Cited by 274Schizophrenia research and treatmentNeurotransmitter Receptor Influence on BehaviorPharmacogenetics and Drug Metabolism

The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.

Effects of the catechol-O-methyltransferase Val158Met polymorphism on executive function: a meta-analysis of the Wisconsin Card Sort Test in schizophrenia and healthy controls

Barnett, J H, Jones, P B, Robbins, T W, Müller, U·2007·Molecular Psychiatry

DOI 10.1038/sj.mp.4001973

Open this paper in CoChat — free account

Abstract

The catechol-O-methyltransferase (COMT) Val(158)Met polymorphism is hypothesized to affect executive function in patient and control populations. Studies inconsistently report better performance on the Wisconsin Card Sort Test (WCST) in individuals with one or more Met alleles. We conducted a meta-analysis of studies published until August 2006 that reported WCST perseverative errors from healthy volunteers or patients with schizophrenia-spectrum disorders. Twelve studies met inclusion criteria (total n=1910) providing 10 samples each of patients and controls. In healthy controls, individuals with the Met/Met genotype performed better than those with the Val/Val genotype (d=0.29; 95% confidence interval (CI) 0.02-0.55; P=0.03), but this was not supported in the patient sample (d=-0.07; 95% CI -0.40 to 0.26; P=0.68). Post hoc analyses suggested that Val and Met alleles are codominant in their effects on cognition. Effect size was greater in studies published at an earlier date and may also be larger in non-Caucasian samples. Gender did not affect the results. There was no evidence of publication bias. We conclude that there is small but significant relationship between Val(158)Met genotype and executive function in healthy individuals but not in schizophrenia.

Integrity signals

Registry

Crossref · 10.1038/sj.mp.4001973

Cites

65 of 65 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Measuring inconsistency in meta-analyses
Higgins, J. P. T., Thompson, S. G., Deeks, J. J., & Altman, D. G. (2003) · BMJ · doi:10.1136/bmj.327.7414.557 · Cited by 63,139
Bias in meta-analysis detected by a simple, graphical test
Egger, M., Smith, G. D., Schneider, M., & Minder, C. (1997) · BMJ · doi:10.1136/bmj.315.7109.629 · Cited by 56,722
Effect of COMT Val 108/158 Met genotype on frontal lobe function and risk for schizophrenia
Egan, M. F., Goldberg, T. E., Kolachana, B. S., Callicott, J. H., Mazzanti, C. M., Straub, R. E., Goldman, D. A., & Weinberger, D. R. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.111134598 · Cited by 2,416
A simple objective technique for measuring flexibility in thinking
Berg, E. A. (1948) · The Journal of General Psychology · doi:10.1080/00221309.1948.9918159 · Cited by 2,255
22q11.2 deletion syndrome
McDonald-McGinn, D. M., Sullivan, K. E., Marino, B., Philip, N., Swillen, A., Vorstman, J. A. S., Zackai, E. H., Emanuel, B. S., Vermeesch, J. R., Morrow, B. E., et al. (2015) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2015.71 · Cited by 2,236
Physiologic Dysfunction of Dorsolateral Prefrontal Cortex in Schizophrenia
Weinberger, D. R. (1986) · Archives of General Psychiatry · doi:10.1001/archpsyc.1986.01800020020004 · Cited by 2,025
Replication validity of genetic association studies
Ioannidis, J. P. A., Ntzani, E., Trikalinos, T. A., & Contopoulos‐Ioannidis, D. G. (2001) · Nature Genetics · doi:10.1038/ng749 · Cited by 1,834
Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: A hypothesis for the etiology of schizophrenia
Grace, A. A. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90196-u · Cited by 1,831
Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders
Lachman, H. M., Papolos, D. F., Saito, T., Yu, Y.-M., Szumlanski, C. L., & Weinshilboum, R. M. (1996) · Pharmacogenetics · doi:10.1097/00008571-199606000-00007 · Cited by 1,788
Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): effects on mRNA, protein, and enzyme activity in postmortem human brain
Chen, J., Lipska, B. K., Halim, N., Ma, Q. D., Matsumoto, M., Melhem, S., Kolachana, B. S., Hyde, T. M., Herman, M. M., Apud, J., et al. (2004) · The American Journal of Human Genetics · doi:10.1086/425589 · Cited by 1,675

