Cited by 150Chronic Myeloid Leukemia TreatmentsAcute Myeloid Leukemia ResearchRetinoids in leukemia and cellular processes

The DOI matches its Crossref record; 79 of the 79 references it cites were found in a registry or an index.

Molecular signature of CD34+ hematopoietic stem and progenitor cells of patients with CML in chronic phase

Diaz-Blanco, E, Bruns, I, Neumann, F, Fischer, J C, Graef, T, Rosskopf, M, Brors, B, Pechtel, S, Bork, S, Koch, A, Baer, A, Rohr, U-P, Kobbe, G, Haeseler, A von, Gattermann, N, Haas, R, Kronenwett, R·2007·Leukemia

DOI 10.1038/sj.leu.2404549

Open this paper in CoChat — free account

Abstract

In this study, we provide a molecular signature of highly enriched CD34+ cells from bone marrow of untreated patients with chronic myelogenous leukemia (CML) in chronic phase in comparison with normal CD34+ cells using microarrays covering 8746 genes. Expression data reflected several BCR-ABL-induced effects in primary CML progenitors, such as transcriptional activation of the classical mitogen-activated protein kinase pathway and the phosphoinositide-3 kinase/AKT pathway as well as downregulation of the proapoptotic gene IRF8. Moreover, novel transcriptional changes in comparison with normal CD34+ cells were identified. These include upregulation of genes involved in the transforming growth factorbeta pathway, fetal hemoglobin genes, leptin receptor, sorcin, tissue inhibitor of metalloproteinase 1, the neuroepithelial cell transforming gene 1 and downregulation of selenoprotein P. Additionally, genes associated with early hematopoietic stem cells (HSC) and leukemogenesis such as HoxA9 and MEIS1 were transcriptionally activated. Differential expression of differentiation-associated genes suggested an altered composition of the CD34+ cell population in CML. This was confirmed by subset analyses of chronic phase CML CD34+ cells showing an increase of the proportion of megakaryocyte-erythroid progenitors, whereas the proportion of HSC and granulocyte-macrophage progenitors was decreased in CML. In conclusion, our results give novel insights into the biology of CML and could provide the basis for identification of new therapeutic targets.

