshikawa, J., Kudo, T., Watanabe-Kusunoki, K., Takeda-Otera, S., et al. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.827388 · Cited by 7 · see citing works
Horton, M., & Low, C. L. (2017) · The American Pharmacists Association eBooks · doi:10.21019/pharmacotherapyfirst.di-kidney_overview · Cited by 7 · see citing works
Athavale, A., Morris, J., Jardine, M., Gallagher, M., Sen, S., Ritchie, A., & Wang, Y. (2020) · Nephrology · doi:10.1111/nep.13783 · Cited by 6 · see citing works
Matsumura, M., Okada, A., Yokoyama, H., Sekiguchi, M., Shimizu, A., Tanaka, T., Nangaku, M., & Takano, H. (2022) · Clinical and Experimental Nephrology · doi:10.1007/s10157-022-02302-0 · Cited by 6 · see citing works
Rankin, A. J., Cannon, E., Gillis, K. A., Crosby, J., Mark, P. B., Geddes, C., Fox, J. G., Mackinnon, B., McQuarrie, E. P., & Kipgen, D. (2019) · Histopathology · doi:10.1111/his.14031 · Cited by 6 · see citing works
A Systematic Review of Treatment for Acute Interstitial Nephritis
Yu, Y., Biroš, E., Chang, X., & Mallett, A. J. (2025) · Kidney International Reports · doi:10.1016/j.ekir.2025.05.009 · Cited by 5 · see citing works
Toxic nephropathy: Adverse renal effects caused by drugs
Unwin, R. J. (2021) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2021.09.008 · Cited by 5 · see citing works
Praga, M., & Caravaca‐Fontán, F. (2022) · Kidney360 · doi:10.34067/kid.0008342021 · Cited by 5 · see citing works
Self-citationCocaine-Induced Acute Interstitial Nephritis: A Comparative Review of 7 Cases
Inayat, F., Bokhari, S. R., Roberts, L., & Rosen, R. M. (2020) · Journal of Investigative Medicine High Impact Case Reports · doi:10.1177/2324709620932450 · Cited by 4 · see citing works
Prognosis of severe drug-induced acute interstitial nephritis requiring renal replacement therapy
Huang, L., Liang, S.-S., Dong, J.-H., Fan, W., Zeng, C., Zhang, T., Cheng, S.-Q., & Ge, Y.-C. (2021) · Renal Failure · doi:10.1080/0886022x.2021.1942914 · Cited by 2 · see citing works
New challenges in tubulointerstitial nephritis induced by drugs.
Juarez, G. F., Pérez, J. V., Caravaca-Fontán, F., Corona, C. C. C., Álamo, B. S., & Ribera, A. T. (2019) · Nefrología · doi:10.1016/j.nefro.2019.02.003 · Cited by 5 · see citing works
Self-citationHematuria Is Associated with More Severe Acute Tubulointerstitial Nephritis
Esteras, R., Fox, J., Geddes, C., Mackinnon, B., Ortiz, A., & Moreno, J. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9072135 · Cited by 4 · see citing works
Severe acute interstitial nephritis secondary to minocycline use in an adolescent girl
Sharma, K., Geagan, N., & Tengsupakul, S. (2020) · SAGE Open Medical Case Reports · doi:10.1177/2050313x20943069 · Cited by 4 · see citing works
Acute Drug-Induced Tubulointerstitial Nephritis: Current Perspectives on Diagnosis and Treatment
Azores‐Moreno, J., Cases‐Corona, C., Álamo, B. S., Maldonado, M., León-Machado, L. M., Rivas, B., Vega, C., Shabaka, A., & Juarez, G. M. F. (2025) · Advances in Kidney Disease and Health · doi:10.1053/j.akdh.2025.06.002 · Cited by 5 · see citing works
Self-citationPrognosis and Outcomes of Acute and Chronic Tubulointerstitial Nephritis
Weber, N., Deleersnijder, D., Kitchlu, A., & Sprangers, B. (2025) · Advances in Kidney Disease and Health · doi:10.1053/j.akdh.2025.07.005 · Cited by 4 · see citing works
Gallagher, M., & Kotwal, S. S. (2022) · Kidney360 · doi:10.34067/kid.0007042021 · Cited by 4 · see citing works
Turner, D., Drak, D., Gracey, D. M., & Anderson, L. A. (2022) · BMC Nephrology · doi:10.1186/s12882-022-02695-w · Cited by 4 · see citing works
Aziz, A., Yaqub, S., Awan, S., Khalid, A., & Razzaque, M. R. A. (2022) · World Journal of Nephrology and Urology · doi:10.14740/wjnu427 · Cited by 4 · see citing works