Show all 65 references

Sorted by citations

Unity and diversity of executive functions: Individual differences as a window on cognitive structure
Friedman, N. P., & Miyake, A. (2017) · Cortex · doi:10.1016/j.cortex.2016.04.023 · Cited by 1,834
Inverted-U–Shaped Dopamine Actions on Human Working Memory and Cognitive Control
Cools, R., & D'Esposito, M. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.03.028 · Cited by 1,673
Handbook of adult resilience
Reich, J. W., Zautra, A., & Hall, J. S. (2010) · Cited by 1,291
Gene-Environment Interactions in Schizophrenia: Review of Epidemiological Findings and Future Directions
van Os, J., Rutten, B. P., & Poulton, R. (2008) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn117 · Cited by 713
The Dual-State Theory of Prefrontal Cortex Dopamine Function with Relevance to Catechol-O-Methyltransferase Genotypes and Schizophrenia
Durstewitz, D., & Seamans, J. K. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.05.015 · Cited by 586
Cognitive Control Deficits in Schizophrenia: Mechanisms and Meaning
Lesh, T. A., Niendam, T. A., Minzenberg, M., & Carter, C. S. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.156 · Cited by 522
The neural and genetic basis of executive function: Attention, cognitive flexibility, and response inhibition
Logue, S. F., & Gould, T. J. (2014) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.08.007 · Cited by 477
A Possible Role for the Striatum in the Pathogenesis of the Cognitive Symptoms of Schizophrenia
Simpson, E. H., Kellendonk, C., & Kandel, E. (2010) · Neuron · doi:10.1016/j.neuron.2010.02.014 · Cited by 478
Neural substrates of pleiotropic action of genetic variation in COMT: a meta-analysis
Mier, D., Kirsch, P., & Meyer-Lindenberg, A. (2010) · Molecular Psychiatry · doi:10.1038/mp.2009.36 · Cited by 464
Human aging magnifies genetic effects on executive functioning and working memory
Nagel, I. E. (2008) · Frontiers in Human Neuroscience · doi:10.3389/neuro.09.001.2008 · Cited by 415
Neuroplasticity of Neocortical Circuits in Schizophrenia
Lewis, D. A., & González‐Burgos, G. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301563 · Cited by 372
Catechol-O-Methyltransferase (COMT): A Gene Contributing to Sex Differences in Brain Function, and to Sexual Dimorphism in the Predisposition to Psychiatric Disorders
Harrison, P. J., & Tunbridge, E. M. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301543 · Cited by 308
Neurobehavioral evidence for changes in dopamine system activity during adolescence
Wahlstrom, D., White, T., & Luciana, M. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.12.007 · Cited by 277
“This effect has been demonstrated and replicated in healthy volunteers and schizophrenic patients (Bilder et al., 2002; Egan et al., 2001; Mattay et al., 2003; though for a recent meta-analysis that suggests the effect of COMT holds in healthy control samples only, see Barnett et al., 2007a,b).”
BackgroundResult
Site-Specific Role of Catechol- O -Methyltransferase in Dopamine Overflow within Prefrontal Cortex and Dorsal Striatum
Yavich, L., Forsberg, M., Karayiorgou, M., Gogos, J. A., & Männistö, P. T. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0665-07.2007 · Cited by 269
Genes, cognition and brain through a COMT lens
Dickinson, D., & Elvevåg, B. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.05.014 · Cited by 259
Age-related decline in brain resources magnifies genetic effects on cognitive functioning
Lindenberger, U. (2008) · Frontiers in Neuroscience · doi:10.3389/neuro.01.039.2008 · Cited by 233
Genetic variation in dopaminergic neuromodulation influences the ability to rapidly and flexibly adapt decisions
Krugel, L. K., Biele, G., Mohr, P. N. C., Li, S.-C., & Heekeren, H. R. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0905191106 · Cited by 229
Dopaminergic control of cognitive flexibility in humans and animals
Klanker, M., Feenstra, M., & Denys, D. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00201 · Cited by 209
Botox for the brain: enhancement of cognition, mood and pro-social behavior and blunting of unwanted memories
de Jongh, R., Bolt, I. L. L. E., Schermer, M., & Olivier, B. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2007.12.001 · Cited by 198