Integrity signals

Registry

Crossref · 10.1038/sj.leu.2404549

Cites

79 of 79 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

In silico prediction of protein-protein interactions in human macrophages
Souiai, O., Guerfali, F. Z., Miled, S. B., Brun, C., & Benkahla, A. (2014) · BMC Research Notes · doi:10.1186/1756-0500-7-157 · Cited by 10,785
Significance analysis of microarrays applied to the ionizing radiation response
Tusher, V. G., Tibshirani, R., & Chu, G. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.091062498 · Cited by 10,568
Minimum information about a microarray experiment (MIAME)-toward standards for microarray data
Brazma, A., Hingamp, P., Quackenbush, J., Sherlock, G., Spellman, P., Stoeckert, C., Aach, J., Ansorge, W., Ball, C. A., Causton, H. C., et al. (2001) · Nature Genetics · doi:10.1038/ng1201-365 · Cited by 4,109
Variance stabilization applied to microarray data calibration and to the quantification of differential expression
Huber, W., von Heydebreck, A., Sültmann, H., Poustka, A., & Vingron, M. (2002) · Bioinformatics · doi:10.1093/bioinformatics/18.suppl_1.s96 · Cited by 2,440
Induction of Chronic Myelogenous Leukemia in Mice by the P210 bcr/abl Gene of the Philadelphia Chromosome
Daley, G. Q., Etten, R. A. V., & Baltimore, D. (1990) · Science · doi:10.1126/science.2406902 · Cited by 2,141
The molecular biology of chronic myeloid leukemia
Deininger, M. W., Goldman, J. M., & Melo, J. V. (2000) · Blood · doi:10.1182/blood.v96.10.3343 · Cited by 1,654
The Biology of Chronic Myeloid Leukemia
Faderl, S. H., Talpaz, M., Estrov, Z. E., O'Brien, S. M., Kurzrock, R., & Kantarjian, H. M. (1999) · New England Journal of Medicine · doi:10.1056/nejm199907153410306 · Cited by 1,322
Intracellular signalling pathways activated by leptin
Frühbeck, G. (2005) · Biochemical Journal · doi:10.1042/bj20051578 · Cited by 851
Rho, Rac and Cdc42 GTPases regulate the organization of the actin cytoskeleton
Tapon, N. (1997) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(97)80156-1 · Cited by 819
Leptin can induce proliferation, differentiation, and functional activation of hemopoietic cells
Gainsford, T., Willson, T. A., Metcalf, D., Handman, E., McFarlane, C., Ng, A. P., Nicola, N. A., Alexander, W. S., & Hilton, D. J. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.25.14564 · Cited by 758
Intracellular signalling pathways activated by leptin
Frühbeck, G. (. (2006) · Deposito Adademico Digital Universidad De Navarra (University of Navarra) · Cited by 745
BCR-ABL independence and LYN kinase overexpression in chronic myelogenous leukemia cells selected for resistance to STI571
Donato, N. J., Wu, J. Y., Stapley, J., Gallick, G. E., Lin, H., Arlinghaus, R. B., & Talpaz, M. (2002) · Blood · doi:10.1182/blood.v101.2.690 · Cited by 677
Immunodeficiency and Chronic Myelogenous Leukemia-like Syndrome in Mice with a Targeted Mutation of the ICSBP Gene
Holtschke, T., Löhler, J., Kanno, Y., Fehr, T., Giese, N., Rosenbauer, F., Lou, J., Knobeloch, K.-P., Gabriele, L., Waring, J. F., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81348-3 · Cited by 644
Gene expression changes associated with progression and response in chronic myeloid leukemia
Radich, J. P., Dai, H., Mao, M., Oehler, V., Schelter, J., Druker, B., Sawyers, C., Shah, N., Stock, W., Willman, C. L., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510423103 · Cited by 583
Transformation of hematopoietic cells by BCR/ABL requires activation of a PI‐3k/Akt‐dependent pathway
