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The polysialic acid mimetics idarubicin and irinotecan stimulate neuronal survival and neurite outgrowth and signal via protein kinase C

Loers, G., Astafiev, S., Hapiak, Y., Saini, V., Mishra, B., Gul, S., Kaur, G., Schachner, M., & Theis, T. (2017) · Journal of Neurochemistry · doi:10.1111/jnc.14076 · Cited by 13 · see citing works

Generation and intracellular trafficking of a polysialic acid-carrying fragment of the neural cell adhesion molecule NCAM to the cell nucleus

Westphal, N., Loers, G., Lutz, D., Theis, T., KLEENE, R. B., & Schachner, M. (2017) · Scientific Reports · doi:10.1038/s41598-017-09468-8 · Cited by 12 · see citing works

Vinorelbine and epirubicin share common features with polysialic acid and modulate neuronal and glial functions

Loers, G., Saini, V., Mishra, B., Gul, S., Chaudhury, S., Wallqvist, A., Kaur, G., & Schachner, M. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13383 · Cited by 11 · see citing works

Introduction to the Complexity of Cell Surface and Tissue Matrix Glycoconjugates

BHAVANANDAN, V. P., & Gowda, D. C. (2014) · Advances in neurobiology · doi:10.1007/978-1-4939-1154-7_1 · Cited by 10 · see citing works

Cell‐autonomous impact of polysialic acid‐producing enzyme ST8SIA2 on developmental migration and distribution of cortical interneurons

Schuster, U. E., Rossdam, C., Röckle, I., Schiff, M., & Hildebrandt, H. (2019) · Journal of Neurochemistry · doi:10.1111/jnc.14896 · Cited by 9 · see citing works

Compromised mammillary body connectivity and psychotic symptoms in mice with di- and mesencephalic ablation of ST8SIA2

Küçükerden, M., Schuster, U. E., Röckle, I., Álvarez-Bolado, G., Schwabe, K., & Hildebrandt, H. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-01816-1 · Cited by 8 · see citing works

The Importance of N- and O-Glycosylation of Brain Cell Surface Glycoproteins

Noël, M., Zürcher, Y. M., Tulin, E. K. C., & Cummings, R. D. (2025) · Glycobiology · doi:10.1093/glycob/cwaf054 · Cited by 7 · see citing works

Histone H1 improves regeneration after mouse spinal cord injury and changes shape and gene expression of cultured astrocytes

KLEENE, R. B., Loers, G., Jakovčevski, I., Mishra, B., & Schachner, M. (2019) · Restorative Neurology and Neuroscience · doi:10.3233/rnn-190903 · Cited by 7 · see citing works

Molecular characterization and expression analyses of ST8Sia II and IV in piglets during postnatal development: lack of correlation between transcription and posttranslational levels

Zhu, X., Chen, Y., Zhang, N., Zheng, Z., Zhao, F., Liu, N., Lv, C., Troy, F. A., & Wang, B. (2015) · Glycoconjugate Journal · doi:10.1007/s10719-015-9622-6 · Cited by 7 · see citing works

Transgenic overexpression of polysialyltransferase ST8SiaIV under the control of a neuron-specific promoter does not affect brain development but impairs exploratory behavior

Fewou, S. N., Röckle, I., Hildebrandt, H., & Eckhardt, M. (2019) · Glycobiology · doi:10.1093/glycob/cwz040 · Cited by 7 · see citing works

Biosynthetic and genetic pathways related to sialic acid metabolism

Huang, S., van de Ven, E. G. P., Tee, T., & Lefeber, D. J. (2026) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2026.111262 · Cited by 6 · see citing works

Polysialic acid regulates glomerular microvasculature formation by interaction with VEGF-A188 in mice

Niculovic, K. M., Vicente, M. M., Wittek, V., Kats, E., Albers, I., Flächsig-Schulz, K., Peters-Bernard, U., Weiss, A., Thiesler, H., Dräger, L. S., et al. (2025) · Angiogenesis · doi:10.1007/s10456-025-09984-6 · Cited by 5 · see citing works

N-Propionylmannosamine stimulates axonal elongation in a murine model of sciatic nerve injury

Witzel, C., Reutter, W. G., Stark, G. B., & Koulaxouzidis, G. (2015) · Neural Regeneration Research · doi:10.4103/1673-5374.150744 · Cited by 6 · see citing works

Polysialic Acid Regulates Sympathetic Outflow by Facilitating Information Transfer within the Nucleus of the Solitary Tract