Ryck, L. D., Delanghe, S. E., Jacobs, C., Fadaei, S., Brochez, L., & Saerens, M. (2022) · Acta Clinica Belgica · doi:10.1080/17843286.2022.2114684 · Cited by 4 · see citing works
Moledina, D. G., Shelton, K., Menez, S. P., Aklilu, A. M., Yamamoto, Y., Kadhim, B. A., Shaw, M. M., Kent, C., Makhijani, A., Hu, D. G., et al. (2024) · Journal of the American Society of Nephrology · doi:10.1681/asn.0000000556 · Cited by 4 · see citing works
Short-term steroid therapy for immune-checkpoint-inhibitor-related acute kidney injury
Tanemoto, M., Iida, Y., & Kasai, T. (2023) · International Urology and Nephrology · doi:10.1007/s11255-023-03734-7 · Cited by 4 · see citing works
Pembrolizumab Induced Acute Tubulointerstitial Nephritis
Mukherjee, A., & Ghosh, R. (2020) · American Journal of Therapeutics · doi:10.1097/mjt.0000000000001248 · Cited by 4 · see citing works
de la Cruz, P. M., Shabaka, A., Mielgo-Rubio, X., Guerrero-Márquez, C., Giménez-Moyano, S., & Fernandez-Juárez, G. (2021) · American Journal of the Medical Sciences · doi:10.1016/j.amjms.2021.04.003 · Cited by 4 · see citing works
Self-citationSevere acute interstitial nephritis induced by valsartan
Chen, T., Xu, P., Hu, S., Yan, T.-K., Jiang, J.-Q., Jia, J.-Y., Wei, L., & Shang, W. (2019) · Medicine · doi:10.1097/md.0000000000014428 · Cited by 4 · see citing works
Lee, T., & Yang, W. S. (2020) · Renal Failure · doi:10.1080/0886022x.2020.1824923 · Cited by 3 · see citing works
Adisa, O., Ananthaneni, A., Rushing, B., Rinehouse, N., & Morisetti, P. P. (2023) · Clinical Nephrology - Case Studies · doi:10.5414/cncs111180 · Cited by 3 · see citing works
Tubulointerstitial nephritis in children and adolescents
Gurevich, E., & Landau, D. (2024) · Pediatric nephrology (Berlin, West) · doi:10.1007/s00467-024-06526-y · Cited by 3 · see citing works
Amoxicillin crystalluria and amoxicillin-induced crystal nephropathy: a narrative review
Vodovar, D., Mousseaux, C., Daudon, M., Jamme, M., & Letavernier, E. (2024) · Kidney International · doi:10.1016/j.kint.2024.09.019 · Cited by 3 · see citing works
Baeg, S., Lee, K., Jeon, J., Lee, J. E., Kwon, G. Y., Huh, W., & Jang, H. (2024) · Clinical Kidney Journal · doi:10.1093/ckj/sfae354 · Cited by 2 · see citing works
Nefritis tubulointersticial aguda. Revisión bibliográfica
Nieto-Ríos, J. F., Ruiz-Velásquez, L. M., Álvarez, L., & Serna-Higuita, L. (2020) · IATREIA · doi:10.17533/udea.iatreia.45 · Cited by 1 · see citing works
Management of Acute Tubulointerstitial Nephritis
Krishnan, N., Caravaca‐Fontán, F., & Praga, M. (2025) · Advances in Kidney Disease and Health · doi:10.1053/j.akdh.2025.03.002 · Cited by 2 · see citing works
Self-citationMansoor, Y., O’Donnell, J. E. M., Al-Dmour, A., Muise, A. M., Chami, R., & Licht, C. P. B. (2026) · Pediatric Nephrology · doi:10.1007/s00467-026-07207-8 · Cited by 2 · see citing works
A rare case of alirocumab (PCSK9 inhibitor)-associated acute interstitial nephritis
Habib, N., Yuan, C. Y., Lightle, A. R., Monrroy, M., & Mehta, S. (2024) · Clinical Nephrology - Case Studies · doi:10.5414/cncs111443 · Cited by 2 · see citing works
Acute interstitial nephritis with only three doses of pantoprazole
Samal, S., Singhania, N., Bansal, S. K., & Singhania, G. (2020) · Clinical Case Reports · doi:10.1002/ccr3.3059 · Cited by 2 · see citing works
Acute interstitial nephritis observed with three different triggering agents
Nobakht, N., Hanna, R. M., Kamgar, M., Sinclair, J., Simon, L., Emami, S., Sisk, A., & Rastogi, A. (2022) · Clinical Case Reports · doi:10.1002/ccr3.5432 · Cited by 1 · see citing works
[Etiologies and prognostic factors of acute interstitial nephritis].