Skorski, T., Bellacosa, A., Nieborowska‐Skorska, M., Majewski, M., Martinez, R., Choi, J. K., Trotta, R., Wlodarski, P., Perrotti, D., Chan, T. O., et al. (1997) · The EMBO Journal · doi:10.1093/emboj/16.20.6151 · Cited by 567
Isolation of primitive human hematopoietic progenitors on the basis of aldehyde dehydrogenase activity
Storms, R. W., Sindram-Trujillo, A. P., Springer, J. B., Shah, L., Colvin, O. M., Ludeman, S. M., & Smith, C. A. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.16.9118 · Cited by 552
Persistence of malignant hematopoietic progenitors in chronic myelogenous leukemia patients in complete cytogenetic remission following imatinib mesylate treatment
Bhatia, R., Holtz, M. S., Niu, N., Gray, R., Snyder, D., Sawyers, C. L., Arber, D. A., Slovak, M. L., & Forman, S. J. (2003) · Blood · doi:10.1182/blood-2002-09-2780 · Cited by 552
Prospective isolation of human clonogenic common myeloid progenitors
Manz, M. G., Miyamoto, T., Akashi, K., & Weissman, I. L. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.172384399 · Cited by 529
The hematopoietic stem cell in its place
Adams, G. B., & Scadden, D. T. (2006) · Nature Immunology · doi:10.1038/ni1331 · Cited by 450
Altered adhesive interactions with marrow stroma of haematopoietic progenitor cells in chronic myeloid leukaemia
Gordon, M. Y., Dowding, C., Riley, G. P., Goldman, J. M., & Greaves, M. F. (1987) · Nature · doi:10.1038/328342a0 · Cited by 436
A Coiled-Coil Oligomerization Domain of Bcr Is Essential for the Transforming Function of Bcr-Abl Oncoproteins
McWhirter, J. R., Galasso, D. L., & Wang, J. Y. J. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.12.7587 · Cited by 422
Phosphatidylinositol-3 kinase activity is regulated by BCR/ABL and is required for the growth of Philadelphia chromosome-positive cells
Skórski, T., Kanakaraj, P., Nieborowska-Skorska, M., Ratajczak, M. Z., Wen, S. C., Zon, G., Gewirtz, A., PERUSSIA, B., & Calabretta, B. (1995) · Blood · doi:10.1182/blood.v86.2.726.bloodjournal862726 · Cited by 405
Dominant negative MYC blocks transformation by ABL oncogenes
Sawyers, C. L., Callahan, W., & Witte, O. N. (1992) · Cell · doi:10.1016/0092-8674(92)90241-4 · Cited by 395
The Bcr-Abl leukemia oncogene activates Jun kinase and requires Jun for transformation.
Raitano, A., Halpern, J., Hambuch, T. M., & Sawyers, C. L. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.25.11746 · Cited by 394
Blockade of the Bcr-Abl Kinase Activity Induces Apoptosis of Chronic Myelogenous Leukemia Cells by Suppressing Signal Transducer and Activator of Transcription 5–Dependent Expression of Bcl-XL
Horita, M., Andreu, E. J., Benito, A., Arbona, C., Sanz, C., Benet, I., Prósper, F., & Fernández-Luna, J. L. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.6.977 · Cited by 366
Hematopoietic cytokines, transcription factors and lineage commitment
Zhu, J., & Emerson, S. G. (2002) · Oncogene · doi:10.1038/sj.onc.1205318 · Cited by 349
Differential expression of Hox, Meis1, and Pbx1 genes in primitive cells throughout murine hematopoietic ontogeny
Pineault, N., Helgason, C. D., Lawrence, H. J., & Humphries, R. K. (2002) · Experimental Hematology · doi:10.1016/s0301-472x(01)00757-3 · Cited by 278
Pharmacological inhibitors of mammalian fatty acid synthase suppress DNA replication and induce apoptosis in tumor cell lines.
Pizer, E. S., Chrest, F. J., DiGiuseppe, J. A., & Han, W. F. (1998) · PubMed · Cited by 250
STAT5 activation contributes to growth and viability in Bcr/Abl-transformed cells