Bokiniec, P., Shahbazian, S., McDougall, S. J., Berning, B. A., Cheng, D., Llewellyn‐Smith, I. J., Burke, P. G. R., McMullan, S., Mühlenhoff, M., Hildebrandt, H., et al. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.0200-17.2017 · Cited by 6 · see citing works

Biochemical Characterization and Analyses of Polysialic‐Acid‐Associated Carrier Proteins and Genes in Piglets during Neonatal Development

Chen, Y., Ren, H., Zhang, N., Troy, F. A., & Wang, B. (2017) · ChemBioChem · doi:10.1002/cbic.201700029 · Cited by 5 · see citing works

Engineering polysialic acid on Schwann cells using polysialyltransferase gene transfer or purified enzyme exposure for spinal cord injury transplantation

Pearse, D. D., Rao, S. N. R., Morales, A. A., Wakarchuk, W. W., Rutishauser, U. S., El-Maarouf, A., & Ghosh, M. (2021) · Neuroscience Letters · doi:10.1016/j.neulet.2021.135690 · Cited by 5 · see citing works

Mosaic expression of SLC35A2 pathogenetic variants impairs neuronal migration and dendritogenesis in the developing cortex

Falace, A., Corbières, L., Silvagnoli, L., Pelorosso, C., Carlo, C. T. D. S., Buhler, E., Hoteit, Z., Bauer, Š., Risso, B., Cesar, Q., et al. (2025) · Human Molecular Genetics · doi:10.1093/hmg/ddaf156 · Cited by 4 · see citing works

Early PSA-NCAM reduction in the dentate gyrus and impaired plasticity in the Alzheimer´s disease 3xTg-mice model

Rodriguez, J. J., Gardenal, E., Zallo, F., Cabot, J., & Busquets, X. (2024) · Acta Histochemica · doi:10.1016/j.acthis.2024.152194 · Cited by 3 · see citing works

Harnessing polysialic acid (PSA)-embedded exudate-absorbing hydrogel for on-demand trigeminal neuralgia treatment

Gao, J., Tao, L., Wen, S.-L., Feng, R.-Q., Zheng, Y., Chen, S.-S., Chen, J.-E., & Xu, X. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.138035 · Cited by 3 · see citing works

Transcription factor AP‐2delta regulates the expression of polysialyltransferase ST8SIA2 in chick retina

Li, X., Persad, A. R. L., Monckton, E. A., & Godbout, R. (2014) · FEBS Letters · doi:10.1016/j.febslet.2014.01.024 · Cited by 3 · see citing works

Interaction Studies of Sialic Acids with Model Receptors Contribute to Nanomedical Therapies

Ruiyan, H. C. S. (2015) · Journal of Neurological Disorders · doi:10.4172/2329-6895.1000212 · Cited by 3 · see citing works

Glycoconjugate journal special issue on: the glycobiology of Parkinson’s disease

Brockhausen, I., Schutzbach, J. S., Wang, J., Fishwick, B., & Brockhausen, J. (2021) · Glycoconjugate Journal · doi:10.1007/s10719-021-10024-w · Cited by 3 · see citing works

Acute adolescent morphine exposure improves dark avoidance memory and enhances long‐term potentiation of ventral hippocampal CA1 during adulthood in rats

Khani, F., Pourmotabbed, A., Hosseinmardi, N., Alaee, E., Fathollahi, Y., & Azizi, H. (2023) · Addiction Biology · doi:10.1111/adb.13308 · Cited by 2 · see citing works

Chemical and biological methods for probing the structure and functions of polysialic acids

Goswami, S., Parashar, S., Dwivedi, V., Shajahan, A., & Sampathkumar, S. (2018) · Emerging Topics in Life Sciences · doi:10.1042/etls20180008 · Cited by 2 · see citing works

With a little help from EphA3 and polysialic acid: Ectodomain shedding of NCAM is gaining momentum

Hildebrandt, H., & Dityatev, A. E. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12514 · Cited by 2 · see citing works

Changes in Protein N -Glycosylation Regulation Occur in the Human Parkinsonian Brain in a Region-Specific MannerPreprint

Rebelo, A. L., Drake, R. R., Marchetti‐Deschmann, M., Saldova, R., & Pandit, A. S. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.05.19.492623 · Cited by 2 · see citing works

Polysialic acid in the rat brainstem and thoracolumbar spinal cord: Distribution, cellular location, and comparison with mouse

