Genome-wide scan supports the existence of a susceptibility locus for schizophrenia and bipolar disorder on chromosome 15q26
Abstract
Schizophrenia (SZ) and bipolar disorder (BPD) are two severe psychiatric diseases with a strong genetic component. In agreement with the 'continuum theory', which suggests an overlap between these disorders, the existence of genes that affect simultaneously susceptibility to SZ and BPD has been hypothesized. In this study we performed a 7.5 cM genome scan in a sample of 16 families affected by SZ and BPD, all originating from the same northeast Italian population. Using both parametric and non-parametric analyses we identified linkage peaks on four regions (1p, 1q, 4p and 15q), which were then subjected to a follow-up study with an increased marker density. The strongest linkage was obtained on chromosome 15q26 with a non-parametric linkage of 3.05 for marker D15S1014 (nominal P=0.00197). Interestingly, evidence for linkage with the same marker has been reported previously by an independent study performed on SZ and BPD families from Quebec. In this region, the putative susceptibility gene ST8SIA2 (also known as SIAT8B) was recently associated with SZ in a Japanese sample. However, our allele frequency analyses of the two single-nucleotide polymorphisms (SNPs) with putative functional outcome (rs3759916 and rs3759914) suggest that these polymorphisms are unlikely to be directly involved in SZ in our population. In conclusion, our results support the presence of a gene in 15q26 that influences the susceptibility to both SZ and BPD.
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Additional areas of interest such as 1p36, 1q43, 4p14 and 15q26 have been identified as common to BD and psychosis.
“Since then, additional areas of interest such as 1p36, 1q43, 4p14 and, of particular note, 15q26 have been identified (186).”
From Childhood Trauma, the HPA Axis and Psychiatric Illnesses: A Targeted Literature Synthesis (2022) · cites this paper as [186]
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“Since then, additional areas of interest such as 1p36, 1q43, 4p14 and, of particular note, 15q26 have been identified (186).”
BackgroundGenome-wide association study of bipolar I disorder in the Han Chinese population
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- Authors
- Vazza, G., Bertolin, C., Scudellaro, E., Vettori, A., Boaretto, F., Rampinelli, S., De Sanctis, G., Perini, G., Peruzzi, P., & Mostacciuolo, M. L.
- Affiliations
- University of Padua (IT)
- Corresponding author
- Vazza, G
- Venue
- Molecular Psychiatry
- Published
- 2006-09-12
- Volume
- 12
- Issue
- 1
- Pages
- 87-93
- ISSN
- 1359-4184 (ISSN-L)
- 1476-5578
- OpenAlex
- W2011968608
- Cited by
- 48
- References
- 34
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 2 · 2019: 2 · 2018: 1 · 2017: 2 · 2016: 1 · 2015: 1 · 2014: 2 · 2013: 4 · 2012: 3
- FWCI
- 3.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Padua Research Archive (University of Padova) (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Keywords
- schizophrenia, bipolar disorder, genetic linkage, genetic susceptibility loci, continuum theory, ST8SIA2, single nucleotide polymorphisms, allele frequency
- MeSH terms
- Bipolar Disorder, Chromosome Mapping, Chromosomes, Human, Pair 15, Female, Follow-Up Studies, Gene Frequency, Genetic Markers, Genotype, Humans, Italy, Genetic Linkage, Male, Schizophrenia, Genetic Predisposition to Disease, Genomics
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