Sillaber, C., Gesbert, F., Frank, D. A., Sattler, M., & Griffin, J. D. (2000) · Blood · doi:10.1182/blood.v95.6.2118 · Cited by 222
The Bcr-Abl tyrosine kinase activates mitogenic signaling pathways and stimulates G1-to-S phase transition in hematopoietic cells
Cortez, D., Reuther, G. W., & Pendergast, A. M. (1997) · Oncogene · doi:10.1038/sj.onc.1201400 · Cited by 221
A MAPK/HNRPK pathway controls BCR/ABL oncogenic potential by regulating MYC mRNA translation
Notari, M., Neviani, P., Santhanam, R., Blaser, B. W., Chang, J.-S., Galietta, A., Willis, A. E., Roy, D., Caligiuri, M. A., Marcucci, G., et al. (2005) · Blood · doi:10.1182/blood-2005-09-3732 · Cited by 202
Expression and Function of Leptin Receptor Isoforms in Myeloid Leukemia and Myelodysplastic Syndromes: Proliferative and Anti-Apoptotic Activities
Konopleva, M. Y., Mikhail, A. A., Estrov, Z. E., Zhao, S., Harris, D., Sanchez‐Williams, G., Kornblau, S. M., Dong, J., Kliche, K. O., Jiang, S., et al. (1999) · Blood · doi:10.1182/blood.v93.5.1668 · Cited by 188
Transforming growth factor inhibits erythropoiesis by blocking proliferation and accelerating differentiation of erythroid progenitors
Zermati, Y., Fichelson, S., Valensi, F., Freyssinier, J. M., Rouyer‐Fessard, P., Cramer, E. M., Guichard, J., Varet, B. R., & Hermine, O. (2000) · Experimental Hematology · doi:10.1016/s0301-472x(00)00488-4 · Cited by 179
Gene expression profiling identifies significant differences between the molecular phenotypes of bone marrow–derived and circulating human CD34+ hematopoietic stem cells
Steidl, U. U., Kronenwett, R., Rohr, U., Fenk, R. R., Kliszewski, S., Maercker, C., Neubert, P., Aivado, M. A., Koch, J., Modlich, O., et al. (2002) · Blood · doi:10.1182/blood.v99.6.2037 · Cited by 148
Self-citation
Expression of Interferon Consensus Sequence Binding Protein (ICSBP) Is Downregulated in Bcr-Abl-Induced Murine Chronic Myelogenous Leukemia-Like Disease, and Forced Coexpression of ICSBP Inhibits Bcr-Abl-Induced Myeloproliferative Disorder
Hao, S. X., & Ren, R. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.4.1149-1161.2000 · Cited by 143
BCR-ABL Induces the Expression of Skp2 through the PI3K Pathway to Promote p27Kip1 Degradation and Proliferation of Chronic Myelogenous Leukemia Cells
Andreu, E. J., Lledó, E., Poch, E., Ivorra, C., Albero, M. P., Martinez-Climent, J. A., Montiel‐Duarte, C., Rifón, J., Pérez‐Calvo, J., Arbona, C., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-1357 · Cited by 142
Molecular profiling of CD34+ cells identifies low expression of CD7, along with high expression of proteinase 3 or elastase, as predictors of longer survival in patients with CML
Yong, A. S. M., Szydlo, R., Goldman, J. M., Apperley, J. F., & Melo, J. V. (2005) · Blood · doi:10.1182/blood-2005-05-2155 · Cited by 139
Expression of Dominant-Negative Mutant DP-1 Blocks Cell Cycle Progression in G 1
Wu, C., Classon, M., Dyson, N. J., & Harlow, E. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.7.3698 · Cited by 139
Bcr/Abl expression stimulates integrin function in hematopoietic cell lines.
Bazzoni, G., Carlesso, N., Griffin, J. D., & Hemler, M. E. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118820 · Cited by 126
Gene expression profiling of CD34+ cells identifies a molecular signature of chronic myeloid leukemia blast crisis
Zheng, C., Li, L., Haak, M., Brors, B., Frank, O., Giehl, M., Fabarius, A. C., Schatz, M. C., Weisser, A., Lorentz, C., et al. (2006) · Leukemia · doi:10.1038/sj.leu.2404227 · Cited by 117
Self-citation