Quantitative role of COMT in dopamine clearance in the prefrontal cortex of freely moving mice
Käenmäki, M., Tammimäki, A., Myöhänen, T. T., Pakarinen, K., Amberg, C., Karayiorgou, M., Gogos, J. A., & Männistö, P. T. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06889.x · Cited by 188
The partisan mind: Is extreme political partisanship related to cognitive inflexibility?
Zmigrod, L., Rentfrow, P. J., & Robbins, T. W. (2019) · Journal of Experimental Psychology General · doi:10.1037/xge0000661 · Cited by 172
Self-citation
Neuropharmacology of performance monitoring
Jocham, G., & Ullsperger, M. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.08.011 · Cited by 177
Influence of the COMT genotype on working memory and brain activity changes during development
Dumontheil, I., Roggeman, C., Ziermans, T., Peyrard-Janvid, M., Matsson, H., Kere, J., & Klingberg, T. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.02.027 · Cited by 165
Catechol-O-methyltransferase gene polymorphism and chronic human pain
Tammimäki, A., & Männistö, P. T. (2012) · Pharmacogenetics and Genomics · doi:10.1097/fpc.0b013e3283560c46 · Cited by 162
Genetic and vascular modifiers of age-sensitive cognitive skills: Effects of COMT, BDNF, ApoE, and hypertension.
Raz, N., Rodrigue, K. M., Kennedy, K. M., & Land, S. J. (2009) · Neuropsychology · doi:10.1037/a0013487 · Cited by 141
A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB
Need, A. C., Attix, D. K., McEvoy, J. M., Cirulli, E. T., Linney, K. L., Hunt, P., Ge, D., Heinzen, E. L., Maia, J. M., Shianna, K. V., et al. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp413 · Cited by 135
The flexible mind is associated with the catechol-O-methyltransferase (COMT) Val158Met polymorphism: Evidence for a role of dopamine in the control of task-switching
Colzato, L. S., Waszak, F., Nieuwenhuis, S., Danielle Posthuma, B., & Hommel, B. (2010) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2010.04.023 · Cited by 132
COMT genetic variation affects fear processing: Psychophysiological evidence.
Montag, C., Buckholtz, J. W., Hartmann, P., Merz, M., Burk, C. L., Hennig, J., & Reuter, M. (2008) · Behavioral Neuroscience · doi:10.1037/0735-7044.122.4.901 · Cited by 128
Meta-analysis of association between genetic variants in COMT and schizophrenia: An update
Okochi, T., Ikeda, M., Kishi, T., Kawashima, K., Kinoshita, Y., Kitajima, T., Yamanouchi, Y., Tomita, M., Inada, T., Ozaki, N., et al. (2009) · Schizophrenia Research · doi:10.1016/j.schres.2009.02.019 · Cited by 126
The neural underpinnings of cognitive flexibility and their disruption in psychotic illness
Waltz, J. A. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2016.06.005 · Cited by 122
“…appear to exhibit a more flexible learning rate, and, thus, more rapid updating, in the context of a PRL-like task (Krugel et al., 2009), Val/Val individuals also, by and large, show worse WCST performance than Met/Met carriers (Egan et al., 2001, Malhotra et al., 2002, Barnett et al., 2007).”
Background
Intermediate: Cognitive phenotypes in bipolar disorder
Langenecker, S. A., Saunders, E. F. H., Kade, A. M., Ransom, M. T., & McInnis, M. G. (2009) · Journal of Affective Disorders · doi:10.1016/j.jad.2009.08.018 · Cited by 107
Cognitive Impairment in Parkinson’s Disease: Epidemiology, Clinical Profile, Protective and Risk Factors
González-Latapí, P., Bayram, E., Litvan, I., & Marras, C. (2021) · Behavioral Sciences · doi:10.3390/bs11050074 · Cited by 128
Candidate genes and neuropsychological phenotypes in children with ADHD: review of association studies
Kébir, O., Tabbane, K., Sengupta, S. M., & Joober, R. (2009) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0913 · Cited by 98
Further evidence for high rates of schizophrenia in 22q11.2 deletion syndrome
Monks, S., Niarchou, M., Davies, A. R., Walters, J. T. R., Williams, N., Owen, M. J., van den Bree, M. B. M., & Murphy, K. C. (2014) · Schizophrenia Research · doi:10.1016/j.schres.2014.01.020 · Cited by 93
MTHFR 677C → T genotype disrupts prefrontal function in schizophrenia through an interaction with COMT 158Val → Met
Roffman, J. L., Gollub, R. L., Calhoun, V. D., Wassink, T. H., Weiss, A. P., Ho, B., White, T. J. H., Clark, V. P., Fries, J. F., Andreasen, N. C., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803727105 · Cited by 98
