Cited by 274Schizophrenia research and treatmentNeurotransmitter Receptor Influence on BehaviorPharmacogenetics and Drug Metabolism

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Effects of the catechol-O-methyltransferase Val158Met polymorphism on executive function: a meta-analysis of the Wisconsin Card Sort Test in schizophrenia and healthy controls

Barnett, J H, Jones, P B, Robbins, T W, Müller, U·2007·Molecular Psychiatry

DOI 10.1038/sj.mp.4001973

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Abstract

The catechol-O-methyltransferase (COMT) Val(158)Met polymorphism is hypothesized to affect executive function in patient and control populations. Studies inconsistently report better performance on the Wisconsin Card Sort Test (WCST) in individuals with one or more Met alleles. We conducted a meta-analysis of studies published until August 2006 that reported WCST perseverative errors from healthy volunteers or patients with schizophrenia-spectrum disorders. Twelve studies met inclusion criteria (total n=1910) providing 10 samples each of patients and controls. In healthy controls, individuals with the Met/Met genotype performed better than those with the Val/Val genotype (d=0.29; 95% confidence interval (CI) 0.02-0.55; P=0.03), but this was not supported in the patient sample (d=-0.07; 95% CI -0.40 to 0.26; P=0.68). Post hoc analyses suggested that Val and Met alleles are codominant in their effects on cognition. Effect size was greater in studies published at an earlier date and may also be larger in non-Caucasian samples. Gender did not affect the results. There was no evidence of publication bias. We conclude that there is small but significant relationship between Val(158)Met genotype and executive function in healthy individuals but not in schizophrenia.

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Authors: Barnett, J. H., Jones, P. B., Robbins, T. W., & Müller, U.
Affiliations: University of Cambridge (GB)
Corresponding author: Barnett, J H
ORCID: Barnett, J H
Jones, P B
Robbins, T W
Venue: Molecular Psychiatry
Publisher: Springer Science and Business Media LLC
Published: 2007-02-27
Volume: 12
Issue: 5
Pages: 502-509
ISSN: 1359-4184 (ISSN-L)
1476-5578
DOI: 10.1038/sj.mp.4001973
OpenAlex: W1982342057
Cited by: 274
References: 65
Citations by year: 2026: 3 · 2025: 4 · 2024: 8 · 2023: 2 · 2022: 8 · 2021: 7 · 2020: 8 · 2019: 11 · 2018: 10 · 2017: 11 · 2016: 14 · 2015: 17 · 2014: 18 · 2013: 26 · 2012: 23
FWCI: 3.93
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Molecular Psychiatry (publishedVersion)
PubMed (publishedVersion)
Funders: Stanley Medical Research Institute
Medical Research Council
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
Keywords: catechol-O-methyltransferase, COMT Val158Met polymorphism, executive function, Wisconsin Card Sorting Test, perseverative errors, schizophrenia, schizophrenia spectrum disorders, genetic association, cognitive performance, healthy controls
MeSH terms: Catechol O-Methyltransferase, Cognition, Female, Gene Frequency, Humans, Male, Neuropsychological Tests, Problem Solving, Reaction Time, Reference Values, Schizophrenia, Case-Control Studies, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide

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Effects of the catechol-O-methyltransferase Val158Met polymorphism on executive function: a meta-analysis of the Wisconsin Card Sort Test in schizophrenia and healthy controls

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