DLC‐1, a Rho GTPase‐activating protein with tumor suppressor function, is essential for embryonic development
Durkin, M. E., Avner, M. R., Huh, C.-G., Yuan, B., Thorgeirsson, S. S., & Popescu, N. C. (2005) · FEBS Letters · doi:10.1016/j.febslet.2004.12.090 · Cited by 116
The Activity of Guanine Exchange Factor NET1 Is Essential for Transforming Growth Factor-β-mediated Stress Fiber Formation
Shen, X., Li, J., Hu, P. P.-C., Waddell, D. S., Zhang, J., & Wang, X. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009534200 · Cited by 116
Chronic myelogenous leukemia molecular signature
Nowicki, M. O., Pawlowski, P., Fischer, T. H., Heß, G., Pawlowski, T., & Skórski, T. (2003) · Oncogene · doi:10.1038/sj.onc.1206620 · Cited by 114
Activation of RhoA and SAPK/JNK signalling pathways by the RhoA‐specific exchange factor mNET1
Alberts, A. S., & Treisman, R. (1998) · The EMBO Journal · doi:10.1093/emboj/17.14.4075 · Cited by 114
Identification of genes involved in imatinib resistance in CML: a gene-expression profiling approach
Villuendas, R., Steegmann, J. L., Pollán, M., Tracey, L., Granda, A., Fernández‐Ruiz, E., Casado, L., Martínez‐López, J., Martinez, P. B., Lombardía, L., et al. (2006) · Leukemia · doi:10.1038/sj.leu.2404197 · Cited by 111
Gene expression signature of primary imatinib-resistant chronic myeloid leukemia patients
Frank, O., Brors, B., Fabarius, A. C., Li, L., Haak, M., Merk, S., Schwindel, U., Zheng, C., Müller, M. C., Gretz, N., et al. (2006) · Leukemia · doi:10.1038/sj.leu.2404270 · Cited by 110
Self-citation
The Adapter Protein Crkl Links Cbl to C3G after Integrin Ligation and Enhances Cell Migration
Uemura, N., & Griffin, J. D. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.53.37525 · Cited by 110
Oncogenic Abl and Src tyrosine kinases elicit the ubiquitin-dependent degradation of target proteins through a Ras-independent pathwayPreprint
Dai, Z., Quackenbush, R. C., Courtney, K. D., Grove, M., Cortez, D., Reuther, G. W., & Pendergast, A. M. (1998) · Genes & Development · doi:10.1101/gad.12.10.1415 · Cited by 109
Expression of matrix metalloproteinases (MMP-2 and -9) and tissue inhibitors of metalloproteinases (TIMP-1 and -2) in acute myelogenous leukaemia blasts: comparison with normal bone marrow cells
Janowska‐Wieczorek, A., Marquez‐Curtis, L. A., Matsuzaki, A., Hashmi, H., Larratt, L. M., Boshkov, L., Turner, A. R., Zhang, M., Edwards, D. R., & Kossakowska, A. E. (1999) · British Journal of Haematology · doi:10.1111/j.1365-2141.1999.01352.x · Cited by 107
Interferon consensus sequence binding protein (ICSBP; IRF-8) antagonizes BCR/ABL and down-regulates bcl-2
Burchert, A. (2003) · Blood · doi:10.1182/blood-2003-08-2970 · Cited by 102
Persistent Transactivation by Meis1 Replaces Hox Function in Myeloid Leukemogenesis Models: Evidence for Co-Occupancy of Meis1-Pbx and Hox-Pbx Complexes on Promoters of Leukemia-Associated Genes
Wang, G. G., Pasillas, M. P., & Kamps, M. P. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.10.3902-3916.2006 · Cited by 97
Tissue inhibitor of metalloproteinases-1 signalling pathway leading to erythroid cell survival
Lambert, E., Boudot, C., Kadri, Z., Soula-Rothhut, M., Sowa, M.-L., Mayeux, P., Hornebeck, W., Haye, B., & Petitfrere, E. (2003) · Biochemical Journal · doi:10.1042/bj20030187 · Cited by 94
Gene-expression profiling of CD34+ cells from various hematopoietic stem-cell sources reveals functional differences in stem-cell activity
