The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Cytokines and depression: fortuitous or causative association?
Abstract
There is an increasingly impressive database concerning the possible involvement of cytokines in depression and their role in the therapeutic effects of antidepressants. Based on the discussions which took place on these issues at a recent meeting held in Roscoff, France, this perspective summarizes in a critical way the evidence in favor of such a possibility, and points out the needs for further research to clarify both the nature of the subtle dysregulations that affect neuroendocrine-immune interactions in depressive disorders and their contribution to psychopathology.
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“Stress and depression can permanently alter the responsiveness of the immune system (41-44).”
From Chronic stress and age-related increases in the proinflammatory cytokine IL-6. (2003) · cites this paper as [43]
Citations
Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,845
Prevention of Allogeneic Fetal Rejection by Tryptophan Catabolism
Munn, D. H., Zhou, M., Attwood, J. T., Bondarev, I. E., Conway, S. J., Marshall, B., Brown, C. C., & Mellor, A. L. (1998) · Science · doi:10.1126/science.281.5380.1191 · Cited by 2,589
Regulation of the Hypothalamic-Pituitary-Adrenal Axis by Cytokines: Actions and Mechanisms of Action
TURNBULL, A. V., & RIVIER, C. L. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.1.1 · Cited by 1,297
Depression and immunity: A meta-analytic review.
Herbert, T. B., & Cohen, S. (1993) · Psychological Bulletin · doi:10.1037/0033-2909.113.3.472 · Cited by 812
Major Depression and Activation of The Inflammatory Response System
Maes, M. (1999) · Advances in Experimental Medicine and Biology · doi:10.1007/978-0-585-37970-8_2 · Cited by 617
Maes, M. H. J. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(98)00088-8 · Cited by 357
Effects of Cytokines on Cerebral Neurotransmission: Comparison with the Effects of Stress
Dunn, A. J., Wang, J., & Ando, T. (1999) · Advances in Experimental Medicine and Biology · doi:10.1007/978-0-585-37970-8_8 · Cited by 316
Anisman, H., Ravindran, A. V., Griffiths, J., & Merali, Z. (1999) · Molecular Psychiatry · doi:10.1038/sj.mp.4000436 · Cited by 310
The monocyte-T-lymphocyte hypothesis of major depression
Maes, M., Smith, R., & Simon, S. (1995) · Psychoneuroendocrinology · doi:10.1016/0306-4530(94)00066-j · Cited by 299
Euthyroid Sick Syndrome: An Overview
McIver, B., & Gorman, C. A. (1997) · Thyroid · doi:10.1089/thy.1997.7.125 · Cited by 258
The Thyroid Axis and Depression
JACKSON, I. M. D. (1998) · Thyroid · doi:10.1089/thy.1998.8.951 · Cited by 230
Cytokines, Stress, and Depression
Dantzer, R., Wollman, E. E., Vitković, L., & Yirmiya, R. (1999) · Advances in experimental medicine and biology · doi:10.1007/978-0-585-37970-8_17 · Cited by 220
Self-citationCytokines, “depression due to a general medical condition”, and antidepressant drugs
Yirmiya, R., Weidenfeld, J., Pollak, Y., Morag, M., Morag, A., Avitsur, R., Barak, O., Reichenberg, A., Cohen, E., Shavit, Y., et al. (1999) · Advances in Experimental Medicine and Biology · doi:10.1007/978-0-585-37970-8_16 · Cited by 208
Self-citationMiller, A. H., Pariante, C. M., & Pearce, B. D. (1999) · Advances in Experimental Medicine and Biology · doi:10.1007/978-0-585-37970-8_7 · Cited by 203
Anhedonic and Anxiogenic Effects of Cytokine Exposure
Anisman, H., & Merali, Z. (1999) · Advances in experimental medicine and biology · doi:10.1007/978-0-585-37970-8_12 · Cited by 185
CSF corticotropin-releasing hormone in depressed patients and normal control subjects
Roy, A., Pickar, D., Paul, S. M., Doran, A., Chrousos, G. P., & Gold, P. W. (1987) · American Journal of Psychiatry · doi:10.1176/ajp.144.5.641 · Cited by 183
Central injection of IL-10 antagonizes the behavioural effects of lipopolysaccharide in rats
Bluthé, R.-M., Castanon, N., Pousset, F., Bristow, A., Ball, C., Lestage, J., Michaud, B., KELLEY, K. W., & Dantzer, R. (1999) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(98)00077-8 · Cited by 179
Self-citationCapuron, L., & Ravaud, A. (1999) · New England Journal of Medicine · doi:10.1056/nejm199904293401716 · Cited by 169
Immune Correlates of Depression
Irwin, M. R. (1999) · Advances in experimental medicine and biology · doi:10.1007/978-0-585-37970-8_1 · Cited by 162
Swiergiel, A. H., Smagin, G. N., Johnson, L. J., & Dunn, A. J. (1997) · Brain Research · doi:10.1016/s0006-8993(97)01009-3 · Cited by 130
Schleifer, S., & Keller, S. E. (1992) · Clinical Neuropharmacology · doi:10.1097/00002826-199202001-00244 · Cited by 101
Mood and cognitive disorders in cancer patients receiving cytokine therapy.