Neonatal pain and COMT Val158Met genotype in relation to serotonin transporter (SLC6A4) promoter methylation in very preterm children at school age
Chau, C. M. Y., Ranger, M., Sulistyoningrum, D. C., Devlin, A. M., Oberlander, T. F., & GRUNAU, R. E. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00409 · Cited by 95
COMT, neuropsychological function and brain structure in schizophrenia: a systematic review and neurobiological interpretation
Ira, E., Zanoni, M., Ruggeri, M., Dazzan, P., & Tosato, S. (2013) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.120178 · Cited by 90
Is Heart Rate Variability Related to Memory Performance in Middle-Aged Men?
Shah, A. J., Su, S., Veledar, E., Bremner, J. D., Goldstein, F. C., Lampert, R. J., Goldberg, J. H., & Vaccarino, V. (2011) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3182227d6a · Cited by 93
Children under stress–COMT genotype and stressful life events predict cortisol increase in an acute social stress paradigm
Armbruster, D., Mueller, A., Strobel, A., Lesch, K.-P., Brocke, B., & Kirschbaum, C. (2012) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145711001763 · Cited by 87
Planning, decision-making and the COMT rs4818 polymorphism in healthy males
Roussos, P., Giakoumaki, S. G., Pavlakis, S., & Bitsios, P. (2008) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2007.10.009 · Cited by 85
Risk Factors Associated With Metabolic Syndrome in Bipolar and Schizophrenia Subjects Treated With Antipsychotics: The Role of Folate Pharmacogenetics
Ellingrod, V. L., Taylor, S. F., Dalack, G., Grove, T. B., Bly, M. J., Brook, R. D., Zöllner, S. K., & Pop-Busui, R. (2012) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e3182485888 · Cited by 84
COMT val158met Genotype Affects Recruitment of Neural Mechanisms Supporting Fluid Intelligence
Bishop, S. J., Fossella, J., Croucher, C. J., & Duncan, J. (2008) · Cerebral Cortex · doi:10.1093/cercor/bhm240 · Cited by 84
Effect of abstinence challenge on brain function and cognition in smokers differs by COMT genotype
Loughead, J., Wileyto, E. P., Valdez, J. N., Sanborn, P. M., Tang, K., Strasser, A. A., Ruparel, K., Ray, R., Gur, R. C., & Lerman, C. E. (2008) · Molecular Psychiatry · doi:10.1038/mp.2008.132 · Cited by 80
Opioid neuropeptide genotypes in relation to heroin abuse: Dopamine tone contributes to reversed mesolimbic proenkephalin expression
Nikoshkov, A., Drakenberg, K., Wang, X., Horváth, M., Keller, É., & Hurd, Y. L. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0710902105 · Cited by 79
Effect of COMT val158met genotype on cognition and personality
Sheldrick, A. J., Krug, A., Markov, V., Leube, D., Michel, T. M., Zerres, K., Eggermann, T., & Kircher, T. T. J. (2008) · European Psychiatry · doi:10.1016/j.eurpsy.2008.05.002 · Cited by 78
The brain-in-motion study: effect of a 6-month aerobic exercise intervention on cerebrovascular regulation and cognitive function in older adults
Tyndall, A. V., Davenport, M. H., Wilson, B., Burek, G. M., Arsenault‐Lapierre, G., Haley, E., Eskes, G. A., Friedenreich, C. M., Hill, M. D., Hogan, D. B., et al. (2013) · BMC Geriatrics · doi:10.1186/1471-2318-13-21 · Cited by 81
Prefrontal Dopamine Levels Determine the Balance between Cognitive Stability and Flexibility
Fallon, S. J., Williams‐Gray, C. H., Barker, R., Owen, A. M., & Hampshire, A. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhs025 · Cited by 82
A Meta-Analysis of the Val158Met COMT Polymorphism and Violent Behavior in Schizophrenia
Singh, J. P., Volavka, J., Czobor, P., & Dorn, R. A. V. (2012) · PLoS ONE · doi:10.1371/journal.pone.0043423 · Cited by 70
Putative role of the COMT gene polymorphism (Val158Met) on verbal working memory functioning in a healthy population
Aguilera, M., Barrantes‐Vidal, N., Arias, B., Moya, J., Villa, H., Ibáñez, M. I., Ruipérez, M. A., Ortet, G., & Fañanás, L. (2008) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30705 · Cited by 70
Modifying Effect of COMT Gene Polymorphism and a Predictive Role for Proteomics Analysis in Children’s Intelligence in Endemic Fluorosis Area in Tianjin, China