Hadded, S., Harzallah, A., Chargui, S., Hajji, M., Kaaroud, H., Goucha, R., Hamida, F. B., Gorsane, I., & Abdallah, T. B. (2021) · Néphrologie & Thérapeutique · doi:10.1016/j.nephro.2020.10.012 · Cited by 2 · see citing works
New challenges in tubulointerstitial nephritis induced by drugs
Juarez, G. F., Pérez, J. V., Fontán, F. C., Corona, C., Alamo, B. S., & Ribera, A. T. (2019) · Nefrología (English Edition) · doi:10.1016/j.nefroe.2019.08.006 · Cited by 1 · see citing works
Self-citationTian, J., Shi, J., Jiao, Y., Liu, X., An, J., Yang, Y., Zou, G., & Zhuo, L. (2024) · Renal Failure · doi:10.1080/0886022x.2024.2379002 · Cited by 1 · see citing works
Azores‐Moreno, J., Cabañas, R., Bellón, T., García‐Fernández, E., Raso, I. V., Barceló, S. A., Maldonado, M., León-Machado, L. M., Shabaka, A., Becerra, B. R., et al. (2025) · Kidney International Reports · doi:10.1016/j.ekir.2025.02.029 · Cited by 1 · see citing works
Self-citationRodelo-Ceballos, J., García-Prada, C., Restrepo-Escobar, M., Lopera-Restrepo, L., Pinto-Diaz, A., & Arias-Restrepo, L. (2025) · International Journal of Nephrology · doi:10.1155/ijne/9980649 · Cited by 2 · see citing works
Auñón, P., Lopes, V., Toral, I. M., Pérez-Romero, P., Ordoñez, K. P., Soto, M. S., Rivera, M., Alonso, F., Valdivia, V. R. M., Moliz, C., et al. (2026) · Clinical Kidney Journal · doi:10.1093/ckj/sfag076 · Cited by 1 · see citing works
RAY, A. S., Errabelli, P. K., Mareedu, N., & Lathiya, M. K. (2026) · World Journal of Nephrology · doi:10.5527/wjn.v15.i1.117950 · Cited by 1 · see citing works
Improvement in renal function after empirical steroid therapy in NSAIDinduced acute kidney injury
Marzec, M. (2023) · Health Sciences Quarterly · doi:10.26900/hsq.1857 · Cited by 1 · see citing works
Síndrome de DRESS inducido por carbamazepina: una grave reacción de hipersensibilidad retardada
Bonilla-Bustos, A. B., Moribe-Quintero, I. C., & Urrego, J. F. G. (2022) · Alergia, Asma e Inmunología Pediátricas · doi:10.35366/109665 · Cited by 1 · see citing works
Case Report: A potential novel treatment for drug-induced acute interstitial nephritis: Benralizumab
Saadia, A., Wald, R., Potruch, A., Pizov, G., Meir, K., Gorin, K., Sarig, I., Ben-Dori, E., Rubin, L., Ribak, Y., et al. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1720992 · Cited by 1 · see citing works
Microsporidium Infection–Associated Acute Kidney Injury in a Patient With HIV
Sy-Go, J. P. T., Wegehaupt, A. K., Sethi, S., Lieske, J., & D'Costa, M. (2021) · Kidney Medicine · doi:10.1016/j.xkme.2021.10.004 · Cited by 2 · see citing works
Management of corticosteroid-dependent eosinophilic interstitial nephritis
Tanabe, K., Matsuoka-Uchiyama, N., Mifune, T., Kawakita, C., Sugiyama, H., & Wada, J. (2021) · Medicine · doi:10.1097/md.0000000000028252 · Cited by 1 · see citing works
"Double whammy" to the kidneys: an unusual etiology of acute kidney disease
Jayaprakash, V., Suganya, M., Karthick, D., Kurien, A. A., & Padmanabhan, R. (2022) · Journal of Nephropathology · doi:10.34172/jnp.2022.17252 · Cited by 1 · see citing works
Mamlouk, O., Lin, J. S., & Abudayyeh, A. (2022) · Springer eBooks · doi:10.1007/978-3-031-00241-0_9 · Cited by 1 · see citing works
Tubulointerstitial Nephritis in Children
Verghese, P. S., Luckritz, K. E., & Eddy, A. A. (2023) · Springer eBooks · doi:10.1007/978-3-031-11665-0_42 · Cited by 1 · see citing works
Enfermedades renales tubulointersticiales. Conceptos generales. Formas agudas
de la Fuente, G. D. A., del Valle, K. M. P., Sevillano, B. H., & Gili, B. Q. (2019) · Medicine - Programa de Formación Médica Continuada Acreditado · doi:10.1016/j.med.2019.06.020
Drug-Induced Acute Tubulointerstitial Nephritis
Rădulescu, D. (2020) · Internal Medicine · doi:10.2478/inmed-2020-0127
Acute Drug-Allergic Tubulointerstitial Nephritis
Rădulescu, D. (2020) · Internal Medicine · doi:10.2478/inmed-2020-0140
Antibioterapia e insuficiencia renal aguda ¿causa o consecuencia?