Meyers, C. A. (1999) · Advances in Experimental Medicine and Biology · doi:10.1007/978-0-585-37970-8_5 · Cited by 98
Azpiroz, A., Fano, E., Garmendia, L., Arregi, A., Cacho, R., Beitia, G., & Brain, P. F. (1999) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(98)00084-5 · Cited by 93
Blunted Sensitivity to Sucrose in Autoimmune MRL-lpr Mice: A Curve-Shift Study
Šakić, B., Denburg, J. A., Denburg, S. D., & Szechtman, H. (1996) · Brain Research Bulletin · doi:10.1016/s0361-9230(96)00190-6 · Cited by 87
Heyes, M. P., Saito, K., Chen, C. Y., Proescholdt, M. G., Nowak, T. S., Li, J., Beagles, K. E., Proescholdt, M. A., Zito, M. A., Kawai, K., et al. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69041519.x · Cited by 82
Varni, J. W., & Katz, E. R. (1997) · Psycho-Oncology · doi:10.1002/(sici)1099-1611(199712)6:4 · Cited by 81
Connor, T. J., Harkin, A., Kelly, J. P., & Leonard, B. E. (1999) · NeuroImmunoModulation · doi:10.1159/000026417 · Cited by 80
Cross-Sensitization Between Immune And Non-Immune Stressors
Tilders, J. H., & Schmidt, E. D. (1999) · Advances in experimental medicine and biology · doi:10.1007/978-0-585-37970-8_11 · Cited by 74
Bauer, J., Hohagen, F., Gimmel, E., Bruns, F., Lis, S., Krieger, S., Ambach, W., Guthmann, A., Grunze, H., Fritsch-Montero, R., et al. (1995) · Biological Psychiatry · doi:10.1016/0006-3223(95)00374-x · Cited by 68
Dynamic Regulation of Proinflammatory Cytokines
Watkins, L. R., Nguyen, K. T., Lee, J. E., & Maier, S. F. (1999) · Advances in Experimental Medicine and Biology · doi:10.1007/978-0-585-37970-8_10 · Cited by 67
Clinical and Subclinical Hypothyroidism in Patients with Chronic and Treatment-Resistant Depression
Hickie, I. B., Bennett, B. K., Mitchell, P. B., Wilhelm, K. A., & Orlay, W. (1996) · Australian & New Zealand Journal of Psychiatry · doi:10.3109/00048679609076101 · Cited by 64
Brain type I but not type II IL-1 receptors mediate the effects of IL-1β on behavior in mice
Cremona, S., Goujon, E., Kelley, K. W., Dantzer, R., & Parnet, P. (1998) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1998.274.3.r735 · Cited by 42
Self-citationStress, Learned Helplessness, and Brain Interleukin-1β
Maier, S. F., Nguyen, K. T., Terrence Deak, B., Milligan, E. D., & Watkins, L. R. (1999) · Advances in experimental medicine and biology · doi:10.1007/978-0-585-37970-8_13 · Cited by 39
Is There Evidence for an Effect of Antidepressant Drugs on Immune Function?
Neveu, P. J., & Castanon, N. (1999) · Advances in experimental medicine and biology · doi:10.1007/978-0-585-37970-8_15 · Cited by 26
Linthorst, A. C. E., & Reul, J. M. H. M. (1999) · Advances in experimental medicine and biology · doi:10.1007/978-0-585-37970-8_9 · Cited by 21
Epidemiology of depression in late life
Ernst, C. (1997) · Current Opinion in Psychiatry · doi:10.1097/00001504-199703000-00009 · Cited by 14
Major Depression and activation of the Inflammatory Response System
West, D. V. (1999) · VUBIR (Vrije Universiteit Brussel) · Cited by 10
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A Meta-Analysis of Cytokines in Major Depression
Dowlati, Y., Herrmann, N., Swardfager, W., Liu, H., Sham, L., Reim, E. K., & Lanctôt, K. L. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.033 · Cited by 4,729
Belmaker, R. H., & Agam, G. (2008) · New England Journal of Medicine · doi:10.1056/nejmra073096 · Cited by 2,166
Ownby, R. L., Crocco, E., Acevedo, A., John, V., & Loewenstein, D. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.5.530 · Cited by 1,493
Chronic stress and age-related increases in the proinflammatory cytokine IL-6.
Kiecolt-Glaser, J. K., Preacher, K. J., MacCallum, R. C., Atkinson, C., Malarkey, W. B., & Glaser, R. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1531903100 · Cited by 1,267
Cytokine-induced sickness behaviour: mechanisms and implications
Konsman, J. P., Parnet, P., & Dantzer, R. (2002) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)02088-9 · Cited by 999
Self-citation
Metadata
- Authors
- Dantzer, R., Wollman, E., Vitkovic, L., & Yirmiya, R.
- Affiliations
- Inserm (FR)
- Centre National de la Recherche Scientifique (FR)
- Hebrew University of Jerusalem (IL)
- Corresponding author
- Dantzer, R
- ORCID
- Venue
- Molecular Psychiatry
- Published
- 1999-07-01
- Volume
- 4
- Issue
- 4
- Pages
- 328-332
- ISSN
- 1359-4184 (ISSN-L)
- 1476-5578
- OpenAlex
- W2063650882
- Cited by
- 174
- References
- 37
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 4 · 2023: 2 · 2022: 7 · 2021: 5 · 2020: 6 · 2019: 2 · 2018: 3 · 2017: 4 · 2016: 4 · 2015: 8 · 2014: 4 · 2013: 4 · 2012: 4
- FWCI
- 4.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Keywords
- cytokines, depression, antidepressants, neuroendocrine-immune interaction, neuroinflammation, psychopathology, cytokine imbalance
- MeSH terms
- Antidepressive Agents, Brain, Depression, Depressive Disorder, Humans, Cytokines
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