Ng, Y. Y., van Kessel, B., Lokhorst, H. M., Baert, M. R. M., van den Burg, C. M. M., Bloem, A. C., & Staal, F. J. T. (2003) · Journal of Leukocyte Biology · doi:10.1189/jlb.0603287 · Cited by 90
Characterization of stage progression in chronic myeloid leukemia by DNA microarray with purified hematopoietic stem cells
Ohmine, K., Ota, J., Ueda, M., Ueno, S., Yoshida, K., Yamashita, Y., Kirito, K., Imagawa, S., Nakamura, Y., Saito, K., et al. (2001) · Oncogene · doi:10.1038/sj.onc.1205029 · Cited by 79
Pharmacogenomic Analysis of Cytogenetic Response in Chronic Myeloid Leukemia Patients Treated with Imatinib
McLean, L. A., Gathmann, I., Capdeville, R., Polymeropoulos, M. H., & Dressman, M. A. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-0784-3 · Cited by 79
Expression and Function of Leptin Receptor Isoforms in Myeloid Leukemia and Myelodysplastic Syndromes: Proliferative and Anti-Apoptotic Activities
Konopleva, M. Y., Mikhail, A. A., Estrov, Z. E., et al. (1999) · Blood · doi:10.1182/blood.v93.5.1668.405a15_1668_1676 · Cited by 78
Immature Leukemic CD34 + CXCR4 + Cells from CML Patients Have Lower Integrin‐Dependent Migration and Adhesion in Response to the Chemokine SDF‐1
Peled, A., Hardan, I., Trakhtenbrot, L., Gur, E., Magid, M., Darash‐Yahana, M., Cohen, N., Grabovsky, V., Franitza, S., Kollet, Ó., et al. (2002) · Stem Cells · doi:10.1634/stemcells.20-3-259 · Cited by 77
Abnormalities in the erythroid progenitor compartments in patients with chronic myelogenous leukemia (CML).
Eaves, A., & Eaves, C. (1979) · PubMed · Cited by 65
Interferon consensus sequence binding protein: Not essential for interferon alpha-mediated antiviral response to vesicular-stomatitis virus infection in HL-60 cells
Park, B.-K. (2001) · Immune Network · doi:10.4110/in.2001.1.2.109 · Cited by 60
Chronic myeloid leukaemia: stem cell derived but progenitor cell driven
Marley, S. B., & Gordon, M. Y. (2005) · Clinical Science · doi:10.1042/cs20040336 · Cited by 59
Distinct molecular phenotype of malignant CD34+ hematopoietic stem and progenitor cells in chronic myelogenous leukemia
Kronenwett, R., Butterweck, U., Steidl, U. U., Kliszewski, S., Neumann, F., Bork, S., Blanco, E. D., Roes, N., Graef, T. T., Brors, B., et al. (2005) · Oncogene · doi:10.1038/sj.onc.1208596 · Cited by 59
Self-citation
Mechanisms underlying abnormal trafficking and expansion of malignant progenitors in CML: BCR/ABL-induced defects in integrin function in CML
Salesse, S., & Verfaillie, C. M. (2002) · Oncogene · doi:10.1038/sj.onc.1206088 · Cited by 54
Characterization of the Biochemical and Transforming Properties of the Neuroepithelial Transforming Protein 1
Qin, H., Carr, H. S., Wu, X., Muallem, D. R., Tran, N. H., & Frost, J. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m412141200 · Cited by 53
Consensus guidelines for microarray gene expression analyses in leukemia from three European leukemia networks
Staal, F. J. T., Cario, G., Cazzaniga, G., Haferlach, T., Heuser, M., Hofmann, W. ‐., Mills, K., Schrappe, M., Stanulla, M., Wingen, L. U., et al. (2006) · Leukemia · doi:10.1038/sj.leu.2404274 · Cited by 53
Expression of the leptin receptor in human leukaemic blast cells
Nakao, T., Hino, M., Yamane, T., Nishizawà, Y., Morii, H., & Tatsumi, N. (1998) · British Journal of Haematology · doi:10.1046/j.1365-2141.1998.00843.x · Cited by 52
Localization of BCR-ABL to F-actin regulates cell adhesion but does not attenuate CML development
Wertheim, J. A., Perera, S. A., Hammer, D. A., Ren, R., Boettiger, D. C., & Pear, W. S. (2003) · Blood · doi:10.1182/blood-2003-01-0062 · Cited by 48
