Genome-wide association study of bipolar I disorder in the Han Chinese population
Abstract
We report the first genome-wide association study in 1000 bipolar I patients and 1000 controls, with a replication of the top hits in another 409 cases and 1000 controls in the Han Chinese population. Four regions with most strongly associated single-nucleotide polymorphisms (SNPs) were detected, of which three were not found in previous GWA studies in the Caucasian populations. Among them, SNPs close to specificity protein 8 (SP8) and ST8 α-N-acetyl- neuraminide α-2,8-sialyltransferase (ST8SIA2) are associated with Bipolar I, with P-values of 4.87 × 10(-7) (rs2709736) and 6.05 × 10(-6) (rs8040009), respectively. We have also identified SNPs in potassium channel tetramerization domain containing 12 gene (KCTD12) (rs2073831, P=9.74 × 10(-6)) and in CACNB2 (Calcium channel, voltage-dependent, β-2 subunit) gene (rs11013860, P=5.15 × 10(-5)), One SNP nearby the rs1938526 SNP of ANK3 gene and another SNP nearby the SNP rs11720452 in chromosome 3 reported in previous GWA studies also showed suggestive association in this study (P=6.55 × 10(-5) and P=1.48 × 10(-5), respectively). This may suggest that there are common and population-specific susceptibility genes for bipolar I disorder.
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- Authors
- Lee, M. T. M., Chen, C. H., Lee, C. S., Chen, C. C., Chong, M. Y., Ouyang, W. C., Chiu, N. Y., Chuo, L. J., Chen, C. Y., Tan, H. K. L., Lane, H. Y., Chang, T. J., Lin, C. H., Jou, S. H., Hou, Y. M., Feng, J., Lai, T. J., Tung, C. L., Chen, T. J., Chang, C. J., Lung, F. W., Chen, C. K., Shiah, I. S., Liu, C. Y., Teng, P. R., Chen, K. H., Shen, L. J., Cheng, C. S., Chang, T. P., Li, C. F., Chou, C. H., Chen, C. Y., Wang, K. H. T., Fann, C. S. J., Wu, J. Y., Chen, Y. T., & Cheng, A. T. A.
- Affiliations
- China Medical University (TW)
- Chang Gung University (TW)
- Jianan Mental Hospital (TW)
- Changhua Christian Hospital (TW)
- Taichung Veterans General Hospital (TW)
- Tao Yuan General Hospital (TW)
- China Medical University Hospital (TW)
- Kaohsiung Municipal Kai-Syuan Psychiatric Hospital (TW)
- Chia-Yi Christian Hospital (TW)
- Far Eastern Memorial Hospital (TW)
- Chung Shan Medical University Hospital (TW)
- E-Da Hospital (TW)
- Cathay General Hospital (TW)
- Zuoying Armed Forces General Hospital (TW)
- Tri-Service General Hospital (TW)
- Chang Bing Show Chwan Memorial Hospital (TW)
- Taipei City Hospital (TW)
- Kaohsiung Medical University Chung-Ho Memorial Hospital (TW)
- Institute of Biomedical Sciences, Academia Sinica (TW)
- Corresponding author
- Cheng, A T A
- ORCID
- Venue
- Molecular Psychiatry
- Published
- 2010-04-13
- Volume
- 16
- Issue
- 5
- Pages
- 548-556
- ISSN
- 1359-4184 (ISSN-L)
- 1476-5578
- OpenAlex
- W2040863019
- Cited by
- 157
- References
- 35
- Citations by year
- 2026: 2 · 2025: 8 · 2024: 4 · 2023: 3 · 2022: 7 · 2021: 7 · 2020: 9 · 2019: 15 · 2018: 5 · 2017: 9 · 2016: 17 · 2015: 10 · 2014: 13 · 2013: 15 · 2012: 15
- FWCI
- 10.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- bipolar I disorder, Han Chinese, single nucleotide polymorphisms, genetic susceptibility, Sp8, ST8SIA2, KCTD12, CACNB2, ANK3, replication
- MeSH terms
- Bipolar Disorder, DNA-Binding Proteins, Female, Genotype, Humans, Male, Phenotype, Proteins, Sialyltransferases, Transcription Factors, Reproducibility of Results, Odds Ratio, Ankyrins, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Calcium Channels, L-Type, Asian People, Genome-Wide Association Study
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