Cited by 174Tryptophan and brain disordersStress Responses and CortisolTreatment of Major Depression

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Cytokines and depression: fortuitous or causative association?

Dantzer, R, Wollman, E, Vitkovic, L, Yirmiya, R·1999·Molecular Psychiatry

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Abstract

There is an increasingly impressive database concerning the possible involvement of cytokines in depression and their role in the therapeutic effects of antidepressants. Based on the discussions which took place on these issues at a recent meeting held in Roscoff, France, this perspective summarizes in a critical way the evidence in favor of such a possibility, and points out the needs for further research to clarify both the nature of the subtle dysregulations that affect neuroendocrine-immune interactions in depressive disorders and their contribution to psychopathology.

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Authors: Dantzer, R., Wollman, E., Vitkovic, L., & Yirmiya, R.
Affiliations: Inserm (FR)
Centre National de la Recherche Scientifique (FR)
Hebrew University of Jerusalem (IL)
Corresponding author: Dantzer, R
ORCID: Dantzer, R
Yirmiya, R
Venue: Molecular Psychiatry
Publisher: Springer Science and Business Media LLC
Published: 1999-07-01
Volume: 4
Issue: 4
Pages: 328-332
ISSN: 1359-4184 (ISSN-L)
1476-5578
DOI: 10.1038/sj.mp.4000572
OpenAlex: W2063650882
Cited by: 174
References: 37
Citations by year: 2026: 1 · 2025: 4 · 2024: 4 · 2023: 2 · 2022: 7 · 2021: 5 · 2020: 6 · 2019: 2 · 2018: 3 · 2017: 4 · 2016: 4 · 2015: 8 · 2014: 4 · 2013: 4 · 2012: 4
FWCI: 4.19
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Molecular Psychiatry (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Topics: Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Keywords: cytokines, depression, antidepressants, neuroendocrine-immune interaction, neuroinflammation, psychopathology, cytokine imbalance
MeSH terms: Antidepressive Agents, Brain, Depression, Depressive Disorder, Humans, Cytokines

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Cytokines and depression: fortuitous or causative association?

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