Integrin inhibition through Lyn-dependent cross talk from CXCR4 chemokine receptors in normal human CD34+ marrow cells
Nakata, Y., Tomkowicz, B. E., Gewirtz, A. M., & Ptasznik, A. (2006) · Blood · doi:10.1182/blood-2005-08-3343 · Cited by 47
Characterization of Cell Cycle Status and E2F Complexes in Mobilized CD34+ Cells Before and After Cytokine Stimulation
Williams, C. D., Linch, D. C., Watts, M., & Thomas, N. S. B. (1997) · Blood · doi:10.1182/blood.v90.1.194 · Cited by 47
Identification and molecular characterization of acyl-CoA synthetase in human erythrocytes and erythroid precursors
Malhotra, K., Malhotra, K., Lubin, B. H., & Kuypers, F. A. (1999) · Biochemical Journal · doi:10.1042/bj3440135 · Cited by 45
A sustained and pancellular reversal of gamma-globin gene silencing in adult human erythroid precursor cells
Bhanu, N. V., Trice, T. A., Lee, Y. T., Gantt, N. M., Oneal, P. A., Schwartz, J. D., Noël, P., & Miller, J. L. (2004) · Blood · doi:10.1182/blood-2004-04-1599 · Cited by 39
Biological effects of stroma-derived factor-1α on normal and CML CD34+ haemopoietic cells
Dürig, J., Rosenthal, C., Elmaagacli, A. H., Heyworth, C. M., Halfmeyer, K., Kasper, C., Novotný, J., & Dührsen, U. (2000) · Leukemia · doi:10.1038/sj.leu.2401875 · Cited by 39
Differences between normal and cml stem cells: Potential targets for clinical exploitation
Eaves, A. C., Barnett, M. J., Ponchio, L., Cashman, J., Petzer, A. L., & Eaves, C. J. (2009) · Stem Cells · doi:10.1002/stem.5530160809 · Cited by 36
GCKR Links the Bcr-Abl Oncogene and Ras to the Stress-Activated Protein Kinase Pathway
Shi, C.-S., Tuscano, J. M., Witte, O. N., & Kehrl, J. H. (1999) · Blood · doi:10.1182/blood.v93.4.1338 · Cited by 34
Differential effects of TGF-beta 1 on normal and leukemic human hematopoietic cell proliferation.
MUROHASHI, I., Endho, K., Nishida, S., Yoshida, S., Jinnai, I., Bessho, M., & HIRASHIMA, K. (1995) · PubMed · Cited by 32
Selectively increased growth of fetal hemoglobin-expressing adult erythroid progenitors after brief treatment of early progenitors with transforming growth factor beta
Böhmer, R. M., Campbell, T. A., & Bianchi, D. W. (2000) · Blood · doi:10.1182/blood.v95.9.2967.009k21_2967_2974 · Cited by 31
Leptin: A Promising Therapeutic Target with Pleiotropic Action Besides Body Weight Regulation
Paraskevas, K. I., Liapis, C. D., & Mikhailidis, D. P. (2006) · Current Drug Targets · doi:10.2174/138945006777435371 · Cited by 27
Impact of BCR/ABL gene expression on the proliferative rate of different subpopulations of haematopoietic cells in chronic myeloid leukaemia
Primo, D., Flores-Montero, J. A., Quijano, S., Sánchez, M. L., Sarasquete, M. E., del Pino‐Montes, J., Gaarder, P. I., González, M., & Órfão, A. (2006) · British Journal of Haematology · doi:10.1111/j.1365-2141.2006.06265.x · Cited by 27
Inhibition of angiogenesis in vitro by αv integrin–directed antisense oligonucleotides
Kronenwett, R., Graef, T. T., Nedbal, W., Weber, M., Steidl, U. U., Rohr, U., Möhler, T., & Haas, R. R. (2002) · Cancer Gene Therapy · doi:10.1038/sj.cgt.7700474 · Cited by 22
Self-citation
Gene expression profiling of Philadelphia chromosome (Ph)-negative CD34+ hematopoietic stem and progenitor cells of patients with Ph-positive CML in major molecular remission during therapy with imatinib
Neumann, F., Teutsch, N., Kliszewski, S., Bork, S., Steidl, U. U., Brors, B., Schimkus, N., Roes, N., Germing, U., Hildebrandt, B., et al. (2004) · Leukemia · doi:10.1038/sj.leu.2403615 · Cited by 20
Self-citation