Zhang, S., Zhang, X., Liu, H., Qu, W., Guan, Z., Zeng, Q., Jiang, C., Gao, H. Y., Zhang, C., Lei, R., et al. (2015) · Toxicological Sciences · doi:10.1093/toxsci/kfu311 · Cited by 70
Cognitive flexibility and religious disbelief
Zmigrod, L., Rentfrow, P. J., Zmigrod, S., & Robbins, T. W. (2018) · Psychological Research · doi:10.1007/s00426-018-1034-3 · Cited by 76
Self-citation
Catechol-O-Methyltransferase and Pain
Kambur, O., & Männistö, P. T. (2010) · International review of neurobiology · doi:10.1016/b978-0-12-381326-8.00010-7 · Cited by 70
Genetics of emotion
Bevilacqua, L. M., & Goldman, D. A. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.07.009 · Cited by 70
Opposite Effects of Catechol-O-Methyltransferase Val158Met on Cortical Function in Healthy Subjects and Patients with Schizophrenia
Prata, D. P., Mechelli, A., Fu, C. H. Y., Picchioni, M., Kane, F., Kalidindi, S., McDonald, C., Howes, O. D., Kravariti, E., Demjaha, A., et al. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.09.027 · Cited by 66
Are genetic variants of COMT associated with addiction?
Tammimäki, A., & Männistö, P. T. (2010) · Pharmacogenetics and Genomics · doi:10.1097/fpc.0b013e328340bdf2 · Cited by 67
COMT genotype affects prefrontal white matter pathways in children and adolescents
Thomason, M. E., Dougherty, R. F., Colich, N. L., Perry, L. M., Rykhlevskaia, E. I., Louro, H. M. C., Hallmayer, J. F., Waugh, C. E., Bammer, R., Glover, G. H., et al. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.01.033 · Cited by 67
Polymorphisms in dopamine system genes are associated with individual differences in attention in infancy.
Holmboe, K., Nemoda, Z., Fearon, P. R. M., Csibra, G., Sasvári‐Székely, M., & Johnson, M. H. (2010) · Developmental Psychology · doi:10.1037/a0018180 · Cited by 69
The Genetic Basis of Cognitive Impairment and Dementia in Parkinson’s Disease
Collins, L., & Williams‐Gray, C. H. (2016) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2016.00089 · Cited by 64
Importance of the COMT Gene for Sex Differences in Brain Function and Predisposition to Psychiatric Disorders
Tunbridge, E. M., & Harrison, P. J. (2010) · Current topics in behavioral neurosciences · doi:10.1007/7854_2010_97 · Cited by 61
Prefrontal executive function and D1, D3, 5-HT2A and 5-HT6 receptor gene variations in healthy adults
Lane, H., Liu, Y.-C., Huang, C., Hsieh, C. L., Chang, Y.-L., Chang, L., Chang, Y.-C., & Chang, W. (2008) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0807 · Cited by 58
Catechol-O-Methyltransferase (COMT) Val158Met Genotype is Associated with BOLD Response as a Function of Task Characteristic
Ettinger, U., Kumari, V., Collier, D. A., Powell, J. F., Luzi, S., Michel, T. M., Zedomi, O., & Williams, S. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301658 · Cited by 59
Genetic associations with performance on a behavioral measure of distress intolerance
Amstadter, A. B., Daughters, S. B., MacPherson, L., Reynolds, E. K., Danielson, C. K., Wang, F. M., Potenza, M. N., Gelernter, J. E., & Lejuez, C. W. (2011) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2011.09.017 · Cited by 60
Tolcapone enhances food-evoked dopamine efflux and executive memory processes mediated by the rat prefrontal cortex
Lapish, C. C., Ahn, S., Evangelista, L., So, K., Seamans, J. K., & Phillips, A. G. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1342-1 · Cited by 60
DRD3, but not COMT or DRD2, genotype affects executive functions in healthy and first‐episode psychosis adolescents
Bombín, I., Arango, C., Mayoral, M., Castro‐Fornieles, J., González-Pinto, A. M., Gonzalez‐Gomez, C., Moreno, D. M., Parellada, M., Baeza, I., Graell, M., et al. (2008) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30710 · Cited by 60
Effects of dopamine‐related gene–gene interactions on working memory component processes
Stelzel, C., Basten, U., Montag, C., Reuter, M., & Fiebach, C. J. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06647.x · Cited by 61
4 A Systems Approach to the Aging Brain: Neuroanatomic Changes, Their Modifiers, and Cognitive Correlates
Raz, N., & Kennedy, K. M. (2009) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780195328875.003.0004 · Cited by 61
Catechol-O-methyltransferase Val158Met polymorphism associates with individual differences in sleep physiologic responses to chronic sleep loss