Trallero, L. E. R., Gutiérrez, A. G., Alijarde, M. J. B., & Al-Cheikh-Felices, P. (2020) · Atalaya Médica Turolense
Nefritis intersticial granulomatosa secundario al uso del anti TNF adalimumab
Valencia, C. A. R., Martinez-Aristizábal, J.-D., & Flórez-Vargas, A. (2021) · Acta Médica Colombiana · doi:10.36104/amc.2021.2050
Dismal Prognosis of Acute Allergic Tubulointerstitial Nephritis in Patients with AA Amyloidosis
Yıldırım, T., Oguz, E. G., Koç, N., Uzerk-Kibar, M., Uner, M., Sağlam, E. A., Yılmaz, Ş., Aylı, D., & Erdem, Y. (2021) · Nephron · doi:10.1159/000520151
Causes of Acute Tubulointerstitial Nephritis: Drugs
Caravaca‐Fontán, F., Trujillo, H., & Praga, M. (2022) · Springer eBooks · doi:10.1007/978-3-030-93438-5_4
Self-citationManagement of Tubulointerstitial Nephritis
Álamo, B. S., Cases‐Corona, C., & Juarez, G. M. F. (2022) · Springer eBooks · doi:10.1007/978-3-030-93438-5_22
Prognosis and Outcomes of Acute Tubulointerstitial Nephritis
Deleersnijder, D., & Sprangers, B. (2022) · Springer eBooks · doi:10.1007/978-3-030-93438-5_23
Take a closer look at TINU syndrome; analysis of a case
Carias, E., Cabrita, A., Neves, P. L., & Silva, A. P. (2022) · Journal of Nephropathology · doi:10.34172/jnp.2022.17349
Miscellaneous Etiologies of Acute Kidney Injury
Joy, C. M., & Vijayan, A. (2022) · Wiley eBooks · doi:10.1002/9781119105954.ch12
- Authors
- Fernandez-Juarez, G., Perez, J. V., Caravaca-Fontán, F., Quintana, L., Shabaka, A., Rodriguez, E., Gadola, L., de Lorenzo, A., Cobo, M. A., Oliet, A., Sierra, M., Cobelo, C., Iglesias, E., Blasco, M., Galeano, C., Cordon, A., Oliva, J., Praga, M., & on behalf of the Spanish Group for the Study of Glomerular Diseases (GLOSEN)
- Affiliations
- Department of Nephrology, Hospital Fundación de Alcorcón, Madrid, Spain;
- Department of Nephrology, Hospital Universitario 12 de Octubre, Madrid, Spain;
- Hospital Clínic de Barcelona (ES)
- Hospital Clínico San Carlos (ES)
- Department of Nephrology, Hospital del Mar, Barcelona, Spain;
- Universidad de la República de Uruguay (UY)
- Department of Nephrology, Hospital de Getafe, Madrid, Spain;
- Department of Nephrology Hospital Universitario General de Canarias, Tenerife, Spain;
- Hospital Universitario Severo Ochoa (ES)
- Hospital San Pedro (ES)
- Hospital Universitario Lucus Augusti (ES)
- Department of Nephrology, Complejo Hospitalario Universitario de Orense, Orense, Spain;
- Hospital Universitario Ramón y Cajal (ES)
- Hospital Universitario Fundación Alcorcón (ES)
- Instituto de Salud Carlos III (ES)
- Hospital Universitario 12 De Octubre (ES)
- Venue
- Clinical Journal of the American Society of Nephrology
- Published
- 2018-11-05
- Volume
- 13
- Issue
- 12
- Pages
- 1851-1858
- ISSN
- 1555-9041 (ISSN-L)
- 1555-905X
- PMC
- PMC6302327
- OpenAlex
- W2900322133
- Cited by
- 133
- References
- 19
- Citations by year
- 2026: 11 · 2025: 19 · 2024: 16 · 2023: 13 · 2022: 29 · 2021: 14 · 2020: 18 · 2019: 10 · 2018: 2 · 2017: 1
- FWCI
- 9.02
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Clinical Journal of the American Society of Nephrology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Nephrology › Acute Kidney Injury Research
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Nephrotoxicity and Medicinal Plants
- Health Sciences › Medicine › Nephrology › Renal Diseases and Glomerulopathies
- Keywords
- drug-induced acute interstitial nephritis, corticosteroid treatment duration, renal function recovery, acute kidney injury, prednisone, nonsteroidal anti-inflammatory drugs, interstitial fibrosis, serum creatinine, chronic dialysis, elderly patients
- MeSH terms
- Acute Disease, Aged, Female, Glucocorticoids, Humans, Kidney, Kidney Function Tests, Male, Middle Aged, Nephritis, Interstitial, Prednisone, Retrospective Studies, Time Factors, Recovery of Function
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