Shahbazian, S., Bokiniec, P., Berning, B. A., McMullan, S., & Goodchild, A. K. (2020) · The Journal of Comparative Neurology · doi:10.1002/cne.24982 · Cited by 1 · see citing works

Immunoglobulin cell adhesion molecules of the Ig-FNIII type and neurodevelopment

Burbach, J. P. H. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-817986-4.00010-9 · Cited by 1 · see citing works

Secondary deficiency of neuraminidase 1 contributes to CNS pathology in neurological mucopolysaccharidoses via hypersialylation of brain glycoproteinsPreprint

Xu, T., Heon‐Roberts, R., Moore, T., Dubot, P., Pan, X., Guo, T., Cairo, C. W., Holley, R. J., Bigger, B., Durcan, T. M., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.04.26.587986 · Cited by 1 · see citing works

Polysialic Acid Presentation on Microporous Scaffolds Supports Neural Repair after Ischemic StrokePreprint

Ouyang, Y., Che, S., Newman, H., Poysungnoen, K., & Segura, T. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.30.674064 · Cited by 2 · see citing works

Plasticity Molecule Reveals Interneuronal Alterations in Alzheimer’s Disease

Nácher, J. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.01.012

Neural Cell Adhesion Molecules in Normal and Abnormal Neural Development

Wang, C., Yin, Q., Patterson, T. A., Liu, S., Zhang, X., Liu, F., Paule, M. G., & Slikker, W. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-809405-1.00002-x

Effect of Blast Exposure on Gene-Gene InteractionsPreprint

Yazdani, A. (2018) · arXiv (Cornell University) · doi:10.48550/arxiv.1809.05095

Sialoglycoconjugates and their role in physiology

Ghosh, S. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-816126-5.00004-4

Introduction to the Complexity of Cell Surface and Tissue Matrix Glycoconjugates

BHAVANANDAN, V. P., & Gowda, D. C. (2022) · Advances in neurobiology · doi:10.1007/978-3-031-12390-0_1

Small Organic Compounds Mimicking the Effector Domain of Myristoylated Alanine-Rich C-Kinase Substrate Stimulate Female-Specific Neurite Outgrowth

Tschang, M., Kumar, S., Young, W., Schachner, M., & Theis, T. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241814271

Deciphering the Glycoproteomic Landscape of Mood Disorders: Unveiling Molecular Association Between CDG and Depression ResiliencePreprint

Kozicz, T., Budhraja, R., Preston, G. J., Joshi, N. S., Muffels, I. J. J., Turecki, G., Frye, M. A., Veldić, M., Morava, É., & Pandey, A. (2025) · Research Square · doi:10.21203/rs.3.rs-6882753/v1

Chronic social defeat stress impairs polysialic acid levels in the hippocampus of mice

Ohno, H., & Aizawa, S. (2025) · Neuroreport · doi:10.1097/wnr.0000000000002228

ST8SIA4-mediated polysialylation is critical for CCR2-driven monocyte egress from the bone marrowPreprint

Boyance, A., Gilles, N., Rotival, M., Stella, A., Gorlt, C., Chaoui, K., Monard, S., Aguiló, N., Mangeat, T., Burlet‐Schiltz, O., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.09.698551

ST8SIA4 and the repair–inflammation axis of lesion remodeling in RRMS

Sökmen, O. (2026) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2026.107325

Polysialic Acid

Sato, C., & Kitajima, K. (2014) · Springer eBooks · doi:10.1007/978-4-431-54836-2_117-1

Brain development needs sugar: the role of polysialic acid in controlling NCAM functions

Mühlenhoff, M., Oltmann‐Norden, I., Weinhold, B., Hildebrandt, H., & Gerardy‐Schahn, R. (2009) · Biological Chemistry · doi:10.1515/bc.2009.078 · Cited by 50 · see citing works

Dissecting polysialic acid and NCAM functions in brain development

Hildebrandt, H., Mühlenhoff, M., Weinhold, B., & Gerardy‐Schahn, R. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04716.x · Cited by 136 · see citing works

News and Views on Polysialic Acid: From Tumor Progression and Brain Development to Psychiatric Disorders, Neurodegeneration, Myelin Repair and Immunomodulation

Thiesler, H., Küçükerden, M., Gretenkort, L., Röckle, I., & Hildebrandt, H. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.871757 · Cited by 32 · see citing works

Polysialyltransferases: major players in polysialic acid synthesis on the neural cell adhesion molecule

Angata, K. (2003) · Biochimie · doi:10.1016/s0300-9084(03)00051-8 · Cited by 205 · see citing works