Goel, N., Banks, S., Lin, L., Mignot, E., & Dinges, D. F. (2011) · PLoS ONE · doi:10.1371/journal.pone.0029283 · Cited by 58
Association between cognitive functioning, exposure to Herpes Simplex Virus type 1, and the COMT Val158Met genetic polymorphism in adults without a psychiatric disorder
Dickerson, F., Stallings, C. R., Sullens, A., Origoni, A. E., Leister, F. J., Krivogorsky, B., & Yolken, R. H. (2008) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2008.04.156 · Cited by 58
The Ultimate Intra-/Extra-Dimensional Attentional Set-Shifting Task for Mice
Scheggia, D., Bebensee, A., Weinberger, D. R., & Papaleo, F. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.05.021 · Cited by 61
Interactive effects of COMT Val108/158Met and MTHFR C677T on executive function in schizophrenia
Roffman, J. L., Weiss, A. P., Deckersbach, T., Freudenreich, O., Henderson, D. C., Wong, D. H., Halsted, C. H., & GOFF, D. C. (2008) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30684 · Cited by 56
A review of molecular genetic studies of neurocognitive deficits in schizophrenia
Zai, G. C., Robbins, T. W., Sahakian, B. J., & Kennedy, J. L. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.10.024 · Cited by 58
Self-citation
Pharmacological and therapeutic directions in ADHD: Specificity in the PFC
Lévy, F. (2008) · Behavioral and Brain Functions · doi:10.1186/1744-9081-4-12 · Cited by 58
The impact of cafeteria diet feeding on physiology and anxiety-related behaviour in male and female Sprague–Dawley rats of different ages
Warneke, W., Klaus, S., Fink, H., Langley‐Evans, S. C., & Voigt, J. (2013) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.11.016 · Cited by 56
COMT as a Drug Target for Cognitive Functions and Dysfunctions
Scheggia, D., Sannino, S., Scattoni, M. L., & Papaleo, F. (2012) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152712800672481 · Cited by 51
COMT val158met predicts reward responsiveness in humans
Lancaster, T. M., Linden, D. E. J., & Heerey, E. A. (2012) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2012.00838.x · Cited by 52
Differential effects of COMT on gait and executive control in aging
Holtzer, R., Ozelius, L. J., Xue, X., Wang, T. C., Lipton, R. B., & Verghese, J. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.05.011 · Cited by 52
Catechol-o-methyl transferase (COMT) val158met polymorphism and adolescent cortical development in patients with childhood-onset schizophrenia, their non-psychotic siblings, and healthy controls
Raznahan, A., GREENSTEIN, D. K., Lee, Y., Long, R., CLASEN, L. S., Gochman, P., Addington, A. M., Giedd, J. N., Rapoport, J. L., & Gogtay, N. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.05.032 · Cited by 50
The Genetic Basis of Creativity
Barbot, B., & Eff, H. (2019) · Cambridge University Press eBooks · doi:10.1017/9781316979839.009 · Cited by 48
COMT and ANKK1-Taq-Ia Genetic Polymorphisms Influence Visual Working Memory
Berryhill, M. E., Wiener, M., Stephens, J. A., Lohoff, F. W., & Coslett, H. B. (2013) · PLoS ONE · doi:10.1371/journal.pone.0055862 · Cited by 57
Gene-sex interactions in schizophrenia: focus on dopamine neurotransmission
Godar, S. C., & Bortolato, M. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00071 · Cited by 46
Effects of the CACNA1C risk allele on neurocognition in patients with schizophrenia and healthy individuals
Hori, H., Yamamoto, N., Fujii, T., Teraishi, T., Sasayama, D., Matsuo, J., Kawamoto, Y., Kinoshita, Y., Ota, M., Hattori, K., et al. (2012) · Scientific Reports · doi:10.1038/srep00634 · Cited by 47
Effects of two dopamine-modulating genes (DAT1 9/10 and COMT Val/Met) on n-back working memory performance in healthy volunteers
Blanchard, M. M., Chamberlain, S. R., Roiser, J. P., Robbins, T. W., & Müller, U. (2010) · Psychological Medicine · doi:10.1017/s003329171000098x · Cited by 51
Self-citation
Differential optimal dopamine levels for set-shifting and working memory in Parkinson's disease
Fallon, S. J., Smulders, K., Esselink, R. A. J., van de Warrenburg, B. P. C., Bloem, B. R., & Cools, R. (2015) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2015.07.031 · Cited by 50
Association of COMT and COMT-DRD2 interaction with creative potential