Sorted by citations

Chronic Myeloid Leukemia: An Update of Concepts and Management Recommendations of European LeukemiaNet
Baccarani, M., Cortes, J. E., Pane, F., Niederwieser, D. W., Saglio, G. N., Apperley, J. F., Cervantes, F., Deininger, M. W., Gratwohl, A. A., Guilhot, F., et al. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2009.25.0779 · Cited by 1,276
The IRF Family Transcription Factors in Immunity and Oncogenesis
Tamura, T., Yanai, H., Savitsky, D., & Taniguchi, T. (2008) · Annual Review of Immunology · doi:10.1146/annurev.immunol.26.021607.090400 · Cited by 1,259
Regulation of immunity and oncogenesis by the IRF transcription factor family
Savitsky, D., Tamura, T., Yanai, H., & Taniguchi, T. (2010) · Cancer Immunology, Immunotherapy · doi:10.1007/s00262-009-0804-6 · Cited by 298
Restricted dendritic cell and monocyte progenitors in human cord blood and bone marrow
Lee, J., Breton, G., Oliveira, T. Y., Zhou, Y. J., Aljoufi, A., Puhr, S., Cameron, M. J., Sékaly, R., Nussenzweig, M. C., & Liu, K. (2015) · The Journal of Experimental Medicine · doi:10.1084/jem.20141442 · Cited by 258
Myc Roles in Hematopoiesis and Leukemia
Delgado, M. D., & León, J. (2010) · Genes & Cancer · doi:10.1177/1947601910377495 · Cited by 253

See all 150

Authors: Diaz-Blanco, E., Bruns, I., Neumann, F., Fischer, J. C., Graef, T., Rosskopf, M., Brors, B., Pechtel, S., Bork, S., Koch, A., Baer, A., Rohr, U.-P., Kobbe, G., Haeseler, A. V., Gattermann, N., Haas, R., & Kronenwett, R.
Affiliations: Heinrich Heine University Düsseldorf (DE)
German Cancer Research Center (DE)
University of Vienna (AT)
Corresponding author: Kronenwett, R
ORCID: Bruns, I
Neumann, F
Fischer, J C
Graef, T
Brors, B
Kobbe, G
Haeseler, A von
Gattermann, N
Haas, R
Kronenwett, R
Venue: Leukemia
Publisher: Springer Science and Business Media LLC
Published: 2007-01-25
Volume: 21
Issue: 3
Pages: 494-504
ISSN: 0887-6924 (ISSN-L)
1476-5551
DOI: 10.1038/sj.leu.2404549
OpenAlex: W2564723484
Cited by: 148
References: 78
Citations by year: 2026: 4 · 2025: 3 · 2024: 6 · 2023: 5 · 2022: 4 · 2021: 10 · 2020: 6 · 2019: 6 · 2018: 2 · 2017: 8 · 2016: 4 · 2015: 10 · 2014: 5 · 2013: 12 · 2012: 7
FWCI: 9.58
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Leukemia (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Hematology › Chronic Myeloid Leukemia Treatments
Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinoids in leukemia and cellular processes
Keywords: chronic myeloid leukemia, chronic phase, CD34+ hematopoietic stem and progenitor cells, BCR-ABL, gene expression signatures, MAPK signaling, phosphoinositide 3-kinase/Akt pathway, IRF8, HOXA9, MEIS1, megakaryocyte-erythroid progenitors, CFU-GM, fetal hemoglobin, selenoprotein P, leukemogenesis, therapeutic target
MeSH terms: Cell Adhesion, Cell Differentiation, Cell Division, DNA, Neoplasm, Hematopoietic Stem Cells, Humans, Neoplasm Proteins, Receptors, Cell Surface, RNA, Messenger, RNA, Neoplasm, Neoplastic Stem Cells, Signal Transduction, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Leukemia, Myeloid, Chronic-Phase, Up-Regulation, Gene Expression Regulation, Leukemic, Fusion Proteins, bcr-abl, Apoptosis, Receptors, Growth Factor, DNA, Complementary, Antigens, CD34, Gene Expression Profiling, Intercellular Signaling Peptides and Proteins, Receptors, Leptin

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Molecular signature of CD34+ hematopoietic stem and progenitor cells of patients with CML in chronic phase

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks