Effekte Akuter Entzündungsreaktionen auf Gedächtnisleistungen, Befindlichkeiten und Neurale Aktivitäten: Effects of an Acute Inflammation on Memory Performance, Mood and Brain Activity
Abstract
Systemic inflammatory processes induced by infectious diseases, sepsis or chronic inflammatory auto-immune diseases can affect mood, neuropsychological functions and behavior. Typically, those behavioral changes include symptoms such as psychomotor slowing, social withdrawal, anhedonia and depressed mood, and are collectively termed “sickness behavior”. It is believed that the increased release of pro- and anti-inflammatory cytokines and hormones are mediating these behavioral effects and that peripheral cytokines are involved in the pathophysiology of neuropsychiatric disorders such as depression and schizophrenia. In humans, the effects of an acute systemic inflammatory response on neuropsychological function can be experimentally analyzed by administering bacterial endotoxins. This review provides an overview of studies in humans investigating the effects of experimentally induced inflammation on cognitive and emotional parameters and corresponding neural activities within the CNS. In addition, possible signaling pathways are outlined, of how information from the peripheral immune system is transmitted to the CNS during peripheral inflammation.
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Studies in experimental animals together with clinical observations in humans suggest a cytokine-mediated modulation of memory functions as a consequence of acute peripheral inflammatory processes.
“Studies in experimental animals together with clinical observations in humans suggest a cytokine-mediated modulation of memory functions as a consequence of acute peripheral inflammatory processes [3], [37].”
From Dose-dependent effects of endotoxin on neurobehavioral functions in humans (2011) · cites this paper as [37]
HPA system activation with increased levels of cortisol and corticotropin releasing hormone have also been suggested to play a role in depressive symptoms and in mediating inflammatory effects on mood and anxiety.
“HPA system activation with increased levels of cortisol and corticotropin releasing hormone have also been suggested to play a role in depressive symptoms and in mediating inflammatory effects on mood and anxiety [6], [28], [37], [63].”
From Dose-dependent effects of endotoxin on neurobehavioral functions in humans (2011) · cites this paper as [37]
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Dose-dependent effects of endotoxin on neurobehavioral functions in humans
Grigoleit, J.-S., Kullmann, J. S., Wolf, O. T., Hammes, F., Wegner, A., Jablonowski, S., Engler, H., Gizewski, E., Oberbeck, R., & Schedlowski, M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028330 · Cited by 241 · see citing works
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Self-citationExperimental endotoxemia as a model to study neuroimmune mechanisms in human visceral pain
Benson, S., Engler, H., Schedlowski, M., & Elsenbruch, S. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06622.x · Cited by 26 · see citing works
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- Authors
- Kullmann, J. S., Grigoleit, J.-S., & Schedlowski, M.
- Affiliations
- Essen University Hospital (DE)
- University of Duisburg-Essen (DE)
- Venue
- Zeitschrift für Medizinische Psychologie
- Publisher
- IOS Press
- Published
- 2011-08
- Volume
- 20
- Issue
- 3
- Pages
- 108-117
- ISSN
- 0940-5569 (ISSN-L)
- 1875-9246
- OpenAlex
- W2288262283
- Cited by
- 3
- References
- 57
- Citations by year
- 2013: 1 · 2012: 1
- FWCI
- 0.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Zeitschrift für Medizinische Psychologie (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- acute systemic inflammation, sickness behavior, cognitive performance, mood, neuronal activity, endotoxin, bacterial lipopolysaccharide, cytokines, neuroinflammation, depression, schizophrenia, anhedonia, psychomotor retardation
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