Zhang, S., Zhang, M., & Zhang, J. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00216 · Cited by 46
Brain imaging, genetics and emotion
Aleman, A., Swart, M., & van Rijn, S. (2008) · Biological Psychology · doi:10.1016/j.biopsycho.2008.01.009 · Cited by 45
Catechol-O-methyl transferase and schizophrenia.
Šagud, M., Mück‐Šeler, D., Mihaljević-Peleš, A., Vuksan‐Ćusa, B., Živković, M., Jakovljević, M., & Pivac, N. (2010) · PubMed · Cited by 45
Dopamine and the Management of Attentional Resources: Genetic Markers of Striatal D2 Dopamine Predict Individual Differences in the Attentional Blink
Colzato, L. S., Slagter, H. A., de Rover, M., & Hommel, B. (2011) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_00049 · Cited by 46
Haplotypic and Genotypic Association of Catechol-O-Methyltransferase rs4680 and rs4818 Polymorphisms and Treatment Resistance in Schizophrenia
Šagud, M., Tudor, L., Uzun, S., Perković, M. N., Živković, M., Konjevod, M., Kozumplik, O., Ćusa, B. V., Štrac, D. Š., Radoš, I., et al. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00705 · Cited by 42
Generation and Characterization of Humanized Mice Carrying COMT158 Met/Val Alleles
Risbrough, V. B., Ji, B., Hauger, R., & Zhou, X. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.29 · Cited by 41
Predicting risk in space: genetic markers for differential vulnerability to sleep restriction
Goel, N., & Dinges, D. F. (2012) · Acta Astronautica · doi:10.1016/j.actaastro.2012.04.002 · Cited by 40
Genetic association studies of performance monitoring and learning from feedback: The role of dopamine and serotonin
Ullsperger, M. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.06.009 · Cited by 41
COMT Val158Met and cognition: main effects and interaction with educational attainment
Enoch, M., Waheed, J., Harris, C. R., Albaugh, B., & Goldman, D. A. (2008) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2008.00441.x · Cited by 40
Schizophrenia aetiology: Do gene-environment interactions hold the key?
The European Network of Schizophrenia Networks for the Study of Gene-Environment Interactions(EU-GEI) (2008) · Schizophrenia Research · doi:10.1016/j.schres.2008.04.003 · Cited by 53
Genetics and Functional Imaging: Effects of APOE, BDNF, COMT, and KIBRA in Aging
Papenberg, G., Salami, A., Persson, J., Lindenberger, U., & Bäckman, L. (2015) · Neuropsychology Review · doi:10.1007/s11065-015-9279-8 · Cited by 39
COMT polymorphism and memory dedifferentiation in old age.
Papenberg, G., Bäckman, L., Nagel, I. E., Nietfeld, W., Schröder, J., Bertram, L., Heekeren, H. R., Lindenberger, U., & Li, S. (2013) · Psychology and Aging · doi:10.1037/a0033225 · Cited by 41
Association Between Polymorphisms of the Dopamine Receptor D2 and Catechol-o-Methyl Transferase Genes and Cognitive Function
Bolton, J. L., Marioni, R. E., Deary, I. J., Harris, S. E., Stewart, M. C. W., Murray, G. D., Fowkes, F. G. R., & Price, J. F. (2010) · Behavior Genetics · doi:10.1007/s10519-010-9372-y · Cited by 39
Dopaminergic Gene Polymorphisms Affect Long-term Forgetting in Old Age: Further Support for the Magnification Hypothesis
Papenberg, G., Bäckman, L., Nagel, I. E., Nietfeld, W., Schröder, J., Bertram, L., Heekeren, H. R., Lindenberger, U., & Li, S. (2013) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_00359 · Cited by 40
Dopamine genes and schizophrenia: case closed or evidence pending?
Talkowski, M. E., Bamne, M., Mansour, H. A., & Nimgaonkar, V. (2007) · Schizophrenia bulletin · doi:10.1093/schbul/sbm076 · Cited by 39
Genetic moderation of the effects of cannabis: Catechol-O-methyltransferase (COMT) affects the impact of Δ 9 -tetrahydrocannabinol (THC) on working memory performance but not on the occurrence of psychotic experiences
Tunbridge, E. M., Dunn, G., Murray, R. M., Evans, N., Lister, R., Stumpenhorst, K., Harrison, P. J., Morrison, P. D., & Freeman, D. H. (2015) · Journal of Psychopharmacology · doi:10.1177/0269881115609073 · Cited by 37
COMT and MTHFR polymorphisms interaction on cognition in schizophrenia: An exploratory study
Kontis, D., Theochari, E., Fryssira, H., Kleisas, S., Sofocleous, C., Andreopoulou, A., Kalogerakou, S., Gazi, A., Boniatsi, L., Chaidemenos, A., et al. (2013) · Neuroscience Letters · doi:10.1016/j.neulet.2013.01.012 · Cited by 36

Authors: Barnett, J. H., Jones, P. B., Robbins, T. W., & Müller, U.
Affiliations: University of Cambridge (GB)
Corresponding author: Barnett, J H
ORCID: Barnett, J H
Jones, P B
Robbins, T W
Venue: Molecular Psychiatry
Publisher: Springer Science and Business Media LLC
Published: 2007-02-27
Volume: 12
Issue: 5
Pages: 502-509
ISSN: 1359-4184 (ISSN-L)
1476-5578
DOI: 10.1038/sj.mp.4001973
OpenAlex: W1982342057
Cited by: 274
References: 65
Citations by year: 2026: 3 · 2025: 4 · 2024: 8 · 2023: 2 · 2022: 8 · 2021: 7 · 2020: 8 · 2019: 11 · 2018: 10 · 2017: 11 · 2016: 14 · 2015: 17 · 2014: 18 · 2013: 26 · 2012: 23
FWCI: 3.93
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Molecular Psychiatry (publishedVersion)
PubMed (publishedVersion)
Funders: Stanley Medical Research Institute
Medical Research Council
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
Keywords: catechol-O-methyltransferase, COMT Val158Met polymorphism, executive function, Wisconsin Card Sorting Test, perseverative errors, schizophrenia, schizophrenia spectrum disorders, genetic association, cognitive performance, healthy controls
MeSH terms: Catechol O-Methyltransferase, Cognition, Female, Gene Frequency, Humans, Male, Neuropsychological Tests, Problem Solving, Reaction Time, Reference Values, Schizophrenia, Case-Control Studies, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Effects of the catechol-O-methyltransferase Val158Met polymorphism on executive function: a meta-analysis of the Wisconsin Card Sort Test in schizophrenia and healthy controls

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks